메뉴 건너뛰기




Volumn 9, Issue 4, 2014, Pages 479-495

Deciphering the therapeutic stem cell strategies of large and midsize pharmaceutical firms

Author keywords

big pharma; cytotherapeutics; disruptive innovation; licensing and partnerships; midsize pharmaceutical firms; radical innovation; stem cells; technology adoption; technology deployment

Indexed keywords

BIOTECHNOLOGY; CELL THERAPY; DECISION MAKING; DRUG INDUSTRY; ECONOMIC EVALUATION; GOVERNMENT REGULATION; HEALTH CARE POLICY; HEMATOPOIETIC STEM CELL; HUMAN; MEDICAL RESEARCH; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SOCIAL MARKETING; STEM CELL TRANSPLANTATION; STRATEGIC PLANNING; ALLOGRAFT; BIOLOGICAL THERAPY; CULTURE TECHNIQUE; ECONOMICS; PROCEDURES; STEM CELL;

EID: 84906730217     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.14.16     Document Type: Review
Times cited : (8)

References (119)
  • 1
    • 0026880552 scopus 로고
    • Between fact and technique: The beginnings of hybridoma technology
    • Cambrosio A, Keating P. Between fact and technique: The beginnings of hybridoma technology. J. Hist. Biol. 25, 175-230 (1992
    • (1992) J. Hist. Biol , vol.25 , pp. 175-230
    • Cambrosio, A.1    Keating, P.2
  • 2
    • 1242285664 scopus 로고    scopus 로고
    • Biotechnology: Identifying advances from the hype
    • Glassman RH, Sun AY. Biotechnology: Identifying advances from the hype. Nat. Rev. Drug Discov. 3, 177-183 (2004
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 177-183
    • Glassman, R.H.1    Sun, A.Y.2
  • 4
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat. Rev. Drug Discov. 9, 767-774 (2010
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 5
    • 84892170718 scopus 로고    scopus 로고
    • What's fueling the biotech engine-2012 to 2013
    • Aggarwal S. What's fueling the biotech engine-2012 to 2013. Nat. Biotechnol. 32, 32-39 (2014
    • (2014) Nat. Biotechnol , vol.32 , pp. 32-39
    • Aggarwal, S.1
  • 6
    • 84906759127 scopus 로고    scopus 로고
    • Biotech products in Big Pharma clinical pipelines have grown dramatically
    • Mullin E. Biotech products in Big Pharma clinical pipelines have grown dramatically. Fierce Biotech, 18 November (2013
    • (2013) Fierce Biotech, 18 November
    • Mullin, E.1
  • 7
    • 33645826067 scopus 로고    scopus 로고
    • Inhibitors of disruptive innovation capability: A conceptual model
    • Assink M. Inhibitors of disruptive innovation capability: A conceptual model. Eur. J. Innov. Manag. 9, 215-233 (2006
    • (2006) Eur. J. Innov. Manag , vol.9 , pp. 215-233
    • Assink, M.1
  • 9
    • 0021441537 scopus 로고
    • Organization strategy and structural differences for radical versus incremental innovation
    • Ettlie J, Bridges WP, O'Keefe RD. Organization strategy and structural differences for radical versus incremental innovation. Manag. Sci. 30, 682-695 (1984
    • (1984) Manag. Sci , vol.30 , pp. 682-695
    • Ettlie, J.1    Bridges, W.P.2    O'keefe, R.D.3
  • 10
    • 0026195225 scopus 로고
    • Corporate imagination and expeditionary marketing
    • Hamel G, Prahalad CK. Corporate imagination and expeditionary marketing. Harv. Bus. Rev. 69, 81-92 (1991
    • (1991) Harv. Bus. Rev , vol.69 , pp. 81-92
    • Hamel, G.1    Prahalad, C.K.2
  • 11
    • 84869431550 scopus 로고
    • Underinvestment and incompetence as responses to radical innovation: Evidence from the photolithographic alignment equipment industry
