-
2
-
-
0032799381
-
Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
-
Trinczek B, Ebneth A, Mandelkow EM, et al. Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J Cell Sci 1999;112:2355-67 (Pubitemid 29381026)
-
(1999)
Journal of Cell Science
, vol.112
, Issue.14
, pp. 2355-2367
-
-
Trinczek, B.1
Ebneth, A.2
Mandelkow, E.-M.3
Mandelkow, E.4
-
3
-
-
71049158071
-
The proline-rich domain of tau plays a role in interactions with actin
-
He HJ, Wang XS, Pan R, et al. The proline-rich domain of tau plays a role in interactions with actin. BMC Cell Biol 2009;10:81
-
(2009)
BMC Cell Biol
, vol.10
, pp. 81
-
-
He, H.J.1
Wang, X.S.2
Pan, R.3
-
4
-
-
33947230065
-
Tau is actin up in Alzheimer's disease
-
DOI 10.1038/ncb0207-133, PII NCB0207-133
-
Gallo G. Tau is actin up in Alzheimer's disease. Nat Cell Biol 2007;9: 133-34 (Pubitemid 46420853)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.2
, pp. 133-134
-
-
Gallo, G.1
-
5
-
-
82755189704
-
Dynamic association of tau with neuronal membranes is regulated by phosphorylation
-
Pooler AM, Usardi A, Evans CJ, et al. Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiol Aging 2012;33:431-38
-
(2012)
Neurobiol Aging
, vol.33
, pp. 431-438
-
-
Pooler, A.M.1
Usardi, A.2
Evans, C.J.3
-
7
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke Iqbal I, Iqbal K, Tung YC, et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986;83:4913-17
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-4917
-
-
Grundke Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
-
8
-
-
0032923260
-
Microtubule-associated protein tau, heparan sulphate and α-synuclein in several neurodegenerative diseases with dementia
-
DOI 10.1007/s004010051034
-
Spillantini MG, Tolnay M, Love S, et al. Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. Acta Neuropathol (Berl) 1999;97:585-94 (Pubitemid 29231676)
-
(1999)
Acta Neuropathologica
, vol.97
, Issue.6
, pp. 585-594
-
-
Spillantini, M.G.1
Tolnay, M.2
Love, S.3
Goedert, M.4
-
9
-
-
0037986815
-
Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease
-
DOI 10.1002/path.1345
-
Treiber-Held S, Distl R, Albert F, et al. Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease. J Pathol 2003;200:95-103 (Pubitemid 36592642)
-
(2003)
Journal of Pathology
, vol.200
, Issue.1
, pp. 95-103
-
-
Treiber-Held, S.1
Distl, R.2
Meske, V.3
Albert, F.4
Ohm, T.G.5
-
10
-
-
0038701804
-
Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain
-
DOI 10.1002/path.1320
-
Distl R, Treiber-Held S, Albert F, et al. Cholesterol storage and taupathology in Niemann-Pick type C disease brain. J Pathol 2003;200: 104-11 (Pubitemid 36592643)
-
(2003)
Journal of Pathology
, vol.200
, Issue.1
, pp. 104-111
-
-
Distl, R.1
Treiber-Held, S.2
Albert, F.3
Meske, V.4
Harzer, K.5
Ohm, T.G.6
-
11
-
-
0034925263
-
Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons
-
Distl R, Meske V, Ohm TG. Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons. Acta Neuropathol 2001; 101:547-54 (Pubitemid 32684752)
-
(2001)
Acta Neuropathologica
, vol.101
, Issue.6
, pp. 547-554
-
-
Distl, R.1
Meske, V.2
Ohm, T.G.3
-
12
-
-
33748746505
-
Paired helical filaments contain small amounts of cholesterol, phosphatidylcholine and sphingolipids
-
DOI 10.1515/BC.2006.157, PII BCHM38791267
-
Gellermann GP, Appel TR, Davies P, et al. Paired helical filaments contain small amounts of cholesterol, phosphatidylcholine and sphingolipids. Biol Chem 2006;387:1267-74 (Pubitemid 44402074)
-
(2006)
Biological Chemistry
, vol.387
, Issue.9
, pp. 1267-1274
-
-
Gellermann, G.P.1
Appel, T.R.2
Davies, P.3
Diekmann, S.4
-
13
-
-
84868204382
-
Frontotemporal lobar degeneration: Current knowledge and future challenges
-
