Does anodal transcranial direct current stimulation modulate sensory perception and pain? A meta-analysis study

Clinical Neurophysiology

Volumn 125, Issue 9, 2014, Pages 1847-1858

  Vaseghi, B ^a   Zoghi, M ^b   Jaberzadeh, S ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Corticospinal excitability; Pain level; Pain threshold; Sensory threshold; Transcranial direct current stimulation (tDCS); Transcranial magnetic stimulation (TMS)

Indexed keywords

ARTICLE; CHRONIC PAIN; DATA BASE; EFFECT SIZE; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PAIN THRESHOLD; PERCEPTIVE THRESHOLD; PREFRONTAL CORTEX; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SAMPLE SIZE; SENSORY CORTEX; TRANSCRANIAL DIRECT CURRENT STIMULATION; VISUAL ANALOG SCALE; ADULT; AGED; ELECTRODE; FEMALE; MALE; MIDDLE AGED; MOTOR CORTEX; NOCICEPTION; PATHOPHYSIOLOGY; PERCEPTION; PHYSIOLOGY; PROCEDURES; SENSATION; SOMATOSENSORY CORTEX; YOUNG ADULT;

ADULT; AGED; CHRONIC PAIN; ELECTRODES; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; PAIN PERCEPTION; PERCEPTION; SENSATION; SOMATOSENSORY CORTEX; TRANSCRANIAL DIRECT CURRENT STIMULATION; YOUNG ADULT;

EID: 84906077099     PISSN: 13882457     EISSN: 18728952     Source Type: Journal    
DOI: 10.1016/j.clinph.2014.01.020     Document Type: Article

References (111)

1. Antal A., Brepohl N., Poreisz C., Boros K., Csifcsak G., Paulus W. Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception. Clin J Pain 2008, 24:56-63.
2. Antal A., Paulus W. Transcranial direct current stimulation and visual perception. Perception 2008, 37:367-374.
3. Antal A., Paulus W. A case of refractory orofacial pain treated by transcranial direct current stimulation applied over hand motor area in combination with NMDA agonist drug intake. Brain Stimul 2011, 4:117-121.
4. Antal A., Polania R., SchmidtSamoa C., Dechent P., Paulus W. Transcranial direct current stimulation over the primary motor cortex during fMRI. Neuroimage 2011, 55(2):590-596. 10.1016/j.neuroimage.2010.11.085.
5. Antal A., Terney D., Kuhnl S., Paulus W. Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition. J Pain Symptom Manage 2010, 39:890-903.
6. Apkarian A.V., Bushnell M.C., Treede R.D., Zubieta J.K. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005, 9:463-484.
7. Apkarian A.V., Sosa Y., Sonty S., Levy R.M., Harden R.N., Parrish T.B., Gitelman D.R. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004, 24:10410-10415.
8. Bachmann C.G., Muschinsky S., Nitsche M.A., Rolke R., Magerl W., Treede R.D., Paulus W. Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts. Clin Neurophysiol 2010, 121(12):2083-2089. 10.1016/j.clinph.2010.05.005.
9. Baliki M.N., Petre B., Torbey S., Herrmann K.M., Huang L., Schnitzer T.J., Fields H.L., Apkarian A.V. Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci 2012, 15:1117-1119.
10. Bax L., Yu L.M., Ikeda N., Moons K.G. A systematic comparison of software dedicated to meta-analysis of causal studies. BMC Med Res Methodol 2007, 7(40):2007.
11. Bingel U., Quante M., Knab R., Bromm B., Weiller C., Buchel C. Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices. Neuroimage 2003, 18:740-748.
12. Boggio P.S., Zaghi S., Fregni F. Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS). Neuropsychologia 2009, 47:212-217.
13. Bolognini N., Pascual-Leone A., Fregni F. Using non-invasive brain stimulation to augment motor training-induced plasticity. J Neuroeng Rehabil 2009, 6. 1743-0003.
