-
1
-
-
79959361633
-
Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML
-
Aichberger KJ, Herndlhofer S, Schernthaner G-H et al (2011) Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML. Am J Hematol 86: 533-539.
-
(2011)
Am J Hematol
, vol.86
, pp. 533-539
-
-
Aichberger, K.J.1
Herndlhofer, S.2
Schernthaner, G.-H.3
-
2
-
-
35448967331
-
Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
-
Apperley JF (2007) Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol 8: 1018-1029.
-
(2007)
Lancet Oncol
, vol.8
, pp. 1018-1029
-
-
Apperley, J.F.1
-
3
-
-
73349122639
-
Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
-
Baccarani M, Cortes J, Pane F (2009) Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 27: 6041-6051.
-
(2009)
J Clin Oncol
, vol.27
, pp. 6041-6051
-
-
Baccarani, M.1
Cortes, J.2
Pane, F.3
-
4
-
-
33749325184
-
Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
-
Bradeen HA, Eide CA, O'Hare T et al (2006) Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood 108: 2332-2338.
-
(2006)
Blood
, vol.108
, pp. 2332-2338
-
-
Bradeen, H.A.1
Eide, C.A.2
O'Hare, T.3
-
5
-
-
4644341516
-
Discontinuation of imatinib therapy after achieving a molecular response
-
Cortes J, O'Brien S, Kantarjian H (2004) Discontinuation of imatinib therapy after achieving a molecular response. Blood 104: 2204-2205.
-
(2004)
Blood
, vol.104
, pp. 2204-2205
-
-
Cortes, J.1
O'Brien, S.2
Kantarjian, H.3
-
6
-
-
0038518619
-
Practical management of patients with chronic myeloid leukemia receiving imatinib
-
Deininger MWN, O'Brien SG, Ford JM et al (2003) Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 21: 1637-1647.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1637-1647
-
-
Deininger, M.W.N.1
O'Brien, S.G.2
Ford, J.M.3
-
7
-
-
33748791111
-
Long-term benefits of imatinib (IM) for patients newly diagnosed with chronic myelogenous leukemia in chronic phase (CML-CP): The 5-year update from the IRIS study
-
Druker BJ, Guilhot F, O'Brien S et al (2006) Long-term benefits of imatinib (IM) for patients newly diagnosed with chronic myelogenous leukemia in chronic phase (CML-CP): the 5-year update from the IRIS study. J Clin Oncol 24: 338S-338S.
-
(2006)
J Clin Oncol
, vol.24
, pp. 338-338
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.3
-
8
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, Ohno S (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2: 561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
-
10
-
-
77954659561
-
Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy
-
Giles FJ, Abruzzese E, Rosti G et al (2010) Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy. Leukemia 24: 1299-1301.
-
(2010)
Leukemia
, vol.24
, pp. 1299-1301
-
-
Giles, F.J.1
Abruzzese, E.2
Rosti, G.3
-
11
-
-
84860785167
-
Nilotinib is effective in imatinib-resistant or-intolerant patients with chronic myeloid leukemia in blastic phase
-
Giles FJ, Kantarjian HM, le Coutre PD et al (2012) Nilotinib is effective in imatinib-resistant or-intolerant patients with chronic myeloid leukemia in blastic phase. Leukemia 26: 959-962.
-
(2012)
Leukemia
, vol.26
, pp. 959-962
-
-
Giles, F.J.1
Kantarjian, H.M.2
le Coutre, P.D.3
-
12
-
-
65649147887
-
Nilotinib in patients with Philadelphia chromosomepositive chronic myelogenous leukemia in blast crisis (CML-BC) who are resistant or intolerant to imatinib-Giles et al. 26 (15 Supplement): 7017-ASCO Meeting Abstracts
-
Giles FJ, Larson RA, Kantarjian HM (2008) Nilotinib in patients with Philadelphia chromosomepositive chronic myelogenous leukemia in blast crisis (CML-BC) who are resistant or intolerant to imatinib-Giles et al. 26 (15 Supplement): 7017-ASCO Meeting Abstracts. J Clin Oncol 26: 7017.
