Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin

Chemico-Biological Interactions

Volumn 221, Issue , 2014, Pages 109-118

  Mamidi, Rao N V S ^a   Proctor, Jim ^a   De Jonghe, Sandra ^b   Feyen, Bianca ^b   Moesen, Esther ^b   Vinken, Petra ^b   Ma, Jing Ying ^b   Bryant, Stewart ^b   Snook, Sandra ^b   Louden, Calvert ^b   Lammens, Godelieve ^b   Ways, Kirk ^a   Kelley, Michael F ^b   Johnson, Mark D ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Canagliflozin; Carbohydrate malabsorption; Hypercalciuria; Kidney tumors; Pheochromocytomas; SGLT2 inhibitor

Indexed keywords

CANAGLIFLOZIN; KIDNEY INJURY MOLECULE 1; CELL ADHESION MOLECULE; GLUCOSIDE; HAVCR1PROTEIN, RAT; SODIUM GLUCOSE COTRANSPORTER 2; THIOPHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM ABSORPTION; CALCIUM EXCRETION; CALCIUM URINE LEVEL; CARBOHYDRATE INTOLERANCE; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; DRUG MEGADOSE; GLUCOSE TRANSPORT; HYPERCALCIURIA; HYPEROSTOSIS; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; KIDNEY INJURY; MALE; NONHUMAN; PH; PHEOCHROMOCYTOMA; RAT; URINARY EXCRETION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISORDERS OF CARBOHYDRATE METABOLISM; KIDNEY; MALABSORPTION; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CARBOHYDRATE METABOLISM, INBORN ERRORS; CARCINOGENESIS; CELL ADHESION MOLECULES; CELL PROLIFERATION; GLUCOSIDES; IMMUNOHISTOCHEMISTRY; KIDNEY; MALABSORPTION SYNDROMES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-GLUCOSE TRANSPORTER 2; THIOPHENES;

EID: 84906841254     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.08.001     Document Type: Article

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