-
1
-
-
0002058353
-
Historical perspective on key advances in the biochemistry and physiology of folates
-
Picciano, M. F., Stokstad, E. L. R. and Greogory, J. F., eds, Wiley-Liss, New York
-
Stokstad, E. L. R. (1990) Historical perspective on key advances in the biochemistry and physiology of folates. Contemporory Issues in Clinical Nutrition: Folic Acid Metabolism in Health and Diesease (Picciano, M. F., Stokstad, E. L. R. and Greogory, J. F., eds), pp. 1-21, Wiley-Liss, New York
-
(1990)
Contemporory Issues in Clinical Nutrition: Folic Acid Metabolism in Health and Diesease
, pp. 1-21
-
-
Stokstad, E.L.R.1
-
2
-
-
84862111486
-
Folate and DNA methylation
-
CrossRef PubMed
-
Ly, A., Hoyt, L., Crowell, J. and Kim, Y. I. (2012) Folate and DNA methylation. Antioxid. Redox Signal. 17, 302-326 CrossRef PubMed
-
(2012)
Antioxid. Redox Signal.
, vol.17
, pp. 302-326
-
-
Ly, A.1
Hoyt, L.2
Crowell, J.3
Kim, Y.I.4
-
3
-
-
3142774934
-
12 in health and disease
-
Discussion S13 CrossRef PubMed
-
12 in health and disease. Nutr. Rev. 62, S3-S12, Discussion S13 CrossRef PubMed
-
(2004)
Nutr. Rev.
, vol.62
-
-
Stover, P.J.1
-
4
-
-
0033808685
-
Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
-
CrossRef PubMed
-
Lucock, M. (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol. Genet. Metab. 71, 121-138 CrossRef PubMed
-
(2000)
Mol. Genet. Metab.
, vol.71
, pp. 121-138
-
-
Lucock, M.1
-
5
-
-
0041305877
-
Membrane Transport of Folates
-
DOI 10.1016/S0083-6729(03)01012-4, PII S0083672903010124
-
Matherly, L. H. and Goldman, D. I. (2003) Membrane transport of folates. Vitam. Horm. 66, 403-456 CrossRef PubMed (Pubitemid 137640823)
-
(2003)
Vitamins and Hormones
, vol.66
, pp. 403-456
-
-
Matherly, L.H.1
Goldman, I.D.2
-
6
-
-
84870710332
-
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
-
CrossRef PubMed
-
Kugel Desmoulin, S., Hou, Z., Gangjee, A. and Matherly, L. H. (2012) The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer Biol. Ther. 13, 1355-1373 CrossRef PubMed
-
(2012)
Cancer Biol. Ther.
, vol.13
, pp. 1355-1373
-
-
Kugel Desmoulin, S.1
Hou, Z.2
Gangjee, A.3
Matherly, L.H.4
-
7
-
-
79960481261
-
Mechanisms of membrane transport of folates into cells and across epithelia
-
CrossRef PubMed
-
Zhao, R., Diop-Bove, N., Visentin, M. and Goldman, I. D. (2011) Mechanisms of membrane transport of folates into cells and across epithelia. Annu. Rev. Nutr. 31, 177-201 CrossRef PubMed
-
(2011)
Annu. Rev. Nutr.
, vol.31
, pp. 177-201
-
-
Zhao, R.1
Diop-Bove, N.2
Visentin, M.3
Goldman, I.D.4
-
8
-
-
84875206514
-
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors
-
CrossRef PubMed
-
Zhao, R. and Goldman, I. D. (2013) Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol. Aspects Med. 34, 373-385 CrossRef PubMed
-
(2013)
Mol. Aspects Med.
, vol.34
, pp. 373-385
-
-
Zhao, R.1
Goldman, I.D.2
-
9
-
-
33947424386
-
Human reduced folate carrier: Translation of basic biology to cancer etiology and therapy
-
DOI 10.1007/s10555-007-9046-2, Special Issue on Transporters in Cancer
-
Matherly, L. H., Hou, Z. and Deng, Y. (2007) Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. Cancer Metastasis Rev. 26, 111-128 CrossRef PubMed (Pubitemid 46452186)
-
(2007)
Cancer and Metastasis Reviews
, vol.26
, Issue.1
, pp. 111-128
-
-
Matherly, L.H.1
Hou, Z.2
Deng, Y.3
-
10
-
-
59849093173
-
Membrane transporters and folate homeostasis: Intestinal absorption and transport into systemic compartments and tissues
-
CrossRef PubMed
-
Zhao, R., Matherly, L. H. and Goldman, I. D. (2009) Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev. Mol. Med. 11, e4 CrossRef PubMed
-
(2009)
Expert Rev. Mol. Med.
