Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions

Journal of Tissue Engineering and Regenerative Medicine

Volumn 8, Issue 9, 2014, Pages 682-693

  Lode, Anja ^a,b   Meissner, Katrin ^c   Luo, Yongxiang ^a,b   Sonntag, Frank ^c   Glorius, Stefan ^d   Nies, Berthold ^d   Vater, Corina ^a,b   Despang, Florian ^a,b   Hanke, Thomas ^b   Gelinsky, Michael ^a,b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c FRAUNHOFER INSTITUTE FOR MATERIAL AND BEAM TECHNOLOGY IWS   (Germany)

^d InnoTERE GmbH   (Germany)

Author keywords

Bone marrow stromal cells; Bone tissue engineering; Calcium phosphate cement; Free form fabrication; Mesenchymal stem cells; Rapid prototyping; Scaffold

Indexed keywords

BIOCOMPATIBILITY; BONE; BONE CEMENT; CALCIUM PHOSPHATE; CELL CULTURE; CELL ENGINEERING; COMPRESSIVE STRENGTH; HYDROXYAPATITE; MECHANICAL STABILITY; RAPID PROTOTYPING; SCAFFOLDS (BIOLOGY); SOLUTIONS; STEM CELLS;

BONE MARROW STROMAL CELLS; BONE TISSUE ENGINEERING; CALCIUM PHOSPHATE BONE CEMENT; CALCIUM PHOSPHATE CEMENT; CONDITION; FREEFORM FABRICATION; MESENCHYMAL STEM CELL; PASTE-LIKE; POROUS SCAFFOLD; RAPID-PROTOTYPING;

FABRICATION;

BONE CEMENT; CALCIUM PHOSPHATE;

AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CELL CULTURE; COMPRESSIVE STRENGTH; CONTROLLED STUDY; GEOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOLECULAR STABILITY; NANOFABRICATION; PASTE; PRIORITY JOURNAL; BONE DEVELOPMENT; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; MATERIALS TESTING; MESENCHYMAL STROMA CELL; METABOLISM; POROSITY; PROCEDURES; TISSUE ENGINEERING; TISSUE SCAFFOLD; ULTRASTRUCTURE;

BONE CEMENTS; CALCIUM PHOSPHATES; CELLS, CULTURED; COMPRESSIVE STRENGTH; HUMANS; MATERIALS TESTING; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; POROSITY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84906937062     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1563     Document Type: Article

References (34)

