-
1
-
-
34547485497
-
Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis:application of a latent linear trajectory model
-
Shand L, Lunt M, Nihtyanova S, et al. Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis:application of a latent linear trajectory model. Arthritis Rheum. 2007;56(7):2422-31.
-
(2007)
Arthritis Rheum.
, vol.56
, Issue.7
, pp. 2422-2431
-
-
Shand, L.1
Lunt, M.2
Nihtyanova, S.3
-
2
-
-
77950261786
-
Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study
-
Nihtyanova SI, Tang EC, Coghlan JG, et al. Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study. QJM. 2010;103:109-15.
-
(2010)
QJM.
, vol.103
, pp. 109-115
-
-
Nihtyanova, S.I.1
Tang, E.C.2
Coghlan, J.G.3
-
3
-
-
70349814390
-
Disease-modifying treatment in systemic sclerosis: current status
-
Quillinan NP, Denton CP. Disease-modifying treatment in systemic sclerosis: current status. Curr Opin Rheumatol. 2009;21(6):636-41.
-
(2009)
Curr Opin Rheumatol.
, vol.21
, Issue.6
, pp. 636-641
-
-
Quillinan, N.P.1
Denton, C.P.2
-
4
-
-
77950259906
-
Th17 polarization in systemic sclerosis is influenced by immunosuppressive treatment regardless time of evolution [abstract]
-
Rodriguez-Reyna TS, Furuzawa-Carballeda J, Cabiedes J, et al. Th17 polarization in systemic sclerosis is influenced by immunosuppressive treatment regardless time of evolution [abstract]. Arthritis Rheum. 2009;60(Suppl):420.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 420
-
-
Rodriguez-Reyna, T.S.1
Furuzawa-Carballeda, J.2
Cabiedes, J.3
-
5
-
-
67650114978
-
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes
-
Radstake TR, van Bon L, Broen J, Hussiani A, et al. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One. 2009;4(6):e5903.
-
(2009)
PLoS One.
, vol.4
, Issue.6
, pp. e5903
-
-
Radstake, T.R.1
van Bon, L.2
Broen, J.3
Hussiani, A.4
-
6
-
-
66749107425
-
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
-
5932
-
Sundrud MS, Koralov SB, Feuerer M, et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009;324(5932):1334-8.
-
(2009)
Science.
, vol.324
, pp. 1334-1338
-
-
Sundrud, M.S.1
Koralov, S.B.2
Feuerer, M.3
-
7
-
-
1442271244
-
Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma
-
Pines M, Snyder D, Yarkoni S, et al. Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. Biol Blood Marrow Transplant. 2003;9(7):417-25.
-
(2003)
Biol Blood Marrow Transplant.
, vol.9
, Issue.7
, pp. 417-425
-
-
Pines, M.1
Snyder, D.2
Yarkoni, S.3
-
8
-
-
23444457756
-
Early T cell activation in the skin from patients with systemic sclerosis
-
Kalogerou A, Gelou E, Mountantonakis S, et al. Early T cell activation in the skin from patients with systemic sclerosis. Ann Rheum Dis. 2005;64(8):1233-5.
-
(2005)
Ann Rheum Dis.
, vol.64
, Issue.8
, pp. 1233-1235
-
-
Kalogerou, A.1
Gelou, E.2
Mountantonakis, S.3
-
9
-
-
77950266596
-
A phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate (MTX) in patients with rheumatoid arthritis (RA) [abstract]
-
Yellin M, Paliienko I, Balanescu A, et al. A phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate (MTX) in patients with rheumatoid arthritis (RA) [abstract]. Arthritis Rheum. 2009;60(Suppl 10):414.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 414
-
-
Yellin, M.1
Paliienko, I.2
Balanescu, A.3
-
10
-
-
69949133374
-
Chemokines as novel therapeutic targets for inflammatory bowel disease
-
Nishimura M, Kuboi Y, Muramoto K, et al. Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann NY Acad Sci. 2009;1173:350-6.
-
(2009)
Ann NY Acad Sci.
, vol.1173
, pp. 350-356
-
-
Nishimura, M.1
Kuboi, Y.2
Muramoto, K.3
-
11
-
-
33749351731
-
Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications
-
Cipriani P, Franca Milia A, Liakouli V, Pacini A, et al. Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications. Arthritis Rheum. 2006;54(9):3022-33.
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.9
, pp. 3022-3033
-
-
Cipriani, P.1
Franca Milia, A.2
Liakouli, V.3
Pacini, A.4
-
12
-
-
34447520313
-
Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis
-
Cipriani P, Guiducci S, Miniati I, Cinelli M, et al. Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum. 2007;56(6):1994-2004.
-
(2007)
Arthritis Rheum.
, vol.56
, Issue.6
, pp. 1994-2004
-
-
Cipriani, P.1
Guiducci, S.2
Miniati, I.3
Cinelli, M.4
-
13
-
-
48749113166
-
CXCR4 pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis
-
Campioni D, Lo Monaco A, Lanza F, Moretti S, Ferrari L, et al. CXCR4 pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis. Haematologica. 2008;93(8):1233-7.
-
(2008)
Haematologica.
, vol.93
, Issue.8
, pp. 1233-1237
-
-
Campioni, D.1
Lo Monaco, A.2
Lanza, F.3
Moretti, S.4
Ferrari, L.5
-
14
-
-
77649189292
-
Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis
-
Keeley EC, Mehrad B, Strieter RM. Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis. Int J Biochem Cell Biol. 2010;42:535-42.
