Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design

BMC Neurology

Volumn 14, Issue 1, 2014, Pages

  Westhall, Erik ^a   Rosén, Ingmar ^a   Rossetti, Andrea O ^b   van Rootselaar, Anne Fleur ^c   Kjaer, Troels W ^d   Horn, Janneke ^c   Ullén, Susann ^e   Friberg, Hans ^a   Nielsen, Niklas ^f   Cronberg, Tobias ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d University of Copenhagen   (Denmark)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f HELSINGBORG HOSPITAL   (Sweden)

Author keywords

Brain injury; EEG; Hypothermia; Interrater variability; Out of hospital cardiac arrest; Prognosis; Resuscitation

Indexed keywords

ANTICONVULSIVE AGENT;

ADULT; ARTICLE; BRAIN INJURY; CLINICAL TRIAL; COMATOSE PATIENT; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; FEMALE; HEART ARREST; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL SPECIALIST; OUT OF HOSPITAL CARDIAC ARREST; OUTCOME ASSESSMENT; PROGNOSIS; PROSPECTIVE STUDY; SEDATION; SEIZURE; TEMPERATURE; WARMING; BODY TEMPERATURE; COMA; CONTROLLED STUDY; METHODOLOGY; PHYSIOLOGY; PILOT STUDY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; SEIZURES;

ADULT; BODY TEMPERATURE; COMA; ELECTROENCEPHALOGRAPHY; HEART ARREST; HUMANS; PILOT PROJECTS; PROGNOSIS; RESEARCH DESIGN; SEIZURES;

EID: 84906832161     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-014-0159-2     Document Type: Article

References (59)

