Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily

Journal of Biological Chemistry

Volumn 289, Issue 34, 2014, Pages 23641-23652

  Miles, Zachary D ^a   Roberts, Sue A ^a   McCarty, Reid M ^a,b   Bandarian, Vahe ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; MAMMALS;

BACTERIAL ENZYMES; DIFFERENTIAL ACTIVITY; MAMMALIAN ENZYMES; MAMMALIAN PROTEINS; REACTION CATALYZED; SMALL VARIATIONS; STRUCTURAL STUDIES; TIME-RESOLVED KINETICS;

ENZYMES;

6 CARBOXY 5,6,7,8 TETRAHYDROPTERIN SYNTHASE; BACTERIAL ENZYME; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; LYASE; PRIMER DNA; QUED PROTEIN, E COLI;

ARTICLE; BETA SHEET; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; ESCHERICHIA COLI; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; STEADY STATE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CARBON-OXYGEN LYASES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 84906546258     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.555680     Document Type: Article

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