FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation

Journal of Neuroimmunology

Volumn 274, Issue 1-2, 2014, Pages 125-131

  Mencl, Stine ^a   Hennig, Nelli ^a   Hopp, Sarah ^a   Schuhmann, Michael K ^a   Albert Weissenberger, Christiane ^a   Sirén, Anna Leena ^a   Kleinschnitz, Christoph ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Blood brain barrier; Edema; FTY720; Inflammation; Lymphocytes; Traumatic brain injury

Indexed keywords

EVANS BLUE; FINGOLIMOD; PLACEBO; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BLOOD LEVEL; BRAIN CONTUSION; BRAIN LEVEL; CELL COUNTING; CELL INVASION; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; DRUG TREATMENT FAILURE; FLOW CYTOMETRY; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MOUSE; MOUSE MODEL; NERVE CELL NECROSIS; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECEPTOR BLOCKING; SINGLE DRUG DOSE; TISSUE DISTRIBUTION; TRAUMATIC BRAIN INJURY;

BLOOD-BRAIN BARRIER; EDEMA; FTY720; INFLAMMATION; LYMPHOCYTES; TRAUMATIC BRAIN INJURY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FLOW CYTOMETRY; IMMUNOSUPPRESSIVE AGENTS; LYMPHOPENIA; MICE; MICE, INBRED C57BL; PROPYLENE GLYCOLS; SIGNAL TRANSDUCTION; SPHINGOSINE; T-LYMPHOCYTES; TREATMENT OUTCOME;

EID: 84906934449     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.07.010     Document Type: Article

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