-
(2010)
Int J Biochem Cell Biol.
, vol.42
, pp. 535-542
-
-
Keeley, E.C.1
Mehrad, B.2
Strieter, R.M.3
-
15
-
-
4043055316
-
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
-
Phillips RJ, Burdick MD, Hong K, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest. 2004;114:438-46.
-
(2004)
J Clin Invest.
, vol.114
, pp. 438-446
-
-
Phillips, R.J.1
Burdick, M.D.2
Hong, K.3
-
16
-
-
0037478581
-
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
-
Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA. 2003;100:8407-11.
-
(2003)
Proc Natl Acad Sci USA.
, vol.100
, pp. 8407-8411
-
-
Ortiz, L.A.1
Gambelli, F.2
McBride, C.3
-
18
-
-
33745918328
-
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
-
Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum. 2006;54(7):2271-9.
-
(2006)
Arthritis Rheum.
, vol.54
, Issue.7
, pp. 2271-2279
-
-
Wang, Y.1
Fan, P.S.2
Kahaleh, B.3
-
19
-
-
35848951176
-
The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis
-
Ghosh AK, Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol. 2007;213:663-71.
-
(2007)
J Cell Physiol.
, vol.213
, pp. 663-671
-
-
Ghosh, A.K.1
Varga, J.2
-
20
-
-
34547758359
-
Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycininduced skin fibrosis
-
Huber LC, Distler JH, Moritz F, et al. Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycininduced skin fibrosis. Arthritis Rheum. 2007;56:2755-64.
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 2755-2764
-
-
Huber, L.C.1
Distler, J.H.2
Moritz, F.3
-
21
-
-
66049096156
-
Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis
-
Hemmatazad H, Rodrigues HM, Maurer B, et al. Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis. Arthritis Rheum. 2009;60(5):1519-29.
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.5
, pp. 1519-1529
-
-
Hemmatazad, H.1
Rodrigues, H.M.2
Maurer, B.3
-
22
-
-
33846142183
-
HDAC inhibitors overcome first hurdle
-
Garber K. HDAC inhibitors overcome first hurdle. Nat Biotechnol. 2007;25(1):17-9.
-
(2007)
Nat Biotechnol.
, vol.25
, Issue.1
, pp. 17-19
-
-
Garber, K.1
-
23
-
-
77950529138
-
Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study
-
Nguyen VA, Eisendle K, Gruber I, Hugl B, Reider D, Reider N. Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study. Rheumatology (Oxford). 2010;49:583-7.
-
(2010)
Rheumatology (Oxford).
, vol.49
, pp. 583-587
-
-
Nguyen, V.A.1
Eisendle, K.2
Gruber, I.3
Hugl, B.4
Reider, D.5
Reider, N.6
-
24
-
-
78650678451
-
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial
-
Matucci-Cerinic M, Denton CP, Furst DE, Mayes MD, Hsu VM, Carpentier P, Wigley FM, Black CM, Fessler BJ, Merkel PA, Pope JE, Sweiss NJ, Doyle MK, Hellmich B, Medsger Jr TA, Morganti A, Kramer F, Korn JH, Seibold JR. Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2011;70(1):32-8.
-
(2011)
Ann Rheum Dis.
, vol.70
, Issue.1
, pp. 32-38
-
-
Matucci-Cerinic, M.1
Denton, C.P.2
Furst, D.E.3
Mayes, M.D.4
Hsu, V.M.5
Carpentier, P.6
Wigley, F.M.7
Black, C.M.8
Fessler, B.J.9
Merkel, P.A.10
Pope, J.E.11
Sweiss, N.J.12
Doyle, M.K.13
Hellmich, B.14
Medsger, T.A.15
Morganti, A.16
Kramer, F.17
Korn, J.H.18
Seibold, J.R.19
-
25
-
-
10444270963
-
Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist
-
Korn JH, Mayes M, Matucci Cerinic M, et al. Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum. 2004;50(12):3985-93.
-
(2004)
Arthritis Rheum.
, vol.50
, Issue.12
, pp. 3985-3993
-
-
Korn, J.H.1
Mayes, M.2
Matucci Cerinic, M.3
-
26
-
-
43049158203
-
Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients
-
García de la Peña-Lefebvre P, Rodríguez Rubio S, Valero Expósito M, Carmona L, et al. Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients. Rheumatology (Oxford). 2008;47(4):464-6.
-
(2008)
Rheumatology (Oxford).
, vol.47
, Issue.4
, pp. 464-466
-
-
García de la Peña-Lefebvre, P.1
Rodríguez Rubio, S.2
Valero Expósito, M.3
Carmona, L.4
-
27
-
-
79551550855
-
An open label trial of the endothelin receptor antagonist bosentan in scleroderma renal crisis (BIRD-1) [abstract]
-
Penn H, Black CM, Denton CP. An open label trial of the endothelin receptor antagonist bosentan in scleroderma renal crisis (BIRD-1) [abstract]. Arthritis Rheum. 2009;60(Suppl 10):451.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 451
-
-
Penn, H.1
Black, C.M.2
Denton, C.P.3
-
28
-
-
27744564115
-
Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy
-
Fries R, Shariat K, von Wilmowsky H, Böhm M. Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy. Circulation. 2005;112(19):2980-5.
-
(2005)
Circulation.