Cerami C, Scarpini E, Cappa SF, et al. Frontotemporal lobar degeneration: Current knowledge and future challenges. J Neurol 2012;259: 2278-86
-
(2012)
J Neurol
, vol.259
, pp. 2278-2286
-
-
Cerami, C.1
Scarpini, E.2
Cappa, S.F.3
-
14
-
-
18544368239
-
Apolipoprotein e gene in frontotemporal dementia: An association study and meta-analysis
-
Verpillat P, Camuzat A, Hannequin D, et al. Apolipoprotein E gene in frontotemporal dementia: An association study and meta-analysis. Eur J Hum Genet 2002;10:399-405
-
(2002)
Eur J Hum Genet
, vol.10
, pp. 399-405
-
-
Verpillat, P.1
Camuzat, A.2
Hannequin, D.3
-
15
-
-
0032875656
-
Apolipoprotein e isoforms and the development of low and high Braak stages of Alzheimer's diseaseYrelated lesions
-
Ohm TG, Scharnagl H, März W, et al. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's diseaseYrelated lesions. Acta Neuropathol (Berl) 1999;98:273-80
-
(1999)
Acta Neuropathol (Berl)
, vol.98
, pp. 273-280
-
-
Ohm Tg, S.1
-
16
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Götz J, Chen F, Barmettler R, et al. Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 2001;276:529-34
-
(2001)
J Biol Chem
, vol.276
, pp. 529-534
-
-
Götz, J.C.1
-
17
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Götz J, Chen F, Van Dorpe J, et al. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 2001; 293:1491-95
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.C.1
-
18
-
-
79953229512
-
Dietary cholesterol and its effect on tau protein: A study in apolipoprotein EYdeficient and P301L human tau mice
-
Glöckner F, Meske V, Lütjohann D, et al. Dietary cholesterol and its effect on tau protein: A study in apolipoprotein EYdeficient and P301L human tau mice. J Neuropathol Exp Neurol 2011;70:292-301
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 292-301
-
-
Glöckner, F.M.1
-
20
-
-
0026758096
-
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes
-
Mercken M, Vandermeeren M, Lubke U, et al. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes. Acta Neuropathol 1992;84:265-72
-
(1992)
Acta Neuropathol
, vol.84
, pp. 265-272
-
-
Mercken, M.1
Vandermeeren, M.2
Lubke, U.3
-
22
-
-
0036715016
-
Niemann-Pick type C disease: Accelerated neurofibrillary tangle formation and amyloid β deposition associated with apolipoprotein E ε4 homozygosity
-
DOI 10.1002/ana.10266
-
Saito Y, Suzuki K, Nanba E, et al. Niemann-Pick type C disease: Accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon4 homozygosity. Ann Neurol 2002;52:351-55 (Pubitemid 35001503)
-
(2002)
Annals of Neurology
, vol.52
, Issue.3
, pp. 351-355
-
-
Saito, Y.1
Suzuki, K.2
Nanba, E.3
Yamamoto, T.4
Ohno, K.5
Murayama, S.6
-
23
-
-
84867876174
-
Apolipoprotein e genotype and neurological disease onset in Niemann-Pick disease, type C1
-
Fu R, Yanjanin NM, Elrick MJ, et al. Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1. Am J Med Genet A 2012;158A:2775-80
-
(2012)
Am J Med Genet A
, vol.158 A
, pp. 2775-2780
-
-
Fu, R.1
Yanjanin, N.M.2
Elrick, M.J.3
-
24
-
-
0032521599
-
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filamentYlike conformation
-
Zheng Fischhofer Q, Biernat J, Mandelkow EM, et al. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filamentYlike conformation. Eur J Biochem 1998;252:2542-52
-
(1998)
Eur J Biochem
, vol.252
, pp. 2542-2552
-
-
Zheng Fischhofer, Q.1
Biernat, J.2
Mandelkow, E.M.3
-
25
-
-
70350495437
-
Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
-
Jansen PJ, Lütjohann D, Thelen KM, et al. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. J Alzheimers Dis 2009;18:319-29
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 319-329
-
-
Jansen Pj, L.1
-
26
-
-
28244461327
-
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
-
Levi O, Lütjohann D, Devir A, et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. J Neurochem 2005;95:987-97