    • Henderson R. Underinvestment and incompetence as responses to radical innovation: Evidence from the photolithographic alignment equipment industry. Rand J. Econ. 24, 248-270 (1993
    • (1993) Rand J. Econ , vol.24 , pp. 248-270
    • Henderson, R.1
  • 12
    • 15744393506 scopus 로고    scopus 로고
    • Implementing radical innovation in mature firms: The role of hubs
    • Leifer R, Colarelli O'Connor G, Rice M. Implementing radical innovation in mature firms: The role of hubs. Acad. Manag. Exec. 15, 102-113 (2001
    • (2001) Acad. Manag. Exec , vol.15 , pp. 102-113
    • Leifer, R.1    Colarelli O'connor, G.2    Rice, M.3
  • 13
    • 0034413724 scopus 로고    scopus 로고
    • How to manage radical innovation
    • Stringer R. How to manage radical innovation. Calif. Manag. Rev. 42, 70-88 (2000
    • (2000) Calif. Manag. Rev , vol.42 , pp. 70-88
    • Stringer, R.1
  • 17
    • 84906759130 scopus 로고    scopus 로고
    • BP Biofuels: Time for the really hard yards in biofuels commercialization
    • 13 March
    • Lane J. BP Biofuels: Time for "the really hard yards" in biofuels commercialization. Biofuels Digest, 13 March (2013
    • (2013) Biofuels Digest
    • Lane, J.1
  • 18
    • 84878150948 scopus 로고    scopus 로고
    • Extracting value form learning curves: Integrating theory and practice
    • Linton JD, Walsh ST. Extracting value form learning curves: Integrating theory and practice. Creativity Innov. Manag. 22, 10-25 (2013
    • (2013) Creativity Innov. Manag , vol.22 , pp. 10-25
    • Linton, J.D.1    Walsh, S.T.2
  • 19
    • 33746286590 scopus 로고    scopus 로고
    • Implementing biofuels on a global scale
    • Vertès AA, Inui M, Yukawa H. Implementing biofuels on a global scale. Nat. Biotechnol. 24, 761-764 (2006
    • (2006) Nat. Biotechnol , vol.24 , pp. 761-764
    • Vertès, A.A.1    Inui, M.2    Yukawa, H.3
  • 20
  • 21
    • 84867302896 scopus 로고    scopus 로고
    • Improving the success of radical innovation projects within established firms: Engaging employees across different hierarchal levels
    • Bruneel J, Van De Velde E, Clarysse B, Gemmel P. Improving the success of radical innovation projects within established firms: Engaging employees across different hierarchal levels. Technol. Anal. Strateg. Manag. 24, 951-965 (2012
    • (2012) Technol. Anal. Strateg. Manag , vol.24 , pp. 951-965
    • Bruneel, J.1    Van De Velde, E.2    Clarysse, B.3    Gemmel, P.4
  • 23
    • 84942597202 scopus 로고    scopus 로고
    • Adoption of therapeutic stem cell technologies by large pharmaceutical companies
    • Prescott CD, Polak J (Eds). CRC Press, FL, USA 153-175
    • Vertès AA. Adoption of therapeutic stem cell technologies by large pharmaceutical companies. In: The Delivery of Regenerative Medicines and Their Impact on Healthcare. Prescott CD, Polak J (Eds). CRC Press, FL, USA, 153-175 (2010
    • (2010) The Delivery of Regenerative Medicines and Their Impact on Healthcare
    • Vertès, A.A.1
  • 25
    • 77952275912 scopus 로고    scopus 로고
    • Stem cell technologies boost regenerative medicine: Symbiotic relationship expected to lead to new therapies for diseases
    • Netterwald J. Stem cell technologies boost regenerative medicine: Symbiotic relationship expected to lead to new therapies for diseases. Genet. Eng. News 29, 18 (2009
    • (2009) Genet. Eng. News , vol.29 , pp. 18
    • Netterwald, J.1
  • 28
    • 77953673558 scopus 로고    scopus 로고
    • Dissecting monoclonal antibody mega-deals
    • Villiger R, Bogdan B. Dissecting monoclonal antibody mega-deals. mAbs 1, 172-178 (2009
