Application of phospholipid complex technique to improve the dissolution and pharmacokinetic of probucol by solvent-evaporation and co-grinding methods

International Journal of Pharmaceutics

Volumn 474, Issue 1-2, 2014, Pages 50-56

  Guo, Bei ^a   Liu, Hongzhuo ^a   Li, Yun ^a   Zhao, Juanhang ^a   Yang, Dan ^a   Wang, Xianglin ^a   Zhang, Tianhong ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Co grinding method; Oral bioavailability; Phospholipid complex; Probucol; Solvent evaporation method

Indexed keywords

ALCOHOL; PHOSPHOLIPID; PROBUCOL; GELUCIRE; SOLVENT; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CHEMICAL INTERACTION; CHEMICAL PARAMETERS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; EVAPORATION; GRINDING; HIGH TEMPERATURE; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTITION COEFFICIENT; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REACTION TIME; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY DIFFRACTION; CO GRINDING METHOD; CRYSTALLINITY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG RELEASE; ELIMINATION HALF-LIFE; MELTING POINT; OIL WATER PARTITION COEFFICIENT; PERMEABILITY; PHOSPHOLIPID COMPLEX TECHNIQUE; PHYSICAL CHEMISTRY; SOLVENT EVAPORATION METHOD; THERMAL BEHAVIOR; X RAY POWDER DIFFRACTION; ANIMAL; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; MALE; MOLECULAR STRUCTURE; PHOSPHOLIPIDS; PROBUCOL; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; WATER;

EID: 84906217766     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.006     Document Type: Article

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