, vol.112
, Issue.19
, pp. 2980-2985
-
-
Fries, R.1
Shariat, K.2
von Wilmowsky, H.3
Böhm, M.4
-
29
-
-
77950263631
-
Nihad, modified-release sildenafil reduces Raynaud's attack frequency in systemic sclerosis [abstract]
-
Herrick AL, van den Hoogen F, Gabrielli A. Nihad, modified-release sildenafil reduces Raynaud's attack frequency in systemic sclerosis [abstract]. Arthritis Rheum. 2009;60(Suppl 10):472.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 472
-
-
Herrick, A.L.1
van den Hoogen, F.2
Gabrielli, A.3
-
30
-
-
77955460984
-
Effect of sildenafil on digital ulcers in systemic sclerosis-analysis from a single centre pilot study
-
Brueckner CS, Becker MO, Kroencke T, et al. Effect of sildenafil on digital ulcers in systemic sclerosis-analysis from a single centre pilot study. Ann Rheum Dis. 2010;69:1475-8.
-
(2010)
Ann Rheum Dis.
, vol.69
, pp. 1475-1478
-
-
Brueckner, C.S.1
Becker, M.O.2
Kroencke, T.3
-
31
-
-
84885377511
-
Efficacy of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis: a double blind randomized placebo controlled parallel group multicentric study [abstract]
-
Agarwal V, Ghosh P, Sharma A, Bhakuni D, Kumar S, Singh U, Vijayvergiya R, Yadav M, Laishram G, Ghosh A, Majhi B, Mukherjee D, Islam S, Kapoor A. Efficacy of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis: a double blind randomized placebo controlled parallel group multicentric study [abstract]. Arthritis Rheum. 2010;62(Suppl 10):2086.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2086
-
-
Agarwal, V.1
Ghosh, P.2
Sharma, A.3
Bhakuni, D.4
Kumar, S.5
Singh, U.6
Vijayvergiya, R.7
Yadav, M.8
Laishram, G.9
Ghosh, A.10
Majhi, B.11
Mukherjee, D.12
Islam, S.13
Kapoor, A.14
-
32
-
-
77950294587
-
Long-term beneficial effects of statins on vascular manifestations in patients with systemic sclerosis registry [abstract]
-
Kuwana M, Okazaki Y, Kaburaki J. Long-term beneficial effects of statins on vascular manifestations in patients with systemic sclerosis registry [abstract]. Arthritis Rheum. 2009;60(Suppl 10):448.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 448
-
-
Kuwana, M.1
Okazaki, Y.2
Kaburaki, J.3
-
33
-
-
33645579919
-
Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years
-
Blann AD. Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years. Thromb Haemost. 2006;95:49-55.
-
(2006)
Thromb Haemost.
, vol.95
, pp. 49-55
-
-
Blann, A.D.1
-
34
-
-
33646355930
-
Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin
-
Louneva N, Huaman G, Fertala J, Jimenez SA. Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006;54:1298-308.
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 1298-1308
-
-
Louneva, N.1
Huaman, G.2
Fertala, J.3
Jimenez, S.A.4
-
35
-
-
0035007171
-
Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction
-
Moriyama T, Kawada N, Nagatoya K, Takeji M, Horio M, Ando A, Imai E, Hori M. Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction. Kidney Int. 2001;59(6):2095-103.
-
(2001)
Kidney Int.
, vol.59
, Issue.6
, pp. 2095-2103
-
-
Moriyama, T.1
Kawada, N.2
Nagatoya, K.3
Takeji, M.4
Horio, M.5
Ando, A.6
Imai, E.7
Hori, M.8
-
36
-
-
0035902491
-
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy
-
Patel R, Nagueh SF, Tsybouleva N, Abdellatif M, Lutucuta S, Kopelen HA, Quinones MA, Zoghbi WA, Entman ML, Roberts R, Marian AJ. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation. 2001;104(3):317-24.
-
(2001)
Circulation.
, vol.104
, Issue.3
, pp. 317-324
-
-
Patel, R.1
Nagueh, S.F.2
Tsybouleva, N.3
Abdellatif, M.4
Lutucuta, S.5
Kopelen, H.A.6
Quinones, M.A.7
Zoghbi, W.A.8
Entman, M.L.9
Roberts, R.10
Marian, A.J.11
-
37
-
-
0034953832
-
Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients
-
Stratton R, Shiwen X, Martini G, Holmes A, Leask A, Haberberger T, Martin GR, Black CM, Abraham D. Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. J Clin Invest. 2001;108(2):241-50.
-
(2001)
J Clin Invest.
, vol.108
, Issue.2
, pp. 241-250
-
-
Stratton, R.1
Shiwen, X.2
Martini, G.3
Holmes, A.4
Leask, A.5
Haberberger, T.6
Martin, G.R.7
Black, C.M.8
Abraham, D.9
-
38
-
-
37749052490
-
Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis?
-
Carulli MT, Handler C, Coghlan JG, Black CM, Denton CP. Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis? Ann Rheum Dis. 2008;67(1):105-9.
-
(2008)
Ann Rheum Dis.
, vol.67
, Issue.1
, pp. 105-109
-
-
Carulli, M.T.1
Handler, C.2
Coghlan, J.G.3
Black, C.M.4
Denton, C.P.5
-
39
-
-
77954573839
-
A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice
-
Zhu Y, Liu Y, Zhou W, Xiang R, Jiang L, Huang K, Xiao Y, Guo Z, Gao J. A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2010;11:34.
-
(2010)
Respir Res.