    • (2009) MAbs , vol.1 , pp. 172-178
    • Villiger, R.1    Bogdan, B.2
  • 29
    • 65349117676 scopus 로고    scopus 로고
    • Technologies for enhancing tissue engineering: Materials and environments for guiding stem cell function
    • Alsberg E, Rowley JA. Technologies for enhancing tissue engineering: Materials and environments for guiding stem cell function. Preface. Tissue Eng. A 15, 203-204 (2009
    • (2009) Preface. Tissue Eng , vol.A15 , pp. 203-204
    • Alsberg, E.1    Rowley, J.A.2
  • 31
    • 84906731640 scopus 로고    scopus 로고
    • Industrial applications of stem cells
    • Hug K, Hermerèn G (Eds Humana Press, New York, NY, USA
    • Rossbach M, Hadenfeld M, Brüstle O. Industrial applications of stem cells. In: Translational Stem Cell Research. Hug K, Hermerèn G (Eds). Humana Press, New York, NY, USA, 91-103 (2011
    • (2011) Translational Stem Cell Research , pp. 91-103
    • Rossbach, M.1    Hadenfeld, M.2    Brüstle, O.3
  • 32
    • 42249105242 scopus 로고    scopus 로고
    • Lonza cell therapy
    • Vanek PG. Lonza cell therapy. Future Med. 3, 237-241 (2008
    • (2008) Future Med , vol.3 , pp. 237-241
    • Vanek, P.G.1
  • 33
    • 34147102870 scopus 로고    scopus 로고
    • The global stem cell patent landscape: Implications for efficient technology transfer and commercial development
    • Bergman K, Graff GD. The global stem cell patent landscape: Implications for efficient technology transfer and commercial development. Nat. Biotechnol. 25, 419-424 (2007
    • (2007) Nat. Biotechnol , vol.25 , pp. 419-424
    • Bergman, K.1    Graff, G.D.2
  • 34
    • 68449088160 scopus 로고    scopus 로고
    • Stem cell patents: A landscape analysis
    • Konski AF, Spielthenner DJ. Stem cell patents: A landscape analysis. Nat. Biotechnol. 27, 722-726 (2009
    • (2009) Nat. Biotechnol , vol.27 , pp. 722-726
    • Konski, A.F.1    Spielthenner, D.J.2
  • 36
    • 0034975453 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century
    • Caplan A, Bruder SP. Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century. Trends Mol. Med. 7, 259-264 (2001
    • (2001) Trends Mol Med , vol.7 , pp. 259-264
    • Caplan, A.1    Bruder, S.P.2
  • 37
    • 84906759122 scopus 로고    scopus 로고
    • J&J gambles $12.5 million in rare Big Pharma bet on a stem cell therapy
    • 6 January
    • Carroll J. J&J gambles $12.5 million in rare Big Pharma bet on a stem cell therapy. Fierce Biotech, 6 January (2014
    • (2014) Fierce Biotech
    • Carroll, J.1
  • 43
    • 84906725406 scopus 로고    scopus 로고
    • Anonymous. Celgene NJ USA
    • Anonymous. Celgene Annual Report. Celgene, NJ, USA (2011
    • (2011) Celgene Annual Report
  • 44
    • 84906759115 scopus 로고    scopus 로고
    • ViaCyte, Inc. Raises $10.6 million in a private financing to support clinical development of its cell therapy product for insulin dependent diabetes
    • 10th July
    • Mullin E. ViaCyte, Inc. raises $10.6 million in a private financing to support clinical development of its cell therapy product for insulin dependent diabetes. Fierce Biotech, 10th July (2013
    • (2013) Fierce Biotech
    • Mullin, E.1
  • 45
    • 84873572366 scopus 로고    scopus 로고
    • Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-Throughput screen
    • Ben-David U, Gan QF, Golan-Lev T et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-Throughput screen. Cell stem cell 12, 167-179 (2013
    • (2013) Cell Stem Cell , vol.12 , pp. 167-179
