Testing ethylglucuronide in maternal hair and nails for the assessment of fetal exposure to alcohol: Comparison with meconium testing

Therapeutic Drug Monitoring

Volumn 35, Issue 3, 2013, Pages 402-407

  Morini, Luca ^a   Marchei, Emilia ^b   Tarani, Luigi ^c   Trivelli, Marzia ^c   Rapisardi, Gherardo ^d   Elicio, Maria Rosaria ^d   Ramis, Juan ^e,f   Garcia Algar, Oscar ^e,f   Memo, Luigi ^g   Pacifici, Roberta ^b   Groppi, Angelo ^a   Danesino, Paolo ^a   Pichini, Simona ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

^d Ospedale Santa Maria Annunziata   (Italy)

^e INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g SAN MARTINO HOSPITAL   (Italy)

Author keywords

Ethylglucuronide; FASD; Meconium; Nails

Indexed keywords

ALCOHOL; ETHYL GLUCURONIDE; FATTY ACID ESTER;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; FEMALE; FETAL ALCOHOL SYNDROME; FETUS; FINGER NAIL; HAIR ANALYSIS; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MECONIUM; NEWBORN; PRENATAL EXPOSURE; PRIORITY JOURNAL;

ALCOHOL DRINKING; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; ESTERS; ETHANOL; FATTY ACIDS; FEMALE; FETAL ALCOHOL SPECTRUM DISORDERS; GLUCURONATES; HAIR; HUMANS; INFANT, NEWBORN; MASS SPECTROMETRY; MATERNAL EXPOSURE; MECONIUM; NAILS; PREGNANCY;

EID: 84880068023     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e318283f719     Document Type: Article

References (19)

1. Sokol RJ, Delaney-Black V, Nordstrom B. Fetal alcohol spectrum disorder. JAMA. 2003;290:2996-2999. (Pubitemid 37505533)
2. Caprara DL, Klein J, Koren G. Diagnosis of fetal alcohol spectrum disorder (FASD): fatty acid ethyl esters and neonatal hair analysis. Ann Ist Super Sanita. 2006;42:39-45. (Pubitemid 44174656)
3. Chan D, Bar-Oz B, Pellerin B, et al. Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit. 2003;25:271-278. (Pubitemid 36638169)
4. Garća-Algar O, Kulaga V, Gareri J, et al. Alarming prevalence of fetal alcohol exposure in a Mediterranean City. Ther Drug Monit. 2008;30: 249-254. (Pubitemid 351521657)
5. Morini L, Marchei E, Pellegrini M, , et al. Liquid chromatography with tandem mass spectrometric detection for the measurement of ethyl glucuronide and ethyl sulfate in meconium: new biomarkers of gestational ethanol exposure? Ther Drug Monit. 2008;30:725-732.
6. Pichini S, Marchei E, Vagnarelli F, et al. Assessment of prenatal exposure to ethanol by meconium analysis: results of an Italian multicentre study. Alcohol Clin Exp Res. 2012;36:417-424.
7. Morini L, Groppi A, Marchei E, et al. Population baseline of meconium ethyl glucuronide and ethyl sulfate concentrations in newborns of nondrinking women in 2 Mediterranean cohorts. Ther Drug Monit. 2010;32: 359-363.
8. Winkler M, Kaufmann E, Thoma D, et al. Detection of ethyl glucuronide in blood spotted on different surfaces. Forensic Sci Int. 2011;210:243-246.
9. Dahl H, Hammarberg A, Franck J, et al. Urinary ethyl glucuronide and ethyl sulphate testing for recent drinking in alcohol-dependent outpatients treated with acamprosate or placebo. Alcohol Alcohol. 2011;46: 553-557.
10. Morini L, Politi L, Acito S, et al. Comparison of ethyl glucuronide in hair with carbohydrate-deficient transferring in serum as markers of chronic high levels of alcohol consumption. Forensic Sci Int. 2009;188:140-143.
11. Morini L, Politi L, Polettini A. Ethyl glucuronide in hair. A sensitive and specific marker of chronic heavy drinking. Addiction. 2009;104:915-920.
12. Morini L, Varango C, Filippi C, et al. Chronic excessive alcohol consumption diagnosis: comparison between traditional biomarkers and ethyl glucuronide in hair, a study on a real population. Ther Drug Monit. 2011;33:654-657.
13. Morini L, Colucci M, Ruberto MG, et al. Determination of ethyl glucuronide in nails by liquid chromatography tandem mass spectrometry as potential new biomarker for chronic alcohol abuse and binge drinking behavior. Anal Bioanal Chem. 2012;402:1865-1870.
14. Pichini S, Pellegrini M, Gareri J, et al. Liquid chromatography-tandem mass spectrometry for fatty acid ethyl esters in meconium: assessment of prenatal exposure to alcohol in two European cohorts. J Pharm Biomed Anal. 2008;48:927-933.
15. Morini L, Politi L, Groppi A, et al. Determination of ethyl glucuronide in hair samples by liquid chromatography/electrospray tandem mass spectrometry. J Mass Spectrom. 2006;41:34-42. (Pubitemid 43164832)
16. Morini L, Marchei E, Vagnarelli F, et al. Ethyl glucuronide and ethyl sulfate in meconium and hair-potential biomarkers of intrauterine exposure to ethanol. Forensic Sci Int. 2010;196:74-77.
17. Battistella G, Bazzo S, Bottarel M, et al. Il consumo di alcol in gravidanza, Azienda ULSS 9 di Treviso [in Italian]. Not Ist Super Sanitá. 2010;23:3-4.
18. Kulaga V, Pragst F, Fulga N, et al. Hair analysis of fatty acid ethyl esters in the detection of excessive drinking in the context of fetal alcohol spectrum disorders. Ther Drug Monit. 2009;31:261-266.
19. Politi L, Morini L, Leone F, et al. Ethyl glucuronide in hair: is it a reliable marker of chronic high levels of alcohol consumption? Addiction. 2006; 101:1408-1412. (Pubitemid 44337764)