Upper-body morbidity after breast cancer: Incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of care

Cancer

Volumn 118, Issue SUPPL.8, 2012, Pages 2237-2249

  Hayes, Sandra C ^a   Johansson, Karin ^b   Stout, Nicole L ^c   Prosnitz, Robert ^d   Armer, Jane M ^e   Gabram, Sheryl ^f   Schmitz, Kathryn H ^d  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MISSOURI   (United States)

^f EMORY UNIVERSITY   (United States)

Author keywords

Breast cancer; Incidence; Lymphedema; Prevention; Treatment; Upper body morbidity

Indexed keywords

ALPHA TOCOPHEROL; BENZOPYRONE DERIVATIVE; PENTOXIFYLLINE; PYRONE DERIVATIVE; SELENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARM DISEASE; ARM SYMPTOM; BREAST CANCER; BREAST SURGERY; BREAST SYMPTOM; CANCER RADIOTHERAPY; CANCER SURVIVAL; CANCER SURVIVOR; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CYTOREDUCTIVE SURGERY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; EARLY DIAGNOSIS; EVIDENCE BASED MEDICINE; HUMAN; IMPEDANCE; INCIDENCE; INTENSITY MODULATED RADIATION THERAPY; LOW LEVEL LASER THERAPY; LYMPHEDEMA; MORBIDITY; MOTOR DYSFUNCTION; PATIENT ASSESSMENT; PATIENT CARE; PATIENT MONITORING; PHYSICAL DISEASE; PHYSIOTHERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION INJURY; RELIABILITY; REVIEW; RISK FACTOR; SENSORY DYSFUNCTION; SPECTROSCOPY; SURGICAL DRAINAGE; SURVIVAL TIME; SYMPTOM;

ADULT; AGED; AMERICAN CANCER SOCIETY; BREAST NEOPLASMS; CONGRESSES AS TOPIC; DELIVERY OF HEALTH CARE, INTEGRATED; DISABILITY EVALUATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LONGITUDINAL STUDIES; LYMPHEDEMA; MASTECTOMY; MIDDLE AGED; MODELS, ORGANIZATIONAL; MUSCLE WEAKNESS; PAIN; POSTOPERATIVE COMPLICATIONS; PRIMARY PREVENTION; PROSPECTIVE STUDIES; QUALITY OF LIFE; RANGE OF MOTION, ARTICULAR; SEVERITY OF ILLNESS INDEX; TIME FACTORS; UPPER EXTREMITY;

EID: 84859635457     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27467     Document Type: Review

References (156)