    • Ben-David, U.1    Gan, Q.F.2    Golan-Lev, T.3
  • 46
    • 84906736620 scopus 로고    scopus 로고
    • Small molecules vs teratomas
    • Lou KJ. Small molecules vs. teratomas. Sci. Bus. Exch. 6, 1-2 (2013
    • (2013) Sci. Bus. Exch , vol.6 , pp. 1-2
    • Lou, K.J.1
  • 47
    • 84906759116 scopus 로고    scopus 로고
    • Roche to lead Israel stem cell consortium
    • Anonymous April
    • Anonymous. Roche to lead Israel stem cell consortium. BioJerusalem, 3 April 2011
    • (2011) BioJerusalem , vol.3
  • 48
    • 84905579114 scopus 로고    scopus 로고
    • Syndicate innovation venturing
    • Vertès AA. Syndicate innovation venturing. Challenges 3, 70-83 (2012
    • (2012) Challenges , vol.3 , pp. 70-83
    • Vertès, A.A.1
  • 52
    • 84906759108 scopus 로고    scopus 로고
    • Pharmasset sets inhibitex-To achillion drugmakers deals: Real m&a
    • 22nd November
    • Tirrell M, Lachapelle T Pharmasset sets Inhibitex-To Achillion drugmakers deals: Real M&A. Business Week, 22nd November (2011
    • (2011) Business Week
    • Tirrell, M.1    Lachapelle, T.2
  • 53
    • 38349098747 scopus 로고    scopus 로고
    • Innovation killers: How financial tools destroy your capacity to do new things
    • 137
    • Christensen CM, Kaufman SP, Shih WC. Innovation killers: How financial tools destroy your capacity to do new things. Harv. Bus. Rev. 86(1), 98-105, 137 (2008
    • (2008) Harv. Bus. Rev , vol.86 , Issue.1 , pp. 98-105
    • Christensen, C.M.1    Kaufman, S.P.2    Shih, W.C.3
  • 54
    • 79751506542 scopus 로고    scopus 로고
    • Gene therapy finds its niche
    • Sheridan C. Gene therapy finds its niche. Nat. Biotechnol. 29, 121-128 (2011
    • (2011) Nat. Biotechnol , vol.29 , pp. 121-128
    • Sheridan, C.1
  • 55
    • 84866899464 scopus 로고    scopus 로고
    • Endgame: Glybera finally recommended for approval as the first gene therapy drug in the European union
    • Yla-Herttuala S. Endgame: Glybera finally recommended for approval as the first gene therapy drug in the European union. Mol. Ther. 20, 1831-1832 (2012
    • (2012) Mol Ther , vol.20 , pp. 1831-1832
    • Yla-Herttuala, S.1
  • 57
    • 84906726063 scopus 로고    scopus 로고
    • Sovaldi makes blockbuster history, ignites drug pricing unrest
    • Senior M. Sovaldi makes blockbuster history, ignites drug pricing unrest. Nat. Biotechnol. 32(6), 501-502 (2014
    • (2014) Nat. Biotechnol , vol.32 , Issue.6 , pp. 501-502
    • Senior, M.1
  • 58
    • 78651297594 scopus 로고    scopus 로고
    • The problems with today's pharmaceutical business-An outsider's view
    • Kessel M. The problems with today's pharmaceutical business-An outsider's view. Nat. Biotechnol. 29, 27-33 (2011
    • (2011) Nat. Biotechnol , vol.29 , pp. 27-33
    • Kessel, M.1
  • 59
    • 78650846239 scopus 로고    scopus 로고
    • Patent watch: The patent cliff steepens
    • Harrison C. Patent watch: The patent cliff steepens. Nat. Rev. Drug Discov. 10, 12-13 (2011
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 12-13
    • Harrison, C.1
  • 60
    • 79955797571 scopus 로고    scopus 로고
    • Cell therapy industry: Billion dollar global business with unlimited potential
    • Mason C, Brindley DA, Culme-Seymour EJ, Davie NL. Cell therapy industry: Billion dollar global business with unlimited potential. Regen. Med. 6, 265-272 (2011
    • (2011) Regen. Med , vol.6 , pp. 265-272
    • Mason, C.1    Brindley, D.A.2    Culme-Seymour, E.J.3    Davie, N.L.4
  • 61
