Effects of mTOR inhibitors on components of the salvador-warts-hippo pathway

Cells

Volumn 1, Issue 4, 2012, Pages 886-904

  Chiang, Jonathan ^a   Martinez Agosto, Julian A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hippo pathway; mTOR pathway; Signal transduction; Sterile 20 like kinase family; TAZ; TEAD1

Indexed keywords

DIMETHYL SULFOXIDE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE 7; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN S6; RAPAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EL SALVADOR; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VERRUCA VULGARIS;

EID: 84906066805     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells1040886     Document Type: Article

References (27)

1. Zhao, B.; Wei, X.; Li, W.; Udan, R.S.; Yang, Q.; Kim, J.; Xie, J.; Ikenoue, T.; Yu, J.; Li, L.; Zheng, P.; Ye, K.; Chinnaiyan, A.; Halder, G.; Lai, Z.-C.; Guan, K.-L. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007, 21, 2747-2761.
2. Sudol, M.; Harvey, K.F. Modularity in the Hippo signaling pathway. Trends BiochemSci. 2010, 35, 627-633.
3. Zhang, H.; Liu, C.-Y.; Zha, Z.-Y.; Zhao, B.; Yao, J.; Zhao, S.; Xiong, Y.; Lei, Q.-Y.; Guan, K.-L. TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition. J. Biol. Chem. 2009, 284, 13355-13362.
4. Zhou, D.; Zhang, Y.; Wu, H.; Barry, E.; Yin, Y.; Lawrence, E.; Dawson, D.; Willis, J.E.; Markowitz, S.D.; Camargo, F.D.; Avruch, J. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc. Natl. Acad. Sci. 2011, 108, E1312-E1320.
5. Wang, K.; Degerny, C.; Xu, M.; Yang, X.-J. YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB's 51st Annual Meeting-Epigenetics and Chromatin Dynamics, and has undergone the Journal's usual peer review process. Biochem. Cell Biol. 2009, 87, 77-91.
6. Harvey, K.; Tapon, N. The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network. Nat. Rev. Cancer 2007, 7, 182-191.
7. Zhao, B.; Li, L.; Lei, Q.; Guan, K.-L. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 2010, 24, 862-874.
8. Grusche, F.A.; Richardson, H.E.; Harvey, K.F. Upstream Regulation of the Hippo Size Control Pathway. Curr. Biol. 2010, 20, R574-R582.
9. Ling, P.; Lu, T.-J.; Yuan, C.-J.; Lai, M.-D. Biosignaling of mammalian Ste20-related kinases. Cell. Signalling 2008, 20, 1237-1247.
10. Dan, I.; Watanabe, N.M.; Kusumi, A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 2001, 11, 220-230.
11. Delpire, E. The mammalian family of sterile 20p-like protein kinases. Pflugers Arch. 2009, 458, 953-967.
12. Mendoza, M.C.; Er, E.E.; Blenis, J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem. Sci. 2011, 36, 320-328.
13. Radu, M.; Chernoff, J. The DeMSTification of Mammalian Ste20 Kinases. Curr. Biol. 2009, 19, R421-R425.
14. Gulhati, P.; Bowen, K.A.; Liu, J.; Stevens, P.D.; Rychahou, P.G.; Chen, M.; Lee, E.Y.; Weiss, H.L.; O'Connor, K.L.; Gao, T.; Evers, B.M. mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways. Cancer Res. 2011, 71, 3246-3256.
15. Oshiro, N.; Yoshino, K.-i.; Hidayat, S.; Tokunaga, C.; Hara, K.; Eguchi, S.; Avruch, J.; Yonezawa, K. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 2004, 9, 359-366;
16. Hsu, P.P.; Kang, S.A.; Rameseder, J.; Zhang, Y.; Ottina, K.A.; Lim, D.; Peterson, T.R.; Choi, Y.; Gray, N.S.; Yaffe, M.B.; Marto, J.A.; Sabatini, D.M. The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling. Science 2011, 332, 1317-1322.
17. Li, H.; Lin, J.; Wang, X.; Yao, G.; Wang, L.; Zheng, H.; Yang, C.; Jia, C.; Liu, A.; Bai, X. Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Breast Cancer Res. Treat. 2012, 134, 1057-1066
18. Cao, X.; Pfaff, S.L.; Gage, F.H. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008, 22, 3320-3334.
19. Liu, Y.; Xin, Y.; Ye, F.; Wang, W.; Lu, Q.; Kaplan, H.J.; Dean, D.C. Taz-Tead1 Links Cell-Cell Contact to Zeb1 Expression, Proliferation, and Dedifferentiation in Retinal Pigment Epithelial Cells. Invest. Ophthalmology Visual Sci. 2010, 51, 3372-3378.
20. Chan, S.W.; Lim, C.J.; Loo, L.S.; Chong, Y.F.; Huang, C.; Hong, W. TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation. J. Biol. Chem. 2009, 284, 14347-14358.
21. Zhao, B.; Ye, X.; Yu, J.; Li, L.; Li, W.; Li, S.; Yu, J.; Lin, J.D.; Wang, C.-Y.; Chinnaiyan, A.M.; Lai, Z.-C.; Guan, K.-L. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008, 22, 1962-1971.
22. Knight, J.F.; Shepherd, C.J.; Rizzo, S.; Brewer, D.; Jhavar, S.; Dodson, A.R.; Cooper, C.S.; Eeles, R.; Falconer, A.; Kovacs, G.; Garrett, M.D.; Norman, A.R.; Shipley, J.; Hudson, D.L. TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer. Br. J. Cancer 2008, 99, 1849-1858.
23. Lei, Q.-Y.; Zhang, H.; Zhao, B.; Zha, Z.-Y.; Bai, F.; Pei, X.-H.; Zhao, S.; Xiong, Y.; Guan, K.-L. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Mol. Cell. Biol. 2008, 28, 2426-2436.
24. Kanai, F.; Marignani, P.A.; Sarbassova, D.; Yagi, R.; Hall, R.A.; Donowitz, M.; Hisaminato, A.; Fujiwara, T.; Ito, Y.; Cantley, L.C.; Yaffe, M.B. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000, 19, 6778-6791.
25. Chan, S.W.; Lim, C.J.; Guo, K.; Ng, C.P.; Lee, I.; Hunziker, W.; Zeng, Q.; Hong, W. A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells. Cancer Res. 2008, 68, 2592-2598.
26. Zhou, Z.; Hao, Y.; Liu, N.; Raptis, L.; Tsao, M.S.; Yang, X. TAZ is a novel oncogene in nonsmall cell lung cancer. Oncogene 2011, 30, 2181-2186.
27. de Cristofaro, T.; Di Palma, T.; Ferraro, A.; Corrado, A.; Lucci, V.; Franco, R.; Fusco, A.; Zannini, M. TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma. Eur. J. Cancer 2011, 47, 926-933.