Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial

Bone

Volumn 68, Issue , 2014, Pages 46-56

  Gaffney Stomberg, Erin ^a   Lutz, Laura J ^a   Rood, Jennifer C ^b   Cable, Sonya J ^c   Pasiakos, Stefan M ^a   Young, Andrew J ^a   McClung, James P ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c Initial Military Training Center of Excellence   (United States)

Author keywords

Bone; Calcium; Exercise; Nutrition; Peripheral QCT; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; CALCIUM ION; CARBOXY TERMINAL TELOPEPTIDE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; VITAMIN D; BIOLOGICAL MARKER; CALCIUM INTAKE; PLACEBO; CALCIFEDIOL;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BASIC COMBAT TRAINING; BODY FAT PERCENTAGE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE MINERALIZATION; BONE REMODELING; BONE STRENGTH; BONE TURNOVER; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; CORTICAL THICKNESS (BONE); DOUBLE BLIND PROCEDURE; ENDOSTEAL CIRCUMFERENCE; FEMALE; HUMAN; HUMAN EXPERIMENT; INITIAL MILITARY TRAINING; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NORMAL HUMAN; OUTCOME ASSESSMENT; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; TIBIA; TRABECULAR BONE; TRAINING; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD; BODY COMPOSITION; DEMOGRAPHY; DIET SUPPLEMENTATION; DRUG EFFECTS; EDUCATION; METABOLISM; PHARMACOLOGY; PHOTON ABSORPTIOMETRY; SOLDIER; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALCIUM METABOLISM; DIETARY INTAKE; HEALTH STATUS; YOUNG ADULT;

ABSORPTIOMETRY, PHOTON; ADULT; BIOLOGICAL MARKERS; BODY COMPOSITION; BONE DENSITY; CALCIUM, DIETARY; DEMOGRAPHY; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MILITARY PERSONNEL; PARATHYROID HORMONE; PLACEBOS; VITAMIN D;

EID: 84906348867     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.08.002     Document Type: Article

References (36)