    • 84870889053 scopus 로고    scopus 로고
    • The global cell therapy industry continues to rise during the second and third quarters of 2012
    • Mason C, McCall MJ, Culme-Seymour EJ et al The global cell therapy industry continues to rise during the second and third quarters of 2012. Cell Stem Cell 11, 735-739 (2012
    • (2012) Cell Stem Cell , vol.11 , pp. 735-739
    • Mason, C.1    McCall, M.J.2    Culme-Seymour, E.J.3
  • 64
    • 84906776765 scopus 로고    scopus 로고
    • Anonymous. Novo Nordisk, Bagsværd, Denmark
    • Anonymous. Novo Nordisk Annual Report 2005. Novo Nordisk, Bagsværd, Denmark (2005
    • (2005) Novo Nordisk Annual Report 2005
  • 65
    • 84906729665 scopus 로고    scopus 로고
    • Anonymous. Novo Nordisk Bagsværd, Denmark
    • Anonymous. Novo Nordisk Annual Report 2010. Novo Nordisk, Bagsværd, Denmark (2010
    • (2010) Novo Nordisk Annual Report 2010
  • 66
    • 24944591025 scopus 로고    scopus 로고
    • New sources of pancreatic beta-cells
    • Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat. Biotechnol. 23, 857-861 (2005
    • (2005) Nat. Biotechnol , vol.23 , pp. 857-861
    • Bonner-Weir, S.1    Weir, G.C.2
  • 67
    • 65649109022 scopus 로고    scopus 로고
    • Stem cells to pancreatic beta-cells: New sources for diabetes cell therapy
    • Guo T, Hebrok M. Stem cells to pancreatic beta-cells: New sources for diabetes cell therapy. Endocr. Rev. 30, 214-227 (2009
    • (2009) Endocr. Rev , vol.30 , pp. 214-227
    • Guo, T.1    Hebrok, M.2
  • 70
    • 3342973104 scopus 로고    scopus 로고
    • Disruptive technology reconsidered: A critique and research agenda
    • Danneels E. Disruptive technology reconsidered: A critique and research agenda. J. Prod. Innov. Manag. 21, 246-258 (2004
    • (2004) J. Prod. Innov. Manag , vol.21 , pp. 246-258
    • Danneels, E.1
  • 71
    • 79960866711 scopus 로고    scopus 로고
    • Concise review: Toward stem cell-based therapies for retinal neurodegenerative diseases
    • Bull ND, Martin KR. Concise review: Toward stem cell-based therapies for retinal neurodegenerative diseases. Stem Cells 29, 1170-1175 (2011
    • (2011) Stem Cells , vol.29 , pp. 1170-1175
    • Bull, N.D.1    Martin, K.R.2
  • 72
    • 70349765282 scopus 로고    scopus 로고
    • Stemming vision loss with stem cells: Seeing is believing
    • Coffey P. Stemming vision loss with stem cells: Seeing is believing. Future Med. 4, 505-507 (2009
    • (2009) Future Med , vol.4 , pp. 505-507
    • Coffey, P.1
  • 73
    • 77649181500 scopus 로고    scopus 로고
    • Allogeneic haematopoietic stem cell transplantation: Individualized stem cell and immune therapy of cancer
    • Jenq RR, Van Den Brink MR. Allogeneic haematopoietic stem cell transplantation: Individualized stem cell and immune therapy of cancer. Nat. Rev. Cancer 10, 213-221 (2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 213-221
    • Jenq, R.R.1    Van Den Brink, M.R.2
  • 74
    • 33750592790 scopus 로고    scopus 로고
    • Concise review: Recent advances on the significance of stem cells in tissue regeneration and cancer therapies
    • Mimeault M, Batra SK. Concise review: Recent advances on the significance of stem cells in tissue regeneration and cancer therapies. Stem Cells 24, 2319-2345 (2006
    • (2006) Stem Cells , vol.24 , pp. 2319-2345
    • Mimeault, M.1    Batra, S.K.2
  • 75
    • 84862296994 scopus 로고    scopus 로고
    • Effect of in vitro exposure of corticosteroid drugs, conventionally used in AMD treatment, on mesenchymal stem cells
