Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population

Journal of Neuroimmunology

Volumn 274, Issue 1-2, 2014, Pages 180-184

  Zhu, Xi Chen ^a   Tan, Lan ^a,b,c   Jiang, Teng ^a   Tan, Meng Shan ^c   Zhang, Wei ^b   Yu, Jin Tai ^a,b,c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Alzheimer's disease; Association; Gene; IL 12; Polymorphism; Pro inflammatory cytokine

Indexed keywords

INTERLEUKIN 12P35; INTERLEUKIN 12P40;

AGED; ALZHEIMER DISEASE; ARTICLE; CHINESE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOSITY; HIGH RISK POPULATION; HUMAN; IL12A GENE; IL12B GENE; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; ONSET AGE; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALZHEIMER'S DISEASE; ASSOCIATION; GENE; IL-12; POLYMORPHISM; PRO-INFLAMMATORY CYTOKINE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-12 SUBUNIT P40; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84906937437     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.06.026     Document Type: Article

References (29)

1. Alloza I., Heggarty S., Goris A., Graham C.A., Dubois B., McDonnell G., et al. Interleukin-12 p40 polymorphism and susceptibility to multiple sclerosis. Ann. Neurol. 2002, 52:524-525.
2. Alvarez-Rodriguez L., Martinez-Taboada V.M., Lopez-Hoyos M., Mata C., Fernandez Prieto L., Agudo-Bilbao M., et al. Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis. Clin. Exp. Rheumatol. 2009, 27:S14-S18.
3. Cargill M., Schrodi S.J., Chang M., Garcia V.E., Brandon R., Callis K.P., et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 2007, 80:273-290.
4. Chen X., Han S., Wang S., Zhou X., Zhang M., Dong J., et al. Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. Clin. Cancer Res. 2009, 15:400-405.
5. Chen T., Liang W., Gao L., Wang Y., Liu Y., Zhang L. Association of single nucleotide polymorphisms in interleukin 12 (IL-12A and -B) with asthma in a Chinese population. Hum. Immunol. 2011, 72:603-606.
6. Deniz-Naranjo M.C., Munoz-Fernandez C., Alemany-Rodriguez M.J., Perez-Vieitez M.C., Aladro-Benito Y., Irurita-Latasa J., et al. Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain. Eur. J. Neurol. Off. J. Eur. Fed. Neurol. Soc. 2008, 15:1080-1084.
7. Jiang T., Yu J.T., Tan L. Novel disease-modifying therapies for Alzheimer's disease. J. Alzheimers Dis. 2012, 31:475-492.
8. Jiang T., Yu J.T., Tian Y., Tan L. Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors. Curr. Alzheimer Res. 2013, 10:852-867.
9. Jiang T., Yu J.T., Tan M.S., Wang H.F., Wang Y.L., Zhu X.C., et al. Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese. Neurobiol. Aging 2014, 35:934. (e1-3).
10. Li J., Gran B., Zhang G.X., Ventura E.S., Siglienti I., Rostami A., et al. Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia. J. Neurol. Sci. 2003, 215:95-103.
11. Li L.J., Pan X.M., Sima X., Li Z.H., Zhang L.S., Sun H., et al. Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm. Mol. Biol. Rep. 2012, 39:11217-11223.
12. Liu L., Xu Y., Liu Z., Chen J., Zhang Y., Zhu J., et al. IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population. Int. J. Cancer 2011, 128:1692-1696.
13. Liu Y., Yu J.T., Zhang W., Zong Y., Lu R.C., Zhou J., et al. Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese. J. Neuroimmunol. 2014, 271:43-48.
14. McGeer P.L., McGeer E.G. Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Arch. Neurol. 2001, 58:1790-1792.
15. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
16. Moons L.M., Kusters J.G., van Delft J.H., Kuipers E.J., Gottschalk R., Geldof H., et al. A pro-inflammatory genotype predisposes to Barrett's esophagus. Carcinogenesis 2008, 29:926-931.
17. Stanilova S., Miteva L. Taq-I polymorphism in 3'UTR of the IL-12B and association with IL-12p40 production from human PBMC. Genes Immun. 2005, 6:364-366.
18. Tan M.S., Yu J.T., Jiang T., Zhu X.C., Wang H.F., Zhang W., et al. NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese. J. Neuroimmunol. 2013, 265:91-95.
19. Tan M.S., Yu J.T., Jiang T., Zhu X.C., Guan H.S., Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J. Alzheimers Dis. 2014, 38:633-646.
20. Town T., Tan J., Flavell R.A., Mullan M. T-cells in Alzheimer's disease. Neruomol. Med. 2005, 7:255-264.
21. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003, 3:133-146.
22. Vom Berg J., Prokop S., Miller K.R., Obst J., Kalin R.E., Lopategui-Cabezas I., et al. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nat. Med. 2012, 18:1812-1819.
23. Wysocka M., Kubin M., Vieira L.Q., Ozmen L., Garotta G., Scott P., et al. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 1995, 25:672-676.
24. Xia M., Yu J.T., Miao D., Lu R.C., Zheng X.P., Tan L. SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population. J. Neurol. Sci. 2013, 336:48-51.
25. Xu S., Yin X., Li S., Jin W., Lou H., Yang L., et al. Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am. J. Hum. Genet. 2009, 85:762-774.
26. Youssef S.S., Abd El Aal A.M., Nasr A.S., el Zanaty T., Seif S.M. Interleukin-12B gene polymorphism frequencies in Egyptians and sex-related susceptibility to hepatitis C infection. J. Interf. Cytokine Res. Off. J. Int. Soc. Interferon Cytokine Res. 2013, 33:415-419.
27. Yu J.T., Tan L., Song J.H., Sun Y.P., Chen W., Miao D., et al. Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease. Brain Res. 2009, 1253:169-175.
28. Yu J.T., Song J.H., Ma T., Zhang W., Yu N.N., Xuan S.Y., et al. Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese. J. Neurol. Sci. 2011, 300:78-80.
29. Yu J.T., Song J.H., Wang N.D., Wu Z.C., Zhang Q., Zhang N., et al. Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's disease. Neurobiol. Aging 2012, 33:1014. (e11-4).