14. Bolton J.E., Wilkinson R.C. Responsiveness of pain scales: a comparison of three pain intensity measures in chiropractic patients. J Manipulative Physiol Ther 1998, 21:1-7.
15. Bornhovd K., Quante M., Glauche V., Bromm B., Weiller C., Buchel C. Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 2002, 125:1326-1336.
16. Casey K.L., Morrow T.J., Lorenz J., Minoshima S. Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. J Neurophysiol 2001, 85:951-959.
17. Chong P.S., Cros D.P. Technology literature review: quantitative sensory testing. Muscle Nerve 2004, 29:734-747.
18. Coghill R.C., Sang C.N., Maisog J.M., Iadarola M.J. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 1999, 82:1934-1943.
19. Csifcsak G., Antal A., Hillers F., Levold M., Bachmann C.G., Happe S., Nitsche M.A., Ellrich J., Paulus W. Modulatory effects of transcranial direct current stimulation on laser-evoked potentials. Pain Med 2009, 10:122-132.
20. Dasilva A.F., Mendonca M.E., Zaghi S., Lopes M., Dossantos M.F., Spierings E.L., Bajwa Z., Datta A., Bikson M., Fregni F. TDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache 2012, 52:1283-1295.
21. de Morton N.A. The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 2009, 55:129-133.
22. Deeks JJ, Higgins JP.Statistical algorithms in Review Manager 5. Statistical Methods Group of The Cochrane Collaboration 2010.
23. Di Lazzaro V., Manganelli F., Dileone M., Notturno F., Esposito M., Capasso M., Dubbioso R., Pace M., Ranieri F., Minicuci G., Santoro L., Uncini A. The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex. J Neural Transm 2012, 119:1499-1506.
24. Dieckhofer A., Waberski T.D., Nitsche M., Paulus W., Buchner H., Gobbele R. Transcranial direct current stimulation applied over the somatosensory cortex - differential effect on low and high frequency SEPs. Clin Neurophysiol 2006, 117:2221-2227.
25. Downs S.H., Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998, 52:377-384.
26. Eng J.J., Teasell R., Miller W.C., Wolfe D.L., Townson A.F., Aubut J.A., Abramson C., Hsieh J.T., Connolly S., Konnyu K. Spinal Cord Injury Rehabilitation Evidence: methods of the SCIRE Systematic Review. Top Spinal Cord Inj Rehabil 2007, 13:1-10.
27. Enomoto H., Ugawa Y., Hanajima R., Yuasa K., Mochizuki H., Terao Y., Shiio Y., Furubayashi T., Iwata N.K., Kanazawa I. Decreased sensory cortical excitability after 1 Hz rTMS over the ipsilateral primary motor cortex. Clin Neurophysiol 2001, 112:2154-2158.
28. Farina D., Arendt-Nielsen L., Merletti R., Graven-Nielsen T. Effect of experimental muscle pain on motor unit firing rate and conduction velocity. J Neurophysiol 2004, 91:1250-1259.
29. Fenton B.W., Palmieri P.A., Boggio P., Fanning J., Fregni F. A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimul 2009, 2:103-107.
30. Fernandez E., Turk D.C. Sensory and affective components of pain: separation and synthesis. Psychol Bull 1992, 112:205-217.
31. Flor H., Braun C., Elbert T., Birbaumer N. Extensive reorganization of primary somatosensory cortex in chronic back pain patients. Neurosci Lett 1997, 224:5-8.
32. Fomberstein K., Qadri S., Ramani R. Functional MRI and pain. Curr Opin Anaesthesiol 2013, 29:29.
33. Fregni F., Boggio P.S., Lima M.C., Ferreira M.J., Wagner T., Rigonatti S.P., Castro A.W., Souza D.R., Riberto M., Freedman S.D., Nitsche M.A., Pascual-Leone A. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 2006, 122:197-209.
34. Fregni F., Freedman S., Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol 2007, 6:188-191.
35. Fregni F., Gimenes R., Valle A.C., Ferreira M.J., Rocha R.R., Natalle L., Bravo R., Rigonatti S.P., Freedman S.D., Nitsche M.A., Pascual-Leone A., Boggio P.S. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum 2006, 54:3988-3998.