-
(2008)
J Clin Oncol
, vol.26
, pp. 7017
-
-
Giles, F.J.1
Larson, R.A.2
Kantarjian, H.M.3
-
13
-
-
84873568081
-
Nilotinib in imatinib-resistant or imatinibintolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study
-
Giles FJ, le Coutre PD, Pinilla-Ibarz J et al (2013) Nilotinib in imatinib-resistant or imatinibintolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia 27: 107-112.
-
(2013)
Leukemia
, vol.27
, pp. 107-112
-
-
Giles, F.J.1
le Coutre, P.D.2
Pinilla-Ibarz, J.3
-
14
-
-
24644435728
-
AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia
-
Golemovic M, Verstovsek S, Giles F et al (2005) AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. Clin Cancer Res 11: 4941-4947.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4941-4947
-
-
Golemovic, M.1
Verstovsek, S.2
Giles, F.3
-
15
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by Bcr-Abl gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K et al (2001) Clinical resistance to STI-571 cancer therapy caused by Bcr-Abl gene mutation or amplification. Science 293: 876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
16
-
-
79952179437
-
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
-
Haouala A, Widmer N, Duchosal MA et al (2011) Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood 117: E75-E87.
-
(2011)
Blood
, vol.117
, pp. 75-87
-
-
Haouala, A.1
Widmer, N.2
Duchosal, M.A.3
-
17
-
-
84879710913
-
Nilotinib is associated with a reduced incidence of Bcr-Abl mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
-
Hochhaus A, Saglio G, Larson RA et al (2013) Nilotinib is associated with a reduced incidence of Bcr-Abl mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 121: 3703-3708.
-
(2013)
Blood
, vol.121
, pp. 3703-3708
-
-
Hochhaus, A.1
Saglio, G.2
Larson, R.A.3
-
18
-
-
84881289808
-
Early responses predicts for better outcomes in patients with newly diagnosed CML: Results with four TKI modalities
-
Jain P, Kantarjian H, Nazha A et al (2013) Early responses predicts for better outcomes in patients with newly diagnosed CML: results with four TKI modalities. Blood 121: 4867-4874.
-
(2013)
Blood
, vol.121
, pp. 4867-4874
-
-
Jain, P.1
Kantarjian, H.2
Nazha, A.3
-
19
-
-
34247574096
-
Safety, pharmacokinetics (PK), metabolism, and mass balance of [C-14]-AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl tyrosine kinase, in healthy subjects
-
Kagan M, Tran P, Fischer V et al (2005) Safety, pharmacokinetics (PK), metabolism, and mass balance of [C-14]-AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl tyrosine kinase, in healthy subjects. Blood 106: 302B-302B.
-
(2005)
Blood
, vol.106
, pp. 302B-302B
-
-
Kagan, M.1
Tran, P.2
Fischer, V.3
-
20
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L et al (2006) Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354: 2542-2551.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
21
-
-
36348968931
-
Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
-
Kantarjian HM, Giles F, Gattermann N et al (2007) Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 110: 3540-3546.
-
(2007)
Blood
, vol.110
, pp. 3540-3546
-
-
Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
-
22
-
-
79251546724
-
Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month followup results
-
Kantarjian HM, Giles FJ, Bhalla KN et al (2011a) Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month followup results. Blood 117: 1141-1145.
-
(2011)
Blood
, vol.117
, pp. 1141-1145
-
-
Kantarjian, H.M.1
Giles, F.J.2
Bhalla, K.N.3
-
23
-
-
80052383499
-
Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
-
Kantarjian HM, Hochhaus A, Saglio G et al (2011b) Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 12: 841-851.
-
(2011)
Lancet Oncol
, vol.12
, pp. 841-851
-
-
Kantarjian, H.M.1
Hochhaus, A.2
Saglio, G.3
-
24
-
-
84878910858
-
Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib
-
Kim TD, Rea D, Schwarz M et al (2013) Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib. Leukemia 27: 1316-1321.
-
(2013)
Leukemia
, vol.27
, pp. 1316-1321
-
-
Kim, T.D.1
Rea, D.2
Schwarz, M.3
-
25
-
-
84867395848
-
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up
-
Larson RA, Hochhaus A, Hughes TP et al (2012) Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up. Leukemia 26: 2197-2203.