, vol.11
-
-
Zhao, R.1
Matherly, L.H.2
Goldman, I.D.3
-
11
-
-
33947362046
-
The folate receptor: What does it promise in tissue-targeted therapeutics?
-
DOI 10.1007/s10555-007-9048-0, Special Issue on Transporters in Cancer
-
Salazar, M. D. and Ratnam, M. (2007) The folate receptor: what does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev. 26, 141-152 CrossRef PubMed (Pubitemid 46452188)
-
(2007)
Cancer and Metastasis Reviews
, vol.26
, Issue.1
, pp. 141-152
-
-
Salazar, M.D.1
Ratnam, M.2
-
12
-
-
84865578333
-
Drug transport by Organic Anion Transporters (OATs)
-
CrossRef PubMed
-
Burckhardt, G. (2012) Drug transport by Organic Anion Transporters (OATs). Pharmacol. Ther. 136, 106-130 CrossRef PubMed
-
(2012)
Pharmacol. Ther.
, vol.136
, pp. 106-130
-
-
Burckhardt, G.1
-
13
-
-
84870710332
-
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
-
CrossRef PubMed
-
Desmoulin, S. K., Hou, Z., Gangjee, A. and Matherly, L. H. (2012) The human proton-coupled folate transporter: biology and therapeutic applications to cancer. Cancer Biol. Ther. 13, 1355-1373 CrossRef PubMed
-
(2012)
Cancer Biol. Ther.
, vol.13
, pp. 1355-1373
-
-
Desmoulin, S.K.1
Hou, Z.2
Gangjee, A.3
Matherly, L.H.4
-
14
-
-
84866844783
-
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter
-
CrossRef PubMed
-
Kugel Desmoulin, S., Wang, L., Polin, L., White, K., Kushner, J., Stout, M., Hou, Z., Cherian, C., Gangjee, A. and Matherly, L. H. (2012) Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Mol. Pharmacol. 82, 591-600 CrossRef PubMed
-
(2012)
Mol. Pharmacol.
, vol.82
, pp. 591-600
-
-
Kugel Desmoulin, S.1
Wang, L.2
Polin, L.3
White, K.4
Kushner, J.5
Stout, M.6
Hou, Z.7
Cherian, C.8
Gangjee, A.9
Matherly, L.H.10
-
15
-
-
0029147794
-
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
-
PubMed
-
Moscow, J. A., Gong, M., He, R., Sgagias, M. K., Dixon, K. H., Anzick, S. L., Meltzer, P. S. and Cowan, K. H. (1995) Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55, 3790-3794 PubMed
-
(1995)
Cancer Res.
, vol.55
, pp. 3790-3794
-
-
Moscow, J.A.1
Gong, M.2
He, R.3
Sgagias, M.K.4
Dixon, K.H.5
Anzick, S.L.6
Meltzer, P.S.7
Cowan, K.H.8
-
16
-
-
4143094813
-
Primary acute lymphoblastic leukemia cells use a novel promoter and 5′noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start
-
DOI 10.1158/1078-0432.CCR-04-0116
-
Flatley, R. M., Payton, S. G., Taub, J. W. and Matherly, L. H. (2004) Primary acute lymphoblastic leukemia cells use a novel promoter and 5′ noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start. Clin. Cancer Res. 10, 5111-5122 CrossRef PubMed (Pubitemid 39099785)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.15
, pp. 5111-5122
-
-
Flatley, R.M.1
Payton, S.G.2
Taub, J.W.3
Matherly, L.H.4
-
17
-
-
0036846897
-
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: Identification of seven non-coding exons and characterization of a novel promoter
-
DOI 10.1042/BJ20020512
-
Whetstine, J. R., Flatley, R. M. and Matherly, L. H. (2002) The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem. J. 367, 629-640 CrossRef PubMed (Pubitemid 35305702)
-
(2002)
Biochemical Journal
, vol.367
, Issue.3
, pp. 629-640
-
-
Whetstine, J.R.1
Flatley, R.M.2
Matherly, L.H.3
-
18
-
-
33847396844
-
Effects of 5′ untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier
-
DOI 10.1016/j.bbaexp.2006.12.006, PII S0167478106002247
-