, vol.11
, pp. 34
-
-
Zhu, Y.1
Liu, Y.2
Zhou, W.3
Xiang, R.4
Jiang, L.5
Huang, K.6
Xiao, Y.7
Guo, Z.8
Gao, J.9
-
40
-
-
77955349716
-
Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis
-
Yoshizaki A, Yanaba K, Yoshizaki A, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis. Arthritis Rheum. 2010;62(8):2476-87.
-
(2010)
Arthritis Rheum.
, vol.62
, Issue.8
, pp. 2476-2487
-
-
Yoshizaki, A.1
Yanaba, K.2
Yoshizaki, A.3
Iwata, Y.4
Komura, K.5
Ogawa, F.6
Takenaka, M.7
Shimizu, K.8
Asano, Y.9
Hasegawa, M.10
Fujimoto, M.11
Sato, S.12
-
41
-
-
70149123508
-
Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
-
Magro L, Mohty M, Catteau B, et al. Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease. Blood. 2009;114:719-22.
-
(2009)
Blood.
, vol.114
, pp. 719-722
-
-
Magro, L.1
Mohty, M.2
Catteau, B.3
-
42
-
-
49449100183
-
Imatinib mesylate treatment of nephrogenic systemic fibrosis
-
Kay J, High WA. Imatinib mesylate treatment of nephrogenic systemic fibrosis. Arthritis Rheum. 2008;58(8):2543-8.
-
(2008)
Arthritis Rheum.
, vol.58
, Issue.8
, pp. 2543-2548
-
-
Kay, J.1
High, W.A.2
-
43
-
-
79955860261
-
Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial
-
Spiera RF, Gordon JK, Mersten JN, Magro CM, Mehta M, Wildman HF, Kloiber S, Kirou KA, Lyman S, Crow MK. Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial. Ann Rheum Dis. 2011;70:1003-9.
-
(2011)
Ann Rheum Dis.
, vol.70
, pp. 1003-1009
-
-
Spiera, R.F.1
Gordon, J.K.2
Mersten, J.N.3
Magro, C.M.4
Mehta, M.5
Wildman, H.F.6
Kloiber, S.7
Kirou, K.A.8
Lyman, S.9
Crow, M.K.10
-
44
-
-
77950208567
-
A proof of concept trial of Gleevec (Imatinib) in active diffuse scleroderma [abstract]
-
Pope J, McBain D, Petrlich L, et al. A proof of concept trial of Gleevec (Imatinib) in active diffuse scleroderma [abstract]. Arthritis Rheum. 2009;60(Suppl 10):608.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 608
-
-
Pope, J.1
McBain, D.2
Petrlich, L.3
-
45
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006;12(8):908-16.
-
(2006)
Nat Med.
, vol.12
, Issue.8
, pp. 908-916
-
-
Kerkelä, R.1
Grazette, L.2
Yacobi, R.3
Iliescu, C.4
Patten, R.5
Beahm, C.6
Walters, B.7
Shevtsov, S.8
Pesant, S.9
Clubb, F.J.10
Rosenzweig, A.11
Salomon, R.N.12
Van Etten, R.A.13
Alroy, J.14
Durand, J.B.15
Force, T.16
-
46
-
-
84859248430
-
A multicenter, open-label, proof of concept study of imatinib mesylate demonstrates no benefit for the treatment of fibrosis in patients with early, diffuse systemic sclerosis
-
Distler O, Distler JH, Varga J, Denton CP, Lafyatis R, Wigley F, Schett G, Matucci-Cerinic M, Wright T, Bertolino A, Gergely P. A multicenter, open-label, proof of concept study of imatinib mesylate demonstrates no benefit for the treatment of fibrosis in patients with early, diffuse systemic sclerosis. Arthritis Rheum. 2010;62(Suppl 10):560.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 560
-
-
Distler, O.1
Distler, J.H.2
Varga, J.3
Denton, C.P.4
Lafyatis, R.5
Wigley, F.6
Schett, G.7
Matucci-Cerinic, M.8
Wright, T.9
Bertolino, A.10
Gergely, P.11
-
47
-
-
84861484141
-
Comparative analysis of change in modified Rodnan Skin score in patients with diffuse systemic sclerosis receiving imatinib mesylate suggests similar disease course to matched patients receiving standard therapy
-
Denton CP, Nihtyanova SI, Varga J, Distler O, Wigley FM, Lafyatis R, Distler JH, Schett G, Matucci-Cerinic M, Wright T, Antunes M, Racine A, Bertolino A, Gergely Jr P. Comparative analysis of change in modified Rodnan Skin score in patients with diffuse systemic sclerosis receiving imatinib mesylate suggests similar disease course to matched patients receiving standard therapy. Arthritis Rheum. 2010;62(Suppl 10):566.
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 566
-
-
Denton, C.P.1
Nihtyanova, S.I.2
Varga, J.3
Distler, O.4
Wigley, F.M.5
Lafyatis, R.6
Distler, J.H.7
Schett, G.8
Matucci-Cerinic, M.9
Wright, T.10
Antunes, M.11
Racine, A.12
Bertolino, A.13
Gergely, P.14
-
48
-
-
59649085854
-
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator activated receptor-gamma
-
Wu M, Melichian DS, Chang E, Warner-Blankenship M, Ghosh AK, Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator activated receptor-gamma. Am J Pathol. 2009;174:519-33.
-
(2009)
Am J Pathol.
