A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions

Angewandte Chemie - International Edition

Volumn 53, Issue 34, 2014, Pages 8913-8918

  Thompson, Stephen ^a   Zhang, Qingzhi ^a   Onega, Mayca ^b   McMahon, Stephen ^a   Fleming, Ian ^c   Ashworth, Sharon ^b   Naismith, James H ^a   Passchier, Jan ^b   O'Hagan, David ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

bioconjugated peptides; enzyme catalysis; fluorinase; fluorine 18; positron emission tomography

Indexed keywords

ACETYLENE; CATALYSIS; FLUORINATION; FLUORINE; HALOGENATION; LIGHTING; PEPTIDES; POSITRON EMISSION TOMOGRAPHY;

AQUEOUS CONDITION; BIO-CONJUGATED; BIO-CONJUGATION; ENZYME CATALYSIS; FLUORINASE; FLUORINE-18; POSITRON EMISSION TOMOGRAPHY (PET); SUBSTRATE SPECIFICITY;

ENZYMES;

EID: 84906101904     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201403345     Document Type: Article

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