    • Nuzzi R, Gunetti M, Rustichelli D et al. Effect of in vitro exposure of corticosteroid drugs, conventionally used in AMD treatment, on mesenchymal stem cells. Stem Cell Int. 2012, 946090 (2012
    • (2012) Stem Cell Int , vol.2012 , pp. 946090
    • Nuzzi, R.1    Gunetti, M.2    Rustichelli, D.3
  • 76
    • 84869790082 scopus 로고    scopus 로고
    • The ceo of novartis on growing after a patent cliff
    • Jimenez J. The CEO of Novartis on growing after a patent cliff. Harv. Bus. Rev. 90, 39-42 (2012
    • (2012) Harv. Bus. Rev , vol.90 , pp. 39-42
    • Jimenez, J.1
  • 77
    • 11144303609 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation as treatment for hematological malignancies: A review
    • Baron F, Storb R. Allogeneic hematopoietic cell transplantation as treatment for hematological malignancies: A review. Springer Semin. Immunopathol. 26, 71-94 (2004
    • (2004) Springer Semin Immunopathol , vol.26 , pp. 71-94
    • Baron, F.1    Storb, R.2
  • 78
    • 75149155592 scopus 로고    scopus 로고
    • History of cord blood transplantation
    • Gluckman E. History of cord blood transplantation. Bone Marrow Transplant. 44, 621-626 (2009
    • (2009) Bone Marrow Transplant , vol.44 , pp. 621-626
    • Gluckman, E.1
  • 79
    • 0032697244 scopus 로고    scopus 로고
    • Bone marrow transplantation: A review
    • Thomas ED. Bone marrow transplantation: A review. Semin. Hematol. 36, 95-103 (1999
    • (1999) Semin. Hematol , vol.36 , pp. 95-103
    • Thomas, E.D.1
  • 81
    • 34347334543 scopus 로고    scopus 로고
    • CD26 inhibition on CD34+ or lineage-human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-Term engraftment into NOD/SCID/Beta2null immunodeficient mice
    • Christopherson KW 2nd, Paganessi LA, Napier S, Porecha NK. CD26 inhibition on CD34+ or lineage-human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-Term engraftment into NOD/SCID/Beta2null immunodeficient mice. Stem Cells Dev. 16, 355-360 (2007
    • (2007) Stem Cells Dev , vol.16 , pp. 355-360
    • Christopherson, I.I.K.W.1    Paganessi, L.A.2    Napier, S.3    Porecha, N.K.4
  • 82
    • 84862777323 scopus 로고    scopus 로고
    • Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rgamma(null) mice
    • Robinson SN, Simmons PJ, Thomas MW et al. Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rgamma(null) mice. Exp. Hematol. 40, 445-456 (2012
    • (2012) Exp. Hematol , vol.40 , pp. 445-456
    • Robinson, S.N.1    Simmons, P.J.2    Thomas, M.W.3
  • 83
    • 84862536697 scopus 로고    scopus 로고
    • Re: Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rgamma(null) mice
    • Sackstein R. Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rgamma(null) mice". Exp. Hematol. 40, 518-519 (2012
    • (2012) Exp Hematol , vol.40 , pp. 518-519
    • Sackstein, R.1
  • 84
    • 84905578035 scopus 로고    scopus 로고
    • Commercialization of regenerative products: The academic-industry partnership
    • doi:10.1089/ten.teb.2012.0683 Epub ahead of print
    • Bayon Y, Ellison S, Vertès AA et al. Commercialization of regenerative products: The academic-industry partnership. Tissue Eng. B doi:10.1089/ten.teb.2012.0683 (2013) (Epub ahead of print
    • (2013) Tissue Eng. B
    • Bayon, Y.1    Ellison, S.2    Vertès, A.A.3
  • 85
    • 34147170980 scopus 로고    scopus 로고
    • Radical innovation in established organizations: Being a knowledge predator
