Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ null mice

Experimental Hematology

Volumn 40, Issue 6, 2012, Pages 445-456

  Robinson, Simon N ^a   Simmons, Paul J ^b   Thomas, Michael W ^a   Brouard, Nathalie ^b   Javni, Jeannie A ^b   Trilok, Suprita ^b   Shim, Jae Seung ^b   Yang, Hong ^a   Steiner, David ^a   Decker, William K ^a   Xing, Dongxia ^a   Shultz, Leonard D ^c   Savoldo, Barbara ^d   Dotti, Gianpietro ^d   Bollard, Catherine M ^d   Miller, Leonard ^e   Champlin, Richard E ^a   Shpall, Elizabeth J ^a   Zweidler McKay, Patrick A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c JACKSON LABORATORY   (United States)

^d CENTER FOR CELL AND GENE THERAPY   (United States)

^e America Stem Cell Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUCOSYLTRANSFERASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2 RECEPTOR GAMMA; CD34 ANTIGEN; FUCOSE; MEMBRANE PROTEIN; P SELECTIN LIGAND PROTEIN; P-SELECTIN LIGAND PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; BONE MARROW CELL; CD34 SELECTION; CELL HOMING; CELL INTERACTION; CELL LINEAGE; CELL VIABILITY; COLONY FORMING UNIT; CONTROLLED STUDY; CORRELATION ANALYSIS; ENGRAFTMENT; EX VIVO STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FUCOSYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE RECONSTITUTION; MICROVASCULATURE; MOUSE; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SEVERE COMBINED IMMUNODEFICIENCY; UMBILICAL CORD BLOOD; ANIMAL; CYTOLOGY; FETUS BLOOD; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; SPLEEN; TRANSPLANTATION; XENOGRAFT;

MUS;

ANIMALS; ANTIGENS, CD34; BONE MARROW CELLS; CELL LINEAGE; FETAL BLOOD; FLOW CYTOMETRY; FUCOSE; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; SPLEEN; TRANSPLANTATION, HETEROLOGOUS;

EID: 84862777323     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2012.01.015     Document Type: Article

References (44)

