-
2
-
-
0035896610
-
RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1
-
PMID:11124939
-
Timchenko NA, Cai ZJ, Welm AL, Reddy S, Ashizawa T, Timchenko LT. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem 2001; 276:7820-6; PMID:11124939; http://dx.doi.org/10.1074/jbc. M005960200
-
(2001)
J Biol Chem
, vol.276
, pp. 7820-7826
-
-
Timchenko, N.A.1
Cai, Z.J.2
Welm, A.L.3
Reddy, S.4
Ashizawa, T.5
Timchenko, L.T.6
-
3
-
-
34948872683
-
Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy
-
PMID:17823658
-
Wang GS, Kearney DL, De Biasi M, Taffet G, Cooper TA. Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. J Clin Invest 2007; 117:2802-11; PMID:17823658; http://dx.doi.org/10.1172/JCI32308
-
(2007)
J Clin Invest
, vol.117
, pp. 2802-2811
-
-
Wang, G.S.1
Kearney, D.L.2
De Biasi, M.3
Taffet, G.4
Cooper, T.A.5
-
4
-
-
33644670784
-
Nuclear RNA foci in the heart in myotonic dystrophy
-
PMID:16254211
-
Mankodi A, Lin X, Blaxall BC, Swanson MS, Thornton CA. Nuclear RNA foci in the heart in myotonic dystrophy. Circ Res 2005; 97:1152-5; PMID:16254211; http://dx.doi.org/10.1161/01.RES.0000193598.89753.e3
-
(2005)
Circ Res
, vol.97
, pp. 1152-1155
-
-
Mankodi, A.1
Lin, X.2
Blaxall, B.C.3
Swanson, M.S.4
Thornton, C.A.5
-
5
-
-
0345526827
-
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2
-
PMID:14681885
-
Mankodi A, Teng-Umnuay P, Krym M, Henderson D, Swanson M, Thornton CA. Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2. Ann Neurol 2003; 54:760-8; PMID:14681885; http://dx.doi.org/10.1002/ana.10763
-
(2003)
Ann Neurol
, vol.54
, pp. 760-768
-
-
Mankodi, A.1
Teng-Umnuay, P.2
Krym, M.3
Henderson, D.4
Swanson, M.5
Thornton, C.A.6
-
6
-
-
0034873099
-
Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy
-
PMID:11528389
-
Savkur RS, Philips AV, Cooper TA. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet 2001; 29:40-7; PMID:11528389; http://dx.doi.org/10.1038/ ng704
-
(2001)
Nat Genet
, vol.29
, pp. 40-47
-
-
Savkur, R.S.1
Philips, A.V.2
Cooper, T.A.3
-
7
-
-
0032076126
-
Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy
-
PMID:9563950
-
Philips AV, Timchenko LT, Cooper TA. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 1998; 280:737-41; PMID:9563950; http://dx.doi.org/10.1126/science.280.5364.737
-
(1998)
Science
, vol.280
, pp. 737-741
-
-
Philips, A.V.1
Timchenko, L.T.2
Cooper, T.A.3
-
8
-
-
11044233708
-
Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons
-
PMID:15496431
-
Jiang H, Mankodi A, Swanson MS, Moxley RT, Thornton CA. Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons. Hum Mol Genet 2004; 13:3079-88; PMID:15496431; http://dx.doi.org/10.1093/hmg/ddh327
-
(2004)
Hum Mol Genet
, vol.13
, pp. 3079-3088
-
-
Jiang, H.1
Mankodi, A.2
Swanson, M.S.3
Moxley, R.T.4
Thornton, C.A.5
-
9
-
-
35748965847
-
Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1
-
PMID:17728322
-
Hino S, Kondo S, Sekiya H, Saito A, Kanemoto S, Murakami T, Chihara K, Aoki Y, Nakamori M, Takahashi MP, et al. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. Hum Mol Genet 2007; 16:2834-43; PMID:17728322; http://dx.doi.org/10.1093/hmg/ddm239
-
(2007)
Hum Mol Genet
, vol.16
, pp. 2834-2843
-
-
Hino, S.1
Kondo, S.2
Sekiya, H.3
Saito, A.4
Kanemoto, S.5
Murakami, T.6
Chihara, K.7
Aoki, Y.8
Nakamori, M.9
Takahashi, M.P.10
-
10
-
-
20144372282
