Characterization of phosphatidylethanol blood concentrations for screening alcohol consumption in early pregnancy

Clinical Toxicology

Volumn 52, Issue 1, 2014, Pages 25-31

  Kwak, Ho Seok ^a   Han, Jung Yeol ^a   Choi, June Seek ^a   Ahn, Hyun Kyong ^a   Ryu, Hyun Mee ^a   Chung, Hee Jung ^a   Cho, Dong Hee ^a   Shin, Chan Young ^b   Velazquez Armenta, E Yadira ^c,d,e   Nava Ocampo, Alejandro A ^c,d,e  

^a Catholic Kwandong University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c PharmaReasons Pharmacological Research and Applied Solutions   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Biochemical markers; Ethanol; Pregnancy

Indexed keywords

ALCOHOL; PHOSPHATIDYLETHANOL; UNCLASSIFIED DRUG;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; NATIONAL HEALTH ORGANIZATION; PREGNANT WOMAN; PRENATAL CARE; SCREENING;

EID: 84892154285     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2013.859263     Document Type: Article

References (26)

1. Gnann H, Engelmann C, Skopp G, Winkler M, Auwärter V, Dresen S, et al. Identification of 48 homologues of phosphatidylethanol in blood by LC-ESI-MS/MS. Anal Bioanal Chem 2010; 396: 2415-2423.
2. Gunnarsson T, Karlsson A, Hansson P, Johnson G, Alling C, Odham G. Determination of phosphatidylethanol in blood from alcoholic males using high-performance liquid chromatography and evaporative light scattering or electrospray mass spectrometric detection. J Chromatogr B Biomed Sci Appl 1998; 705: 243-249.
3. Helander A, Zheng Y. Molecular species of the alcohol biomarker phosphatidylethanol in human blood measured by LC-MS. Clin Chem 2009; 55: 1395-1405.
4. Kwak HS, Han JY, Ahn HK, Kim MH, Ryu HM, Kim MY, et al. Blood levels of phosphatidylethanol in pregnant women reporting positive alcohol ingestion, measured by an improved LC-MS/MS analytical method. Clin Toxicol (Phila) 2012; 50: 886-891.
5. United States National Institute on Alcohol Abuse and Alcoholism. Alcohol use and alcohol use disorders in the United States, a 3-year follow-up: Main findings from the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). U.S. Alcohol Epidemiologic Data Reference Manual Vol. 8, No. 2; NIH Publication No. 10-7677. Bethesda, MD; 2010.
6. Flegel K, MacDonald N, Hébert PC. Binge drinking: all too prevalent and hazardous. CMAJ 2011; 183: 411.
7. Houjou T, Yamatani K, Imagawa M, Shimizu T, Taguchi R. A shotgun tandem mass spectrometric analysis of phospholipids with normalphase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2005; 19: 654-666.
8. Stewart SH, Law TL, Randall PK, Newman R. Phosphatidylethanol and alcohol consumption in reproductive age women. Alcohol Clin Exp Res 2010; 34: 488-492.
9. Varga A, Hansson P, Johnson G, Alling C. Normalization rate and cellular localization of phosphatidylethanol in whole blood from chronic alcoholics. Clin Chim Acta 2000; 299: 141-150.
10. Gnann H, Weinmann W, Thierauf A. Formation of phosphatidylethanol and its subsequent elimination during an extensive drinking experiment over 5 days. Alcohol Clin Exp Res 2012; 36: 1507-1511.
11. Viel G, Boscolo-Berto R, Cecchetto G, Fais P, Nalesso A, Ferrara SD. Phosphatidylethanol in blood as a marker of chronic alcohol use: a systematic review and meta-analysis. Int J Mol Sci 2012; 13: 14788-14812.
12. Varga A, Hansson P, Lundqvist C, Alling C. Phosphatidylethanol in blood as a marker of ethanol consumption in healthy volunteers: comparison with other markers. Alcohol Clin Exp Res 1998; 22: 1832-1837.
13. Connors GJ, Volk RJ. Self-report screening for alcohol problems among adults. In: Allen JP, Wilson VB, eds. Assessing alcohol problems: a guide for clinicians and researchers. NIH Publication No. 03-3745. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, 2003: 21-35.
14. Littner Y, Bearer CF. Detection of alcohol consumption during pregnancy-current and future biomarkers. Neurosci Biobehav Rev 2007; 31: 261-269.
15. Maenhout TM, De Buyzere ML, Delanghe Jr. Non-oxidative ethanol metabolites as a measure of alcohol intake. Clin Chim Acta 2013; 415: 322-329.
16. Hartmann S, Aradottir S, Graf M, Wiesbeck G, Lesch O, Ramskogler K, et al. Phosphatidylethanol as a sensitive and specific biomarker: comparison with gamma-glutamyl transpeptidase, mean corpuscular volume and carbohydrate- deficient transferrin. Addict Biol 2007; 12: 81-84.
17. Hahn JA, Dobkin LM, Mayanja B, Emenyonu NI, Kigozi IM, Shiboski S, et al. Phosphatidylethanol (PEth) as a biomarker of alcohol consumption in HIV-positive patients in sub-Saharan Africa. Alcohol Clin Exp Res 2012; 36: 854-862.
18. Han JY, Choi JS, Ahn HK, Kim MH, Chung JH, Ryu HM, et al. Foetal and neonatal outcomes in women reporting ingestion of low or very low alcohol intake during pregnancy. J Matern Fetal Neonatal Med 2012; 25: 2186-2189.
19. Falgreen Eriksen HL, Mortensen EL, Kilburn T, Underbjerg M, Bertrand J, Støvring H, et al. The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old children. BJOG 2012; 119: 1191-1200.
20. Skogerbø Å, Kesmodel US, Wimberley T, Støvring H, Bertrand J, Landrø NI, Mortensen EL. The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on executive function in 5-year-old children. BJOG 2012; 119: 1201-1210
21. erratum in BJOG 2012; 119: 1683.
22. Underbjerg M, Kesmodel US, Landrø NI, Bakketeig L, Grove J, Wimberley T, et al. The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on selective and sustained attention in 5-year-old children. BJOG 2012; 119: 1211-1221
23. erratum in BJOG 2012; 119: 1683.
24. Kesmodel US, Eriksen HL, Underbjerg M, Kilburn TR, Støvring H, Wimberley T, Mortensen EL. The effect of alcohol binge drinking in early pregnancy on general intelligence in children. BJOG 2012; 119: 1222-1231
25. erratum in BJOG 2012; 119: 1683.
26. Bay B, Støvring H, Wimberley T, Denny CH, Mortensen EL, Eriksen HL, Kesmodel US. Low to moderate alcohol intake during pregnancy and risk of psychomotor deficits. Alcohol Clin Exp Res 2012; 36: 807-814.