36. Fuller G.N., Guiloff R.J. The conduction velocities of peripheral nerve fibres conveying sensations of warming and cooling. J Neurol Neurosurg Psychiatry. 1989, 52(6):810-812.
37. Furubayashi T., Terao Y., Arai N., Okabe S., Mochizuki H., Hanajima R., Hamada M., Yugeta A., Inomata-Terada S., Ugawa Y. Short and long duration transcranial direct current stimulation (tDCS) over the human hand motor area. Exp Brain Res 2008, 185:279-286.
38. Gamboa O.L., Antal A., Moliadze V., Paulus W. Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation. Exp Brain Res 2010, 204:181-187.
39. Garcia-Larrea L., Peyron R., Mertens P., Gregoire M.C., Lavenne F., Le Bars D., Convers P., Mauguiere F., Sindou M., Laurent B. Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain 1999, 83:259-273.
40. Giesecke T., Gracely R.H., Williams D.A., Geisser M.E., Petzke F.W., Clauw D.J. The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum 2005, 52:1577-1584.
41. Graven-Nielsen T., Lund H., Arendt-Nielsen L., Danneskiold-Samsoe B., Bliddal H. Inhibition of maximal voluntary contraction force by experimental muscle pain: a centrally mediated mechanism. Muscle Nerve 2002, 26:708-712.
42. Grundmann L., Rolke R., Nitsche M.A., Pavlakovic G., Happe S., Treede R.D., Paulus W., Bachmann C.G. Effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perception. Brain Stimul 2011, 4:253-260.
43. Hansen N., Obermann M., Poitz F., Holle D. Diener HC., Antal A., Paulus W., Katsarava Z., Modulation of human trigeminal and extracranial nociceptive processing by transcranial direct current stimulation of the motor cortex. Cephalalgia. 2011, 31(6):661-670. 10.1177/0333102410390394.
44. Higgins, Green S. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane Collaboration 2011.
45. Hodges P.W., Ervilha U.F., Graven-Nielsen T. Changes in motor unit firing rate in synergist muscles cannot explain the maintenance of force during constant force painful contractions. J Pain 2008, 9:1169-1174.
46. Hodges P.W., Moseley G.L. Pain and motor control of the lumbopelvic region: effect and possible mechanisms. J Electromyogr Kinesiol 2003, 13:361-370.
47. Hosomi K., Shimokawa T., Ikoma K., Nakamura Y., Sugiyama K., Ugawa Y., Uozumi T., Yamamoto T., Saitoh Y. Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: a randomized, multicenter, double-blind, crossover, sham-controlled trial. Pain 2013, 154:1065-1072.
48. Islam N., Aftabuddin M., Moriwaki A., Hattori Y., Hori Y. Increase in the calcium level following anodal polarization in the rat brain. Brain Res 1995, 684:206-208.
49. Jeffery D.T., Norton J.A., Roy F.D., Gorassini M.A. Effects of transcranial direct current stimulation on the excitability of the leg motor cortex. Exp Brain Res 2007, 182:281-287.
50. Jette F., Cote I., Meziane H.B., Mercier C. Effect of single-session repetitive transcranial magnetic stimulation applied over the hand versus leg motor area on pain after spinal cord injury. Neurorehabil Neural Repair 2013, 27:636-643.
51. Joseph A. (2011). "Plot Digitizer 2.5.1 ", from http://plotdigitizer.sourceforge.net/.
52. Jurgens T.P., Schulte A., Klein T. May A, Transcranial direct current stimulation does neither modulate results of a quantitative sensory testing protocol nor ratings of suprathreshold heat stimuli in healthy volunteers. Eur. J. Pain. 2012, 16(9):1251-1263. 10.1002/j.1532-2149.2012.00135.x.
53. Kanda M., Nagamine T., Ikeda A., Ohara S., Kunieda T., Fujiwara N., Yazawa S., Sawamoto N., Matsumoto R., Taki W., Shibasaki H. Primary somatosensory cortex is actively involved in pain processing in human. Brain Res 2000, 853:282-289.