-
RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2
-
PMID:15788409
-
Timchenko NA, Wang GL, Timchenko LT. RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2. J Biol Chem 2005; 280:20549-57; PMID:15788409; http://dx.doi.org/10.1074/jbc.M409563200
-
(2005)
J Biol Chem
, vol.280
, pp. 20549-20557
-
-
Timchenko, N.A.1
Wang, G.L.2
Timchenko, L.T.3
-
11
-
-
33845922855
-
Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver
-
PMID:16931514
-
Timchenko LT, Salisbury E, Wang GL, Nguyen H, Albrecht JH, Hershey JW, Timchenko NA. Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. J Biol Chem 2006; 281:32806-19; PMID:16931514; http://dx.doi.org/10.1074/jbc.M605701200
-
(2006)
J Biol Chem
, vol.281
, pp. 32806-32819
-
-
Timchenko, L.T.1
Salisbury, E.2
Wang, G.L.3
Nguyen, H.4
Albrecht, J.H.5
Hershey, J.W.6
Timchenko, N.A.7
-
12
-
-
84865201988
-
Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins
-
PMID:22901804
-
Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, et al. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell 2012; 150:710-24; PMID:22901804; http://dx.doi.org/10.1016/j.cell.2012.06.041
-
(2012)
Cell
, vol.150
, pp. 710-724
-
-
Wang, E.T.1
Cody, N.A.2
Jog, S.3
Biancolella, M.4
Wang, T.T.5
Treacy, D.J.6
Luo, S.7
Schroth, G.P.8
Housman, D.E.9
Reddy, S.10
-
13
-
-
79960066418
-
Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy
-
PMID:21685920
-
Rau F, Freyermuth F, Fugier C, Villemin JP, Fischer MC, Jost B, Dembele D, Gourdon G, Nicole A, Duboc D, et al. Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy. Nat Struct Mol Biol 2011; 18:840-5; PMID:21685920; http://dx.doi.org/10.1038/nsmb.2067
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 840-845
-
-
Rau, F.1
Freyermuth, F.2
Fugier, C.3
Villemin, J.P.4
Fischer, M.C.5
Jost, B.6
Dembele, D.7
Gourdon, G.8
Nicole, A.9
Duboc, D.10
-
14
-
-
84873043215
-
Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients
-
PMID:23139243
-
Fernandez-Costa JM, Garcia-Lopez A, Zuñiga S, Fernandez-Pedrosa V, Felipo-Benavent A, Mata M, Jaka O, Aiastui A, Hernandez-Torres F, Aguado B, et al. Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients. Hum Mol Genet 2013; 22:704-16; PMID:23139243; http://dx.doi.org/10.1093/hmg/dds478
-
(2013)
Hum Mol Genet
, vol.22
, pp. 704-716
-
-
Fernandez-Costa, J.M.1
Garcia-Lopez, A.2
Zuñiga, S.3
Fernandez-Pedrosa, V.4
Felipo-Benavent, A.5
Mata, M.6
Jaka, O.7
Aiastui, A.8
Hernandez-Torres, F.9
Aguado, B.10
-
15
-
-
68449097694
-
GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy
-
PMID:19571675
-
Jin J, Wang GL, Salisbury E, Timchenko L, Timchenko NA. GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell Cycle 2009; 8:2356-9; PMID:19571675; http://dx.doi.org/10.4161/cc.8.15.9248
-
(2009)
Cell Cycle
, vol.8
, pp. 2356-2359
-
-
Jin, J.1
Wang, G.L.2
Salisbury, E.3
Timchenko, L.4
Timchenko, N.A.5
-
16
-
-
84870480784
-
GSK3β mediates muscle pathology in myotonic dystrophy
-
PMID:23160194
-
Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT. GSK3β mediates muscle pathology in myotonic dystrophy. J Clin Invest 2012; 122:4461-72; PMID:23160194; http://dx.doi.org/10.1172/JCI64081
-
(2012)
J Clin Invest
, vol.122
, pp. 4461-4472
-
-
Jones, K.1
Wei, C.2
Iakova, P.3
Bugiardini, E.4
Schneider-Gold, C.5
Meola, G.6
Woodgett, J.7
Killian, J.8
