Role of α-synuclein in neurodegeneration: Implications for the pathogenesis of Parkinson's disease

Essays in Biochemistry

Volumn 56, Issue 1, 2014, Pages 125-135

  Yu, Shun ^a   Chan, Piu ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Dopamine transporter; Dopaminergic neuron; Lewy body; Mitochondria; NMDA receptor; Parkinson's disease; Substantia nigra; Synaptic plasticity; Vesicle recycling

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; OXSR1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

ANIMAL; BIOSYNTHESIS; HUMAN; METABOLISM; MITOCHONDRION; PARKINSON DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SECRETION (PROCESS); SYNAPSE; SYNAPTIC TRANSMISSION;

ALPHA-SYNUCLEIN; ANIMALS; DOPAMINE; HUMANS; MITOCHONDRIA; PARKINSON DISEASE; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84906273091     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0560125     Document Type: Article

References (39)

1. Clayton, D.F. and George, J.M. (1998) The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21, 249-254
2. Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997) Mutation in the alphα-synuclein gene identifi ed in families with Parkinson's disease. Science 276, 2045-2047
3. Cheng, F., Vivacqua, G. and Yu, S. (2011) The role of α-synuclein in neurotransmission and synaptic plasticity. J. Chem. Neuroanat. 42, 242-248
4. Zhang, L., Zhang, C., Zhu, Y., Cai, Q., Chan, P., Ueda, K., Yu, S. and Yang, H. (2008) Semiquantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specifi c monoclonal antibody. Brain Res. 1244, 40-52
5. Yu, S., Li, X., Liu, G., Han, J., Zhang, C., Li, Y., Xu, S., Liu, C., Gao, Y., Yang, H. et al. (2007) Extensive nuclear localization of α-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 145, 539-555
6. Cockcroft, S. (2001) Signalling roles of mammalian phospholipase D1 and D2. Cell. Mol. Life Sci. 58, 1674-1687
7. Bellani, S., Sousa, V.L., Ronzitti, G., Valtorta, F., Meldolesi, J., and Chieregatti, E. (2010) The regulation of synaptic function by a-synuclein. Commun. Integr. Biol. 3, 106-109
8. Goda, Y. (1997) SNAREs and regulated vesicle exocytosis. Proc. Natl. Acad. Sci. U.S.A. 94, 769-772
9. Yavich, L., Tanila, H., Vepsalainen, S. and Jakala, P. (2004) Role of α-synuclein in presynaptic dopamine recruitment. J. Neurosci. 24, 11165-11170
10. Gureviciene, I., Gurevicius, K., and Tanila, H. (2007) Role of α-synuclein in synaptic glutamate release. Neurobiol. Dis. 28, 83-89
11. Liu, S., Fa, M., Ninan, I., Trinchese, F., Dauer, W. and Arancio, O. (2007) a-Synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25, 3583-3596
12. Gureviciene, I., Gurevicius, K. and Tanila, H. (2009) Aging and α-synuclein affect synaptic plasticity in the dentate gyrus. J. Neural Transm. 116, 13-22
13. Kisos, H., Ben-Gedalya, T. and Sharon, R. (2013) The clathrin-dependent localization of dopamine transporter to surface membranes is affected by a-synuclein. J. Mol. Neurosci. 52, 167-176
14. Oaks, A.W. and Sidhu, A. (2011) Synuclein modulation of monoamine transporters. FEBS Lett. 585, 1001-1006
15. Ben, G.T., Loeb, V., Israeli, E., Altschuler, Y., Selkoe, D.J. and Sharon, R. (2009) α-Synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffi c 10, 218-234
16. Cheng, F., Li, X., Li, Y., Wang, C., Wang, T., Liu, G., Baskys, A., Ueda, K., Chan, P. and Yu, S. (2011) α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death. J. Neurochem. 119, 815-825
17. Wu, B., Liu, Q., Duan, C., Li, Y., Yu, S., Chan, P., Ueda, K. and Yang, H. (2011) Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells. Acta Histochem. 113, 32-35
18. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J.T., Schols, L. and Riess, O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108
19. Appel-Cresswell, S., Vilarino-Guell, C., Encarnacion, M., Sherman, H., Yu, I., Shah, B., Weir, D., Thompson, C., Szu-Tu, C., Trinh, J. et al. (2013) α-Synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov. Disord. 28, 811-813