1. Jones B.H., Thacker S.B., Gilchrist J., Kimsey C.D., Sosin D.M. Prevention of lower extremity stress fractures in athletes and soldiers: a systematic review. Epidemiol Rev 2002, 24(2):228-247.
2. Knapik J., Montain S.J., McGraw S., Grier T., Ely M., Jones B.H. Stress fracture risk factors in basic combat training. Int J Sports Med 2012, 33(11):940-946.
3. Ruohola J.P., Laaksi I., Ylikomi T., Haataja R., Mattila V.M., Sahi T., et al. Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men. J Bone Miner Res 2006, 21(9):1483-1488.
4. Andersen N.E., Karl J.P., Cable S.J., Williams K.W., Rood J.C., Young A.J., et al. Vitamin D status in female military personnel during combat training. J Int Soc Sports Nutr 2010, 7:38.
5. Lutz L.J., Karl J.P., Rood J.C., Cable S.J., Williams K.W., Young A.J., et al. Vitamin D status, dietary intake, and bone turnover in female soldiers during military training: a longitudinal study. J Int Soc Sports Nutr 2012, 9(1):38.
6. Valimaki V.V., Alfthan H., Lehmuskallio E., Loyttyniemi E., Sahi T., Suominen H., et al. Risk factors for clinical stress fractures in male military recruits: a prospective cohort study. Bone 2005, 37(2):267-273.
7. Lappe J., Cullen D., Haynatzki G., Recker R., Ahlf R., Thompson K. Calcium and vitamin D supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res 2008, 23(5):741-749.
8. Brown E.M. Role of the calcium-sensing receptor in extracellular calcium homeostasis. Best Pract Res Clin Endocrinol Metab 2013, 27(3):333-343.
9. Silva B.C., Costa A.G., Cusano N.E., Kousteni S., Bilezikian J.P. Catabolic and anabolic actions of parathyroid hormone on the skeleton. J Endocrinol Invest 2011, 34(10):801-810.
10. McClung J.P., Karl J.P. Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms. Nutr Rev 2010, 68(6):365-369.
11. Hughes J.M., Petit M.A. Biological underpinnings of Frost's mechanostat thresholds: the important role of osteocytes. J Musculoskelet Neuronal Interact 2010, 10(2):128-135.
12. Evans R.K., Negus C.H., Centi A.J., Spiering B.A., Kraemer W.J., Nindl B.C. Peripheral QCT sector analysis reveals early exercise-induced increases in tibial bone mineral density. J Musculoskelet Neuronal Interact 2012, 12(3):155-164.
13. Simpson K., Redmond J.E., Cohen B.S., Hendrickson N.R., Spiering B.A., Steelman R., et al. Quantification of physical activity performed during US Army basic combat training. US Army Med Dep J 2013, 4-13:55-65.
14. Knapik J.J., Sharp M.A., Darakjy S., Jones S.B., Hauret K.G., Jones B.H. Temporal changes in the physical fitness of US Army recruits. Sports Med 2006, 36(7):613-634.
15. Nindl B.C., McClung J.P., Miller J.K., Karl J.P., Pierce J.R., Scofield D.E., et al. Bioavailable IGF-I is associated with fat-free mass gains after physical training in women. Med Sci Sports Exerc 2011, 43(5):793-799.
16. Margolis L.M., Pasiakos S.M., Karl J.P., Rood J.C., Cable S.J., Williams K.W., et al. Differential effects of military training on fat-free mass and plasma amino acid adaptations in men and women. Nutrients 2012, 4(12):2035-2046.
17. Pasiakos S.M., Karl J.P., Lutz L.J., Murphy N.E., Margolis L.M., Rood J.C., et al. Cardiometabolic risk in US Army recruits and the effects of basic combat training. PLoS One 2012, 7(2):e31222.
18. Jackson A.S., Pollock M.L. Generalized equations for predicting body density of men. Br J Nutr 1978, 40(3):497-504.
19. Jackson A.S., Pollock M.L., Ward A. Generalized equations for predicting body density of women. Med Sci Sports Exerc 1980, 12(3):175-181.
20. USDA food and nutrient database for dietary studies B, MD: Food Surveys Research Group, Agricultural Research Service, US Dept of Agriculture Available at:, (Accessed November 14). http://www.ars.usda.gov/Services/docs.htm?docid=12082.
21. Bowman S.A., FJ, Moshfegh A. MyPyramid equivalents database 2.0 for USDA survey foods, 2003-2004 2008, Food Surveys Research Group, Agricultural Research Service, US Dept of Agriculture, Beltsville, MD, (Available at: http://www.ars.usda.gov/Services/docs.htm?docid=23871. Accessed November 14, 2013).
22. Mares-Perlman J.A., Klein B.E., Klein R., Ritter L.L., Fisher M.R., Freudenheim J.L. A diet history questionnaire ranks nutrient intakes in middle-aged and older men and women similarly to multiple food records. J Nutr 1993, 123(3):489-501.
23. Block G., Woods M., Potosky A., Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 1990, 43(12):1327-1335.
24. Lutz L.J., Gaffney-Stomberg E., Scisco J.L., Cable S.J., Karl J.P., Young A.J., et al. Assessment of dietary intake using the healthy eating index during military training. US Army Med Dep J 2013, 91-97.
25. Kontulainen S., Liu D., Manske S., Jamieson M., Sievanen H., McKay H. Analyzing cortical bone cross-sectional geometry by peripheral QCT: comparison with bone histomorphometry. J Clin Densitom 2007, 10(1):86-92.
26. Kontulainen S.A., Johnston J.D., Liu D., Leung C., Oxland T.R., McKay H.A. Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis. J Musculoskelet Neuronal Interact 2008, 8(4):401-409.
27. Hasegawa Y., Schneider P., Reiners C. Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius. J Biomech 2001, 34(4):497-503.
28. Webb A.R., Holick M.F. The role of sunlight in the cutaneous production of vitamin D3. Annu Rev Nutr 1988, 8:375-399.
29. Tzotzas T., Papadopoulou F.G., Tziomalos K., Karras S., Gastaris K., Perros P., et al. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab 2010, 95(9):4251-4257.
30. Heaney R.P., Saville P.D., Recker R.R. Calcium absorption as a function of calcium intake. J Lab Clin Med 1975, 85(6):881-890.
31. Milgrom C., Finestone A., Novack V., Pereg D., Goldich Y., Kreiss Y., et al. The effect of prophylactic treatment with risedronate on stress fracture incidence among infantry recruits. Bone 2004, 35(2):418-424.
32. Szulc P., BDC, Eastell R. Primer on the metabolic bone diseases and disorders of mineral metabolism 2013, vol. 8:297-302. ASBMR. C.J. Rosen (Ed.).
33. Sukumar D., Ambia-Sobhan H., Zurfluh R., Schlussel Y., Stahl T., Gordon C., et al. Areal and volumetric bone mineral density and geometry at two levels of protein intake during caloric restriction: a randomized controlled trial. J Bone Miner Res 2011, 26(6):1339-1348.
34. Hansen S., Hauge E.M., Beck Jensen J.E., Brixen K. Differing effects of PTH 1-34, PTH 1-84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: an 18-month open-labeled observational study using HR-pQCT. J Bone Miner Res 2013, 28(4):736-745.
35. Lester M.E., Urso M.L., Evans R.K., Pierce J.R., Spiering B.A., Maresh C.M., et al. Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training. Bone 2009, 45(4):768-776.
36. Warden S.J., Hurst J.A., Sanders M.S., Turner C.H., Burr D.B., Li J. Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. J Bone Miner Res 2005, 20(5):809-816.