, vol.174
, pp. 519-533
-
-
Wu, M.1
Melichian, D.S.2
Chang, E.3
Warner-Blankenship, M.4
Ghosh, A.K.5
Varga, J.6
-
49
-
-
69449094871
-
Loss of PPARg in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
-
Kapoor M, McCann M, Liu S, et al. Loss of PPARg in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum. 2009;60:2822-9.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 2822-2829
-
-
Kapoor, M.1
McCann, M.2
Liu, S.3
-
51
-
-
2542422760
-
Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
-
Shegogue D, Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem. 2004;279:23166-75.
-
(2004)
J Biol Chem.
, vol.279
, pp. 23166-23175
-
-
Shegogue, D.1
Trojanowska, M.2
-
52
-
-
27144527959
-
Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity
-
Mazereeuw-Hautier J, Gres S, Fanguin M, Cariven C, Fauvel J, Perret B, Chap H, Salles JP, Saulnier-Blache JS. Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity. J Invest Dermatol. 2005;125(3):421-7.
-
(2005)
J Invest Dermatol.
, vol.125
, Issue.3
, pp. 421-427
-
-
Mazereeuw-Hautier, J.1
Gres, S.2
Fanguin, M.3
Cariven, C.4
Fauvel, J.5
Perret, B.6
Chap, H.7
Salles, J.P.8
Saulnier-Blache, J.S.9
-
53
-
-
70350532016
-
Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
-
Bridle KR, Popa C, Morgan ML, Sobbe AL, Clouston AD, Fletcher LM, et al. Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways. Liver Transpl. 2009;15:1315-24.
-
(2009)
Liver Transpl.
, vol.15
, pp. 1315-1324
-
-
Bridle, K.R.1
Popa, C.2
Morgan, M.L.3
Sobbe, A.L.4
Clouston, A.D.5
Fletcher, L.M.6
-
54
-
-
74049137551
-
Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis
-
Wang S, Wilkes MC, Leof EB, Hirschberg R. Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Am J Physiol Renal Physiol. 2009;298:F142-9.
-
(2009)
Am J Physiol Renal Physiol.
, vol.298
, pp. F142-F149
-
-
Wang, S.1
Wilkes, M.C.2
Leof, E.B.3
Hirschberg, R.4
-
55
-
-
69949138951
-
Proliferation signal inhibitors for the treatment of refractory autoimmune rheumatic diseases: a new therapeutic option
-
Yoon KH. Proliferation signal inhibitors for the treatment of refractory autoimmune rheumatic diseases: a new therapeutic option. Ann N Y Acad Sci. 2009;1173:752-6.
-
(2009)
Ann N Y Acad Sci.
, vol.1173
, pp. 752-756
-
-
Yoon, K.H.1
-
56
-
-
58149096523
-
Efficacy of rapamycin in scleroderma: a case study
-
Fried L, Kirsner RS, Bhandarkar S, Arbiser JL. Efficacy of rapamycin in scleroderma: a case study. Lymphat Res Biol. 2008;6(3-4):217-9.
-
(2008)
Lymphat Res Biol.
, vol.6
, Issue.3-4
, pp. 217-219
-
-
Fried, L.1
Kirsner, R.S.2
Bhandarkar, S.3
Arbiser, J.L.4
-
57
-
-
17144399488
-
Successful treatment of a severe case of idiopathic pulmonary fibrosis with rapamycin
-
Buschhausen L, Kamm M, Arns W, Schulze-Lohoff E, Weber M. Successful treatment of a severe case of idiopathic pulmonary fibrosis with rapamycin. Med Klin (Munich). 2005;100(3):161-4.
-
(2005)
Med Klin (Munich).
, vol.100
, Issue.3
, pp. 161-164
-
-
Buschhausen, L.1
Kamm, M.2
Arns, W.3
Schulze-Lohoff, E.4
Weber, M.5
-
58
-
-
73249139173
-
Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study
-
Su TI, Khanna D, Furst DE, et al. Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study. Arthritis Rheum. 2009;60(12):3821-30.
-
(2009)
Arthritis Rheum.
, vol.60
, Issue.12
, pp. 3821-3830
-
-
Su, T.I.1
Khanna, D.2
Furst, D.E.3
-
59
-
-
33846250366
-
Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
-
Denton CP, Merkel PA, Furst DE, et al. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum. 2007;56(1):323-33.
-
(2007)
Arthritis Rheum.
, vol.56
, Issue.1
, pp. 323-333
-
-
Denton, C.P.1
Merkel, P.A.2
Furst, D.E.3
-
60
-
-
84925549112
-
The paradigm of IL-6: from basic science to medicine
-
Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res. 2002;4(Suppl 3):S233-42.
-
(2002)
Arthritis Res.
, vol.4
, pp. S233-S242
-
-
Naka, T.1
Nishimoto, N.2
Kishimoto, T.3
-
61
-
-
0033121274
-
Endogenous IL-1 from systemic sclerosis fibroblasts induces IL-6 and PDGF-A
-
Kawaguchi Y, Hara M, Wright TM. Endogenous IL-1 from systemic sclerosis fibroblasts induces IL-6 and PDGF-A. J Clin Invest. 1999;103:1253-60.
-
(1999)
J Clin Invest.
, vol.103
, pp. 1253-1260
-
-
Kawaguchi, Y.1
Hara, M.2
Wright, T.M.3
-
62
-
-
0038305966
-
Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation
-
Moodley YP, Scaffidi AK, Misso NL, Keerthisingam C, McAnulty RJ, Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA. Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation. Am J Pathol. 2003;163(1):345-54.