54. Lang N., Siebner H.R., Ward N.S., Lee L., Nitsche M.A., Paulus W., Rothwell J.C., Lemon R.N., Frackowiak R.S. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?. Eur J Neurosci 2005, 22:495-504.
55. Latremoliere A., Woolf C.J. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 2009, 10:895-926.
56. Laurent B., Peyron R. Garcia Larrea L, Mauguiere F. Positron emission tomography to study central pain integration. Rev Neurol 2000, 156:341-351.
57. Lefaucheur J.P., Ayache S.S., Sorel M., Farhat W.H., Zouari H.G., Ciampi de Andrade D., Ahdab R., Menard-Lefaucheur I., Brugieres P., Goujon C. Analgesic effects of repetitive transcranial magnetic stimulation of the motor cortex in neuropathic pain: influence of theta burst stimulation priming. Eur J Pain 2012, 16:1403-1413.
58. Lefaucheur J.P., Drouot X., Menard-Lefaucheur I., Keravel Y., Nguyen J.P. Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain. Neurology 2006, 67:1568-1574.
59. Leon-Sarmiento F.E., Granadillo E., Bayona E.A. Present and future of the transcranial magnetic stimulation. Invest Clin 2013, 54:74-89.
60. Liebetanz D., Nitsche M.A., Tergau F., Paulus W. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain 2002, 125:2238-2247.
61. Lorenz J., Minoshima S., Casey K.L. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 2003, 126:1079-1091.
62. Luedtke K., Rushton A., Wright C., Geiss B., Juergens T.P., May A. Transcranial direct current stimulation for the reduction of clinical and experimentally induced pain: a systematic review and meta-analysis. Clin J Pain 2012, 28:452-461.
63. Lund J.P., Donga R., Widmer C.G., Stohler C.S. The pain-adaptation model: a discussion of the relationship between chronic musculoskeletal pain and motor activity. Can J Physiol Pharmacol 1991, 69:683-694.
64. Maher C.G., Sherrington C., Herbert R.D., Moseley A.M., Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther 2003, 83:713-721.
65. Mendonca M.E., Santana M.B., Baptista A.F., Datta A., Bikson M., Fregni F., Araujo C.P. Transcranial DC stimulation in fibromyalgia: optimized cortical target supported by high-resolution computational models. J Pain 2011, 12:610-617.
66. Miranda P.C., Lomarev M., Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol 2006, 117:1623-1629.
67. Mori F., Codeca C., Kusayanagi H., Monteleone F., Buttari F., Fiore S., Bernardi G., Koch G. Centonze D. Effects of anodal transcranial direct current stimulation on chronic neuropathic pain in patients with multiple sclerosis, J Pain 2010, 11(5):436-442. 10.1016/j.jpain.2009.08.011.
68. Moseley A.M., Herbert R.D., Sherrington C., Maher C.G. Evidence for physiotherapy practice: a survey of the Physiotherapy Evidence Database (PEDro). Aust J Physiother 2002, 48:43-49.
69. Moseley G.L., Brugger P. Interdependence of movement and anatomy persists when amputees learn a physiologically impossible movement of their phantom limb. Proc Natl Acad Sci USA 2009, 106:18798-18802.
70. Mouraux A., Diukova A., Lee M.C., Wise R.G., Iannetti G.D. A multisensory investigation of the functional significance of the "pain matrix". Neuroimage 2011, 54:2237-2249.
71. Mylius V., Borckardt J.J., Lefaucheur J.P. Noninvasive cortical modulation of experimental pain. Pain 2012, 153:1350-1363.
72. Nitsche M.A., Boggio P.S., Fregni F., Pascual-Leone A. Treatment of depression with transcranial direct current stimulation (tDCS): a review. Exp Neurol 2009, 219:14-19.