Payton, S. G., Haska, C. L., Flatley, R. M., Ge, Y. and Matherly, L. H. (2007) Effects of 5′ untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier. Biochim. Biophys. Acta 1769, 131-138 CrossRef PubMed (Pubitemid 46341446)
-
(2007)
Biochimica et Biophysica Acta - Gene Structure and Expression
, vol.1769
, Issue.2
, pp. 131-138
-
-
Payton, S.G.1
Haska, C.L.2
Flatley, R.M.3
Ge, Y.4
Matherly, L.H.5
-
19
-
-
0032532415
-
Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier
-
DOI 10.1016/S0005-2736(98)00118-7, PII S0005273698001187
-
Wong, S. C., Zhang, L., Proefke, S. A. and Matherly, L. H. (1998) Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier. Biochim. Biophys. Acta 1375, 6-12 CrossRef PubMed (Pubitemid 28511388)
-
(1998)
Biochimica et Biophysica Acta - Biomembranes
, vol.1375
, Issue.1-2
, pp. 6-12
-
-
Wong, S.C.1
Zhang, L.2
Proefke, S.A.3
Matherly, L.H.4
-
20
-
-
59149107224
-
Oligomeric structure of the human reduced folate carrier: Identification of homo-oligomers and dominant-negative effects on carrier expression and function
-
CrossRef PubMed
-
Hou, Z. and Matherly, L. H. (2009) Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function. J. Biol. Chem. 284, 3285-3293 CrossRef PubMed
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3285-3293
-
-
Hou, Z.1
Matherly, L.H.2
-
21
-
-
77957224999
-
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors
-
CrossRef PubMed
-
Kugel Desmoulin, S., Wang, Y., Wu, J., Stout, M., Hou, Z., Fulterer, A., Chang, M. H., Romero, M. F., Cherian, C., Gangjee, A. and Matherly, L. H. (2010) Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Mol. Pharmacol. 78, 577-587 CrossRef PubMed
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 577-587
-
-
Kugel Desmoulin, S.1
Wang, Y.2
Wu, J.3
Stout, M.4
Hou, Z.5
Fulterer, A.6
Chang, M.H.7
Romero, M.F.8
Cherian, C.9
Gangjee, A.10
Matherly, L.H.11
-
22
-
-
14044262904
-
Structure and regulation of the murine reduced folate carrier gene: Identification of four noncoding exons and promoters and regulation by dietary folates
-
DOI 10.1074/jbc.M412662200
-
Liu, M., Ge, Y., Cabelof, D. C., Aboukameel, A., Heydari, A. R., Mohammad, R. and Matherly, L. H. (2005) Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates. J. Biol. Chem. 280, 5588-5597 CrossRef PubMed (Pubitemid 40280037)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5588-5597
-
-
Liu, M.1
Ge, Y.2
Cabelof, D.C.3
Aboukameel, A.4
Heydari, A.R.5
Mohammad, R.6
Matherly, L.H.7
-
23
-
-
0021720510
-
A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system
-
Sirotnak, F. M., Moccio, D. M. and Yang, C. H. (1984) A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system. J. Biol. Chem. 259, 13139-13144 PubMed (Pubitemid 15223834)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.21
, pp. 13139-13144
-
-
Sirotnak, F.M.1
Moccio, D.M.2
Yang, C.-H.3
-
24
-
-
0025016121
-
Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates
-
PubMed
-
Jansen, G., Westerhof, G. R., Jarmuszewski, M. J., Kathmann, I., Rijksen, G. and Schornagel, J. H. (1990) Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates. J. Biol. Chem. 265, 18272-18277 PubMed
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18272-18277
-
-
Jansen, G.1
Westerhof, G.R.2
Jarmuszewski, M.J.3
Kathmann, I.4
Rijksen, G.5
Schornagel, J.H.6
-
25
-
-
0026075874
-
Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport
-
PubMed
-
Matherly, L. H., Czajkowski, C. A. and Angeles, S. M. (1991) Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport. Cancer Res. 51, 3420-3426 PubMed
-
(1991)
Cancer Res.