Timchenko, N.A.9
Timchenko, L.T.10
-
17
-
-
44949120812
-
Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1
-
PMID:18570922
-
Salisbury E, Sakai K, Schoser B, Huichalaf C, Schneider-Gold C, Nguyen H, Wang GL, Albrecht JH, Timchenko LT. Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1. Exp Cell Res 2008; 314:2266-78; PMID:18570922; http://dx.doi.org/10. 1016/j.yexcr.2008.04.018
-
(2008)
Exp Cell Res
, vol.314
, pp. 2266-2278
-
-
Salisbury, E.1
Sakai, K.2
Schoser, B.3
Huichalaf, C.4
Schneider-Gold, C.5
Nguyen, H.6
Wang, G.L.7
Albrecht, J.H.8
Timchenko, L.T.9
-
18
-
-
34948834723
-
Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
-
PMID:17936705
-
Kuyumcu-Martinez NM, Wang GS, Cooper TA. Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell 2007; 28:68-78; PMID:17936705; http://dx.doi.org/10.1016/j.molcel.2007. 07.027
-
(2007)
Mol Cell
, vol.28
, pp. 68-78
-
-
Kuyumcu-Martinez, N.M.1
Wang, G.S.2
Cooper, T.A.3
-
19
-
-
72849117063
-
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1
-
PMID:19907076
-
Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest 2009; 119:3797-806; PMID:19907076; http://dx.doi.org/10.1172/JCI37976
-
(2009)
J Clin Invest
, vol.119
, pp. 3797-3806
-
-
Wang, G.S.1
Kuyumcu-Martinez, M.N.2
Sarma, S.3
Mathur, N.4
Wehrens, X.H.5
Cooper, T.A.6
-
20
-
-
84882733817
-
MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases
-
PMID:23949219
-
Botta A, Malena A, Tibaldi E, Rocchi L, Loro E, Pena E, Cenci L, Ambrosi E, Bellocchi MC, Pagano MA, et al. MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases. Cell Death Dis 2013; 4:e770; PMID:23949219; http://dx.doi.org/10.1038/cddis.2013.291
-
(2013)
Cell Death Dis
, vol.4
-
-
Botta, A.1
Malena, A.2
Tibaldi, E.3
Rocchi, L.4
Loro, E.5
Pena, E.6
Cenci, L.7
Ambrosi, E.8
Bellocchi, M.C.9
Pagano, M.A.10
-
21
-
-
84855259402
-
Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target
-
PMID:21908410
-
Krzyzosiak WJ, Sobczak K, Wojciechowska M, Fiszer A, Mykowska A, Kozlowski P. Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target. Nucleic Acids Res 2012; 40:11-26; PMID:21908410; http://dx.doi.org/10.1093/nar/gkr729
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 11-26
-
-
Krzyzosiak, W.J.1
Sobczak, K.2
Wojciechowska, M.3
Fiszer, A.4
Mykowska, A.5
Kozlowski, P.6
-
22
-
-
67650828361
-
Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA
-
PMID:19608921
-
Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA. Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA. Science 2009; 325:336-9; PMID:19608921; http://dx.doi.org/10.1126/ science.1173110
-
(2009)
Science
, vol.325
, pp. 336-339
-
-
Wheeler, T.M.1
Sobczak, K.2
Lueck, J.D.3
Osborne, R.J.4
Lin, X.5
Dirksen, R.T.6
Thornton, C.A.7
-
23
-
-
84864439453
-
Targeting nuclear RNA for in vivo correction of myotonic dystrophy
-
PMID:22859208
-
Wheeler TM, Leger AJ, Pandey SK, MacLeod AR, Nakamori M, Cheng SH, Wentworth BM, Bennett CF, Thornton CA. Targeting nuclear RNA for in vivo correction of myotonic dystrophy. Nature 2012; 488:111-5; PMID:22859208; http://dx.doi.org/10.1038/nature11362
-
(2012)
Nature
, vol.488
, pp. 111-115
-
-
Wheeler, T.M.1
Leger, A.J.2
Pandey, S.K.3
MacLeod, A.R.4
Nakamori, M.5
Cheng, S.H.6
Wentworth, B.M.7
Bennett, C.F.8
Thornton, C.A.9
-
24
-
-
69549126597
-
Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy
