Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2552-2562

  Shaw, Arthur Y ^a   Chang, Chun Yi ^a   Liau, Hao Han ^a   Lu, Pei Jung ^b   Chen, Hui Ling ^b   Yang, Chia Ning ^c   Li, Hao Yi ^c  

^a TAMKANG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

Author keywords

2 Styrylchromone; Antiproliferation; Carcinoma cells

Indexed keywords

2 (2 BENZO[1,3]DIOXOL 5 YLVINYL) 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (3,5 DIMETHOXY PHENYL)VINYL] 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (4 BROMO PHENYL)VINYL] 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (4 CHLOROPHENYL)VINYL] 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (4 CYCLOPROPYLMETHOXY PHENYL)VINYL] 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (4 FLUORO PHENYL) VINYL] 5,7 DIMETHOXY CHROMEN 4 ONE; 2 [2 (4 TRIFLUOROMETHOXY PHENYL) VINYL]CHROMEN 4 ONE; 5 METHOXY 2 [2 (4 TRIFLUOROMETHOXY PHENYL)VINYL]CHROMEN 4 ONE; 5,7 DIMETHOXY 2 (2 PYRIDIN 4 YLVINYL)CHROMEN 4 ONE; 5,7 DIMETHOXY 2 [2 (4 METHOXY PHENYL)VINYL]CHROMEN 4 ONE; 5,7 DIMETHOXY 2 [2 (4 NITRO PHENYL)VINYL]CHROMEN 4 ONE; 5,7 DIMETHOXY 2 [2 (4 TRIFLUOROMETHOXY PHENYL) VINYL]CHROMEN 4 ONE; 5,7 DIMETHOXY 2 [2 (4 TRIFLUOROMETHYLPHENYL)VINYL]CHROMEN 4 ONE; 5,7 DIMETHOXY 2 STYRYL 4H CHROMEN 4 ONE; 6 METHOXY 2 [2 (4 TRIFLUOROMETHOXY PHENYL) VINYL]CHROMEN 4 ONE; 7 METHOXY 2 [2 (4 TRIFLUOROMETHOXY PHENYL)VINYL]CHROMEN 4 ONE; 7,8 DIMETHOXY 2 [2 (4 TRIFLUOROMETHOXY PHENYL)VINYL]CHROMEN 4 ONE; CHROMONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; STYRENES; TIME FACTORS;

EID: 64249167990     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.01.034     Document Type: Article

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