-
(2003)
Am J Pathol.
, vol.163
, Issue.1
, pp. 345-354
-
-
Moodley, Y.P.1
Scaffidi, A.K.2
Misso, N.L.3
Keerthisingam, C.4
McAnulty, R.J.5
Laurent, G.J.6
Mutsaers, S.E.7
Thompson, P.J.8
Knight, D.A.9
-
63
-
-
33845739191
-
Functional implications of the IL-6 signaling pathway in keloid pathogenesis
-
Ghazizadeh M, Tosa M, Shimizu H, Hyakusoku H, Kawanami O. Functional implications of the IL-6 signaling pathway in keloid pathogenesis. J Invest Dermatol. 2007;127(1):98-105.
-
(2007)
J Invest Dermatol.
, vol.127
, Issue.1
, pp. 98-105
-
-
Ghazizadeh, M.1
Tosa, M.2
Shimizu, H.3
Hyakusoku, H.4
Kawanami, O.5
-
64
-
-
34447104560
-
Interleukin-6 (IL-6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL-6KO mice
-
Luckett LR, Gallucci RM. Interleukin-6 (IL-6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL-6KO mice. Br J Dermatol. 2007;156(6):1163-71.
-
(2007)
Br J Dermatol.
, vol.156
, Issue.6
, pp. 1163-1171
-
-
Luckett, L.R.1
Gallucci, R.M.2
-
65
-
-
77950216793
-
A clinically defined subset of dcSSc is associated with elevated serum IL-6 level [abstract]
-
Ong V, Nihtyanova S, Black CM, et al. A clinically defined subset of dcSSc is associated with elevated serum IL-6 level [abstract]. Arthritis Rheum. 2009;60(Suppl):440.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 440
-
-
Ong, V.1
Nihtyanova, S.2
Black, C.M.3
-
66
-
-
77955487468
-
Signals that influence T follicular helper cell differentiation and function
-
Linterman MA, Vinuesa CG. Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol. 2010;32(2):183-96.
-
(2010)
Semin Immunopathol.
, vol.32
, Issue.2
, pp. 183-196
-
-
Linterman, M.A.1
Vinuesa, C.G.2
-
67
-
-
36849012184
-
LPA1 receptor activation promotes renal interstitial fibrosis
-
Pradère JP, Klein J, Grès S, Guigné C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP. LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol. 2007;18(12):3110-8.
-
(2007)
J Am Soc Nephrol.
, vol.18
, Issue.12
, pp. 3110-3118
-
-
Pradère, J.P.1
Klein, J.2
Grès, S.3
Guigné, C.4
Neau, E.5
Valet, P.6
Calise, D.7
Chun, J.8
Bascands, J.L.9
Saulnier-Blache, J.S.10
Schanstra, J.P.11
-
68
-
-
67649196923
-
Elevated serum levels of arachidonoyllysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis
-
Tokumura A, Carbone LD, Yoshioka Y, Morishige J, Kikuchi M, Postlethwaite A, Watsky MA. Elevated serum levels of arachidonoyllysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. Int J Med Sci. 2009;6(4):168-76.
-
(2009)
Int J Med Sci.
, vol.6
, Issue.4
, pp. 168-176
-
-
Tokumura, A.1
Carbone, L.D.2
Yoshioka, Y.3
Morishige, J.4
Kikuchi, M.5
Postlethwaite, A.6
Watsky, M.A.7
-
69
-
-
0035007140
-
Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo
-
Balazs L, Okolicany J, Ferrebee M, Tolley B, Tigyi G. Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo. Am J Physiol Regul Integr Comp Physiol. 2001;280(2):R466-72.
-
(2001)
Am J Physiol Regul Integr Comp Physiol.
, vol.280
, Issue.2
, pp. R466-R472
-
-
Balazs, L.1
Okolicany, J.2
Ferrebee, M.3
Tolley, B.4
Tigyi, G.5
-
70
-
-
38049091636
-
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
-
Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med. 2008;14(1):45-54.
-
(2008)
Nat Med.
, vol.14
, Issue.1
, pp. 45-54
-
-
Tager, A.M.1
LaCamera, P.2
Shea, B.S.3
Campanella, G.S.4
Selman, M.5
Zhao, Z.6
Polosukhin, V.7
Wain, J.8
Karimi-Shah, B.A.9
Kim, N.D.10
Hart, W.K.11
Pardo, A.12
Blackwell, T.S.13
Xu, Y.14
Chun, J.15
Luster, A.D.16
-
71
-
-
79951995418
-
Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist
-
Swaney JS, Chapman C, Correa LD, Stebbins KJ, Broadhead AR, Bain G, Santini AM, Darlington J, King CD, Baccei CS, Lee C, Parr TA, Roppe JR, Seiders TJ, Ziff J, Prasit P, Hutchinson JH, Evans JF, Lorrain DS. Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. J Pharmacol Exp Ther. 2011;336(3):693-700.
-
(2011)
J Pharmacol Exp Ther.
, vol.336
, Issue.3
, pp. 693-700
-
-
Swaney, J.S.1
Chapman, C.2
Correa, L.D.3
Stebbins, K.J.4
Broadhead, A.R.5
Bain, G.6
Santini, A.M.7
Darlington, J.8
King, C.D.9
Baccei, C.S.10
Lee, C.11
Parr, T.A.12
Roppe, J.R.13
Seiders, T.J.14
Ziff, J.15
Prasit, P.16
Hutchinson, J.H.17
Evans, J.F.18
Lorrain, D.S.19
-
72
-
-
77953964266
-
The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment
-
Svejda B, Kidd M, Giovinazzo F, Eltawil K, Gustafsson BI, Pfragner R, Modlin IM. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010;116(12):2902-12.