1. Atwood C, Eisenberg MS, Herlitz J, Rea TD. Incidence of EMS-treated out-of-hospital cardiac arrest in Europe. Resuscitation 2005, 67(1):75-80. 10.1016/j.resuscitation.2005.03.021, 16199289.
2. Rea TD, Eisenberg MS, Sinibaldi G, White RD. Incidence of EMS-treated out-of-hospital cardiac arrest in the United States. Resuscitation 2004, 63(1):17-24. 10.1016/j.resuscitation.2004.03.025, 15451582.
3. Adielsson A, Hollenberg J, Karlsson T, Lindqvist J, Lundin S, Silfverstolpe J, Svensson L, Herlitz J. Increase in survival and bystander CPR in out-of-hospital shockable arrhythmia: bystander CPR and female gender are predictors of improved outcome. Experiences from Sweden in an 18-year perspective. Heart 2011, 97(17):1391-1396. 10.1136/hrt.2011.222711, 21715444.
4. Kitamura T, Iwami T, Kawamura T, Nitta M, Nagao K, Nonogi H, Yonemoto N, Kimura T. Nationwide improvements in survival from out-of-hospital cardiac arrest in Japan. Circulation 2012, 126(24):2834-2843. 10.1161/CIRCULATIONAHA.112.109496, 23035209.
5. Stiell IG, Wells GA, Field B, Spaite DW, Nesbitt LP, De Maio VJ, Nichol G, Cousineau D, Blackburn J, Munkley D, Luinstra-Toohey L, Campeau T, Dagnone E, Lyver M. Advanced cardiac life support in out-of-hospital cardiac arrest. N Engl J Med 2004, 351(7):647-656. 10.1056/NEJMoa040325, 15306666.
6. Dragancea I, Rundgren M, Englund E, Friberg H, Cronberg T. The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest. Resuscitation 2013, 84(3):337-342. 10.1016/j.resuscitation.2012.09.015, 23000363.
7. Samaniego EA, Persoon S, Wijman CA. Prognosis after cardiac arrest and hypothermia: a new paradigm. Curr Neurol Neurosci Rep 2011, 11(1):111-119. 10.1007/s11910-010-0148-9, 20927660.
8. Oddo M, Rossetti AO. Predicting neurological outcome after cardiac arrest. Curr Opin Crit Care 2011, 17(3):254-259. 21346563.
9. Rundgren M, Rosen I, Friberg H. Amplitude-integrated EEG (aEEG) predicts outcome after cardiac arrest and induced hypothermia. Intensive Care Med 2006, 32(6):836-842. 10.1007/s00134-006-0178-6, 16715325.
10. Rundgren M, Westhall E, Cronberg T, Rosen I, Friberg H. Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med 2010, 38(9):1838-1844. 20562694.
11. Rossetti AO, Logroscino G, Liaudet L, Ruffieux C, Ribordy V, Schaller MD, Despland PA, Oddo M. Status epilepticus: an independent outcome predictor after cerebral anoxia. Neurology 2007, 69(3):255-260. 10.1212/01.wnl.0000265819.36639.e0, 17636063.
12. Rossetti AO, Oddo M, Liaudet L, Kaplan PW. Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology 2009, 72(8):744-749. 10.1212/01.wnl.0000343006.60851.62, 19237704.
13. Legriel S, Bruneel F, Sediri H, Hilly J, Abbosh N, Lagarrigue MH, Troche G, Guezennec P, Pico F, Bedos JP. Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study. Neurocrit Care 2009, 11(3):338-344. 10.1007/s12028-009-9246-4, 19588273.
14. Wennervirta JE, Ermes MJ, Tiainen SM, Salmi TK, Hynninen MS, Sarkela MO, Hynynen MJ, Stenman UH, Viertio-Oja HE, Saastamoinen KP, Pettila¨ VY, Vakkuri AP. Hypothermia-treated cardiac arrest patients with good neurological outcome differ early in quantitative variables of EEG suppression and epileptiform activity. Crit Care Med 2009, 37(8):2427-2435. 19487928.
15. Bouwes A, van Poppelen D, Koelman JH, Kuiper MA, Zandstra DF, Weinstein HC, Tromp SC, Zandbergen EG, Tijssen MA, Horn J. Acute posthypoxic myoclonus after cardiopulmonary resuscitation. BMC Neurol 2012, 12:63. 10.1186/1471-2377-12-63, 22853736.
16. Hovland A, Nielsen EW, Kluver J, Salvesen R. EEG should be performed during induced hypothermia. Resuscitation 2006, 68(1):143-146. 10.1016/j.resuscitation.2005.05.019, 16325321.
17. Westhall Erik RM, Lilja G, Friberg H, Cronberg T: Postanoxic status epilepticus can be identified and treatment guided successfully by continuous electroencephalography: a case report. Ther Hypothermia Temp Manag 2013, In Press.
18. Deakin CD, Nolan JP, Soar J, Sunde K, Koster RW, Smith GB, Perkins GD. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation 2010, 81(10):1305-1352. 10.1016/j.resuscitation.2010.08.017, 20956049.
19. Claassen J, Taccone FS, Horn P, Holtkamp M, Stocchetti N, Oddo M. Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM. Intensive Care Med 2013, 39(8):1337-1351. 10.1007/s00134-013-2938-4, 23653183.
