The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and bodyweight in rats fed a high-fat or a free-choice high sugar diet

Journal of Physiology and Pharmacology

Volumn 65, Issue 4, 2014, Pages 487-496

  Wierucka Rybak, Magdalena ^a   Wolak, M ^a   Bojanowska, E ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Cannabidiol; Cannabinoid 1 receptor antagonist; Endocannabinoids; Energy expenditure; Food intake; Free choice diet; High fat diet; Leptin

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DRUG COMBINATION; LEPTIN; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; SUGAR INTAKE;

ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BODY WEIGHT; DRUG COMBINATION; DRUG EFFECTS; EATING; LIPID DIET; MALE; SUGAR INTAKE; WISTAR RAT;

ANIMALS; BODY WEIGHT; CANNABIDIOL; CANNABINOID RECEPTOR ANTAGONISTS; DIET, HIGH-FAT; DIETARY SUCROSE; DRUG COMBINATIONS; EATING; LEPTIN; MALE; PIPERIDINES; PYRAZOLES; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1;

EID: 84906856789     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Jovanovic Z, Yeo GS. Central leptin signalling: beyond the arcuate nucleus. Auton Neurosci 2010; 156: 8-14.
2. Sahu A. A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 2004; 145: 2613-2620.
3. Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007; 8: 21-34.
4. Ueno N, Dube MG, Inui A, Kalra PS, Kalra SP. Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology 2004; 145: 4176-4184.
5. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 1997; 94: 10455-10460.
6. Unniappan S, Kieffer TJ. Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitumfed rats. Am J Physiol 2008; 295: R51-R58.
7. Williams DL, Baskin DG, Schwartz MW. Leptin regulation of the enorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 2006; 55: 3387-3393.
8. Bojanowska E, Nowak A. Interactions between leptin and exendin-4, a glucagon-like peptide-1 agonist, in the regulation of food intake in the rat. J Physiol Pharmacol 2007; 58: 349-360.
9. Berridge KC, Ho CY, Richard JM, DiFeliceantonio AG. The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders. Brain Res 2010; 1350: 43-64.
10. Fulton S. Appetite and reward. Front Neuroendocrinol 2010; 31: 85-103.
11. Domingos AI, Vaynshteyn J, Voss HU, et al. Leptin regulates the reward value of nutrient. Nat Neurosci 2011; 14: 1562-1568.
12. Enriori PJ, Sinnayah P, Simonds SE. Garcia Rudaz C, Cowley MA. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci 2011; 24: 12189-12197.
13. Andre A, Gonthier MP. The endocannabinoid system: Its roles in energy balance and potential as a target for obesity treatment. J Biochem Cell Biol 2010; 42: 1788-1801.
14. Silvestri C, Di Marzo V. The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metab 2013; 17: 475-490.
15. Bermudez-Silva FJ, Viveros MP, McPartland JM, Rodriguez de Fonseca F. The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning? Pharmacol Biochem Behav 2010; 95: 375-382.
16. Randall PA, Vemuri VK, Segovia KN, et al. The novel cannabinoid CB1 antagonist AM 6545 suppresses food intake and food-reinforced behavior. Pharmacol Biochem Behav 2010; 97: 179-184.
17. Rasmussen EB, Reilly W, Buckley J, Boomhower SR. Rimonabant reduces the essential value of food in the genetically obese Zucker rat: an exponential demand analysis. Physiol Behav 2012; 105: 734-741.
18. Droste M, Saland SK, Schlitter EK, Rodefer JS. AM 251 differentially effects food-maintained responding depending on food palatability. Pharmacol Biochem Behav 2010; 95: 443-448.
19. Ignatowska-Jankowska B, Jankowski MM, Swiergiel AH. Cannabidiol decreases body weight gain in rats: involvement of CB2 receptors. Neurosci Letters 2011; 490: 82-84.
20. Scopinho AA, Guimaraes FS, Correa FM, Resstel LB. Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists. Pharmacol Biochem Behav 2011; 98: 268-272.
21. Wallace JL, Flannigan KL, McKnight W, Wang L, Ferraz JG, Tuitt D. Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract. J Physiol Pharmacol 2013; 64: 167-175.
22. Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimaraes FS. Multiple mechanisms involved in the largespectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci 2012; 367: 3364-3378.