-
PMID:19667189
-
Mulders SA, van den Broek WJ, Wheeler TM, Croes HJ, van Kuik-Romeijn P, de Kimpe SJ, Furling D, Platenburg GJ, Gourdon G, Thornton CA, et al. Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy. Proc Natl Acad Sci U S A 2009; 106:13915-20; PMID:19667189; http://dx.doi.org/10.1073/pnas.0905780106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 13915-13920
-
-
Mulders, S.A.1
Van Den Broek, W.J.2
Wheeler, T.M.3
Croes, H.J.4
Van Kuik-Romeijn, P.5
De Kimpe, S.J.6
Furling, D.7
Platenburg, G.J.8
Gourdon, G.9
Thornton, C.A.10
-
25
-
-
84878866085
-
Design and analysis of effects of triplet repeat oligonucleotides in cell models for myotonic dystrophy
-
PMID:23511335
-
González-Barriga A, Mulders SA, van de Giessen J, Hooijer JD, Bijl S, van Kessel ID, van Beers J, van Deutekom JC, Fransen JA, Wieringa B, et al. Design and analysis of effects of triplet repeat oligonucleotides in cell models for myotonic dystrophy. Mol Ther Nucleic Acids 2013; 2:e81; PMID:23511335; http://dx.doi.org/10.1038/mtna.2013.9
-
(2013)
Mol Ther Nucleic Acids
, vol.2
-
-
González-Barriga, A.1
Mulders, S.A.2
Van De Giessen, J.3
Hooijer, J.D.4
Bijl, S.5
Van Kessel, I.D.6
Van Beers, J.7
Van Deutekom, J.C.8
Fransen, J.A.9
Wieringa, B.10
-
26
-
-
84873414139
-
RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy
-
PMID:23183533
-
Sobczak K, Wheeler TM, Wang W, Thornton CA. RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy. Mol Ther 2013; 21:380-7; PMID:23183533; http://dx.doi.org/10.1038/mt.2012.222
-
(2013)
Mol Ther
, vol.21
, pp. 380-387
-
-
Sobczak, K.1
Wheeler, T.M.2
Wang, W.3
Thornton, C.A.4
-
27
-
-
78650987610
-
Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs
-
PMID:21186365
-
François V, Klein AF, Beley C, Jollet A, Lemercier C, Garcia L, Furling D. Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs. Nat Struct Mol Biol 2011; 18:85-7; PMID:21186365; http://dx.doi.org/10.1038/nsmb.1958
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 85-87
-
-
François, V.1
Klein, A.F.2
Beley, C.3
Jollet, A.4
Lemercier, C.5
Garcia, L.6
Furling, D.7
-
28
-
-
67650506996
-
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3
-
PMID:19552411
-
Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. J Am Chem Soc 2009; 131:9767-79; PMID:19552411; http://dx.doi.org/10.1021/ja9020149
-
(2009)
J Am Chem Soc
, vol.131
, pp. 9767-9779
-
-
Pushechnikov, A.1
Lee, M.M.2
Childs-Disney, J.L.3
Sobczak, K.4
French, J.M.5
Thornton, C.A.6
Disney, M.D.7
-
29
-
-
70349493012
-
A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding
-
PMID:19805260
-
Arambula JF, Ramisetty SR, Baranger AM, Zimmerman SC. A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding. Proc Natl Acad Sci U S A 2009; 106:16068-73; PMID:19805260; http://dx.doi.org/10.1073/pnas.0901824106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16068-16073
-
-
Arambula, J.F.1
Ramisetty, S.R.2
Baranger, A.M.3
Zimmerman, S.C.4
-
30
-
-
84862105985
-
Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive
-
PMID:22332923
-
Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS Chem Biol 2012; 7:856-62; PMID:22332923; http://dx.doi.org/10.1021/cb200408a
-
(2012)
ACS Chem Biol
, vol.7
, pp. 856-862
-
-
Childs-Disney, J.L.1
Hoskins, J.2
Rzuczek, S.G.3
Thornton, C.A.4
Disney, M.D.5
-
31
-
-