-
(2012)
Leukemia
, vol.26
, pp. 2197-2203
-
-
Larson, R.A.1
Hochhaus, A.2
Hughes, T.P.3
-
26
-
-
84881270972
-
Nilotinib vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 4-year update
-
abstr. 7052
-
Larson RA, Hochhaus A, Saglio G et al. (2013) Nilotinib vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): ENESTnd 4-year update. J Clin Oncol (suppl) 31: abstr. 7052.
-
(2013)
J Clin Oncol (suppl)
, vol.31
-
-
Larson, R.A.1
Hochhaus, A.2
Saglio, G.3
-
27
-
-
41349083969
-
Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is active in patients with imatinib-resistant or-intolerant accelerated-phase chronic myelogenous leukemia
-
le Coutre P, Ottmann OG, Giles F et al (2008) Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is active in patients with imatinib-resistant or-intolerant accelerated-phase chronic myelogenous leukemia. Blood 111: 1834-1839.
-
(2008)
Blood
, vol.111
, pp. 1834-1839
-
-
le Coutre, P.1
Ottmann, O.G.2
Giles, F.3
-
28
-
-
80052649493
-
Severe peripheral arterial disease during nilotinib therapy
-
le Coutre P, Rea D, Abruzzese E et al (2011) Severe peripheral arterial disease during nilotinib therapy. J Natl Cancer Inst 103: 1347-1348.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 1347-1348
-
-
le Coutre, P.1
Rea, D.2
Abruzzese, E.3
-
29
-
-
84862028031
-
Nilotinib in patients with Ph+ chronic myeloid leukemia in accelerated phase following imatinib resistance or intolerance: 24-month followup results
-
le Coutre PD, Giles FJ, Hochhaus A et al (2012) Nilotinib in patients with Ph+ chronic myeloid leukemia in accelerated phase following imatinib resistance or intolerance: 24-month followup results. Leukemia 26: 1189-1194.
-
(2012)
Leukemia
, vol.26
, pp. 1189-1194
-
-
le Coutre, P.D.1
Giles, F.J.2
Hochhaus, A.3
-
30
-
-
84879381539
-
Is going for cure in chronic myeloid leukemia possible and justifiable?
-
Mahon F-X (2012) Is going for cure in chronic myeloid leukemia possible and justifiable? Hematology Am Soc Hematol Educ Program 2012: 122-128.
-
(2012)
Hematology Am Soc Hematol Educ Program
, vol.2012
, pp. 122-128
-
-
Mahon, F.-X.1
-
31
-
-
78049528573
-
Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre stop imatinib (STIM) trial
-
Mahon F-X, Rea D, Guilhot J et al (2010) Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre stop imatinib (STIM) trial. Lancet Oncol 11: 1029-1035.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1029-1035
-
-
Mahon, F.-X.1
Rea, D.2
Guilhot, J.3
-
32
-
-
7044231291
-
Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDCFR kinases
-
Manley PW, Breitenstein W, Brüggen J et al (2004) Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDCFR kinases. Bioorg Med Chem Lett 14: 5793-5797.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 5793-5797
-
-
Manley, P.W.1
Breitenstein, W.2
Brüggen, J.3
-
33
-
-
34548825795
-
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
-
O'Hare T, Eide CA, Deininger MWN (2007) Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110: 2242-2249.
-
(2007)
Blood
, vol.110
, pp. 2242-2249
-
-
O'Hare, T.1
Eide, C.A.2
Deininger, M.W.N.3
-
34
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP et al (2005) In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 65: 4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
36
-
-
34247506325
-
Identification of Bcr-Abl point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study
-
Ray A, Cowan-Jacob SW, Manley PW et al (2007) Identification of Bcr-Abl point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study. Blood 109: 5011-5015.
-
(2007)
Blood
, vol.109
, pp. 5011-5015
-
-
Ray, A.1
Cowan-Jacob, S.W.2
Manley, P.W.3
-
37
-
-
84860840888
-
Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable Bcr-Abl transcripts: Results from the French CML group (FILMC)
-
Rea D, Rousselot P, Nicolini FE et al (2011) Discontinuation of dasatinib or nilotinib in chronic myeloid leukemia (CML) patients (pts) with stable undetectable Bcr-Abl transcripts: results from the French CML group (FILMC). ASH Annual Meeting Abstracts 118: 604.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 604
-
-
Rea, D.1
Rousselot, P.2
Nicolini, F.E.3
-
38
-
-
84867904395
-
Three novel patient-derived BCR/ABL mutants show different sensitivity to second and third generation tyrosine kinase inhibitors
-
Redaelli S, Mologni L, Rostagno R et al (2012) Three novel patient-derived BCR/ABL mutants show different sensitivity to second and third generation tyrosine kinase inhibitors. Am J Hematol 87: E125-E128.