1. Engel J, Kerr J, Schlesigner-Raab A, Eckel R, Sauer H, Holzel D. Predictors of quality of life of breast cancer patients. Acta Oncol. 2003;42:710-718. (Pubitemid 37445290)
2. Karki A, Simonen R, Malkia E, Selfe J. Impairments, activity limitations and participation restrictions 6 and 12 months after breast cancer operation. J Rehabil Med. 2005;37:180-188. (Pubitemid 40775158)
3. Kwan W, Jackson J, Weir LM, Dingee C, McGregor G, Olivotto IA. Chronic arm morbidity after curative breast cancer treatment: prevalence and impact on quality of life. J Clin Oncol. 2002;20:4242-4248. (Pubitemid 35191027)
4. Hayes S, Rye S, Battistutta D, DiSipio T, Newman B. Upper-body morbidity following breast cancer treatment is common, may persist longer-term and adversely influences quality of life. Health Qual Life Outcomes. 2010;8:92.
5. Petrek JA, Heelan MC. Incidence of breast carcinoma-related lymphedema. Cancer. 1998;83:2776-2781. (Pubitemid 29024266)
6. Carter BJ. Women's experiences of lymphoedema. Oncol Nurs Forum. 1997;24:875-882.
7. Johansson K, Holmstrom H, Nilsson I, Ingvar C, Albertsson M, Ekdahl C. Breast cancer patients' experiences of lymphodema. Scand J Caring Sci. 2003;17:35-42. (Pubitemid 36308238)
8. Bafford A, Gadd M, Gu X, Lipsitz S, Golshan M. Diminishing morbidity with the increased use of sentinel node biopsy in breast carcinoma. Am J Surg. 2010;200:374-377.
9. Lucci A, McCall LM, Beitsch PD, et al. Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011. J Clin Oncol. 2007;25:3657-3663. (Pubitemid 47372604)
10. Teh B, Woo S, Butler B. Intensity modulated radiation therapy (IMRT): a new promising technology in radiation oncology. Oncologist. 1999;4:433-442. (Pubitemid 30013177)
11. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26:2085-2092.
12. Gomide LB, Matheus JPC, Candido dos Reis FJ. Morbidity after breast cancer treatment and physiotherapeutic performance. Int J Clin Pract. 2007;61:972-982. (Pubitemid 46744058)
13. Rietman JS, Kijkstra PU, Hoekstra HJ, et al. Late morbidity after treatment of breast cancer in relation to daily activities and quality of life: a systematic review. Eur J Surg Oncol. 2003;29:229-238. (Pubitemid 36395557)
14. Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA. 2009;302:1985-1992.
15. Torres Lacomba M, Mayoral del Moral O, Coperias Zazo JL, Gerwin RD, Goni AZ. Incidence of myofascial pain syndrome in breast cancer surgery: a prospective study. Clin J Pain. 2010;26:320-325.
16. Archambeau JO, Pezner R, Wasserman T. Pathophysiology of irradiated skin and breast. Int J Radiat Oncol Biol Phys. 1995;31:1171-1185.
17. Cooper JS, Fu K, Marks J, Silverman S. Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys. 1995;31:1141-1164.
18. Lopez E, Guerrero R, Nunez MI, et al. Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes. Breast Cancer Res. 2005;7:R690-R698.
19. Pugliese GN, Green RF, Antonacci A. Radiation-induced long thoracic nerve palsy. Cancer. 1987;60:1247-1248. (Pubitemid 17152902)
20. Gerber L, Lampert M, Wood C, et al. Comparison of pain, motion, and edema after modified radical mastectomy vs. local excision with axillary dissection and radiation. Breast Cancer Res Treat. 1992;21:139-145.
21. Wallgren A. Late effects of radiotherapy in the treatment of breast cancer. Acta Oncol. 1992;31:237-242.
22. Albert U, Koller M, Kopp I, Lorenz W, Schulz K, Wagner U. Early self-reported impairments in arm functioning of primary breast cancer patients predict late side effects of axillary lymph node dissection: results from a population-based cohort study. Breast Cancer Res Treat. 2006;100:285-292. (Pubitemid 44707922)
23. Arndt V, Stegmaier C, Ziegler H, Brenner H. A population-based study of the impact of specific symptoms on quality of life in women with breast cancer 1 year after diagnosis. Cancer. 2006;107:2496-2503. (Pubitemid 44748535)
24. Engel J, Kerr J, Schlesinger-Rabb A, Sauer H, Holzel D. Axilla surgery severely affects quality of life: results of a 5-year prospective study in breast cancer patients. Breast Cancer Res Treat. 2003;79:47-57. (Pubitemid 36561042)
25. Ernst MF, Voogd AC, Balder W, Klinkenbijl JHG, Roukema JA. Early and late morbidity associated with axillary levels I-III dissection in breast cancer. J Surg Oncol. 2002;79:151-155.
26. Gill G; SNAC Trial Group of the Royal Australasian College of Surgeons (RACS) and NHMRC Clinical Trials Centre. Sentinel-lymph-node-based management or routine axillary clearance? One-year outcomes of sentinel node biopsy versus axillary clearance (SNAC): a randomised controlled surgical trial. Ann Surg Oncol. 2009;16:266-275.