    • Castiaux A. Radical innovation in established organizations: Being a knowledge predator. J. Eng. Technol. Manag. 24, 36-52 (2007
    • (2007) J. Eng. Technol. Manag , vol.24 , pp. 36-52
    • Castiaux, A.1
  • 86
    • 84906730635 scopus 로고    scopus 로고
    • Anonymous. Cephalon PA, USA
    • Anonymous. 2010 Cephalon Annual Report. Cephalon, PA, USA (2010
    • (2010) 2010 Cephalon Annual Report
  • 90
    • 84861867722 scopus 로고    scopus 로고
    • Deal watch: Shire increases focus on regenerative medicine
    • Crunkhorn S. Deal watch: Shire increases focus on regenerative medicine. Nat. Rev. Drug Discov. 11(6), 430 (2012
    • (2012) Nat. Rev. Drug Discov , vol.11 , Issue.6 , pp. 430
    • Crunkhorn, S.1
  • 91
    • 79952608903 scopus 로고    scopus 로고
    • The story of Advanced BioHealing: Commercializing bioengineered tissue products
    • Tozer D. The story of Advanced BioHealing: Commercializing bioengineered tissue products. Future Med. 6, 157-161 (2011
    • (2011) Future Med , vol.6 , pp. 157-161
    • Tozer, D.1
  • 94
    • 33646846847 scopus 로고    scopus 로고
    • Oti-010 osiris therapeutics/jcr pharmaceuticals
    • Taupin P. OTI-010 Osiris Therapeutics/JCR Pharmaceuticals. Curr. Opin. Investig. Drugs 7, 473-481 (2006
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , pp. 473-481
    • Taupin, P.1
  • 96
    • 49549099775 scopus 로고    scopus 로고
    • Launch of a national mandatory chronic disease prevention program in japan
    • Kobayashi A. Launch of a National Mandatory Chronic Disease Prevention Program in Japan. Dis. Manag. Health Outcomes 16(4), 217-225 (2008
    • (2008) Dis. Manag. Health Outcomes , vol.16 , Issue.4 , pp. 217-225
    • Kobayashi, A.1
  • 99
    • 84879585559 scopus 로고    scopus 로고
    • Japan to offer fast-Track approval path for stem cell therapies
    • Cyranoski D. Japan to offer fast-Track approval path for stem cell therapies. Nat. Med. 19, 510 (2013
    • (2013) Nat. Med , vol.19 , Issue.510
    • Cyranoski, D.1
  • 101
    • 77649159797 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells
    • Kunisato A, Wakatsuki M, Kodama Y, Shinba H, Ishida I, Nagao K. Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells. Stem Cells Dev. 19, 229-238 (2010
    • (2010) Stem Cells Dev , vol.19 , pp. 229-238
    • Kunisato, A.1    Wakatsuki, M.2    Kodama, Y.3    Shinba, H.4    Ishida, I.5    Nagao, K.6
  • 103
    • 78149340082 scopus 로고    scopus 로고
    • Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes
    • Imamura M, Aoi T, Tokumasu A et al. Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes. Mol. Reprod. Dev. 77, 802-811 (2010
    • (2010) Mol. Reprod. Dev , vol.77 , pp. 802-811
    • Imamura, M.1    Aoi, T.2    Tokumasu, A.3
  • 107
    • 77956620353 scopus 로고    scopus 로고
    • Pharma's developing interest in stem cells
    • McKernan R, McNeish J, Smith D. Pharma's developing interest in stem cells. Cell Stem Cell 6, 517-520 (2010
    • (2010) Cell Stem Cell , vol.6 , pp. 517-520
    • McKernan, R.1    McNeish, J.2    Smith, D.3
  • 108
    • 84860713852 scopus 로고    scopus 로고
    • Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer
    • Gardner TA, Elzey BD, Hahn NM. Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer. Hum. Vaccines Immunother. 8, 534-539 (2012
    • (2012) Hum. Vaccines Immunother , vol.8 , pp. 534-539
    • Gardner, T.A.1    Elzey, B.D.2    Hahn, N.M.3
  • 110
    • 84880672247 scopus 로고    scopus 로고
    • What matters most in commercial success: First-in-class or best-in-class?
