Synthesis of chlorinated flavonoids with anti-inflammatory and pro-apoptotic activities in human neutrophils

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 153-164

  Freitas, Marisa ^a   Ribeiro, Daniela ^a   Tomé, Sara M ^b   Silva, Artur M S ^b   Fernandes, Eduarda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

Apoptosis; Caspase 3; Flavonoids; Neutrophils; Reactive species

Indexed keywords

3 DICHLORO 3',4',5,7 TETRAHYDROXYFLAVONE; 3,8 DICHLORO 3',4',5,7 TETRAHYDROXYFLAVONE; 6,8 DICHLORO 3',4',5,7 TETRAHYDROXYFLAVONE; 8 CHLORO 3',4',5,7 TETRAHYDROXYFLAVONE; ANTIINFLAMMATORY AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CATALASE; FLAVONE; FLAVONOID; LIPOCORTIN 5; LUMINOL; LUTEOLIN; PHORBOL 13 ACETATE 12 MYRISTATE; QUERCETIN; UNCLASSIFIED DRUG; CHLORINATED HYDROCARBON; NONSTEROID ANTIINFLAMMATORY AGENT; 3 CHLORO 3',4',5,7 TETRAHYDROXYFLAVONE;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BINDING ASSAY; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CHEMICAL STRUCTURE; CHLORINATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IC 50; NEUTROPHIL; NORMAL HUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RESPIRATORY BURST; TRYPAN BLUE ASSAY; VOLUNTEER; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; CELL ACTIVITY; CELL ISOLATION; DRUG MECHANISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; HYDROCARBONS, CHLORINATED; MOLECULAR STRUCTURE; NEUTROPHILS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906518198     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.035     Document Type: Article

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