20. Tortorici MA, Kochanek PM, Poloyac SM. Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med 2007, 35(9):2196-2204. 17855837.
21. Prior PF, Scott DF. Outcome after severe brain damage. Lancet 1973, 1(7806):770. 10.1016/S0140-6736(73)92155-7, 4120744.
22. Scollo-Lavizzari G, Bassetti C. Prognostic value of EEG in post-anoxic coma after cardiac arrest. Eur Neurol 1987, 26(3):161-170. 10.1159/000116329, 3569370.
23. Synek VM. EEG abnormality grades and subdivisions of prognostic importance in traumatic and anoxic coma in adults. Clinical EEG 1988, 19(3):160-166. 10.1177/155005948801900310.
24. Bassetti C, Karbowski K. Prognostic value of electroencephalography in non-traumatic comas. Schweiz Med Wochenschr 1990, 120(39):1425-1434. 2218465.
25. Young GB, McLachlan RS, Kreeft JH, Demelo JD. An electroencephalographic classification for coma. Can J Neurol Sci 1997, 24(4):320-325. 9398979.
26. Grant AC, Abdel-Baki SG, Weedon J, Arnedo V, Chari G, Koziorynska E, Lushbough C, Maus D, McSween T, Mortati KA, Reznikov A, Omurtaq A. EEG interpretation reliability and interpreter confidence: a large single-center study. Epilepsy Behav 2014, 32:102-107. 10.1016/j.yebeh.2014.01.011, 24531133.
27. Mani R, Arif H, Hirsch LJ, Gerard EE, LaRoche SM. Interrater reliability of ICU EEG research terminology. J Clin Neurophysiol 2012, 29(3):203-212. 10.1097/WNP.0b013e3182570f83, 22659712.
28. Abend NS, Gutierrez-Colina A, Zhao H, Guo R, Marsh E, Clancy RR, Dlugos DJ. Interobserver reproducibility of electroencephalogram interpretation in critically ill children. J Clin Neurophysiol 2011, 28(1):15-19. 10.1097/WNP.0b013e3182051123, 21221016.
29. Hirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, Mani R, Arif H, Jette N, Minazad Y, Kerrigan JF, Vespa P, Hantus S, Claassen J, Young GB, So E, Kaplan PW, Nuwer MR, Fountain NB, Drislane FW. American clinical neurophysiology society's standardized critical care EEG terminology: 2012 version. J Clin Neurophysiol 2013, 30(1):1-27. 10.1097/WNP.0b013e3182784729, 23377439.
30. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med 2013, 369(23):2197-2206. 10.1056/NEJMoa1310519, 24237006.
31. Nielsen N, Wetterslev J, Al-Subaie N, Andersson B, Bro-Jeppesen J, Bishop G, Brunetti I, Cranshaw J, Cronberg T, Edqvist K, Erlinge D, Gasche Y, Glover G, Hassager C, Horn J, Hovdenes J, Johnsson J, Kjaergaard J, Kuiper M, Langørgen J, Macken L, Martinell L, Martner P, Pellis T, Pelosi P, Petersen P, Persson S, Rundgren M, Saxena M, Svensson R, et al. Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design. Am Heart J 2012, 163(4):541-548. 10.1016/j.ahj.2012.01.013, 22520518.
32. Westhall E, Rose´n I, Rossetti AO, van Rootselaar AF, Wesenberg Kjaer T, Horn J, Ulle´n S, Cronberg T. Interrater agreement of EEG interpretation in comatose post cardiac arrest patients. Abstract, 30th International Congress of Clinical Neurophysiology, Berlin, 2014 2014, Accepted (march 2014) for publication in Clinical Neurophysiology, Elsevier.
33. Crepeau AZ, Rabinstein AA, Fugate JE, Mandrekar J, Wijdicks EF, White RD, Britton JW. Continuous EEG in therapeutic hypothermia after cardiac arrest: prognostic and clinical value. Neurology 2013, 80(4):339-344. 10.1212/WNL.0b013e31827f089d, 23284064.
34. Kawai M, Thapalia U, Verma A. Outcome from therapeutic hypothermia and EEG. J Clin Neurophysiol 2011, 28(5):483-488. 21946362.
35. Oh SH, Park KN, Kim YM, Kim HJ, Youn CS, Kim SH, Choi SP, Kim SC, Shon YM. The prognostic value of continuous amplitude-integrated electroencephalogram applied immediately after return of spontaneous circulation in therapeutic hypothermia-treated cardiac arrest patients. Resuscitation 2013, 84(2):200-205. 10.1016/j.resuscitation.2012.09.031, 23032690.
36. Bassetti C, Bomio F, Mathis J, Hess CW. Early prognosis in coma after cardiac arrest: a prospective clinical, electrophysiological, and biochemical study of 60 patients. J Neurol Neurosurg Psychiatry 1996, 61(6):610-615. 10.1136/jnnp.61.6.610, 8971110.
37. Rothstein TL, Thomas EM, Sumi SM. Predicting outcome in hypoxic-ischemic coma. A prospective clinical and electrophysiologic study. Electroencephalogr Clin Neurophysiol 1991, 79(2):101-107. 10.1016/0013-4694(91)90046-7, 1713822.
38. Zandbergen EG, Hijdra A, Koelman JH, Hart AA, Vos PE, Verbeek MM, de Haan RJ. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology 2006, 66(1):62-68. 10.1212/01.wnl.0000191308.22233.88, 16401847.
