A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes

Connective Tissue Research

Volumn 55, Issue SUPPL. 1, 2014, Pages 129-133

  Ren, Y ^a   Lin, S ^a   Jing, Y ^a   Dechow, P C ^a   Feng, Jian Q ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

Author keywords

DMP1; FITC; Imaris; Osteocyte quantification

Indexed keywords

DENTIN MATRIX PROTEIN 1; FLUORESCEIN ISOTHIOCYANATE; DMP1 PROTEIN, MOUSE; SCLEROPROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL STRUCTURE; CELL SURFACE; CELL VOLUME; COMPARATIVE STUDY; COMPUTER PROGRAM; CONFERENCE PAPER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITE; HUMAN; HUMAN TISSUE; MALE; MORPHOLOGY; MOUSE; NONHUMAN; OSTEOCYTE; OSTEOMALACIA; RAT; SCANNING ELECTRON MICROSCOPY; ANIMAL; BONE; CYTOLOGY; DEFICIENCY; GENETICS; METABOLISM; PROCEDURES; THREE DIMENSIONAL IMAGING;

ANIMALS; BONE AND BONES; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMAGING, THREE-DIMENSIONAL; MICE; MICROSCOPY, CONFOCAL; OSTEOCYTES; RATS;

EID: 84906654037     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2014.923879     Document Type: Conference Paper

References (8)

1. Bellido T. Downregulation of SOST/sclerostin by PTH: A novel mechanism of hormonal control of bone formation mediated by osteocytes. J Musculosk Neur Interact 2006;6:358-9
2. Galli C, Passeri G, Macaluso GM. Osteocytes and WNT: The mechanical control of bone formation. J Dent Res 2010;89:331-43
3. Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 2011;17: 1231-4
4. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 2006;38:1310-15
5. Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y. Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metab 2013;18:749-58
6. Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res: The official journal of the American Society for Bone and Mineral Research 2002;17:1822-31
7. Ye L, Mishina Y, Chen D, Huang H, Dallas SL, Dallas MR, Sivakumar P, Kunieda T, Tsutsui TW, Boskey A, Bonewald LF, Feng JQ. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem 2005;280:6197-203
8. Erben RG. Embedding of bone samples in methylmethacrylate: An improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry. J Histochem Cytochem: Official journal of the Histochemistry Society 1997;45:307-13