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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 17, 2014, Pages 4266-4270

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

(8) Hasegawa, Futoshi a Niidome, Kazumi a Migihashi, Chiaki a Murata, Makoto a Negoro, Toshiyuki a Matsumoto, Takafumi a Kato, Kaori a Fujii, Akihito a

a DAINIPPON SUMITOMO PHARMA CO LTD (Japan)

Author keywords

Furan 2 carbohydrazide; Glucagon; Glucagon receptor antagonist; Hyperglucagonemia; Type 2 diabetes

Indexed keywords

2 NITROPHENOL; FURAN 2 CARBOHYDRAZIDE; HORMONE RECEPTOR BLOCKING AGENT; HYDRAZIDE DERIVATIVE; PHENOL; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; GLUCAGON RECEPTOR; HYDRAZINE DERIVATIVE;

ACIDITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DOSE RESPONSE; DRUG DEVELOPMENT; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; HYDRAZINES; MOLECULAR STRUCTURE; RATS; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906936443 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.07.025 Document Type: Article

Times cited : (57)

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