    • Schulze U, Ringel M. What matters most in commercial success: First-in-class or best-in-class? Nat. Rev. Drug Discov. 12, 419-420 (2013
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 419-420
    • Schulze, U.1    Ringel, M.2
  • 111
    • 65349091115 scopus 로고    scopus 로고
    • Graft-versus-host disease: A complex long-Term side effect of hematopoietic stem cell transplant
    • Barton-Burke M, Dwinell DM, Kafkas L et al. Graft-versus-host disease: A complex long-Term side effect of hematopoietic stem cell transplant. Oncology (Williston Park) 22, 31-45 (2008
    • (2008) Oncology (Williston Park) , vol.22 , pp. 31-45
    • Barton-Burke, M.1    Dwinell, D.M.2    Kafkas, L.3
  • 112
    • 84859173432 scopus 로고    scopus 로고
    • History of hematopoietic stem cell transplantation: Evolution and perspectives
    • Gratwohl A, Niederwieser D. History of hematopoietic stem cell transplantation: Evolution and perspectives. Curr. Probl. Dermatol. 43, 81-90 (2012
    • (2012) Curr. Probl. Dermatol , vol.43 , pp. 81-90
    • Gratwohl, A.1    Niederwieser, D.2
  • 113
    • 38449092179 scopus 로고    scopus 로고
    • A brief definition of regenerative medicine
    • Mason C, Dunnill P. A brief definition of regenerative medicine. Regen. Med. 3, 1-5 (2008
    • (2008) Regen. Med , vol.3 , pp. 1-5
    • Mason, C.1    Dunnill, P.2
  • 114
    • 77952584405 scopus 로고    scopus 로고
    • Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-Tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning
    • Baron F, Lechanteur C, Willems E et al. Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-Tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Biol. Blood Marrow Transplant. 16, 838-847 (2010
    • (2010) Biol. Blood Marrow Transplant , vol.16 , pp. 838-847
    • Baron, F.1    Lechanteur, C.2    Willems, E.3
  • 115
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363, 1439-1441 (2004
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 116
    • 60349129494 scopus 로고    scopus 로고
    • Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium
    • von Bonin M, Stolzel F, Goedecke A et al. Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium. Bone Marrow Transplant. 43, 245-251 (2009
    • (2009) Bone Marrow Transplant , vol.43 , pp. 245-251
    • Von Bonin, M.1    Stolzel, F.2    Goedecke, A.3
  • 118
    • 80955157840 scopus 로고    scopus 로고
    • Stem cells for retinal replacement therapy
    • Stern JH, Temple S. Stem cells for retinal replacement therapy. Neurotherapeutics 8, 736-743 (2011
    • (2011) Neurotherapeutics , vol.8 , pp. 736-743
    • Stern, J.H.1    Temple, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.