Weight training is not harmful for women with breast cancer-related lymphoedema: A systematic review

Journal of Physiotherapy

Volumn 60, Issue 3, 2014, Pages 136-143

  Paramanandam, Vincent Singh ^a   Roberts, Dave ^b  

^a TATA MEMORIAL HOSPITAL   (India)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

Breast neoplasm; Exercise; Lymphoedema; Weight training

Indexed keywords

ADVERSE EFFECTS; BODY MASS; BREAST TUMOR; COMPLICATION; EDEMA; FEMALE; HUMAN; LYMPHATIC DISEASES; META ANALYSIS; MIDDLE AGED; MUSCLE STRENGTH; QUALITY OF LIFE; RESISTANCE TRAINING; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

BODY MASS INDEX; BREAST NEOPLASMS; EDEMA; FEMALE; HUMANS; LYMPHATIC DISEASES; MIDDLE AGED; MUSCLE STRENGTH; QUALITY OF LIFE; RESISTANCE TRAINING; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84906055461     PISSN: 18369553     EISSN: 18369561     Source Type: Journal    
DOI: 10.1016/j.jphys.2014.07.001     Document Type: Article

References (49)

1. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61(2):69-90. 10.3322/caac.20107.
2. Cancer Research UK. Breast cancer - UK incidence statistics: Cancer Research UK. 2011. Available at: Accessed December 15, 2011. http://info.cancerresearchuk.org/cancerstats/types/breast/incidence/.
3. Coleman M.P., Quaresma M., Berrino F., Lutz J.-M., De Angelis R., Capocaccia R., et al. Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol 2008, 9(8):730-756. 10.1016/S1470-2045(08)70179-7.
4. Cheema B., Gaul C.A., Lane K., Fiatarone Singh M.A. Progressive resistance training in breast cancer: a systematic review of clinical trials. Breast Cancer Res Treat 2008, 109(1):9-26. 10.1007/s10549-007-9638-0.
5. Hayes S., Sipio T.D., Rye S., Lopez J.A., Saunders C., et al. Prevalence and prognostic significance of secondary lymphedema following breast cancer. Lymphat Res Biol 2011, 9(3):135-141. 10.1089/lrb.2011.0007.
6. Hayes S.C., Johansson K., Stout N.L., Prosnitz R., Armer J.M., Gabram S., et al. Upper-body morbidity after breast cancer: incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of care. Cancer 2012, 118(8 Suppl):2237-2249. 10.1002/cncr.27467.
7. Woods M. Lymphoedema care 2007, Oxford: Blackwell, c.
8. Britton T.M.B., Purushotham A.D. Understanding breast cancer-related lymphoedema. Surg Edinb Univ Press 2009, 7(2):120-124.
9. Hayes S.C., Cornish B., Newman B. Comparison of methods to diagnose lymphoedema among breast cancer survivors: 6-month follow-up. Breast Cancer Res Treat 2005, 89(3):221-226. 10.1007/s10549-004-2045-x.
10. Hayes S.C., Janda M., Cornish B., Battistutta D., Newman B. Lymphedema after breast cancer: incidence, risk factors, and effect on upper body function. J Clin Oncol 2008, 26(21):3536-3542.
11. Cheifetz O., Haley L. Management of secondary lymphedema related to breast cancer. Can Fam Physician 2010, 56(12):1277-1284.
12. McLaughlin S.A., Wright M.J., Morris K.T., Giron G.L., Sampson M.R., Brockway J.P., et al. Prevalence of Lymphedema in Women With Breast Cancer 5 Years After Sentinel Lymph Node Biopsy or Axillary Dissection: Objective Measurements. J Clin Oncol 2008, 26(32):5213-5219. 10.1200/JCO.2008.16.3725.
13. Petrek J.A., Senie R.T., Peters M., Rosen P.P. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer 2001, 92(6):1368-1377. 92:6<1368::AID-CNCR1459>3.0.CO;2-9. 10.1002/1097-0142(20010915).
14. Johansson K., Branje E. Arm lymphoedema in a cohort of breast cancer survivors 10 years after diagnosis. Acta Oncol Stockh Swed 2010, 49(2):166-173. 10.3109/02841860903483676.
15. McKenzie D.C. Abreast in a Boat -- a race against breast cancer. CMAJ Can Med Assoc J 1998, 159(4):376-378.
16. Johansson K., Tibe K., Weibull A., Newton R.C. Low intensity resistance exercise for breast cancer patients with arm lymphedema with or without compression sleeve. Lymphology 2005, 38(4):167-180.