, vol.51
, pp. 3420-3426
-
-
Matherly, L.H.1
Czajkowski, C.A.2
Angeles, S.M.3
-
26
-
-
0038798674
-
Folate uptake in the human intestine: Promoter activity and effect of folate deficiency
-
DOI 10.1002/jcp.10324
-
Subramanian, V. S., Chatterjee, N. and Said, H. M. (2003) Folate uptake in the human intestine: promoter activity and effect of folate deficiency. J. Cell. Physiol. 196, 403-408 CrossRef PubMed (Pubitemid 36775889)
-
(2003)
Journal of Cellular Physiology
, vol.196
, Issue.2
, pp. 403-408
-
-
Subramanian, V.S.1
Chatterjee, N.2
Said, H.M.3
-
27
-
-
51049093216
-
The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis
-
CrossRef PubMed
-
Ifergan, I., Jansen, G. and Assaraf, Y. G. (2008) The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis. J. Biol. Chem. 283, 20687-20695 CrossRef PubMed
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 20687-20695
-
-
Ifergan, I.1
Jansen, G.2
Assaraf, Y.G.3
-
28
-
-
11144237445
-
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier
-
DOI 10.1158/1078-0432.CCR-04-0932
-
Zhao, R., Chattopadhyay, S., Hanscom, M. and Goldman, I. D. (2004) Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. Clin. Cancer Res. 10, 8735-8742 CrossRef PubMed (Pubitemid 40053443)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.24
, pp. 8735-8742
-
-
Zhao, R.1
Chattopadhyay, S.2
Hanscom, M.3
Goldman, I.D.4
-
29
-
-
27744481239
-
Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods
-
DOI 10.1074/jbc.M507295200
-
Hou, Z., Stapels, S. E., Haska, C. L. and Matherly, L. H. (2005) Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods. J. Biol. Chem. 280, 36206-36213 CrossRef PubMed (Pubitemid 41633893)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.43
, pp. 36206-36213
-
-
Hou, Z.1
Stapels, S.E.2
Haska, C.L.3
Matherly, L.H.4
-
30
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
PubMed
-
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 PubMed
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
31
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
CrossRef PubMed
-
Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 CrossRef PubMed
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
32
-
-
33846879411
-
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: A report from the children's oncology group
-
DOI 10.1158/1078-0432.CCR-06-2145
-
Ge, Y., Haska, C. L., LaFiura, K., Devidas, M., Linda, S. B., Liu, M., Thomas, R., Taub, J. W. and Matherly, L. H. (2007) Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Clin. Cancer Res. 13, 451-457 CrossRef PubMed (Pubitemid 46225349)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.2 I
, pp. 451-457
-
-
Ge, Y.1
Haska, C.L.2
LaFiura, K.3
Devidas, M.4
Linda, S.B.5
Liu, M.6
Thomas, R.7
Taub, J.W.8
Matherly, L.H.9
-
33
-
-
8744267535
-
Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: Localization of a substrate binding domain to transmembrane domains 7-12
-
DOI 10.1074/jbc.M408696200
-
Witt, T. L., Stapels, S. E. and Matherly, L. H. (2004) Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12. J. Biol. Chem. 279, 46755-46763 CrossRef PubMed (Pubitemid 39518324)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.45
, pp. 46755-46763
-
-
Witt, T.L.1
Stapels, S.E.2
Matherly, L.H.3
-
34
-
-
0023130109
-
The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue
-
Matherly, L. H., Barlowe, C. K., Phillips, V. M. and Goldman, I. D. (1987) The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue. J. Biol. Chem. 262, 710-717 PubMed (Pubitemid 17005241)
-
(1987)
Journal of Biological Chemistry
, vol.262
, Issue.2
, pp. 710-717
-
-
Matherly, L.H.1
Barlowe, C.K.2
Phillips, V.M.3
Goldman, I.D.4
-
35
-
-
0037193691
-
The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells
-
DOI 10.1016/S0378-1119(02)00591-7, PII S0378111902005917
-
Sadasivan, E., Regec, A. and Rothenberg, S. P. (2002) The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells. Gene 291, 149-158 CrossRef PubMed (Pubitemid 34722385)
-
(2002)
Gene
, vol.291
, Issue.1-2
, pp. 149-158
-
-
Sadasivan, E.1
Regec, A.2
Rothenberg, S.P.3
-
36
-
-
15744376100
-
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation
-
DOI 10.1124/mol.104.008250
-
Ifergan, I., Jansen, G. and Assaraf, Y. G. (2005) Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation. Mol. Pharmacol. 67, 1349-1359 CrossRef PubMed (Pubitemid 40410436)
-
(2005)
Molecular Pharmacology
, vol.67
, Issue.4
, pp. 1349-1359
-
-
Ifergan, I.1
Jansen, G.2
Assaraf, Y.G.3
-
37
-
-
79959481888
-
Protein folding and modification in the mammalian endoplasmic reticulum
-
CrossRef PubMed
-
Braakman, I. and Bulleid, N. J. (2011) Protein folding and modification in the mammalian endoplasmic reticulum. Annu. Rev. Biochem. 80, 71-99 CrossRef PubMed
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 71-99
-
-
Braakman, I.1
Bulleid, N.J.2
|