Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1)

Journal of Biological Chemistry

Volumn 289, Issue 35, 2014, Pages 24366-24373

  An, Daniel ^a,b   Kim, Kyunghwan ^a   Lu, Wange ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; GENE EXPRESSION;

CELL-CYCLE PROGRESSION; CONTINUOUS PROCESS; ECTOPIC EXPRESSIONS; INTERACTION STUDIES; MOLECULAR MECHANISM; NUCLEAR FACTOR OF ACTIVATED T-CELLS; OSTEOCLAST DIFFERENTIATION; SIGNALING PATHWAYS;

GENE EXPRESSION REGULATION;

NUCLEAR PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PROTEIN DIM1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DIM1 PROTEIN, MOUSE; NFATC1 PROTEIN, MOUSE; PRIMER DNA; TNFSF11 PROTEIN, MOUSE; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE INACTIVATION; GENE SILENCING; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL DIVISION; CELL LINE; CYTOLOGY; DOWN REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; DNA PRIMERS; DOWN-REGULATION; MICE; MICE, INBRED C57BL; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; OSTEOCLASTS; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 84906871870     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.563817     Document Type: Article

References (32)

1. Karsenty, G., and Wagner, E. F. (2002) Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406 (Pubitemid 34436569)
2. Zaidi, M. (2007) Skeletal remodeling in health and disease. Nat. Med. 13, 791-801
3. Zelzer, E., and Olsen, B. R. (2003) The genetic basis for skeletal diseases. Nature 423, 343-348 (Pubitemid 40852709)
4. Novack, D. V., and Teitelbaum, S. L. (2008) The osteoclast: friend or foe? Annu. Rev. Pathol. 3, 457-484 (Pubitemid 351488289)
5. Rodan, G. A., and Martin, T. J. (2000) Therapeutic approaches to bone diseases. Science 289, 1508-1514
6. Tanaka, S., Nakamura, K., Takahasi, N., and Suda, T. (2005) Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol. Rev. 208, 30-49 (Pubitemid 41746383)
7. Baron, R. (2004) Arming the osteoclast. Nat. Med. 10, 458-460
8. Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-Hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., Penninger, J. M., and Takayanagi, H. (2011) Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat. Med. 17, 1231-1234
9. Lacey, D. L., Timms, E., Tan, H. L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y. X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., and Boyle, W. J. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (Pubitemid 28180851)
10. Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N., and Suda, T. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. U.S.A. 95, 3597-3602
11. Teitelbaum, S. L. (2000) Bone resorption by osteoclasts. Science 289, 1504-1508
12. Asagiri, M., and Takayanagi, H. (2007) The molecular understanding of osteoclast differentiation. Bone 40, 251-264 (Pubitemid 46054562)
13. Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., and Inoue, J. (2005) RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J. 24, 790-799 (Pubitemid 40396108)
14. Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I. R., Schwarz, E. M., Takeshita, S., Wagner, E. F., Noda, M., Matsuo, K., Xing, L., and Boyce, B. F. (2007) NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J. Biol. Chem. 282, 18245-18253 (Pubitemid 47100255)
15. Ishida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., and Takeya, T. (2002) Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J. Biol. Chem. 277, 41147-41156 (Pubitemid 35215706)
16. Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. (2005) DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202, 345-351 (Pubitemid 41126951)
17. Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., and Takayanagi, H. (2005) Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. J. Biol. Chem. 280, 32905-32913 (Pubitemid 41368340)
18. Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., and Takayanagi, H. (2005) Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med. 202, 1261-1269 (Pubitemid 41586956)
19. Chen, S., and Pan, M. (2013) NFAT signaling and bone homeostasis. Hematol. Thromb. Dis. 10.4172/2329-8790.1000102
20. Berry, L. D., Feoktistova, A., Wright, M. D., and Gould, K. L. (1999) The Schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function. Mol. Cell. Biol. 19, 2535-2546 (Pubitemid 29144497)
21. Reuter, K., Nottrott, S., Fabrizio, P., Lührmann, R., and Ficner, R. (1999) Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein. J. Mol. Biol. 294, 515-525
22. Zhang, Y. Z., Gould, K. L., Dunbrack, R. L., Cheng, H., Roder, H., and Golemis, E. A. (1999) The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily. Physiol. Genomics 1, 109-118 (Pubitemid 129622458)
23. Zhang, Y., Lindblom, T., Chang, A., Sudol, M., Sluder, A. E., and Golemis, E. A. (2000) Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. Gene. 257, 33-43
24. Simeoni, F., Arvai, A., Bello, P., Gondeau, C., Hopfner, K. P., Neyroz, P., Heitz, F., Tainer, J., and Divita, G. (2005) Biochemical characterization and crystal structure of a Dim1 family-associated protein: Dim2. Biochemistry 44, 11997-12008 (Pubitemid 41285697)
25. Mehrabadi, M., Hussain, M., and Asgari, S. (2013) Cloning and characterization of a Dim1-like mitosis gene of Spodoptera frugiperda cells (Sf9) induced by Autographa californica multiple nucleopolyhedrovirus. J. Invertebr. Pathol. 113, 152-159
26. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T., and Taniguchi, T. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (Pubitemid 35460788)
27. Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi, S., Calame, K., and Takayanagi, H. (2010) Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc. Natl. Acad. Sci. U.S.A. 107, 3117-3122
28. Zhao, B., Takami, M., Yamada, A., Wang, X., Koga, T., Hu, X., Tamura, T., Ozato, K., Choi, Y., Ivashkiv, L. B., Takayanagi, H., and Kamijo, R. (2009) Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat. Med. 15, 1066-1071
29. Matsuo, K., Galson, D. L., Zhao, C., Peng, L., Laplace, C., Wang, K. Z., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., and Wagner, E. F. (2004) Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J. Biol. Chem. 279, 26475-26480 (Pubitemid 38798801)
30. Vaira, S., Alhawagri, M., Anwisye, I., Kitaura, H., Faccio, R., and Novack, D. V. (2008) RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J. Clin. Invest. 118, 2088-2097 (Pubitemid 351872328)
31. Kim, K., Kim, J. H., Lee, J., Jin, H. M., Kook, H., Kim, K. K., Lee, S. Y., and Kim, N. (2007) MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood 109, 3253-3259 (Pubitemid 46572510)
32. Zhao, B., and Ivashkiv, L. B. (2011) Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthritis Res. Ther. 13, 234