17. Lane K.N., Dolan L.B., Worsley D., McKenzie D.C. Upper extremity lymphatic function at rest and during exercise in breast cancer survivors with and without lymphedema compared with healthy controls. J Appl Physiol 2007, 103(3):917-925. 10.1152/japplphysiol.00077.2007.
18. Kwan M.L., Cohn J.C., Armer J.M., Stewart B.R., Cormier J.N. Exercise in patients with lymphedema: a systematic review of the contemporary literature. J Cancer Surviv Res Pract 2011, 5(4):320-336. 10.1007/s11764-011-0203-9.
19. Schmitz K.H. Balancing lymphedema risk: exercise versus deconditioning for breast cancer survivors. Exerc Sport Sci Rev 2010, 38(1):17-24. 10.1097/JES.0b013e3181c5cd5a.
20. Breast Cancer Care. Risk of lymphoedema | Breast Cancer Care. 2011. Available at: Accessed December 16, 2011. http://www.breastcancercare.org.uk/breast-cancer-information/treating-breast-cancer/lymphoedema/risk-lymphoedema.
21. Schmitz K.H., Ahmed R.L., Troxel A., Cheville A., Smith R., Lewis-Grant L., et al. Weight Lifting in Women with Breast-Cancer-Related Lymphedema. N Engl J Med 2009, 361(7):664-673. 10.1056/NEJMoa0810118.
22. Schmitz K.H., Ahmed R.L., Troxel A.B., Cheville A., Smith R., Lewis-Grant L., et al. Weight Lifting for Women at Risk for Breast Cancer-Related Lymphedema: A Randomized Trial. JAMA J Am Med Assoc 2010, 304(24):2699-2705. 10.1001/jama.2010.1837.
23. American College of Sports Medicine ACSM's guidelines for exercise testing and prescription 2009, Lippincott Williams & Wilkins, London. 8th ed.
24. Garber C.E., Blissmer B., Deschenes M.R., Franklin B.A., Lamonte M.J., Lee I.M., et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 2011, 43(7):1334-1359. 10.1249/MSS.0b013e318213fefb.
25. Cramp F., Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev Online 2008, (2):CD006145. 10.1002/14651858.CD006145.pub2.
26. Courneya K.S., Segal R.J., Mackey J.R., Gelmon K., Reid R.D., Friedenreich C.M., et al. Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial. J Clin Oncol 2007, 25(28):4396-4404. 10.1200/JCO.2006.08.2024.
27. Schwartz A., Winters-Stone K., Gallucci B. Exercise Effects on Bone Mineral Density in Women With Breast Cancer Receiving Adjuvant Chemotherapy. Oncol Nurs Forum 2007, 34(3):627-633. 10.1188/07.ONF.627-633.
28. Milne H., Wallman K., Gordon S., Courneya K. Effects of a combined aerobic and resistance exercise program in breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 2008, 108(2):279-288. 10.1007/s10549-007-9602-z.
29. Irwin M.L., McTiernan A., Manson J.E., Thomson C.A., Sternfeld B., Stefanick M.L., et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative. Cancer Prev Res Phila Pa 2011, 4(4):522-529. 10.1158/1940-6207.CAPR-10-0295.
30. Chan D.N.S., Lui L.Y.Y., So W.K.W. Effectiveness of exercise programmes on shoulder mobility and lymphoedema after axillary lymph node dissection for breast cancer: systematic review. J Adv Nurs 2010, 66(9):1902-1914. 10.1111/j.1365-2648.2010.05374.x.
31. McNeely ML, Campbell K, Ospina M, Rowe BH, Dabbs K, Klassen TP, et al. Exercise interventions for upper-limb dysfunction due to breast cancer treatment. The Cochrane Coll-aboration, McNeely ML, eds. Cochrane Database Syst Rev. 2010. Available at: Accessed December 20, 2011. http://summaries.cochrane.org/CD005211/exercise-interventions-for-upper-limb-dysfunction-due-to-breast-cancer.
32. Centre for Reviews and Dissemination Systematic Reviews CRD's guidance for undertaking reviews in health care 2009, CRD, University of York, York, UK, Accessed July 20, 2012. http://www.york.ac.uk/inst/crd/pdf/Systematic_Reviews.pdf.