-
(2005)
J Neurochem
, vol.95
, pp. 987-997
-
-
Levi, O.L.1
-
27
-
-
0035901715
-
Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice
-
Eckert GP, Kirsch C, Mueller WE. Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice. NeuroReport 2001;12:883-87 (Pubitemid 32281439)
-
(2001)
NeuroReport
, vol.12
, Issue.5
, pp. 883-887
-
-
Eckert, G.P.1
Kirsch, C.2
Mueller, W.E.3
-
28
-
-
0035834416
-
CNS synaptogenesis promoted by glia-derived cholesterol
-
DOI 10.1126/science.294.5545.1354
-
Mauch DH, Nagler K, Schumacher S, et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001;294:1354-57 (Pubitemid 33063104)
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1354-1357
-
-
Mauch, D.H.1
Nagier, K.2
Schumacher, S.3
Goritz, C.4
Muller, E.-C.5
Otto, A.6
Pfrieger, F.W.7
-
29
-
-
38549141572
-
Cellular cholesterol trafficking and compartmentalization
-
DOI 10.1038/nrm2336, PII NRM2336
-
Ikonen E. Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol 2008;9:125-38 (Pubitemid 351158918)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.2
, pp. 125-138
-
-
Ikonen, E.1
-
30
-
-
33847003020
-
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor {beta}lll spectrin
-
Johansson M, Rocha N, Zwart W, et al. Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor {beta}lll spectrin. J Cell Biol 2007;176:459-71
-
(2007)
J Cell Biol
, vol.176
, pp. 459-471
-
-
Johansson, M.1
Rocha, N.2
Zwart, W.3
-
31
-
-
60549091933
-
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis
-
Pacheco CD, Elrick MJ, Lieberman AP. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet 2009;18:956-65
-
(2009)
Hum Mol Genet
, vol.18
, pp. 956-965
-
-
Pacheco, C.D.1
Elrick, M.J.2
Lieberman, A.P.3
-
32
-
-
33846118789
-
Multiple-motor based transport and its regulation by Tau
-
DOI 10.1073/pnas.0607919104
-
Vershinin M, Carter BC, Razafsky DS, et al. Multiple-motor based transport and its regulation by Tau. Proc Natl Acad Sci USA 2007;104: 87-92 (Pubitemid 46067989)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.1
, pp. 87-92
-
-
Vershinin, M.1
Carter, B.C.2
Razafsky, D.S.3
King, S.J.4
Gross, S.P.5
-
33
-
-
77955941947
-
Functional implications of the association of tau with the plasma membrane
-
Pooler AM, Hanger DP. Functional implications of the association of tau with the plasma membrane. Biochem Soc Trans 2010;38:1012-15
-
(2010)
Biochem Soc Trans
, vol.38
, pp. 1012-1015
-
-
Pooler, A.M.1
Hanger, D.P.2
-
34
-
-
36849003349
-
Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols
-
DOI 10.1074/jbc.M703653200
-
Yamauchi Y, Reid PC, Sperry JB, et al. Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols. J Biol Chem 2007;282:34994-5004 (Pubitemid 350232452)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.48
, pp. 34994-35004
-
-
Yamauchi, Y.1
Reid, P.C.2
Sperry, J.B.3
Furukawa, K.4
Takeya, M.5
Chang, C.C.Y.6
Chang, T.-Y.7
-
35
-
-
84866850013
-
Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons
-
Whitehead SN, Gangaraju S, Aylsworth A, et al. Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons. Biosci Trends 2012;6:183-91
-
(2012)
Biosci Trends
, vol.6
, pp. 183-191
-
-
Whitehead, S.N.1
Gangaraju, S.2
Aylsworth, A.3
-
36
-
-
0037340949
-
Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells
-
DOI 10.1046/j.1471-4159.2003.01596.x
-
Sawamura N, Gong JS, Chang TY, et al. Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1Ydeficient cells. J Neurochem 2003;84:1086-96 (Pubitemid 36330661)
-
(2003)
Journal of Neurochemistry
, vol.84
, Issue.5
, pp. 1086-1096
-
-
Sawamura, N.1
Gong, J.-S.2
Chang, T.-Y.3
Yanagisawa, K.4
Michikawa, M.5
-
37
-
-
84868677556
-
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
-
Mandelkow EM, Mandelkow E. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2012;2:a006247