84878073420
-
A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1
-
PMID:23480597
-
Jahromi AH, Nguyen L, Fu Y, Miller KA, Baranger AM, Zimmerman SC. A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1. ACS Chem Biol 2013; 8:1037-43; PMID:23480597; http://dx.doi.org/10.1021/cb400046u
-
(2013)
ACS Chem Biol
, vol.8
, pp. 1037-1043
-
-
Jahromi, A.H.1
Nguyen, L.2
Fu, Y.3
Miller, K.A.4
Baranger, A.M.5
Zimmerman, S.C.6
-
32
-
-
84880523180
-
Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules
-
Jahromi AH, Honda M, Zimmerman SC, Spies M. Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules. Nucleic Acids Res 2013; 41:6687-97; http://dx.doi.org/10.1093/nar/gkt330
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 6687-6697
-
-
Jahromi, A.H.1
Honda, M.2
Zimmerman, S.C.3
Spies, M.4
-
33
-
-
73249132978
-
Pentamidine reverses the splicing defects associated with myotonic dystrophy
-
PMID:19822739
-
Warf MB, Nakamori M, Matthys CM, Thornton CA, Berglund JA. Pentamidine reverses the splicing defects associated with myotonic dystrophy. Proc Natl Acad Sci U S A 2009; 106:18551-6; PMID:19822739; http://dx.doi.org/10.1073/pnas. 0903234106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 18551-18556
-
-
Warf, M.B.1
Nakamori, M.2
Matthys, C.M.3
Thornton, C.A.4
Berglund, J.A.5
-
34
-
-
84894303874
-
High content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC independent pathway in Myotonic Dystrophy cell lines
-
PMID:24179176
-
Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, et al. High content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC independent pathway in Myotonic Dystrophy cell lines. Hum Mol Genet 2013; 23:1551-62; PMID:24179176; http://dx.doi.org/10.1093/hmg/ddt542
-
(2013)
Hum Mol Genet
, vol.23
, pp. 1551-1562
-
-
Ketley, A.1
Chen, C.Z.2
Li, X.3
Arya, S.4
Robinson, T.E.5
Granados-Riveron, J.6
Udosen, I.7
Morris, G.E.8
Holt, I.9
Furling, D.10
-
35
-
-
0042850318
-
Small molecule inhibitors of the RNA-dependent protein kinase
-
PMID:12890478
-
Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun 2003; 308:50-7; PMID:12890478; http://dx.doi.org/10.1016/S0006-291X(03)01318-4
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 50-57
-
-
Jammi, N.V.1
Whitby, L.R.2
Beal, P.A.3
-
36
-
-
79958751326
-
Identification of new inhibitors of protein kinase R guided by statistical modeling
-
PMID:21632247
-
Bryk R, Wu K, Raimundo BC, Boardman PE, Chao P, Conn GL, Anderson E, Cole JL, Duffy NP, Nathan C, et al. Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett 2011; 21:4108-14; PMID:21632247; http://dx.doi.org/10.1016/j.bmcl.2011.04.149
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 4108-4114
-
-
Bryk, R.1
Wu, K.2
Raimundo, B.C.3
Boardman, P.E.4
Chao, P.5
Conn, G.L.6
Anderson, E.7
Cole, J.L.8
Duffy, N.P.9
Nathan, C.10
-
37
-
-
55949137191
-
A chemical compound commonly used to inhibit PKR, 8-(imidazol-4- ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one, protects neurons by inhibiting cyclin-dependent kinase
-
PMID:19046382
-
Chen HM, Wang L, D'Mello SR. A chemical compound commonly used to inhibit PKR, 8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci 2008; 28 : 2003-16; PMID:19046382; http://dx.doi.org/10.1111/j.1460-9568.2008.06491.x
-
(2008)
Eur J Neurosci
, vol.28
, pp. 2003-2016
-
-
Chen, H.M.1