33. Liberati A., Altman D.G., Tetzlaff J., Mulrow C., Gotzsche P.C., Ioannidis J.P.A., et al. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration. PLoS Med 2009, 6(7):e1000100. 10.1371/journal.pmed.1000100.
34. Maher C.G., Sherrington C., Herbert R.D., Moseley A.M., Elkins M. Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials. Phys Ther 2003, 83(8):713-721.
35. De Morton N.A. The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 2009, 55(2):129-133.
36. Higgins JP, Deeks JJ. Chapter 7: Selecting studies and collecting data. In: Higgins JP, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 ed. 5.1.0. The Cochrane Coll-aboration; 2011. Available at: Accessed December 22, 2011. http://www.cochrane-handbook.org/.
37. Verbeek J., Ruotsalainen J., Hoving J.L. Synthesizing study results in a systematic review. Scand J Work Environ Health 2012, 10.5271/sjweh.3201.
38. Deeks JJ, Higgins JP, Altman DG. Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JP, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 ed. 5.1.0. The Cochrane Coll-aboration; 2011. Available at: Accessed December 22, 2011. http://www.cochrane-handbook.org/.
39. Ahmed R.L., Thomas W., Yee D., Schmitz K.H. Randomized Controlled Trial of Weight Training and Lymphedema in Breast Cancer Survivors. J Clin Oncol 2006, 24(18):2765-2772. 10.1200/JCO.2005.03.6749.
40. Anderson R.T., Kimmick G., McCoy T., Hopkins J., Levine E., Miller G., et al. A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. J Cancer Surviv 2012, 6(2):172-181. 10.1007/s11764-011-0208-4.
41. Ohira T., Schmitz K.H., Ahmed R.L., Yee D. Effects of weight training on quality of life in recent breast cancer survivors. Cancer 2006, 106(9):2076-2083. 10.1002/cncr.21829.
42. Schmitz K.H., Ahmed R.L., Hannan P.J., Yee D. Safety and Efficacy of Weight Training in Recent Breast Cancer Survivors to Alter Body Composition, Insulin, and Insulin-Like Growth Factor Axis Proteins. Cancer Epidemiol Biomarkers Prev 2005, 14(7):1672-1680. 10.1158/1055-9965.EPI-04-0736.
43. Speck R.M., Gross C.R., Hormes J.M., Ahmed R.L., Lytle L.A., Hwang W.-T., Schmitz K.H. Changes in the Body Image and Relationship Scale following a one-year strength training trial for breast cancer survivors with or at risk for lymphedema. Breast Cancer Res Treat 2010, 121(2):421-430. 10.1007/s10549-009-0550-7.
44. Sagen Å., Kåresen R., Risberg M. Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randomized controlled trial with two years follow-up. Acta Oncol 2009, 48(8):1102-1110. 10.3109/02841860903061683.
45. Kilbreath S.L., Refshauge K., Beith J., Ward L.C., Simpson J.M., Hansen R.D. Upper limb progressive resistance training and stretching exercises following surgery for early breast cancer: a randomized controlled trial. Breast Cancer Res Treat 2012, 133(2):667-676. 10.1007/s10549-012-1964-1.
46. Kim D.S., Sim Y.-J., Jeong H.J., Kim G.C. Effect of active resistive exercise on breast cancer-related lymphedema: a randomized controlled trial. Arch Phys Med Rehabil 2010, 91(12):1844-1848. 10.1016/j.apmr.2010.09.008.
47. Kilbreath S.L., Refshauge K.M., Beith J.M., Ward L.C., Simpson J.M., Hansen R.D. Progressive resistance training and stretching following surgery for breast cancer: study protocol for a randomised controlled trial. BMC Cancer 2006, 6:273. 10.1186/1471-2407-6-273.
48. Bartolucci A.A., Hillegass W.B. Overview, Strengths, and Limitations of Systematic Reviews and Meta-Analyses. Evidence-Based Practice: Toward Optimizing Clinical Outcomes 2010, 17-33. Springer Berlin Heidelberg, Berlin, Heidelberg, Accessed February 12, 2014. http://link.springer.com/10.1007/978-3-642-05025-1_2, F. Chiappelli (Ed.).
49. Fong D.Y.T., Ho J.W.C., Hui B.P.H., Lee A.M., Macfarlane D.J., Leung S.S.K., et al. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ 2012, 344. 10.1136/bmj.e70.