39. Edgren E, Hedstrand U, Nordin M, Rydin E, Ronquist G. Prediction of outcome after cardiac arrest. Crit Care Med 1987, 15(9):820-825. 3621954.
40. Lemmi H, Hubbert CH, Faris AA. The electroencephalogram after resuscitation of cardiocirculatory arrest. J Neurol Neurosurg Psychiatry 1973, 36(6):997-1002. 10.1136/jnnp.36.6.997, 4772731.
41. Young GB, Doig G, Ragazzoni A. Anoxic-ischemic encephalopathy: clinical and electrophysiological associations with outcome. Neurocrit Care 2005, 2(2):159-164. 10.1385/NCC:2:2:159, 16159058.
42. Hockaday JM, Potts F, Epstein E, Bonazzi A, Schwab RS. Electroencephalographic changes in acute cerebral anoxia from cardiac or respiratory arrest. Electroencephalogr Clin Neurophysiol 1965, 18:575-586. 10.1016/0013-4694(65)90075-1, 14296835.
43. Berkhoff M, Donati F, Bassetti C. Postanoxic alpha (theta) coma: a reappraisal of its prognostic significance. Clin Neurophysiol 2000, 111(2):297-304. 10.1016/S1388-2457(99)00246-1, 10680565.
44. Vignaendra V, Wilkus RJ, Copass MK, Chatrian GE. Electroencephalographic rhythms of alpha frequency in comatose patients after cardiopulmonary arrest. Neurology 1974, 24(6):582-588. 10.1212/WNL.24.6.582, 4857554.
45. Kaplan PW, Genoud D, Ho TW, Jallon P. Etiology, neurologic correlations, and prognosis in alpha coma. Clin Neurophysiol 1999, 110(2):205-213. 10.1016/S1388-2457(98)00046-7, 10210610.
46. Chokroverty S. "Alpha-like" rhythms in electroencephalograms in coma after cariac arrest. Neurology 1975, 25(7):655-663. 10.1212/WNL.25.7.655, 1171398.
47. Grindal AB, Suter C, Martinez AJ. Alpha-pattern coma: 24 cases with 9 survivors. Ann Neurol 1977, 1(4):371-377. 10.1002/ana.410010408, 617254.
48. Rittenberger JC, Popescu A, Brenner RP, Guyette FX, Callaway CW. Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac arrest subjects treated with hypothermia. Neurocrit Care 2012, 16(1):114-122. 10.1007/s12028-011-9565-0, 21638118.
49. Rossetti AO, Oddo M, Logroscino G, Kaplan PW. Prognostication after cardiac arrest and hypothermia: a prospective study. Ann Neurol 2010, 67(3):301-307. 20373341.
50. Rossetti AO, Carrera E, Oddo M. Early EEG correlates of neuronal injury after brain anoxia. Neurology 2012, 78(11):796-802. 10.1212/WNL.0b013e318249f6bb, 22323758.
51. Zhang Y, Su YY, Haupt WF, Zhao JW, Xiao SY, Li HL, Pang Y, Yang QL. Application of electrophysiologic techniques in poor outcome prediction among patients with severe focal and diffuse ischemic brain injury. J Clin Neurophysiol 2011, 28(5):497-503. 21946368.
52. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975, 1(7905):480-484. 10.1016/S0140-6736(75)92830-5, 46957.
53. Cronberg T, Rundgren M, Westhall E, Englund E, Siemund R, Rosen I, Widner H, Friberg H. Neuron-specific enolase correlates with other prognostic markers after cardiac arrest. Neurology 2011, 77(7):623-630. 10.1212/WNL.0b013e31822a276d, 21775743.
54. Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006, 67(2):203-210. 10.1212/01.wnl.0000227183.21314.cd, 16864809.
55. Sandroni C, Cavallaro F, Callaway CW, D'Arrigo S, Sanna T, Kuiper MA, Biancone M, Della Marca G, Farcomeni A, Nolan JP. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 2: patients treated with therapeutic hypothermia. Resuscitation 2013, 84(10):1324-1338. 10.1016/j.resuscitation.2013.06.020, 23831242.
56. Sandroni C, Cavallaro F, Callaway CW, Sanna T, D'Arrigo S, Kuiper M, Della Marca G, Nolan JP. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 1: patients not treated with therapeutic hypothermia. Resuscitation 2013, 84(10):1310-1323. 10.1016/j.resuscitation.2013.05.013, 23811182.
57. Hirsch LJ, Brenner RP, Drislane FW, So E, Kaplan PW, Jordan KG, Herman ST, LaRoche SM, Young B, Bleck TP, Scheuer ML, Emerson RG. The ACNS subcommittee on research terminology for continuous EEG monitoring: proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patients. J Clin Neurophysiol 2005, 22(2):128-135. 10.1097/01.WNP.0000158701.89576.4C, 15805813.
58. Sessler CN, Grap MJ, Ramsay MA. Evaluating and monitoring analgesia and sedation in the intensive care unit. Crit Care 2008, 12 Suppl 3:S2. 10.1186/cc6148, 18495053.
59. Oddo M, Rossetti AO: Early multimodal outcome prediction after cardiac arrest in patients treated with hypothermia. Crit Care Med 2014, doi:10.1097/CCM.0000000000000211.