Synthesis of phosphine and antibody-azide probes for in vivo staudinger ligation in a pretargeted imaging and therapy approach

Bioconjugate Chemistry

Volumn 22, Issue 10, 2011, Pages 2072-2081

  Vugts, Danielle J ^a   Vervoort, Annelies ^a   Stigter Van Walsum, Marijke ^a   Visser, Gerard W M ^a   Robillard, Marc S ^b   Versteegen, Ron M ^c   Vulders, Roland C M ^b   Herscheid, J D M ^a   Van Dongen, Guus A M S ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

^c SyMO Chem   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; MAMMALS; MOLECULES; MONOCLONAL ANTIBODIES; PHARMACOKINETICS; PHOSPHORUS COMPOUNDS; PROBES; REACTION KINETICS; SOLUTIONS; SURFACE PLASMON RESONANCE; TUMORS;

DESFERRIOXAMINE; IN-VITRO; IN-VIVO; NUCLEAR IMAGING; NUDE MICE; RADIATION BURDEN; RADIOIMMUNOTHERAPY; STAUDINGER LIGATION; TARGETING MOLECULES; TUMOR-TARGETING;

EFFICIENCY;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; AZIDE; DEFEROXAMINE; GALLIUM 68; IODINE 123; LUTETIUM 177; PHOSPHINE; UNCLASSIFIED DRUG; ZIRCONIUM 89; ZIRCONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; IMAGING SYSTEM; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STAUDINGER REACTION; TUMOR XENOGRAFT;

MUS; MUS MUSCULUS;

EID: 80054800130     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200298v     Document Type: Article

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