73. Nitsche M.A., Cohen L.G., Wassermann E.M., Priori A., Lang N., Antal A., Paulus W., Hummel F., Boggio P.S., Fregni F., Pascual-Leone A. Transcranial direct current stimulation: State of the art 2008. Brain Stimul 2008, 1:206-223.
74. Nitsche M.A., Koschack J., Pohlers H., Hullemann S., Paulus W., Happe S. Effects of frontal transcranial direct current stimulation on emotional state and processing in healthy humans. Front Psychiatry 2012, 3:00058.
75. Nitsche M.A., Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000, 3:633-639.
76. Nitsche M.A., Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 2001, 57:1899-1901.
77. Nitsche M.A., Seeber A., Frommann K., Klein C.C., Rochford C., Nitsche M.S., Fricke K., Liebetanz D., Lang N., Antal A., Paulus W., Tergau F. Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex. J Physiol 2005, 568:291-303.
78. O'Connell N.E., Cossar J., Marston L., Wand B.M., Bunce D., Moseley G.L., De Souza L.H. Rethinking clinical trials of transcranial direct current stimulation: participant and assessor blinding is inadequate at intensities of 2mA. PLoS One 2012, 7:17.
79. O'Connell N.E., Wand B.M., Marston L., Spencer S., Desouza L.H. Non-invasive brain stimulation techniques for chronic pain. A report of a Cochrane systematic review and meta-analysis. Eur J Phys Rehabil Med 2011, 47:309-326.
80. Oliviero A., Esteban M.R., de la Cruz F.S., Cabredo L.F., Di Lazzaro V. Short-lasting impairment of temperature perception by high frequency rTMS of the sensorimotor cortex. Clin Neurophysiol 2005, 116:1072-1076.
81. Palm U., Reisinger E., Keeser D., Kuo M.F., Pogarell O., Leicht G., Mulert C., Nitsche M.A., Padberg F. Evaluation of sham transcranial direct current stimulation for randomized, placebo-controlled clinical trials. Brain Stimul 2013, 6:690-695.
82. Passard A., Attal N., Benadhira R., Brasseur L., Saba G., Sichere P., Perrot S., Januel D., Bouhassira D. Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widespread pain in fibromyalgia. Brain 2007, 130:2661-2670.
83. Perocheau D., Laroche F., Perrot S. Relieving pain in rheumatology patients: Repetitive transcranial magnetic stimulation (rTMS), a developing approach. Joint Bone Spine 2013, 17. 00116-00114.
84. Petrovic P., Petersson K.M., Ghatan P.H., Stone-Elander S., Ingvar M. Pain-related cerebral activation is altered by a distracting cognitive task. Pain 2000, 85:19-30.
85. Peyron R., Garcia-Larrea L., Deiber M.P., Cinotti L., Convers P., Sindou M., Mauguiere F., Laurent B. Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study. Pain 1995, 62:275-286.
86. Peyron R., Garcia-Larrea L., Gregoire M.C., Costes N., Convers P., Lavenne F., Mauguiere F., Michel D., Laurent B. Haemodynamic brain responses to acute pain in humans: sensory and attentional networks. Brain 1999, 122:1765-1780.
87. Peyron R., Laurent B., Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin 2000, 30:263-288.
88. Ploghaus A., Tracey I., Gati J.S., Clare S., Menon R.S., Matthews P.M., Rawlins J.N. Dissociating pain from its anticipation in the human brain. Science 1999, 284:1979-1981.
89. Porro C.A. Functional imaging and pain: behavior, perception, and modulation. Neuroscientist 2003, 9:354-369.
90. Ragert P., Vandermeeren Y., Camus M., Cohen L.G. Improvement of spatial tactile acuity by transcranial direct current stimulation. Clin Neurophysiol 2008, 119:805-811.
91. Rainville P. Brain mechanisms of pain affect and pain modulation. Curr Opin Neurobiol 2002, 12:195-204.
92. Reidler J.S., Mendonca M.E., Santana M.B., Wang X., Lenkinski R., Motta A.F., Marchand S., Latif L., Fregni F. Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects. J Pain 2012, 13:450-458.
