Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding

Journal of Endocrinology

Volumn 203, Issue 2, 2009, Pages 281-290

  Judge, M K ^a   Zhang, Y ^a,b   Scarpace, P J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; LEPTIN; STAT3 PROTEIN; UNCOUPLING PROTEIN 1;

AGING; ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BODY COMPOSITION; CALORIC INTAKE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG RESPONSE; HYPERPHAGIA; LEAN BODY WEIGHT; LIPID DIET; LOW DRUG DOSE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SIGNAL TRANSDUCTION; WEIGHT CHANGE; WEIGHT REDUCTION;

AGE FACTORS; ANIMALS; APPETITE DEPRESSANTS; BODY COMPOSITION; DIETARY FATS; ENERGY INTAKE; HYPERPHAGIA; ION CHANNELS; LEPTIN; MALE; MITOCHONDRIAL PROTEINS; OBESITY; PIPERIDINES; PYRAZOLES; RATS; RATS, INBRED F344; RECEPTOR, CANNABINOID, CB1; STAT3 TRANSCRIPTION FACTOR; WEIGHT GAIN;

EID: 70449459081     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0210     Document Type: Article

References (23)

1. Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G & Wakil SJ 2000 The subcellular localization of acetyl-coA carboxylase 2. PNAS 97 1444-1449.
2. Arnone M, Maruani J, Chaperon F, Thiébot MH, Poncelet M, Soubrié P & Le Fur G 1997 Selective inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology 132 104-106.
3. Bellocchio L, Cervino C, Pasquali R & Pagotto U 2008 The endocannabinoid system and energy metabolism. Journal of Neuroendocrinology 20 850-857.
4. Engeli S 2008 Dysregulation of the endocannabinoid system in obesity. Journal of Neuroendocrinology 20 110-115.
5. Harrold JA, Elliott JC, King PJ, Widdowson PS & Williams G 2002 Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rat with dietary obesity: a role for endogenous cannabinoids in driving apetite for palatable food? Brain Research 952 232-238.
6. Higgs S, Williams CM & Kirkham TC 2002 Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after Dgr9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR 141716. Psychopharmacology 165 370-377. (Pubitemid 36223078)
7. Hildebrandt AL, Kelly-Sullivan DM & Black SC 2003 Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology 462 125-132. (Pubitemid 36183743)
8. Judge MK, Zhang J, Tumer N, Carter CS, Daniels MJ & Scarpace PJ 2008 Prolonged hyperphagia with HF feeding contributes to exacerbated weight gain in rats with adult-onset obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 295 R773-R780.
9. Levin BE, Dunn-Meynell AA & Banks AS 2004 Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 286 R143-R150.
10. Maccarrone M, Fride E, Bisogno T, Bari M, Cascio MG, Battista N, Finazzi Agró A, Suris R, Mechoulam R & Di Marzo V 2005 Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. Molecular Human Reproduction 11 21-28. (Pubitemid 40330999)
11. Di Marzo V, Goparaju SK,Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura Tet al. 2001 Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410 822-825.
12. Matias I & Di Marzo V 2006 Enodcannabinoids and the control of energy balance. Trends in Endocrinology and Metabolism 18 27-37.
13. Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R et al. 2006 Regulation, function, and dysregulation of endocannabinoids in models of adipose and B-pancreatic cells and in obesity and hyperglycemia. Journal of Clinical Endocrinology and Metabolism 91 3171-3180.
14. Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Bátkai S, Harvey-White J, Mackie K, Offertáler L, Wang L et al. 2005 Endocannabinoids activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet induced obesity. Journal of Clinical Investigation 115 1298-1305. (Pubitemid 40629049)
15. Pagotto U, Vicennati V & Passquali R 2005 The endocannabinoid system and the treatment of obesity. Annals of Medicine 37 270-275.
16. Scarpace P & Zhang J 2007 Elevated leptin: consequence or cause of obesity. Frontiers in Bioscience 12 3531-3544.
17. Scarpace P & Zhang Y 2009 Leptin resistance: a predisposing factor for diet-induced obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 296 R492-R500.
18. Simiand J, Keane M, Keane P & Soubrie P 1998 SR141716, a CB1 cannabinoid receptor antagonist, selectively reduced sweet food intake in marmoset. Behavioural Pharmacology 9 179-181. (Pubitemid 28186515)
19. Tinsley F, Taicher G & Heiman M 2004 Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obesity Research 12 150-160. (Pubitemid 41137499)
20. Valassi E, Massimo S & Cavagnini F 2008 Neuroendocrine control of food intake. Nutrition, Metabolism, and Cardiovascular Diseases 18 158-168.
21. Vickers S, Webster L, Wyatt A, Dourish C & Kennett G 2003 Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology 167 103-111. (Pubitemid 36535298)
22. Wilsey J, Zolotukhin S, Prima V & Scarpace PJ 2003 Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 285 R1011-R1020. (Pubitemid 37296352)
23. Zhang J, Matheny M, Tümer N, Mitchell M & Scarpace P 2007 Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292 R868-R874. (Pubitemid 46207742)