27. Hayes SC, Rye S, Battistutta D, Newman B. Prevalence of upper-body symptoms following breast cancer and its relationship with upper-body function and lymphedema. Lymphology. 2010;43:178-187.
28. Husted Madsen A, Haugaard K, Soerensen J, et al. Arm morbidity following sentinel lymph node biopsy or axillary lymph node dissection: a study from the Danish Breast Cancer Cooperative Group. Breast. 2008;17:138-147. (Pubitemid 351478254)
29. Janz N, Mujahad M, Lantz P, et al. Population-based study of the relationship of treatment and sociodemographics on quality of life for early stage breast cancer. Qual Life Res. 2005;14:1467-1479. (Pubitemid 40848230)
30. Lauridsen MC, Torsleff KR, Husted H, Erichsen C. Physiotherapy treatment of late symptoms following surgical treatment of breast cancer. Breast. 2000;9:45-51. (Pubitemid 30171127)
31. Leidenius M, Leppanen E, Krogerus L, Von Smitten K. Motion restriction and axillary web syndrome after sentinel node biopsy and axillary clearance in breast cancer. Am J Surg. 2003;185:127-130. (Pubitemid 36143900)
32. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. J Natl Cancer Inst. 2006;98:599-609. (Pubitemid 43904843)
33. McCredie MRE, Dite GS, Porter L, et al. Prevalence of self-reported arm morbidity following treatment for breast cancer in the Australian Breast Cancer Family Study. Breast. 2001;10:515-522. (Pubitemid 33150367)
34. Paskett ED, Naughton MJ, McCoy TP, Case LD, Abbott JM. The epidemiology of arm and hand swelling in premenopausal breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2007;16:775-782. (Pubitemid 46650581)
35. Purushotham AD, Upponi S, Klevesath MB, et al. Morbidity after sentinel lymph node biopsy in primary breast cancer: results from a randomized controlled trial. J Clin Oncol. 2005;23:4312-4321. (Pubitemid 46209968)
36. Rietman JS, Dijkstra PU, Geertzen JHB, et al. Short-term morbidity of the upper limb after sentinel lymph node biopsy or axillary lymph node dissection for stage I or II breast carcinoma. Cancer. 2003;98:690-696. (Pubitemid 36959263)
37. Rietman JS, Geertzen JHB, Hoekstra HJ, et al. Long term treatment related upper limb morbidity and quality of life after sentinel lymph node biopsy for stage I or II breast cancer. Euro J Surg Oncol. 2006;32:148-152. (Pubitemid 43257114)
38. Thomas-MacLean RL, Hack T, Kwan W, Towers A, Miedema B, Tilley A. Arm morbidity and disability after breast cancer: new directions for Care. Oncol Nurs Forum. 2008;35:65-71.
39. Ronka R, von Smitten K, Tasmuth T, Leidenius M. One-year morbidity after sentinel node biopsy and breast surgery. Breast. 2005;14:28-36. (Pubitemid 40197824)
40. So WK, Marsh G, Ling WM, et al. The symptom cluster of fatigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: a multicenter study. Oncol Nurs Forum. 2009;36:E205-E214.
41. Yang EJ, Park WB, Seo KS, Kim SW, Heo CY, Lim JY. Longitudinal change of treatment-related upper limb dysfunction and its impact on late dysfunction in breast cancer survivors: a prospective cohort study. J Surg Oncol. 2010;101:84-91.
42. Janz NK, Mujahid M, Chung LK, et al. Symptom experience and quality of life of women following breast cancer treatment. J Womens Health. 2007;16:1348-1361. (Pubitemid 350125860)
43. Schmitz KH, Speck RM, Rye SA, DiSipio T, Hayes SC. Prevalence of breast cancer treatment sequelae over 6 years of follow-up: the Pulling Through Study. Cancer. 2012;118(suppl 8):2217-2225.
44. Cheville AL, McGarvey CL, Petrek JA, Russo SA, Thiadens SR, Taylor ME. The grading of lymphedema in oncology clinical trials. Semin Radiat Oncol. 2003;13:214-225. (Pubitemid 36962645)
45. Casley-Smith JR. Alterations of untreated lymphedema and its grades over time. Lymphology. 1995;28:174-185. (Pubitemid 26009460)
46. Armer JM, Stewart BR. A comparison of four diagnostic criteria for lymphedema in a post-breast cancer population. Lymphat Res Biol. 2005;3:208-217. (Pubitemid 43115788)
47. Czerniec SA, Ward LC, Refshauge KM, et al. Assessment of breast cancer-related arm lymphedema - comparison of physical measurement methods and self-report. Cancer Invest. 2010;28:54-62.
48. Hayes S, Cornish B, Newman B. Comparison of methods to diagnose lymphoedema among breast cancer survivors: 6-month follow-up. Breast Cancer Res Treat. 2005;89:221-226. (Pubitemid 43293068)
49. Cornish BH, Thomas BJ, Ward LC, Hirst C, Bunce IH. A new technique for the quantification of peripheral edema with application in both unilateral and bilateral cases. Angiology. 2002;53:41-47. (Pubitemid 34141889)
50. Norman SA, Miller LT, Erikson HB, Norman MF, McCorkle R. Development and validation of a telephone questionnaire to characterize lymphedema in women treated for breast cancer. Phys Ther. 2001;81:1192-1205. (Pubitemid 32553060)
