Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis in cervical cancer cells in vitro and in vivo

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 7, 2014, Pages 4016-4023

  Wang, Ning ^a   Wei, Heng ^a   Yin, Duo ^a   Lu, Yanming ^a   Zhang, Yao ^a   Jiang, Di ^a   Jiang, Yan ^a   Zhang, Shulan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cervical cancer; Cyclin D1b; Proliferation

Indexed keywords

CYCLIN D1; ISOPROTEIN;

ANIMAL; APOPTOSIS; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; GENETICS; HELA CELL LINE; HUMAN; IN VITRO STUDY; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUNEL ASSAY; UTERINE CERVIX TUMOR; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CYCLIN D1; FEMALE; FLOW CYTOMETRY; HELA CELLS; HETEROGRAFTS; HUMANS; IN SITU NICK-END LABELING; IN VITRO TECHNIQUES; MICE; MICE, NUDE; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UTERINE CERVICAL NEOPLASMS;

EID: 84906224808     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
3. Shi JF, Canfell K, Lew JB and Qiao YL. The burden of cervical cancer in China: synthesis of the evidence. Int J Cancer 2012; 130: 641-652.
4. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJ and Meijer CJ. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.
5. Glick SB, Clarke AR, Blanchard A and Whitaker AK. Cervical cancer screening, diagnosis and treatment interventions for racial and ethnic minorities: a systematic review. J Gen Intern Med 2012; 27: 1016-1032.
6. Bonilla C, Lefevre JH, Winney B, Johnstone E, Tonks S, Colas C, Day T, Hutnik K, Boumertit A, Midgley R, Kerr D, Parc Y and Bodmer WF. Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients. J Hum Genet 2011; 56: 58-63.
7. Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S and Koike K. Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. Proc Natl Acad Sci U S A 2011; 108: 780-785.
8. Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP and Sicinski P. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011; 474: 230-234.
9. Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD and Heighway J. Alternate splicing produces a novel cyclin D1 transcript. On-cogene 1995; 11: 1005-1011.
10. Burd CJ, Petre CE, Morey LM, Wang Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM, Li J, Knudsen ES, Wong J and Knudsen KE. Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A 2006; 103: 2190-2195.
11. Kim CJ, Nishi K, Isono T, Okuyama Y, Tambe Y, Okada Y and Inoue H. Cyclin D1b variant promotes cell invasiveness independent of binding to CDK4 in human bladder cancer cells. Mol Carcinog 2009; 48: 953-964.
12. Zhu J, Sen S, Wei C and Frazier ML. Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor alpha-mediated transcription. Int J On-col 2010; 36: 39-48.
13. Krieger S, Gauduchon J, Roussel M, Troussard X and Sola B. Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma. BMC Cancer 2006; 6: 238.
14. Wang N, Qian X, Wang S, Gao H, Wang L, Huo Y and Zhang S. CCND1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in Chinese population. Mol Carcinog 2012; 51: 196-205.
15. Lu F, Gladden AB and Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 2003; 63: 7056-7061.
16. Abramson VG, Troxel AB, Feldman M, Mies C, Wang Y, Sherman L, McNally S, Diehl A and Demichele A. Cyclin D1b in human breast carcinoma and coexpression with cyclin D1a is associated with poor outcome. Anticancer Res 2010; 30: 1279-1285.
17. Millar EK, Dean JL, McNeil CM, O'Toole SA, Henshall SM, Tran T, Lin J, Quong A, Comstock CE, Witkiewicz A, Musgrove EA, Rui H, Lem-archand L, Setiawan VW, Haiman CA, Knudsen KE, Sutherland RL and Knudsen ES. Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome. Oncogene 2009; 28: 1812-1820.
18. Li R, An SJ, Chen ZH, Zhang GC, Zhu JQ, Nie Q, Xie Z, Guo AL, Mok TS and Wu YL. Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients. Hum Pathol 2008; 39: 1792-1801.
19. Kim CJ, Tambe Y, Mukaisho K, Sugihara H, Is-ono T, Sonoda H, Shimizu T, Kondoh G and Inoue H. Female-specific rectal carcinogenesis in cyclin D1b transgenic mice. Carcinogenesis 2014; 35: 227-236.
20. Coqueret O. Linking cyclins to transcriptional control. Gene 2002; 299: 35-55.
21. Kim JK and Diehl JA. Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 2009; 220: 292-296.
22. Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ and Knudsen ES. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 2003; 278: 30339-30347.
23. Leveque C, Marsaud V, Renoir JM and Sola B. Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes. Exp Cell Res 2007; 313: 2719-2729.
24. Schiffman M and Castle PE. Human papillomavirus: epidemiology and public health. Arch Pathol Lab Med 2003; 127: 930-934.
25. Narisawa-Saito M and Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci 2007; 98: 1505-1511.
26. Moody CA and Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer 2010; 10: 550-560.
27. Gao P and Zheng J. High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer. Virol J 2010; 7: 238.
28. Mighty KK and Laimins LA. The role of human papillomaviruses in oncogenesis. Recent Results Cancer Res 2014; 193: 135-148.
29. Cho NH, Kim YT and Kim JW. Alteration of cell cycle in cervical tumor associated with human papillomavirus: cyclin-dependent kinase inhibitors. Yonsei Med J 2002; 43: 722-728.