-
(2010)
Cancer.
, vol.116
, Issue.12
, pp. 2902-2912
-
-
Svejda, B.1
Kidd, M.2
Giovinazzo, F.3
Eltawil, K.4
Gustafsson, B.I.5
Pfragner, R.6
Modlin, I.M.7
-
73
-
-
33748798900
-
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis
-
Ruddell RG, Oakley F, Hussain Z, Yeung I, Bryan-Lluka LJ, Ramm GA, Mann DA. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol. 2006;169(3):861-76.
-
(2006)
Am J Pathol.
, vol.169
, Issue.3
, pp. 861-876
-
-
Ruddell, R.G.1
Oakley, F.2
Hussain, Z.3
Yeung, I.4
Bryan-Lluka, L.J.5
Ramm, G.A.6
Mann, D.A.7
-
74
-
-
85026473946
-
Platelet derived serotonin (5-HT) plays a crucial role for experimental fibrosis [abstract]
-
Dees C, Akhmetshina A, Busch N, Zwerina J, Bader M, Schett G, et al. Platelet derived serotonin (5-HT) plays a crucial role for experimental fibrosis [abstract]. Arthritis Rheum. 2009;60(Suppl 10):1063.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 1063
-
-
Dees, C.1
Akhmetshina, A.2
Busch, N.3
Zwerina, J.4
Bader, M.5
Schett, G.6
-
75
-
-
78149303247
-
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention
-
Königshoff M, Dumitrascu R, Udalov S, Amarie OV, Reiter R, Grimminger F, Seeger W, Schermuly RT, Eickelberg O. Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention. Thorax. 2010;65(11):949-55.
-
(2010)
Thorax.
, vol.65
, Issue.11
, pp. 949-955
-
-
Königshoff, M.1
Dumitrascu, R.2
Udalov, S.3
Amarie, O.V.4
Reiter, R.5
Grimminger, F.6
Seeger, W.7
Schermuly, R.T.8
Eickelberg, O.9
-
76
-
-
0034794451
-
Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitor fluoxetine
-
Coleiro B, Marshall SE, Denton CP, Howell K, Blann A, Welsh KI, Black CM. Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitor fluoxetine. Rheumatology (Oxford). 2001;40(9):1038-43.
-
(2001)
Rheumatology (Oxford).
, vol.40
, Issue.9
, pp. 1038-1043
-
-
Coleiro, B.1
Marshall, S.E.2
Denton, C.P.3
Howell, K.4
Blann, A.5
Welsh, K.I.6
Black, C.M.7
-
77
-
-
2442696430
-
Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension
-
Marcos E, Fadel E, Sanchez O, Humbert M, Dartevelle P, Simonneau G, Hamon M, Adnot S, Eddahibi S. Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ Res. 2004;94(9):1263-70.
-
(2004)
Circ Res.
, vol.94
, Issue.9
, pp. 1263-1270
-
-
Marcos, E.1
Fadel, E.2
Sanchez, O.3
Humbert, M.4
Dartevelle, P.5
Simonneau, G.6
Hamon, M.7
Adnot, S.8
Eddahibi, S.9
-
78
-
-
49449087811
-
Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
-
Akhmetshina A, Dees C, Pileckyte M, Szucs G, Spriewald BM, Zwerina J, Distler O, Schett G, Distler JH. Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts. Arthritis Rheum. 2008;58(8):2553-64.
-
(2008)
Arthritis Rheum.
, vol.58
, Issue.8
, pp. 2553-2564
-
-
Akhmetshina, A.1
Dees, C.2
Pileckyte, M.3
Szucs, G.4
Spriewald, B.M.5
Zwerina, J.6
Distler, O.7
Schett, G.8
Distler, J.H.9
-
79
-
-
0036236193
-
Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction
-
Nagatoya K, Moriyama T, Kawada N, Takeji M, Oseto S, Murozono T, Ando A, Imai E, Hori M. Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int. 2002;61(5):1684-95.
-
(2002)
Kidney Int.
, vol.61
, Issue.5
, pp. 1684-1695
-
-
Nagatoya, K.1
Moriyama, T.2
Kawada, N.3
Takeji, M.4
Oseto, S.5
Murozono, T.6
Ando, A.7
Imai, E.8
Hori, M.9
-
80
-
-
40149090411
-
Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis
-
Skhirtladze C, Distler O, Dees C, Akhmetshina A, Busch N, Venalis P, Zwerina J, Spriewald B, Pileckyte M, Schett G, Distler JH. Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis. Arthritis Rheum. 2008;58(5):1475-84.
-
(2008)
Arthritis Rheum.
, vol.58
, Issue.5
, pp. 1475-1484
-
-
Skhirtladze, C.1
Distler, O.2
Dees, C.3
Akhmetshina, A.4
Busch, N.5
Venalis, P.6
Zwerina, J.7
Spriewald, B.8
Pileckyte, M.9
Schett, G.10
Distler, J.H.11
-
81
-
-
46749154199
-
Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
-
Akhmetshina A, Dees C, Pileckyte M, Maurer B, Axmann R, Jüngel A, Zwerina J, Gay S, Schett G, Distler O, Distler JH. Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis. FASEB J. 2008;22(7):2214-22.