Wang, L.2
D'Mello, S.R.3
-
38
-
-
83255171042
-
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ mediated disinhibition
-
PMID:22153080
-
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, et al. Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ mediated disinhibition. Cell 2011; 147:1384-96; PMID:22153080; http://dx.doi.org/10.1016/ j.cell.2011.11.029
-
(2011)
Cell
, vol.147
, pp. 1384-1396
-
-
Zhu, P.J.1
Huang, W.2
Kalikulov, D.3
Yoo, J.W.4
Placzek, A.N.5
Stoica, L.6
Zhou, H.7
Bell, J.C.8
Friedlander, M.J.9
Krnjević, K.10
-
39
-
-
33750458339
-
Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress
-
PMID:17055645
-
Shimazawa M, Hara H. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. Neurosci Lett 2006; 409:192-5; PMID:17055645; http://dx.doi.org/10.1016/j.neulet.2006.09.074
-
(2006)
Neurosci Lett
, vol.409
, pp. 192-195
-
-
Shimazawa, M.1
Hara, H.2
-
40
-
-
34648843411
-
Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage
-
PMID:17652745
-
Shimazawa M, Ito Y, Inokuchi Y, Hara H. Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest Ophthalmol Vis Sci 2007; 48:3729-36; PMID:17652745; http://dx.doi.org/10.1167/ iovs.06-1122
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, pp. 3729-3736
-
-
Shimazawa, M.1
Ito, Y.2
Inokuchi, Y.3
Hara, H.4
-
41
-
-
33646125605
-
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease
-
PMID:16581193
-
Page G, Rioux Bilan A, Ingrand S, Lafay-Chebassier C, Pain S, Perault Pochat MC, Bouras C, Bayer T, Hugon J. Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience 2006; 139:1343-54; PMID:16581193; http://dx.doi.org/10.1016/j.neuroscience. 2006.01.047
-
(2006)
Neuroscience
, vol.139
, pp. 1343-1354
-
-
Page, G.1
Rioux Bilan, A.2
Ingrand, S.3
Lafay-Chebassier, C.4
Pain, S.5
Perault Pochat, M.C.6
Bouras, C.7
Bayer, T.8
Hugon, J.9
-
42
-
-
20444452898
-
Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy
-
PMID:15843400
-
Ho TH, Bundman D, Armstrong DL, Cooper TA. Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet 2005; 14:1539-47; PMID:15843400; http://dx.doi.org/10.1093/hmg/ddi162
-
(2005)
Hum Mol Genet
, vol.14
, pp. 1539-1547
-
-
Ho, T.H.1
Bundman, D.2
Armstrong, D.L.3
Cooper, T.A.4
-
43
-
-
58149492467
-
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
-
PMID:19075228
-
Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB, Cooper TA. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A 2008; 105:20333-8; PMID:19075228; http://dx.doi.org/10.1073/pnas.0809045105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20333-20338
-
-
Kalsotra, A.1
Xiao, X.2
Ward, A.J.3
Castle, J.C.4
Johnson, J.M.5
Burge, C.B.6
Cooper, T.A.7
-
44
-
-
84859768482
-
CUGBP1 and MBNL1 preferentially bind to 3 2 UTRs and facilitate mRNA decay
-
PMID:22355723
-
Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito M, Andresen BS, Ohno K. CUGBP1 and MBNL1 preferentially bind to 3 2 UTRs and facilitate mRNA decay. Sci Rep 2012; 2:209; PMID:22355723; http://dx.doi.org/10.1038/srep00209
-
(2012)
Sci Rep
, vol.2
, pp. 209
-
-
Masuda, A.1
Andersen, H.S.2
Doktor, T.K.3
Okamoto, T.4
Ito, M.5
Andresen, B.S.6
Ohno, K.7
-
45
-
-
59249087922
-
SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing
-
PMID: 19047369
-
Sen S, Talukdar I, Webster NJ. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol 2009; 29 : 871-80; PMID: 19047369; http://dx.doi.org/10.1128/MCB.01709-08
