Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

Molecular and Cellular Biochemistry

Volumn 395, Issue 1-2, 2014, Pages 1-10

  Makrecka, Marina ^a,b   Kuka, Janis ^a   Volska, Kristine ^b   Antone, Unigunde ^a   Sevostjanovs, Eduards ^a   Cirule, Helena ^a   Grinberga, Solveiga ^a   Pugovics, Osvalds ^a   Dambrova, Maija ^a,b   Liepinsh, Edgars ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b RIGA STRADINS UNIVERSITY   (Latvia)

Author keywords

Cardiac mitochondria; Energy metabolism; Lactate; Long chain acylcarnitine; Pyruvate

Indexed keywords

ACYLCARNITINE; FATTY ACID; LACTIC ACID; LONG CHAIN ACYLCARNITINE; PALMITOYLCARNITINE; PYRUVIC ACID; UNCLASSIFIED DRUG; CARNITINE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; GLUCOSE UTILIZATION; HEART MITOCHONDRION; HEART MUSCLE CELL; MALE; NONHUMAN; PLASMA; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL MODEL; DIET RESTRICTION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; WISTAR RAT;

RATTUS;

ANIMALS; CARNITINE; ENERGY METABOLISM; FASTING; FATTY ACIDS; GLUCOSE; MALE; MICE; MICE, INBRED ICR; MITOCHONDRIA, HEART; MODELS, ANIMAL; PALMITOYLCARNITINE; RATS; RATS, WISTAR;

EID: 84906318337     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2106-3     Document Type: Article

References (36)

1. Larsen TS, Aasum E (2008) Metabolic (in)flexibility of the diabetic heart. Cardiovasc Drugs Ther 22:91-95
2. Hue L, Taegtmeyer H (2009) The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 297:E578-E591
3. Liepinsh E, Makrecka M, Kuka J, Makarova E, Vilskersts R, Cirule H, Sevostjanovs E, Grinberga S, Pugovics O, Dambrova M (2014) The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism 63:127-136
4. Randle PJ (1998) Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14:263-283
5. van de Weijer T, Sparks LM, Phielix E, Meex RC, van Herpen NA, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB (2013) Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. PLoS One 8:e51648
6. Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE (1999) Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc Natl Acad Sci USA 96:1129-1134 (Pubitemid 29072195)
7. Schooneman MG, Vaz FM, Houten SM, Soeters MR (2013) A-cylcarnitines: reflecting or inflicting insulin resistance? Diabetes 62:1-8
8. Dobrzyn P, Pyrkowska A, Jazurek M, Dobrzyn A (2012) Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation. Mitochondrion 12:132-137
9. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7:45-56
10. Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP (2010) Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 18:1695-1700
11. Ramos-Roman MA, Sweetman L, Valdez MJ, Parks EJ (2012) Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity. Metabolism 61:202-212
12. van den Broek NM, Ciapaite J, De Feyter HM, Houten SM, Wanders RJ, Jeneson JA, Nicolay K, Prompers JJ (2010) Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats. FASEB J 24:1354-1364
13. Hansford RG (1977) Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria. J Biol Chem 252:1552-1560
14. Ocloo A, Shabalina IG, Nedergaard J, Brand MD (2007) Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1. Am J Physiol Regul Integr Comp Physiol 293:R1086-R1093 (Pubitemid 47358928)
15. Liepinsh E, Skapare E, Kuka J, Makrecka M, Cirule H, Vavers E, Sevostjanovs E, Grinberga S, Pugovics O, Dambrova M (2013) Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion. Naunyn Schmiedebergs Arch Pharmacol 386:541-550
16. Blachnio-Zabielska AU, Koutsari C, Jensen MD (2011) Measuring long-chain acyl-coenzyme A concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring. Rapid Commun Mass Spectrom 25:2223-2230
17. IUPAC-IUB (1967) IUPAC-IUB Commission on Biochemical Nomenclature (CBN). The nomenclature of lipids. Eur J Biochem 2:127-131
18. Borutaite V, Morkuniene R, Brown GC (1999) Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation. Biochim Biophys Acta 1453:41-48 (Pubitemid 29065456)
19. Kuka J, Vilskersts R, Cirule H, Makrecka M, Pugovics O, Kalvinsh I, Dambrova M, Liepinsh E (2012) The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. J Cardiovasc Pharmacol Ther 17:215-222
20. Campbell SE, Tandon NN, Woldegiorgis G, Luiken JJ, Glatz JF, Bonen A (2004) A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J Biol Chem 279:36235-36241 (Pubitemid 39128959)
21. Yoshida Y, Holloway GP, Ljubicic V, Hatta H, Spriet LL, Hood DA, Bonen A (2007) Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle. J Physiol 582:1317-1335 (Pubitemid 47104356)
22. Toleikis A, Majiene D, Trumbeckaite S, Dagys A, Jasaitis A (1996) The effect of collagenase and temperature on mitochondrial respiratory parameters in saponin-skinned cardiac fibers. Biosci Rep 16:513-519 (Pubitemid 27129851)
23. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev 90:207-258
24. Zhao G, Jeoung NH, Burgess SC, Rosaaen-Stowe KA, Inagaki T, Latif S, Shelton JM, McAnally J, Bassel-Duby R, Harris RA, Richardson JA, Kliewer SA (2008) Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 294:H936-H943 (Pubitemid 351253306)
25. Sugden MC, Kraus A, Harris RA, Holness MJ (2000) Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Biochem J 346(Pt 3):651-657 (Pubitemid 30171025)
26. Wu P, Sato J, Zhao Y, Jaskiewicz J, Popov KM, Harris RA (1998) Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J 329(Pt 1):197-201 (Pubitemid 28022309)
27. Ashour B, Hansford RG (1983) Effect of fatty acids and ketones on the activity of pyruvate dehydrogenase in skeletal-muscle mitochondria. Biochem J 214:725-736
28. Smith SJ, Saggerson ED (1979) Regulation of pyruvate dehydrogenase activity in white adipocyte mitochondria by palmitoyl carnitine and citrate. Int J Biochem 10:785-790 (Pubitemid 10190048)
29. Bugger H, Abel ED (2010) Mitochondria in the diabetic heart. Cardiovasc Res 88:229-240
30. Martins AR, Nachbar RT, Gorjao R, Vinolo MA, Festuccia WT, Lambertucci RH, Cury-Boaventura MF, Silveira LR, Curi R, Hirabara SM (2012) Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids Health Dis 11:30
31. Viscarra JA, Ortiz RM (2013) Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation. Metabolism 62:889-897
32. Soeters MR, Sauerwein HP, Duran M, Wanders RJ, Ackermans MT, Fliers E, Houten SM, Serlie MJ (2009) Muscle acylcarnitines during short-term fasting in lean healthy men. Clin Sci (Lond) 116:585-592
33. Bell JA, Reed MA, Consitt LA, Martin OJ, Haynie KR, Hulver MW, Muoio DM, Dohm GL (2010) Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. J Clin Endocrinol Metab 95:3400-3410
34. Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM (2005) Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 280:33588-33598 (Pubitemid 41397160)
35. Muoio DM, Neufer PD (2012) Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab 15:595-605
36. Tominaga H, Katoh H, Odagiri K, Takeuchi Y, Kawashima H, Saotome M, Urushida T, Satoh H, Hayashi H (2008) Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 295:H105-H112