Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor α-mediated transcription

International Journal of Oncology

Volumn 36, Issue 1, 2010, Pages 39-48

  Zhu, Jing ^a,b   Sen, Subrata ^a   Wei, Chongjuan ^a   Frazier, Marsha L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Cyclin D1b; Estrogen receptor ; Transcriptional regulation

Indexed keywords

CYCLIN D1; CYCLIN D1B; ESTROGEN RECEPTOR ALPHA; ISOPROTEIN; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER REGRESSION; CELL PROLIFERATION; FUNCTIONAL PROTEOMICS; GENE ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTO ONCOGENE; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; BINDING SITES; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; NUCLEAR RECEPTOR COACTIVATOR 1; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION, GENETIC;

EID: 74549136917     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000473     Document Type: Article

References (35)

1. Arnold A, Kim HG, Gaz RD, et al: Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 83: 2034-2040, 1989.
2. Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD and Heighway J: Alternate splicing produces a novel cyclin D1 transcript. Oncogene 11: 1005-1011, 1995.
3. Hosokawa Y, Gadd M, Smith AP, Koerner FC, Schmidt EV and Arnold A: Cyclin D1 (PRAD1) alternative transcript b: fulllength cDNA cloning and expression in breast cancers. Cancer Lett 113: 123-130, 1997.
4. Leveque C, Marsaud V, Renoir JM and Sola B: Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes. Exp Cell Res 313: 2719-2729, 2007.
5. Lu F, Gladden AB and Diehl JA: An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 63: 7056-7061, 2003.
6. Solomon DA, Wang Y, Fox SR, et al: Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 278: 30339-30347, 2003.
7. Coqueret O: Linking cyclins to transcriptional control. Gene 299: 35-55, 2002.
8. Opitz OG and Rustgi AK: Interaction between Sp1 and cell cycle regulatory proteins is important in transactivation of a differentiation-related gene. Cancer Res 60: 2825-2830, 2000.
9. Bienvenu F, Gascan H and Coqueret O: Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J Biol Chem 276: 16840-16847, 2001.
10. Inoue K and Sherr CJ: Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol Cell Biol 18: 1590-1600, 1998.
11. Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R and Michalides RJ: CDK-independent activation of estrogen receptor by cyclin D1. Cell 88: 405-415, 1997.
12. Neuman E, Ladha MH, Lin N, et al: Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol Cell Biol 17: 5338-5347, 1997.
13. Lamb J, Ladha MH, McMahon C, Sutherland RL and Ewen ME: Regulation of the functional interaction between cyclin D1 and the estrogen receptor. Mol Cell Biol 20: 8667-8675, 2000.
14. Knudsen KE, Cavenee WK and Arden KC: D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res 59: 2297-2301, 1999.
15. Petre CE, Wetherill YB, Danielsen M and Knudsen KE: Cyclin D1: mechanism and consequence of androgen receptor corepressor activity. J Biol Chem 277: 2207-2215, 2002.
16. Lin HM, Zhao L and Cheng SY: Cyclin D1 is a ligand-independent co-repressor for thyroid hormone receptors. J Biol Chem 277: 28733-28741, 2002.
17. Reutens AT, Fu M, Wang C, et al: Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol Endocrinol 15: 797-811, 2001.
18. McMahon C, Suthiphongchai T, DiRenzo J and Ewen ME: P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor. Proc Natl Acad Sci USA 96: 5382-5387, 1999.
19. Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ and Bernards R: Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev 12: 3488-3498, 1998.
20. Lazaro JB, Bailey PJ and Lassar AB: Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 16: 1792-1805, 2002.
21. Adnane J, Shao Z and Robbins PD: Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription. Oncogene 18: 239-247, 1999.
22. Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai MJ and O'Malley BW: Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol 9: 43-49, 1989.
23. Graham FL and van der Eb AJ: A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467, 1973.
24. Meng Q, Rayala SK, Gururaj AE, Talukder AH, O'Malley BW and Kumar R: Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc Natl Acad Sci USA 104: 5866-5871, 2007.
25. Altucci L, Addeo R, Cicatiello L, et al: 17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Oncogene 12: 2315-2324, 1996.
26. Sabbah M, Courilleau D, Mester J and Redeuilh G: Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc Natl Acad Sci USA 96: 11217-11222, 1999.
27. Wang C, Fan S, Li Z, et al: Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res 65: 6557-6567, 2005.
28. Alt JR, Cleveland JL, Hannink M and Diehl JA: Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 14: 3102-3114, 2000.
29. Takahashi-Yanaga F and Sasaguri T: GSK-3beta regulates cyclin D1 expression: A new target for chemotherapy. Cell Signal 20: 581-589, 2008.
30. Zou Y, Ewton DZ, Deng X, Mercer SE and Friedman E: Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem 279: 27790-27798, 2004.
31. Kong S, Amos CI, Luthra R, Lynch PM, Levin B and Frazier ML: Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer. Cancer Res 60: 249-252, 2000.
32. Ceschi M, Sun CL, Van Den Berg D, Koh WP, Yu MC and Probst-Hensch N: The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore. Carcinogenesis 26: 1457-1464, 2005.
33. Shu XO, Moore DB, Cai Q, et al: Association of cyclin D1 genotype with breast cancer risk and survival. Cancer Epidemiol Biomarkers Prev 14: 91-97, 2005.
34. Yu CP, Yu JC, Sun CA, Tzao C, Ho JY and Yen AM: Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1. Breast Cancer Res Treat 107: 95-102, 2008.
35. Normanno N, Di Maio M, De Maio E, et al: Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer. Endocr Relat Cancer 12: 721-747, 2005.