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Mandelkow, E.M.1
Mandelkow, E.2
-
38
-
-
0028172930
-
Apolipoprotein e in animal models of CNS injury and in Alzheimer's disease
-
Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994;17:525-30
-
(1994)
Trends Neurosci
, vol.17
, pp. 525-530
-
-
Poirier, J.1
-
39
-
-
0028898620
-
Effects of apoprotein e on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake
-
Schwiegelshohn B, Presley JF, Gorecki M, et al. Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake. J Biol Chem 1995;270:1761-69
-
(1995)
J Biol Chem
, vol.270
, pp. 1761-1769
-
-
Schwiegelshohn, B.1
Presley, J.F.2
Gorecki, M.3
-
40
-
-
0030885417
-
Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins
-
Igbavboa U, Avdulov NA, Chochina SV, et al. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 1997;69:1661-67 (Pubitemid 27406967)
-
(1997)
Journal of Neurochemistry
, vol.69
, Issue.4
, pp. 1661-1667
-
-
Igbavboa, U.1
Avdulov, N.A.2
Chochina, S.V.3
Wood, W.G.4
-
41
-
-
0345171818
-
Apolipoprotein E and β-amyloid (1-42) regulation of glycogen synthase kinase-3β
-
DOI 10.1046/j.1471-4159.2003.02088.x
-
Cedazo-Minguez A, Popescu BO, Blanco-Millan JM, et al. Apolipoprotein E and beta-amyloid (1Y42) regulation of glycogen synthase kinase-3beta. J Neurochem 2003;87:1152-64 (Pubitemid 37492856)
-
(2003)
Journal of Neurochemistry
, vol.87
, Issue.5
, pp. 1152-1164
-
-
Cedazo-Minguez, A.1
Popescu, B.O.2
Blanco-Millan, J.M.3
Akterin, S.4
Pei, J.-J.5
Winblad, B.6
Cowburn, R.F.7
-
42
-
-
0032031784
-
Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways
-
DOI 10.1002/(SICI)1097-4547(19980301)51:5<658::AID-JNR13>3.0.CO;2-Z
-
Wang X, Luebbe P, Gruenstein E, et al. Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways. J Neurosci Res 1998;51:658-65 (Pubitemid 28115067)
-
(1998)
Journal of Neuroscience Research
, vol.51
, Issue.5
, pp. 658-665
-
-
Wang, X.-S.1
Luebbe, P.2
Gruenstein, E.3
Zemlan, F.4
-
43
-
-
0028947294
-
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
-
Cataldo AM, Barnett JL, Berman SA, et al. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system. Neuron 1995;14: 671-80
-
(1995)
Neuron
, vol.14
, pp. 671-680
-
-
Cataldo, A.M.1
Barnett, J.L.2
Berman, S.A.3
-
44
-
-
79955969705
-
Autophagy failure in Alzheimer's diseaseVlocating the primary defect
-
Nixon RA, Yang DS. Autophagy failure in Alzheimer's diseaseVlocating the primary defect. Neurobiol Dis 2011;43:38-45
-
(2011)
Neurobiol Dis
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
45
-
-
84892848771
-
The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability
-
Meske V, Erz J, Priesnitz T, et al. The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability. Neurobiol Dis 2014;64C:88-97
-
(2014)
Neurobiol Dis
, vol.64
, pp. 88-97
-
-
Meske, V.1
Erz, J.2
Priesnitz, T.3
-
46
-
-
84861726112
-
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1
-
Ordonez MP, Roberts EA, Kidwell CU, et al. Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet 2012;21:2651-62
-
(2012)
Hum Mol Genet
, vol.21
, pp. 2651-2662
-
-
Ordonez, M.P.1
Roberts, E.A.2
Kidwell, C.U.3
-
47
-
-
66349132298
-
Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells
-
Pacheco CD, Elrick MJ, Lieberman AP. Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells. Autophagy 2009;5:548-50
-
(2009)
Autophagy
, vol.5
, pp. 548-550
-
-
Pacheco, C.D.1
Elrick, M.J.2
Lieberman, A.P.3
-
48
-
-
57349172663
-
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
-
Ittner LM, Fath T, Ke YD, et al. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci USA 2008;105:15997-6002
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15997-16002
-
-
Ittner, L.M.1
Fath, T.2
Ke, Y.D.3
|