-
(2009)
Mol Cell Biol
, vol.29
, pp. 871-880
-
-
Sen, S.1
Talukdar, I.2
Webster, N.J.3
-
46
-
-
80052716635
-
Cellular toxicity of expanded RNA repeats: Focus on RNA foci
-
PMID:21729883
-
Wojciechowska M, Krzyzosiak WJ. Cellular toxicity of expanded RNA repeats: focus on RNA foci. Hum Mol Genet 2011; 20:3811-21; PMID:21729883; http://dx.doi.org/10.1093/hmg/ddr299
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3811-3821
-
-
Wojciechowska, M.1
Krzyzosiak, W.J.2
-
47
-
-
0034783271
-
Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2
-
PMID:11590133
-
Mankodi A, Urbinati CR, Yuan QP, Moxley RT, Sansone V, Krym M, Henderson D, Schalling M, Swanson MS, Thornton CA. Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. Hum Mol Genet 2001; 10:2165-70; PMID:11590133; http://dx.doi.org/10.1093/hmg/10.19.2165
-
(2001)
Hum Mol Genet
, vol.10
, pp. 2165-2170
-
-
Mankodi, A.1
Urbinati, C.R.2
Yuan, Q.P.3
Moxley, R.T.4
Sansone, V.5
Krym, M.6
Henderson, D.7
Schalling, M.8
Swanson, M.S.9
Thornton, C.A.10
-
48
-
-
33745248133
-
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy
-
PMID:16717059
-
Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA. Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet 2006; 15:2087-97; PMID:16717059; http://dx.doi.org/10.1093/hmg/ddl132
-
(2006)
Hum Mol Genet
, vol.15
, pp. 2087-2097
-
-
Lin, X.1
Miller, J.W.2
Mankodi, A.3
Kanadia, R.N.4
Yuan, Y.5
Moxley, R.T.6
Swanson, M.S.7
Thornton, C.A.8
-
49
-
-
59649107040
-
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
-
PMID:19136955
-
Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol 2009; 16:130-7; PMID:19136955; http://dx.doi.org/10. 1038/nsmb.1545
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 130-137
-
-
Yeo, G.W.1
Coufal, N.G.2
Liang, T.Y.3
Peng, G.E.4
Fu, X.D.5
Gage, F.H.6
-
50
-
-
84864020005
-
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain
-
PMID:22802532
-
Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev 2012; 26:1626-42; PMID:22802532; http://dx.doi.org/10.1101/gad.191338.112
-
(2012)
Genes Dev
, vol.26
, pp. 1626-1642
-
-
Licatalosi, D.D.1
Yano, M.2
Fak, J.J.3
Mele, A.4
Grabinski, S.E.5
Zhang, C.6
Darnell, R.B.7
-
51
-
-
69749101003
-
Absence of a differentiation defect in muscle satellite cells from DM2 patients
-
PMID:19632331
-
Pelletier R, Hamel F, Beaulieu D, Patry L, Haineault C, Tarnopolsky M, Schoser B, Puymirat J. Absence of a differentiation defect in muscle satellite cells from DM2 patients. Neurobiol Dis 2009; 36 :181-90; PMID:19632331; http://dx.doi.org/10.1016/j.nbd.2009.07.009
-
(2009)
Neurobiol Dis
, vol.36
, pp. 181-190
-
-
Pelletier, R.1
Hamel, F.2
Beaulieu, D.3
Patry, L.4
Haineault, C.5
Tarnopolsky, M.6
Schoser, B.7
Puymirat, J.8
-
52
-
-
79956023002
-
Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference
-
PMID:21247881
-
de Mezer M, Wojciechowska M, Napierala M, Sobczak K, Krzyzosiak WJ. Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference. Nucleic Acids Res 2011; 39:3852-63; PMID:21247881; http://dx.doi.org/10.1093/nar/gkq1323
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3852-3863
-
-
De Mezer, M.1
Wojciechowska, M.2
Napierala, M.3
Sobczak, K.4
Krzyzosiak, W.J.5
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