Dose-response and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure

Prenatal Diagnosis

Volumn 34, Issue 9, 2014, Pages 831-838

  Kwak, Ho Seok ^a   Han, Jung Yeol ^a   Choi, June Seek ^a   Ahn, Hyun Kyong ^a   Kwak, Dong Wook ^a   Lee, Yeon Kyung ^a   Koh, Sun Young ^a   Jeong, Go Un ^a   Velázquez Armenta, E Yadira ^b   Nava Ocampo, Alejandro A ^b,c,d  

^a Catholic Kwandong University   (South Korea)

^b PharmaReasons Pharmacological Research and Applied Solutions   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; ESTER; FATTY ACID; TERATOGENIC AGENT; ETHYL LAURATE; ETHYL LINOLENATE; ETHYL MYRISTATE; ETHYL PALMITOLEATE; ETHYL STEARATE; FATTY ACID ESTER; LAURIC ACID DERIVATIVE; LINOLEIC ACID ETHYL ESTER; MYRISTIC ACID; OLEIC ACID ETHYL ESTER; PALMITIC ACID ETHYL ESTER; PALMITOLEIC ACID; STEARIC ACID; UNCLASSIFIED DRUG;

ADULT; ALCOHOLIC BEVERAGE; CHEMISTRY; DOSE RESPONSE; DRINKING BEHAVIOR; ENVIRONMENTAL EXPOSURE; EVALUATION STUDY; FEMALE; HUMAN; MATERNAL BEHAVIOR; MECONIUM; MIDDLE AGED; NEWBORN; PREGNANCY; SELF REPORT; STATISTICAL MODEL; TIME; ARTICLE; CONCENTRATION (PARAMETERS); DOSE TIME EFFECT RELATION; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; MAJOR CLINICAL STUDY; PREGNANCY OUTCOME; PREGNANT WOMAN; PRENATAL EXPOSURE; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY;

ADULT; ALCOHOL DRINKING; ALCOHOLIC BEVERAGES; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTERS; ETHANOL; FATTY ACIDS; FEMALE; HUMANS; INFANT, NEWBORN; LINEAR MODELS; MATERNAL BEHAVIOR; MATERNAL EXPOSURE; MECONIUM; MIDDLE AGED; PREGNANCY; PREGNANCY TRIMESTERS; SELF REPORT; TERATOGENS; TIME FACTORS;

EID: 84906841969     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.4374     Document Type: Article

References (30)