23. Dardeno TA, Chou SH, Moon HS, Chamberland JP, Fiorenza CG, Mantzoros CS. Leptin in human physiology and therapeutics. Front Neuroendocrinol 2010; 31: 377-393.
24. Quarta C, Mazza R, Obici S, Pasquali R, Pagotto U. Energy balance regulation by endocannabinoids at central and peripheral levels. Trends Mol Med 2011; 17: 518-526.
25. Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001; 410: 822-825.
26. Jelsing J, Larsen P, Vrang N. The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion. Neurosci Lett 2009; 463: 125-129.
27. Jo YH, Chen YJ, CChua SC, Talmage DA, Rolel LW. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 2005; 48: 1055-1066.
28. Bermudez-Silva FJ, Cardinal P, Cota D. The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. J Psychopharmacol 2012; 26: 114-124.
29. Boustany-Kari CM, Jackson VM, Gibbons CP, Swick AG. Leptin potentiates the anti-obesity effects of rimonabant. Eur J Pharmacol 2011; 658: 270-276.
30. Akar F, Mutlu O, Komsuoglu Celikyurt I, et al. Effects of 7- NI and ODQ on memory in the passive avoidance, novel object recognition, and social transmission of food preference tests in mice. Med Sci Monit Basic Res 2014; 20: 27-35.
31. Radziszewska E, Wolak M, Bojanowska E. Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, highcarbohydrate diet. Behav Pharmacol 2014; 25: 53-60.
32. Figlewicz DP, Bennett JL, Naleid AM, Davis C, Grimm JW. Intraventricular insulin and leptin decrease sucrose selfadministration in rats. Physiol Behav 2006; 89: 611-616.
33. Domingos AI, Vaynshteyn J, Sordillo A, Friedman JM. The reward value of sucrose in leptin-deficient obese mice. Mol Metab 2014; 3: 73-80.
34. Harris RB, Apolzan JW. Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose, and chow. Am J Physiol 2012; 302: R1327-R1339.
35. Judge MK, Zhang Y, Scarpace PJ. Responses to the cannabinoid receptor-1 antagonist, AM 251, are more robust with age and with high-fat feeding. J Endocrinol 2009; 203: 281-290.
36. Merroun I, Sanchez-Gonzalez C, Martinez R, et al. Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats. Metabolism 2013; 62: 1641-1650.
37. McLaughlin PJ, Winston K, Swezey L, et al. The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats. Behav Pharmacol 2003; 14: 583-588.
38. Rivera P, Luque-Rojas MJ, Pastor A, et al. Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats. Eur J Neurosci 2013; 37: 105-117.
39. Chiu P, Karler R, Craven C, Olsen DM, Turkanis SA. The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption. Res Commun Chem Pathol Pharmacol 1975; 12: 267-286.
40. Fernandes M, Schabarek A, Coper H, Hill R. Modification of delta9-THC-actions by cannabinol and cannabidiol in the rat. Psychopharmacologia 1974; 38: 329-338.
41. Wiley JL, Burston JJ, Leggett DC, et al. CB1 cannabinoid receptor-mediated modulation of food intake in mice. Br J Pharmacol 2005; 145: 293-300.
42. Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. Br J Pharmacol 2009; 156: 1154-1166.
43. Ignatowska-Jankowska B, Jankowski MM, Torczynska A. Kurek A, Swiergiel AH. Effects of repeated administration of cannabidiol on body weight gain, food intake and accumulation of adipose tissue in rats. Acta Neurobiol Exp 2011; 71 (Suppl.): 59.
44. Sofia RD, Knobloch LC. Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats. Pharmacol Biochem Behav 1976; 4: 591-599.
45. Farrimond JA, Whalley BJ, Williams CM. Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. Psychopharmacology (Berl) 2012; 223: 117-129.
46. Chambers AP, Sharkey KA, Koopman HS. Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rats. Physiol Behav 2004; 83: 863-869.
47. Wang JL, Chinookoswong N, Yin S, Shi ZQ. Calorigenic actions of leptin are additive to, but not dependent on, those of thyroid hormones. Am J Physiol 2000; 279: E1278-E1285.
48. Bojanowska E, Radziszewska E. Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat. J Physiol Pharmacol 2011; 62: 395-402.
49. Sakr HF. Modulation of metabolic and cardiac dysfunctions by swimming in overweight rats on a high cholesterol and fructose diet: possible role of adiponectin. J Physiol Pharmacol 2013; 64: 231-240.