Trans-cyclooctene tag with improved properties for tumor pretargeting with the Diels-Alder reaction

Molecular Pharmaceutics

Volumn 11, Issue 9, 2014, Pages 3090-3096

  Rossin, Raffaella ^a,b   Van Duijnhoven, Sander M J ^a   Läppchen, Tilman ^b   Van Den Bosch, Sandra M ^b   Robillard, Marc S ^a  

^a Tagworks Pharmaceuticals   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

blood clearance; Diels Alder; pretargeting; tetrazine; trans cyclooctene

Indexed keywords

ANTIBODY CONJUGATE; CYCLOOCTANE DERIVATIVE; MONOCLONAL ANTIBODY; RADIOPHARMACEUTICAL AGENT;

ANIMAL; BAGG ALBINO MOUSE; CARCINOMA; CHEMISTRY; COLONIC NEOPLASMS; CYCLOADDITION; FEMALE; HALF LIFE TIME; HUMAN; IMMUNOLOGY; MOUSE; NUDE MOUSE; PROCEDURES; RADIOIMMUNOTHERAPY; RADIOMETRY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLOADDITION REACTION; CYCLOOCTANES; FEMALE; HALF-LIFE; HUMANS; IMMUNOCONJUGATES; MICE; MICE, INBRED BALB C; MICE, NUDE; RADIOIMMUNOTHERAPY; RADIOMETRY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 84906902913     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500275a     Document Type: Article

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