-
(2012)
Am J Hematol
, vol.87
, pp. 125-128
-
-
Redaelli, S.1
Mologni, L.2
Rostagno, R.3
-
39
-
-
37049014938
-
Chemical proteomic profiles of the Bcr-Abl inhibitors imatinib, nilotinib, and dasatinib, reveal novel kinase and nonkinase targets
-
Rix U, Hantschel O, Duernberger G et al (2007) Chemical proteomic profiles of the Bcr-Abl inhibitors imatinib, nilotinib, and dasatinib, reveal novel kinase and nonkinase targets. Blood 110: 4055-4063.
-
(2007)
Blood
, vol.110
, pp. 4055-4063
-
-
Rix, U.1
Hantschel, O.2
Duernberger, G.3
-
40
-
-
84886917643
-
Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: Results from the TWISTER study
-
Ross DM, Branford S, Seymour JF et al (2013) Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study. Blood 122: 515-522.
-
(2013)
Blood
, vol.122
, pp. 515-522
-
-
Ross, D.M.1
Branford, S.2
Seymour, J.F.3
-
41
-
-
77953691179
-
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
-
Saglio G, Kim D-W, Issaragrisil S et al (2010) Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 362: 2251-2259.
-
(2010)
N Engl J Med
, vol.362
, pp. 2251-2259
-
-
Saglio, G.1
Kim, D.-W.2
Issaragrisil, S.3
-
42
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E et al (2002) Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 99: 3530-3539.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
43
-
-
0001686739
-
Multiple Bcr-Abl kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B et al (2002) Multiple Bcr-Abl kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2: 117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
44
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ (2002) Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 99: 1928-1937.
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
45
-
-
75749119275
-
Clinical pharmacokinetics of the Bcr-Abl tyrosine kinase inhibitor nilotinib
-
Tanaka C, Yin OQP, Sethuraman V et al (2009) Clinical pharmacokinetics of the Bcr-Abl tyrosine kinase inhibitor nilotinib. Clin Pharmacol Ther 87: 197-203.
-
(2009)
Clin Pharmacol Ther
, vol.87
, pp. 197-203
-
-
Tanaka, C.1
Yin, O.Q.P.2
Sethuraman, V.3
-
46
-
-
78649304183
-
Effects of rifampin and ketoconazole on the pharmacokinetics of nilotinib in healthy participants
-
Tanaka C, Yin OQP, Smith T et al (2011) Effects of rifampin and ketoconazole on the pharmacokinetics of nilotinib in healthy participants. J Clin Pharmacol 51: 75-83.
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 75-83
-
-
Tanaka, C.1
Yin, O.Q.P.2
Smith, T.3
-
47
-
-
33745069351
-
Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)
-
von Bubnoff N, Manley PW, Mestan J et al (2006) Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107). Blood 108: 1328-1333.
-
(2006)
Blood
, vol.108
, pp. 1328-1333
-
-
von Bubnoff, N.1
Manley, P.W.2
Mestan, J.3
-
48
-
-
33745114173
-
AMN107 (nilotinib): A novel and selective inhibitor of Bcr-Abl
-
Weisberg E, Manley P, Mestan J et al (2006) AMN107 (nilotinib): a novel and selective inhibitor of Bcr-Abl. Br J Cancer 94: 1765-1769.
-
(2006)
Br J Cancer
, vol.94
, pp. 1765-1769
-
-
Weisberg, E.1
Manley, P.2
Mestan, J.3
-
49
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W et al (2005) Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 7: 129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
50
-
-
75749106656
-
Effect of grapefruit juice on the pharmacokinetics of nilotinib in healthy participants
-
Yin OQP, Gallagher N, Li A et al (2010) Effect of grapefruit juice on the pharmacokinetics of nilotinib in healthy participants. J Clin Pharmacol 50: 188-194.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 188-194
-
-
Yin, O.Q.P.1
Gallagher, N.2
Li, A.3
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