Detection of sibutramine in adulterated dietary supplements using attenuated total reflectance-infrared spectroscopy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 100, Issue , 2014, Pages 279-283

  Deconinck, E ^a   Cauwenbergh, T ^a   Bothy, J L ^a   Custers, D ^a,b   Courselle, P ^a   De Beer, J O ^a  

^a SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Adulterated dietary supplements; ATR IR; Chemometrics; Mobile detection approaches; Sibutramine

Indexed keywords

SIBUTRAMINE; ANOREXIGENIC AGENT; CYCLOBUTANE DERIVATIVE;

ARTICLE; CHEMOMETRIC ANALYSIS; DIET SUPPLEMENTATION; DRUG SCREENING; FALSE POSITIVE RESULT; INFRARED SPECTROSCOPY; K NEAREST NEIGHBOR; PREDICTION; PRIORITY JOURNAL; ANALYSIS; DECISION TREE; DRUG CONTAMINATION; EVALUATION STUDY; INFRARED SPECTROPHOTOMETRY; LABORATORY DIAGNOSIS; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; REGRESSION ANALYSIS; REPRODUCIBILITY; STANDARDS; ATTENUATED TOTAL REFLECTANCE INFRARED SPECTROSCOPY;

APPETITE DEPRESSANTS; CYCLOBUTANES; DECISION TREES; DIETARY SUPPLEMENTS; DRUG CONTAMINATION; FALSE POSITIVE REACTIONS; LEAST-SQUARES ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, INFRARED;

EID: 84906725058     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.08.009     Document Type: Article

References (19)

1. Tang M.H.Y., Chen S.P.L., Ng S.W., Chan A.Y.W., Mak T.W.L. Case series on a diversity of illicit weight-reducing agents: from the well-known to the unexpected. Br. J. Clin. Pharmacol. 2011, 71:250-253.
2. Kim H.J., Lee J.H., Park H.J., Cho S.H., Cho S., Kim W.S. Monitoring of 29 weight-loss compounds in foods and dietary supplements by LC-MS/MS. Food Addit. Contam. A: Chem. Anal. Control Expo. Risk Assess. 2014, 31:777-783.
3. de Carvalho L.M., Martini M., Moreira A.P.L., de Lima A.P.S., Correia D., Falcao T., Garcia S.C., de Bairros A.V., do Nascimento P.C., Bohrer D. Presence of synthetic pharmaceuticals as aldulterants in slimming phytotherapeutic formulations and their analytical determination. Forensic Sci. Int. 2011, 204:6-12.
4. Venhuis B.J., Vredenbregt M.V., Kaun N., Mauri J.K., Fijalek Z., de Kaste D. The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the Internet. J. Pharm. Biomed. Anal. 2011, 54:21-26.
5. Chen Y., Zhao L., Lu F., Chai Y., Wu Y. Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS/MS. Food Addit. Contam. A: Chem. Anal. Control Expo. Risk Assess. 2009, 26:595-603.
6. Wang J., Chen B., Yao S. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit. Contam. A: Chem. Anal. Control Expo. Risk Assess. 2008, 25:822-830.
7. Bae J.W., Choi C.I., Lee S.Y. Simultaneous determination of sibutramine and its active metabolites in human plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomed. Chromatogr. 2011, (in press). 10.1002/bmc.1587.
8. Kim S.H., Lee J., Yoon T., Choi J., Choi D., Kim D., Won Kwon S. Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. Biomed. Chromatogr. 2009, 23:1259-1265.
9. Diefenbach I.C., Friedrich M., Dos Santos M.R., Bittencourt C.F. Development and validation of a column high-performance liquid chromatographic method for determination of sibutramine in capsules. J. AOAC Int. 2009, 92:148-151.
10. Song F., Monroe D., El-Demerdash A., Palmer C. Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 2014, 88:136-143.
11. Deconinck E., Sacré P.Y., Courselle P., De Beer J.O. Chromatography in the detection and characterization of illegal pharmaceutical preparations. J. Chromatogr. Sci. 2013, 51:791-806.
12. Sacré P.-Y., Deconinck E., De Beer T., Courselle P., Vancauwenberghe R., Chiap P., Crommen J., De Beer J.O. Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. J. Pharm. Biomed. Anal. 2010, 53:445-453.
13. Deconinck E., Sacré P.-Y., Coomans D., De Beer J. Classification trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medicines. J. Pharm. Biomed. Anal. 2012, 57:68-75.
14. Massart D.L., Vandeginste B.G.M., Buydens L.M.C., De Jong S., Lewi P.J., Smeyers-Verbeke J. Handbook of Chemometrics and Qualimetrics - Part A 1997, Elsevier Science, Amsterdam.
15. Croux C., Ruiz-Gazen A. COMPSTAT: Proceedings in Computational Statistiques 1996, 211-217. Physica-Verlag, Heidelberg.
16. Breiman L., Friedman J.H., Olshen R.A., Stone C.J. Classification and Regression Trees 1984, Wadsworth & Brooks, Monterey.
17. Deconinck E., Hancock T., Coomans D., Massart D.L., Vander Heyden Y. Classification of drugs in absorption-classes using the Classification And Regression Trees (CART)-methodology. J. Pharm. Biomed. Anal. 2005, 39:91-103.
18. Breiman L. Random forests. Mach. Learn. 2001, 45:5-32.
19. Snee R.D. Validation of regression models: methods and examples. Technometrics 1977, 19:415-428.