1. Wagner J.E., Rosenthal J., Sweetman R., et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood 1996, 88:795-802.
2. Kurtzberg J., Laughlin M., Graham M.L., et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 1996, 335:157-166.
3. Gluckman E., Rocha V., Boyer-Chammard A., et al. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997, 337:373-381.
4. Rocha V., Wagner J.E., Sobocinski K.A., et al. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 2000, 342:1846-1854.
5. Bensinger W.I., Clift R., Martin P., et al. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation. Blood 1996, 88:2794-2800.
6. Bensinger W.I., Weaver C.H., Appelbaum F.R., et al. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor. Blood 1995, 85:1655-1658.
7. Bensinger W.I., Martin P.J., Storer B., et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. N Engl J Med 2001, 344:175-181.
8. McGlave P., Bartsch G., Anasetti C., et al. Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program. Blood 1993, 81:543-550.
9. Kernan N.A., Bartsch G., Ash R.C., et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 1993, 328:593-602.
10. Schiller G., Feig S.A., Territo M., et al. Treatment of advanced acute leukaemia with allogeneic bone marrow transplantation from unrelated donors. Br J Haematol 1994, 88:72-78.
11. Szydlo R., Goldman J.M., Klein J.P., et al. Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol 1997, 15:1767-1777.
12. Berthou C., Legros-Maida S., Soulie A., et al. Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes. Blood 1995, 85:1540-1546.
13. Majhail N.S., Mothukuri J.M., Brunstein C.G., Weisdorf D.J. Costs of hematopoietic cell transplantation: comparison of umbilical cord blood and matched related donor transplantation and the impact of posttransplant complications. Biol Blood Marrow Transplant 2009, 15:564-573.
14. Frenette P.S., Subbarao S., Mazo I.B., von Andrian U.H., Wagner D.D. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A 1998, 95:14423-14428.
15. Mazo I.B., Gutierrez-Ramos J.C., Frenette P.S., et al. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med 1998, 188:465-474.
16. Katayama Y., Hidalgo A., Furie B.C., et al. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood 2003, 102:2060-2067.
17. Papayannopoulou T., Craddock C., Nakamoto B., Priestley G.V., Wolf N.S. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci U S A 1995, 92:9647-9651.
18. Papayannopoulou T., Priestley G.V., Nakamoto B., Zafiropoulos V., Scott L.M. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 2001, 98:2403-2411.
19. Vermeulen M., Le P.F., Gagnerault M.C., et al. Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 1998, 92:894-900.
20. Dimitroff C.J., Lee J.Y., Rafii S., Fuhlbrigge R.C., Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol 2001, 153:1277-1286.
21. Avigdor A., Goichberg P., Shivtiel S., et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 2004, 103:2981-2989.
22. Schweitzer K.M., Dräger A.M., van der Valk P., et al. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol 1996, 148:165-175.
23. McEver R.P., Moore K.L., Cummings R.D. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem 1995, 270:11025-11028.
24. Peled A., Grabovsky V., Habler L., et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J Clin Invest 1999, 104:1199-1211.
25. Hidalgo A., Weiss L.A., Frenette P.S. Functional selectin ligands mediating human CD34(+) cell interactions with bone marrow endothelium are enhanced postnatally. J Clin Invest 2002, 110:559-569.
26. Rubinstein P., Carrier C., Scaradavou A., et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998, 339:1565-1577.
27. Gluckman E., Rocha V., Arcese W., et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 2004, 32:397-407.
28. Wagner J.E., Barker J.N., Defor T.E., et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002, 100:1611-1618.
29. Xia L., McDaniel J.M., Yago T., Doeden A., McEver R.P. Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood 2004, 104:3091-3096.
30. Hidalgo A., Frenette P.S. Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow. Blood 2005, 105:567-575.
31. Shultz L.D., Lyons B.L., Burzenski L.M., et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005, 174:6477-6489.
32. Kobzdej M.M., Leppanen A., Ramachandran V., Cummings R.D., McEver R.P. Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells. Blood 2002, 100:4485-4494.
33. Xia L., Sperandio M., Yago T., et al. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest 2002, 109:939-950.
34. Matsuura N., Puzon-McLaughlin W., Irie A., Morikawa Y., Kakudo K., Takada Y. Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells. Am J Pathol 1996, 148:55-61.
35. Winkler I.G., Snapp K.R., Simmons P.J., Levesque J.P. Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Blood 2004, 103:1685-1692.
36. Greenberg A.W., Kerr W.G., Hammer D.A. Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development. Blood 2000, 95:478-486.
37. Steiner D., Gelovani J., Savoldo B., et al. Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells. Stem Cells 2009, 27:1932-1940.
38. Laakso M.M., Sutton R.E. Replicative fidelity of lentiviral vectors produced by transient transfection. Virology 2006, 348:406-417.
39. Kelly P.F., Vandergriff J., Nathwani A., Nienhuis A.W., Vanin E.F. Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein. Blood 2000, 96:1206-1214.
40. Martin F.H., Suggs S.V., Langley K.E., et al. Primary structure and functional expression of rat and human stem cell factor DNAs. Cell 1990, 63:203-211.
41. Shanafelt A.B., Johnson K.E., Kastelein R.A. Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity. J Biol Chem 1991, 266:13804-13810.
42. Yang Y.C., Ciarletta A.B., Temple P.A., et al. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 1986, 47:3-10.
43. Wagemaker G., Burger H., van Gils F.C., van Leen R.W., Wielenga J.J. Interleukin-3. Biotherapy 1990, 2:337-345.
44. Sackstein R., Merzaban J.S., Cain D.W., et al. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med 2008, 14:181-187.