K63-linked polyubiquitination of IRF1: An essential step in the IL-1 signaling cascade

Cellular and Molecular Immunology

Volumn 11, Issue 5, 2014, Pages 407-409

  Wang, Tianxiao ^a   Wang, Jianli ^b  

^a SHANDONG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1; RANTES;

ANIMAL; BIOSYNTHESIS; HUMAN; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CHEMOKINE CCL5; CHEMOKINE CXCL10; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERLEUKIN-1; SIGNAL TRANSDUCTION;

EID: 84906859353     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2014.35     Document Type: Article

References (15)

1. Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 2002; 13: 323-340.
2. Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci 2002; 27: 474-482.
3. Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 2007; 204: 1025-1036.
4. Inoue J, Gohda J, Akiyama T. Characteristics and biological functions of TRAF6. Adv Exp Med Biol 2007; 597: 72-79.
5. Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D et al. Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci USA 2013; 110: 15247-15252.
6. Chen ZJ. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 2005; 7: 758-765.
7. Deng L, Wang C, Spencer E, Yang L, Braun A, You J et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103: 351-361.
8. Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor-and Toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol 2008; 28: 3538-3547.
9. Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T et al. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. J Immunol 2010; 184: 3341-3345.
10. Balkhi MY, Fitzgerald KA, Pitha PM. Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol 2008; 28: 7296-7308.
11. Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC et al. K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol 2014; 15: 231-238.
12. Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 2010; 465: 1084-1088.
13. Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T et al. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 2008; 112: 1382-1391.
14. Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007; 12: 445-456.
15. Tada Y, Ho A, Matsuyama T, Mak TW. Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J Exp Med 1997; 185: 231-238.