1. Athanasiou K, Zhu CF, Lanctot DR et al. 2000; Fundamentals of biomechanics in tissue engineering of bone. Tissue Eng 6: 361-381.
2. Bergmann C, Lindner M, Zhang W et al. 2010; 3D printing of bone substitute implants using calcium phosphate and bioactive glasses. J Eur Ceram Soc 30: 2563-2567.
3. Detsch R, Uhl F, Deisinger U et al. 2008; 3D cultivation of bone marrow stromal cells on hydroxyapatite scaffolds fabricated by dispense-plotting and negative mould technique. J Mater Sci Mater Med 19: 1491-1496.
4. Detsch R, Dieser R, Deisinger U et al. 2010; Biofunctionalization of dispense-plotted hydroxyapatite scaffolds with peptides: quantification and cellular response. J Biomed Mater Res 92A: 493-503.
5. Espanol M, Perez RA, Montufar EB et al. 2009; Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications. Acta Biomater 5: 2752-2762.
6. Fedorovich NE, De Wijn JR, Verbout AJ et al. 2008; Three-dimensional fiber deposition of cell-laden, viable, patterned constructs for bone tissue printing. Tissue Eng Part A 14: 127-133.
7. Fernandez E, Ginebra MP, Bermudez O et al. 1995; Dimensional and thermal behaviour of calcium phosphate cements during setting compared to PMMA bone cements. J Mater Sci Lett 14: 4-5.
8. Gbureck U, Vorndran E, Mueller FA et al. 2007; Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. J Contr Release 122: 173-180.
9. Gbureck U, Hoelzel T, Biermann I et al. 2008; Preparation of tricalcium phosphate/calcium pyrophosphate structures via rapid prototyping. J Mater Sci Mater Med 19: 1559-1563.
10. Hutmacher DW, Schantz T, Zein I et al. 2001; Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 55: 203-216.
11. Hutmacher DW, Sittinger M, Risbud MV. 2004; Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol 22: 354-362.
12. Khairoun I, Boltong MG, Driessens FC et al. 1997; Effect of calcium carbonate on clinical compliance of apatitic calcium phosphate bone cement. J Biomed Mater Res 38: 356-360.
13. Khalyfa A, Vogt S, Weisser J et al. 2007; Development of a new calcium phosphate powder-binder system for the 3D printing of patient-specific implants. J Mater Sci Mater Med 18: 909-916.
14. Kim GH, Son JG. 2009; 3D polycaprolactone (PCL) scaffold with hierarchical structure fabricated by a piezoelectric transducer (PZT)-assisted bioplotter. Appl Phys A 94: 781-785.
15. Landers R, Muelhaupt R. 2000; Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromol Mater Eng 282: 17-22.
16. Landers R, Huebner U, Schmelzeisen R et al. 2002; Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23: 4437-4447.
17. Maher PS, Keatch RP, Donnelly K et al. 2009; Construction of 3D biological matrices using rapid prototyping technology. Rapid Prototyp J 15: 204-210.
18. Martinez-Vazquez FJ, Perera FH, Miranda P et al. 2010; Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration. Acta Biomater 6: 4361-4368.
19. Martins A, Chung S, Pedro AJ et al. 2009; Hierarchical starch-based fibrous scaffold for bone tissue engineering applications. J Tissue Eng Regen Med 3: 37-42.
20. Miranda P, Saiz E, Gryn K et al. 2006; Sintering and robocasting of β-tricalcium phosphate scaffolds for orthopaedic applications. Acta Biomater 2: 457-466.
21. Miranda P, Pajares A, Saiz E et al. 2007; Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. J Biomed Mater Res A 83: 646-655.
22. Mironov V, Reis N, Derby B. 2006; Review: bioprinting; a beginning. Tissue Eng 12: 631-634.
23. Oliveira AL, Costa SA, Sousa RA et al. 2009; Nucleation and growth of biomimetic apatite layers on 3D plotted biodegradable polymeric scaffolds: effect of static and dynamic coating conditions. Acta Biomat 5: 1626-1638.
24. Pfister A, Landers R, Laib A et al. 2004; Biofunctional rapid prototyping for tissue-engineering applications: 3D bioplotting versus 3D printing. J Polym Sci A Polym Chem 42: 624-638.
25. Rauh J, Despang F, Gelinsky M et al. 2009; Einfluss von Peressigsaeure-Ethanol auf die biomechanischen Eigenschaften humaner spongieoser Knochentransplantate. Presentation to the German Congress for Orthopaedics and Trauma Surgery, Berlin, Germany, 21-24 October; DocPO17-23. doi: 10.3205/09dkou683
26. Sachs E, Cima M, Cornie J et al. 1993; Three-dimensional printing: the physics and implications of additive manufacturing. CIRP Ann Manufact Technol 42: 257-260.
27. Schumacher M, Deisinger U, Detsch R et al. 2010; Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties. J Mater Sci Mater Med 21: 3119-3127.
28. Seitz H, Rieder W, Irsen S et al. 2005; Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res B 74B: 782-788.
29. Seitz H, Deisinger U, Leukers B et al. 2009; Different calcium phosphate granules for 3D printing of bone tissue engineering scaffolds. Adv Engin Mater 11: B41-46.
30. Silva NA, Salgado AJ, Sousa RA et al. 2010; Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair. Tissue Eng Part A 16: 45-54.
31. Sobral JM, Caridade SG, Sousa RA et al. 2011; Three-dimensional plotted scaffolds with controlled pore size gradients: effect of scaffold geometry on mechanical performance and cell seeding efficiency. Acta Biomater 7: 1009-1018.
32. Wilson CE, van Blitterswijk CA, Verbout AJ et al. 2011; Scaffolds with a standardized macro-architecture fabricated from several calcium phosphate ceramics using an indirect rapid prototyping technique. J Mater Sci Mater Med 22: 97-105.
33. Wu C, Luo Y, Cuniberti G et al. 2011; 3D-plotting hierarchical and tough mesoporous bioactive glass scaffolds with controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater 2011, 7: 2644-2650.
34. Zein I, Hutmacher DW, Tan KC et al. 2002; Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 23: 1169-1185.