1. Landgraf MN, Nothacker M, Kopp IB, Heinen F. The diagnosis of fetal alcohol syndrome. Dtsch Arztebl Int 2013;110(42):703-10.
2. Borucki K, Dierkes J, Wartberg J, et al. In heavy drinkers, fatty acid ethyl esters remain elevated for up to 99hours. Alcohol Clin Exp Res 2007;31(3):423-7.
3. Kwak HS, Han JY, Choi JS, et al. Characterization of phosphatidylethanol blood concentrations for screening alcohol consumption in early pregnancy. Clin Toxicol (Phila) 2014;52(1):25-31.
4. Laposata M. Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake. Clin Chem 1997;43(8):1527-34.
5. Bearer CF, Stoler JM, Cook JD, Carpenter SJ. Biomarkers of alcohol use in pregnancy. Alcohol Res Health 2004-2005;28(1):38-43.
6. Burd L, Hofer R. Biomarkers for detection of prenatal alcohol exposure: a critical review of fatty acid ethyl esters in meconium. Birth Defects Res A Clin Mol Teratol 2008;82(7):487-93.
7. Han JY, Choi JS, Ahn HK, et al. Foetal and neonatal outcomes in women reporting ingestion of low or very low alcohol intake during pregnancy. J Matern Fetal Neonatal Med 2012;25(11):2186-9.
8. Patra J, Bakker R, Irving H, et al. Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA) - a systematic review and meta-analyses. BJOG 2011;118(12):1411-21.
9. Alati R, Davey Smith G, Lewis SJ, et al. Effect of prenatal alcohol exposure on childhood academic outcomes: contrasting maternal and paternal associations in the ALSPAC study. PLoS One 2013;8:e74844.
10. Kelly Y, Iacovou M, Quigley MA, et al. Light drinking versus abstinence in pregnancy - behavioural and cognitive outcomes in 7-year-old children: a longitudinal cohort study. BJOG 2013;120(11):1340-7.
11. Kesmodel US, Eriksen HL, Underbjerg M, et al. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012;119(10):1222-31 [Erratum in: BJOG 2012;119(13):1683].
12. Robinson M, Oddy WH, McLean NJ, et al. Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study. BJOG 2010;117(9):1139-50.
13. Connors GJ, Volk RJ. Self-report screening for alcohol problems among adults. In Assessing Alcohol Problems: A Guide for Clinicians and Researchers, Allen JP, Wilson VB (eds). NIH Publication No. 03-3745. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, 2003;21-35.
14. United States National Institute on Alcohol Abuse and Alcoholism. Alcohol use and alcohol use disorders in the United States, a 3-year follow-up: main findings from the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). U.S. Alcohol Epidemiologic Data Reference Manual Vol. 8, No. 2. Bethesda, MD: NIH Publication No. 10-7677, 2010.
15. Flegel K, MacDonald N, Hébert PC. Binge drinking: all too prevalent and hazardous. CMAJ 2011;183(4):411.
16. Kwak HS, Kang YS, Han KO, et al. Quantitation of fatty acid ethyl esters in human meconium by an improved liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878(21):1871-4.
17. Ostrea EM Jr, Romero A, Knapp DK, et al. Postmortem drug analysis of meconium in early-gestation human fetuses exposed to cocaine: clinical implications. J Pediatr 1994;124(3):477-9.
18. O'Leary CM, Taylor C, Zubrick SR, et al. Prenatal alcohol exposure and educational achievement in children aged 8-9years. Pediatrics 2013;132(2):e468-75.
19. Sayal K, Draper ES, Fraser R, et al. Light drinking in pregnancy and mid-childhood mental health and learning outcomes. Arch Dis Child 2013;98(2):107-11.
20. Feldman HS, Jones KL, Lindsay S, et al. Prenatal alcohol exposure patterns and alcohol-related birth defects and growth deficiencies: a prospective study. Alcohol Clin Exp Res 2012;36(4):670-6.
21. Nava-Ocampo AA, Velázquez-Armenta Y, Brien JF, Koren G. Elimination kinetics of ethanol in pregnant women. Reprod Toxicol 2004;18(4):613-7.
22. Burd L, Roberts D, Olson M, Odendaal H. Ethanol and the placenta: a review. J Matern Fetal Neonatal Med 2007;20(5):361-75.
23. Chan D, Knie B, Boskovic R, Koren G. Placental handling of fatty acid ethyl esters: perfusion and subcellular studies. J Pharmacol Exp Ther 2004;310(1):75-82.
24. Chan D, Bar-Oz B, Pellerin B, et al. Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit 2003;25(3):271-8 [Erratum in: Ther Drug Monit 2004;26(5):583].
25. Moore C, Jones J, Lewis D, Buchi K. Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 2003;49(1):133-6.
26. Hicks MS. Meconium alcohol and drug screening. PhD Thesis. Supervisors: Sauve R, Tough S. Department of Community Health Sciences, University of Alberta. Calgary, Alberta, 2007. Available from: http://dspace.ucalgary.ca/bitstream/1880/45041/3/Hicks_PhD_2007_Med.pdf
27. Bakdash A, Burger P, Goecke TW, et al. Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study. Anal Bioanal Chem 2010;396(7):2469-77.
28. Morini L, Marchei E, Tarani L, et al. Testing ethylglucuronide in maternal hair and nails for the assessment of fetal exposure to alcohol: comparison with meconium testing. Ther Drug Monit 2013;35(3):402-7.
29. Jacobson SW, Chiodo LM, Sokol RJ, Jacobson JL. Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome. Pediatrics 2002;109(5):815-25.
30. Derauf C, Katz AR, Easa D. Agreement between maternal self-reported ethanol intake and tobacco use during pregnancy and meconium assays for fatty acid ethyl esters and cotinine. Am J Epidemiol 2003;158(7):705-9.