20. Braak, H., Rüb, U. and Del Tredici, K. (2006) Cognitive decline correlates with neuropathological stage in Parkinson's disease. J. Neurol. Sci. 248, 255-258
21. Maraganore, D.M., de Andrade, M., Elbaz, A., Farrer, M.J., Ioannidis, J.P., Kruger, R., Rocca, W.A., Schneider, N.K., Lesnick, T.G., Lincoln, S.J. et al. (2006) Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease. JAMA 296, 661-670
22. Baba, M., Nakajo, S., Tu, P.H., Tomita, T., Nakaya, K., Lee, V.M., Trojanowski, J.Q. and Iwatsubo, T. (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879-884
23. Frigerio, R., Fujishiro, H., Ahn, T.B., Josephs, K.A., Maraganore, D.M., DelleDonne, A., Parisi, J.E., Klos, K.J., Boeve, B.F., Dickson, D.W. and Ahlskog, J.E. (2011) Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol. Aging 32, 857-863
24. Milber, J.M., Noorigian, J.V., Morley, J.F., Petrovitch, H., White, L., Ross, G.W. and Duda, J.E. (2012) Lewy pathology is not the fi rst sign of degeneration in vulnerable neurons in Parkinson disease. Neurology 79, 2307-2314
25. Karpinar, D.P., Balija, M.B., Kugler, S., Opazo, F., Rezaei-Ghaleh, N., Wender, N., Kim, H.Y., Taschenberger, G., Falkenburger, B.H., Heise, H. et al. (2009) Pre-fi brillar α-synuclein variants with impaired ß-structure increase neurotoxicity in Parkinson's disease models. EMBO J. 28, 3256-3268
26. Choi, J.H., Stubblefi eld, B., Cookson, M.R., Goldin, E., Velayati, A., Tayebi, N. and Sidransky, E. (2011) Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations. Mol. Genet. Metab. 104, 185-188
27. Yu, S., Ueda, K. and Chan, P. (2005) αa-Synuclein and dopamine metabolism. Mol. Neurobiol. 31, 243-254
28. Venda, L.L., Cragg, S.J., Buchman, V.L. and Wade-Martins, R. (2010) α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends Neurosci. 33, 559-568
29. Petrucelli, L., O'Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J. and Cookson, M.R. (2002) Parkin protects against the toxicity associated with mutant a-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36, 1007-1019
30. Xu, J., Kao, S.Y., Lee, F.J., Song, W., Jin, L.W. and Yankner, B.A. (2002) Dopaminedependent neurotoxicity of a-synuclein: A mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8, 600-606
31. Conway, K.A., Rochet, J.C., Bieganski, R.M. and Lansbury, Jr, P.T. (2001) Kinetic stabilization of the α-synuclein protofi bril by a dopamine-a-synuclein adduct. Science 294, 1346-1349
32. Volles, M.J. and Lansbury, Jr, P.T. (2007) Relationships between the sequence of α-synuclein and its membrane affi nity, fi brillization propensity, and yeast toxicity. J. Mol. Biol. 366, 1510-1522
33. Jenner, P. (2003) Oxidative stress in Parkinson's disease. Ann. Neurol. 53, S26-S36
34. Disgenes, M.J., Dias, R.B., Rombo, D.M., Vicente, M.H., Maiolino, F., Guerreiro, P., Nasstrom, T., Franquelim, H.G., Oliveira, L.M., Castanho, M.A. et al. (2012) Extracellular α-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J. Neurosci. 32, 11750-11762
35. Bonini, N.M. and Giasson, B.I. (2005) Snaring the function of α-synuclein. Cell 123, 359-361
36. Chandra, S., Gallardo, G., Fernandez-Chacon, R., Schluter, O.M. and Sudhof, T.C. (2005) ) a-Synuclein cooperates with CSPa in preventing neurodegeneration. Cell 123, 383-396
37. Nakamura, K., Nemani, V.M., Azarbal, F., Skibinski, G., Levy, J.M., Egami, K., Munishkina, L., Zhang, J., Gardner, B., Wakabayashi, J. et al. (2011) Direct membrane association drives mitochondrial fi ssion by the Parkinson disease-associated protein ) a-synuclein. J. Biol. Chem. 286, 20710-20726
38. Olanow, C.W. and Brundin, P. (2013) Parkinson's disease and a synuclein: is Parkinson's disease a prion-like disorder? Mov. Disord. 28, 31-40
39. Vekrellis, K., Xilouri, M., Emmanouilidou, E., Rideout, H.J. and Stefanis, L. (2011) Pathological roles of α-synuclein in neurological disorders. Lancet Neurol. 10, 1015-1025