What's deficient in reward deficiency?

Journal of Psychiatry and Neuroscience

Volumn 39, Issue 5, 2014, Pages 291-293

  Leyton, Marco ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; BEHAVIOR DISORDER; CENTRAL NERVOUS SYSTEM FUNCTION; CLINICAL FEATURE; DOPAMINERGIC TRANSMISSION; DRUG SEEKING BEHAVIOR; EDITORIAL; HUMAN; REWARD DEFICIENCY SYNDROME; RISK ASSESSMENT; SUBSTANCE ABUSE; ADDICTION; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGICAL MODEL; PSYCHOLOGY; REWARD;

DOPAMINE; HUMANS; MODELS, PSYCHOLOGICAL; REWARD; SUBSTANCE-RELATED DISORDERS;

EID: 84906813592     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.140204     Document Type: Editorial

References (33)

1. Leventhal AM, Brightman M, Ameringer KJ, et al. Anhedonia associated with stimulant use and dependence in a population-based sample of American adults. Exp Clin Psychopharmacol 2010;18:562-9.
2. Kushner MG, Wall MW, Krueger RF, et al. Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: evidence from a national sample. Alcohol Clin Exp Res 2012;36:325-31.
3. Conway KP, Compton W, Stinson FS, et al. Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiological Survey on Alcohol and Related Disorders. J Clin Psychiatry 2006;67:247-57.
4. Stautz K, Cooper A. Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. Clin Psychol Rev 2013;33:574-92.
5. Leyton M, Vezina P. Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model. Trends Pharmacol Sci 2014;35:268-76.
6. Gawin FH, Kleber HD. Abstinence symptomatology and psychiatric diagnosis in cocaine abusers: clinical observations. Arch Gen Psychiatry 1986;43:107-13.
7. Koob GF. Addiction is a reward deficit and stress surfeit disorder. Front Psychiatry 2013;4:72.
8. Leventhal AM, Kahler CW, Ray LA, et al. Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder. Am J Addict 2008;17:218-23.
9. Bindra D, Stewart J, editors. Motivation. Penguin; 1966.
10. Toates F. Motivational Systems. Cambridge (UK): Cambridge University Press; 1986.
11. Schuckit MA. Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 1984;41:879-84.
12. Schuckit MA, Smith TL, Kalmijn J, et al. Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol 2000;35:242-8.
13. Setiawan E, Pihl RO, Dagher A, et al. Differential striatal dopamine responses following oral alcohol in individuals at varying risk for dependence. Alcohol Clin Exp Res 2014;38:126-34.
14. Tremblay LK, Naranjo CA, Cardenas L, et al. Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine. Arch Gen Psychiatry 2002;59:409-16.
15. Quinn PD, Fromme K. Subjective response to alcohol challenge: a quantitative review. Alcohol Clin Exp Res 2011;35:1759-70.
16. de Wit H, Phillips TJ. Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev 2012;36:1565-76.
17. Blum K, Braverman ER, Holder JM, et al. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 2000;32(Suppl i-iv):1-112.
18. Blum K, Gardner E, Oscar-Berman M, et al. "Liking" and "wanting" linked to reward deficiency syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Curr Pharm Des 2012;18:113-8.
19. Berridge KC, Robinson TE. Parsing reward. Trends Neurosci 2003; 26:507-13.
20. Salamone JD. Functions of mesolimbic dopamine: changing concepts and shifting paradigms. Psychopharmacology (Berl) 2007; 191:389.
21. Venugopalan VV, Casey KF, O'Hara C, et al. Acute phenylalanine/ tyrosine depletion reduces motivation to smoke across stages of addiction. Neuropsychopharmacology 2011;36:2469-76.
22. Liggins J, Pihl RO, Benkelfat C, et al. The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers. PLoS ONE 2012;7:e28370.
23. Wise RA. Dopamine, learning and motivation. Nat Rev Neurosci 2004;5:483-94.
24. Volkow ND, Wang G-J, Fowler JS, et al. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol 2012;52:321-36.
25. Trifilieff P, Martinez D. Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. Neuropharmacology 2014;76 Pt B:498-509.
26. Casey KF, Benkelfat C, Cherkasova MV, et al. Reduced dopamine response to amphetamine in subjects at ultra high risk for addiction. Biol Psychiatry 2014;76:23-30.
27. Little KY, Krolewski DM, Zhang L, et al. Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users. Am J Psychiatry 2003;160:47-55.
28. Leyton M, Vezina P. Striatal ups and downs: their roles in vulnerability to addictions in humans. Neurosci Biobehav Rev 2013;37(9 Pt A):1999-2014.
29. Oberlin BG, Dzemidzic M, Tran SM, et al. Beer flavor provokes striatal dopamine release in male drinkers: mediation by family history of alcoholism. Neuropsychopharmacology 2013;38:1617-24.
30. Leyton M. Conditioned and sensitized responses to stimulant drugs in humans. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:1601-13.
31. Stewart J. Psychological and neural mechanisms of relapse. Philos Trans R Soc Lond B Biol Sci 2008;363:3147-58.
32. Stewart J, de Wit H, Eikelboom R. The role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 1984;91:251-68.
33. Salamone JD, Correa M, Farrar A, et al. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl) 2007;191:461-82.