-
(2008)
FASEB J.
, vol.22
, Issue.7
, pp. 2214-2222
-
-
Akhmetshina, A.1
Dees, C.2
Pileckyte, M.3
Maurer, B.4
Axmann, R.5
Jüngel, A.6
Zwerina, J.7
Gay, S.8
Schett, G.9
Distler, O.10
Distler, J.H.11
-
82
-
-
79551534563
-
Tyrosine kinase inhibitors (TKI) are promising therapeutic agents for the proliferative vasculopathy in SSc [abstract]
-
Maurer B, Busch N, Jüngel A, Gay R, Schett G, Michel B, Gay S, Distler J, Distler O. Tyrosine kinase inhibitors (TKI) are promising therapeutic agents for the proliferative vasculopathy in SSc [abstract]. Arthritis Rheum. 2009;60(Suppl 10):1263.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 1263
-
-
Maurer, B.1
Busch, N.2
Jüngel, A.3
Gay, R.4
Schett, G.5
Michel, B.6
Gay, S.7
Distler, J.8
Distler, O.9
-
83
-
-
33746920906
-
Aggregated IgG inhibits the differentiation of human fibrocytes
-
Pilling D, Tucker NM, Gomer RH. Aggregated IgG inhibits the differentiation of human fibrocytes. J Leukoc Biol. 2006;79(6):1242-51.
-
(2006)
J Leukoc Biol.
, vol.79
, Issue.6
, pp. 1242-1251
-
-
Pilling, D.1
Tucker, N.M.2
Gomer, R.H.3
-
84
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med. 2010;363(14):1303-12.
-
(2010)
N Engl J Med.
, vol.363
, Issue.14
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
85
-
-
62849108810
-
A randomized placebo-controlled study of INCB018424, a selective Janus Kinase1& 2 (JAK1&2) inhibitor in rheumatoid arthritis (RA)
-
Williams W, Scherle P, Shi J, Newton R, McKeever E, Fridman J, Burn T, Vaddi K, Levy R, Moreland L. A randomized placebo-controlled study of INCB018424, a selective Janus Kinase1& 2 (JAK1&2) inhibitor in rheumatoid arthritis (RA). Arthritis Rheum. 2008;58:S431.
-
(2008)
Arthritis Rheum.
, vol.58
, pp. S431
-
-
Williams, W.1
Scherle, P.2
Shi, J.3
Newton, R.4
McKeever, E.5
Fridman, J.6
Burn, T.7
Vaddi, K.8
Levy, R.9
Moreland, L.10
-
86
-
-
77951031498
-
Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis
-
Koppikar P, Abdel-Wahab O, Hedvat C, Marubayashi S, Patel J, Goel A, Kucine N, Gardner JR, Combs AP, Vaddi K, Haley PJ, Burn TC, Rupar M, Bromberg JF, Heaney ML, de Stanchina E, Fridman JS, Levine RL. Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood. 2010;115(14):2919-27.
-
(2010)
Blood.
, vol.115
, Issue.14
, pp. 2919-2927
-
-
Koppikar, P.1
Abdel-Wahab, O.2
Hedvat, C.3
Marubayashi, S.4
Patel, J.5
Goel, A.6
Kucine, N.7
Gardner, J.R.8
Combs, A.P.9
Vaddi, K.10
Haley, P.J.11
Burn, T.C.12
Rupar, M.13
Bromberg, J.F.14
Heaney, M.L.15
de Stanchina, E.16
Fridman, J.S.17
Levine, R.L.18
-
88
-
-
54049086247
-
Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers
-
Abou-Raya A, Abou-Raya S, Helmii M. Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers. J Rheumatol. 2008;35:1801-8.
-
(2008)
J Rheumatol.
, vol.35
, pp. 1801-1808
-
-
Abou-Raya, A.1
Abou-Raya, S.2
Helmii, M.3
-
89
-
-
77950433107
-
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts
-
Shi-wen X, Eastwood M, Stratton RJ, Denton CP, Leask A, Abraham DJ. Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. Rheumatology (Oxford). 2010;49(2):259-63.
-
(2010)
Rheumatology (Oxford).
, vol.49
, Issue.2
, pp. 259-263
-
-
Shi-wen, X.1
Eastwood, M.2
Stratton, R.J.3
Denton, C.P.4
Leask, A.5
Abraham, D.J.6
-
90
-
-
79955559412
-
Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model
-
Castelino FV, Seiders J, Bain G, Brooks SF, King C, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM. Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model. Arthritis Rheum. 2011. doi: 10.1002/art.30262.
-
(2011)
Arthritis Rheum
-
-
Castelino, F.V.1
Seiders, J.2
Bain, G.3
Brooks, S.F.4
King, C.5
Swaney, J.S.6
Lorrain, D.S.7
Chun, J.8
Luster, A.D.9
Tager, A.M.10
-
91
-
-
0034668925
-
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase
-
Fang X, Yu S, LaPushin R, Lu Y, Furui T, Penn LZ, Stokoe D, Erickson JR, Bast RC Jr, Mills GB. Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. Biochem J. 2000;352 Pt 1:135-43.
-
(2000)
Biochem J.
, vol.352
, pp. 135-143
-
-
Fang, X.1
Yu, S.2
LaPushin, R.3
Lu, Y.4
Furui, T.5
Penn, L.Z.6
Stokoe, D.7
Erickson, J.R.8
Bast, R.C.9
Mills, G.B.10
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