93. Riberto M., Marcon Alfieri F., Monteiro de Benedetto Pacheco K., Dini Leite V., Nemoto Kaihami H., Fregni F., Rizzo Battistella L. Efficacy of transcranial direct current stimulation coupled with a multidisciplinary rehabilitation program for the treatment of fibromyalgia. Open Rheumatol J 2011, 5:45-50.
94. Rogalewski A., Breitenstein C., Nitsche M.A., Paulus W., Knecht S. Transcranial direct current stimulation disrupts tactile perception. Eur J Neurosci 2004, 20:313-316.
95. Roizenblatt S., Fregni F., Gimenez R., Wetzel T., Rigonatti S.P., Tufik S., Boggio P.S., Valle A.C. Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: a randomized, sham-controlled study. Pain Pract 2007, 7:297-306.
96. Russo R., Wallace D., Fitzgerald P.B., Cooper N.R. Perception of comfort during active and sham transcranial direct current stimulation: a double blind study. Brain Stimul 2013, 6:946-951.
97. Sawamoto N., Honda M., Okada T., Hanakawa T., Kanda M., Fukuyama H., Konishi J., Shibasaki H. Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study. J Neurosci 2000, 20:7438-7445.
98. Scarpazza C., Sartori G., De Simone M.S., Mechelli A. When the single matters more than the group: very high false positive rates in single case Voxel Based Morphometry. Neuroimage 2013, 70:175-188.
99. Simoes C., Hari R. Relationship between responses to contra- and ipsilateral stimuli in the human second somatosensory cortex SII. Neuroimage 1999, 10:408-416.
100. Smith B.H., Elliott A.M., Chambers W.A., Smith W.C., Hannaford P.C., Penny K. The impact of chronic pain in the community. Fam Pract 2001, 18:292-299.
101. Soler M.D., Kumru H., Pelayo R., Vidal J., Tormos J.M., Fregni F., Navarro X., Pascual-Leone A. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury. Brain 2010, 133(9):2565-2577. 10.1093/brain/awq184.
102. Summers J., Johnson S., Pridmore S., Oberoi G. Changes to cold detection and pain thresholds following low and high frequency transcranial magnetic stimulation of the motor cortex. Neurosci Lett 2004, 368:197-200.
103. Timmermann L., Ploner M., Haucke K., Schmitz F., Baltissen R., Schnitzler A. Differential coding of pain intensity in the human primary and secondary somatosensory cortex. J Neurophysiol 2001, 86:1499-1503.
104. Tsubokawa T., Katayama Y., Yamamoto T., Hirayama T., Koyama S. Chronic motor cortex stimulation in patients with thalamic pain. J Neurosurg 1993, 78:393-401.
105. Valle A., Roizenblatt S., Botte S., Zaghi S., Riberto M., Tufik S., Boggio P.S., Fregni F. Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial. J Pain Manag 2009, 2:353-361.
106. Wager T.D., Rilling J.K., Smith E.E., Sokolik A., Casey K.L., Davidson R.J., Kosslyn S.M., Rose R.M., Cohen J.D. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 2004, 303:1162-1167.
107. Willis W.D., Westlund K.N. Neuroanatomy of the pain system and of the pathways that modulate pain. J Clin Neurophysiol 1997, 14:2-31.
108. Wolff B.B. The Relationship of Experimental Pain Tolerance to Pain Threshold: A Critique of Gelfand's Paper. Can J Psychol 1964, 18:249-253.
109. Wood L., Egger M., Gluud L.L., Schulz K.F., Juni P., Altman D.G., Gluud C., Martin R.M., Wood A.J., Sterne J.A. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. Bmj 2008, 336:601-605.
110. Zaehle T., Beretta M., Jancke L., Herrmann C.S., Sandmann P. Excitability changes induced in the human auditory cortex by transcranial direct current stimulation: direct electrophysiological evidence. Exp Brain Res 2011, 215:135-140.
111. Ziemann U., Siebner H.R. Modifying motor learning through gating and homeostatic metaplasticity. Brain Stimul 2008, 1:60-66.