Rationally induced RNA:DNA G-Quadruplex structures elicit an anticancer effect by inhibiting endogenous eIF-4E expression

Biochemistry

Volumn 53, Issue 33, 2014, Pages 5461-5470

  Bhattacharyya, Debmalya ^a   Nguyen, Kim ^b   Basu, Soumitra ^a  

^a KENT STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DNA; GENE EXPRESSION; OLIGONUCLEOTIDES; PHYSIOLOGICAL MODELS; PROTEINS; RNA;

5'-UNTRANSLATED REGIONS; BIOCHEMICAL METHODS; DOSE-DEPENDENT MANNER; G-QUADRUPLEX STRUCTURE; OLIGONUCLEOTIDE SEQUENCES; PROTEIN CODING REGIONS; PROTEIN EXPRESSIONS; THERMODYNAMIC PARAMETER;

DNA SEQUENCES;

GUANINE QUADRUPLEX; INITIATION FACTOR 4E; MESSENGER RNA; 5' UNTRANSLATED REGION; ANTINEOPLASTIC AGENT; OLIGONUCLEOTIDE;

5' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; DNA RNA HYBRIDIZATION; DNA SEQUENCE; DNA STRUCTURE; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; HELA CELL LINE; HUMAN; HUMAN CELL; MULTIPLE CANCER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REPORTER GENE; THERMODYNAMICS; TRANSLATION INITIATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; PLASMID; PROTEIN SYNTHESIS; TEMPERATURE;

5' UNTRANSLATED REGIONS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CIRCULAR DICHROISM; EUKARYOTIC INITIATION FACTOR-4E; G-QUADRUPLEXES; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; OLIGONUCLEOTIDES; PLASMIDS; PROTEIN BIOSYNTHESIS; TEMPERATURE;

EID: 84906656923     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5008904     Document Type: Article

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