51. Armer JM, Radina ME, Porock D, Culbertson SD. Predicting breast cancer-related lymphedema using self-reported symptoms. Nurs Res. 2003;52:370-379.
52. Klernas P, Kristjanson LJ, Johansson K. Assessment of quality of life in lymphedema patients: validity and reliability of the Swedish version of the Lymphedema Quality of Life Inventory (LQOLI). Lymphology. 2010;43:135-145.
53. Brady M, Cella D, Mo F, et al. Reliability and validity of the Functional Assessment of Cancer Therapy-Breast (FACT-B) quality of life instrument. J Clin Oncol. 1997;15:974-986. (Pubitemid 27106280)
54. Sprangers MA, Groenvold M, Arraras JI, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996;14:2756-2768. (Pubitemid 26329662)
55. Armer J, Stewart B. Post-breast cancer lymphedema: incidence increases from 12 to 30 to 60 months. Lymphology. 2010;43:118-127.
56. Hayes SC, Janda M, Cornish B, Battistutta D, Newman B. Lymphoedema secondary to breast cancer: how choice of measure influences diagnosis, prevalence and identifiable risk factors. Lymphology. 2008;41:18-28. (Pubitemid 351747151)
57. Hayes SC. Review of Research Evidence on Secondary Lymphoedema: Incidence, Prevention, Risk Factors and Treatment. National Breast and Ovarian Cancer Centre; 2008.
58. National Health and Medical Research Council. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines, pilot program 2005-2007, Canberra, Australia.
59. Clark B, Sitzia J, Harlow W. Incidence and risk of arm oedema following treatment for breast cancer: a three-year follow-up study. Q J Med. 2005;98:343-348. (Pubitemid 40663122)
60. Hayes SC, Janda M, Cornish B, Battistutta D, Newman B. Lymphoedema following breast cancer: incidence, risk factors and effect on upper body function. J Clin Oncol. 2008;26:3536-3542.
61. Norman S, Localio A, Potashnik S, et al. Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptoms. J Clin Oncol. 2009;27:390-397.
62. Bar Ad V, Cheville A, Solin LJ, Dutta P, Both S, Harris EE. Time course of mild arm lymphedema after breast conservation treatment for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2010;76:85-90.
63. Gosselink R, Rouffaer L, Vanhelden P, Piot W, Troosters T, Christiaens M. Recovery of upper limb function after axillary dissection. J Surg Oncol. 2003;83:204-211. (Pubitemid 36936004)
64. Haid A, Koberle-Wuhrer R, Knauer M, et al. Morbidity of breast cancer patients following complete axillar dissection or sentinel node biopsy only: a comparative evaluation. Breast Cancer Res Treat. 2002;73:31-36. (Pubitemid 34548163)
65. Peintinger F, Reitsamer R, Stranzi H, Ralph G. Comparison of quality of life and arm complaints after axillary lymph node dissection vs sentinel lymph node biopsy in breast cancer patients. Br J Cancer. 2003;89:648-652. (Pubitemid 37076167)
66. Rietman JS, Kijkstra PU, Geertzen JHB, et al. Treatment-related upper limb morbidity 1 year after sentinel lymph node biopsy or axillary lymph node dissection for stage I or II breast cancer. Ann Surg Oncol. 2004;11:1018-1024. (Pubitemid 40486669)
67. Schrenk P, Rieger R, Shamiyeh A, Wayand W. Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma. Cancer. 2000;88:608-614. (Pubitemid 30056936)
68. Mostafa A, Mokbel K, Engledow A, et al. Is dissection of the internerve tissue during axillary lymphadenectomy for breast cancer necessary? Eur J Surg Oncol. 2000;26:153-154. (Pubitemid 30242937)
69. Duncan MA, Lotze MT, Gerber LH, Rosenberg SA. Incidence, recovery, and management of serratus anterior muscle palsy after axillary node dissection. Phys Ther. 1983;63:1243-1247. (Pubitemid 13029348)
70. Rodemann HP, Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother Oncol. 1995;35:83-90.
71. Johansson S, Svensson H, Denekamp J. Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys. 2000;48:745-750.
72. Bajrovic A, Rades D, Fehlauer F, et al. Is there a life-long risk of brachial plexopathy after radiotherapy of supraclavicular lymph nodes in breast cancer patients? Radiother Oncol. 2004;71:297-301. (Pubitemid 38686667)
73. Powell S, Cooke J, Parsons C. Radiation-induced brachial plexus injury: follow-up of two different fractionation schedules. Radiother Oncol. 1990;18:213-220. (Pubitemid 20221782)
74. Edwards TL. Prevalence and aetiology of lymphoedema after breast cancer treatment in southern Tasmania. Aust N Z J Surg. 2000;70:412-418. (Pubitemid 30367639)
75. Petrek JA. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer. 2001;92:1368-1377. (Pubitemid 32947819)
76. Segerstrom K, Bjerle P, Graffman S, Nystrom A. Factors that influence the incidence of brachial oedema after treatment of breast cancer. Scand J Plast Reconst Surg Hand Surg. 1992;26:223-227.
77. Kopanski Z, Wojewoda T, Wojewoda A, Schlegel-Zawadzka M, Wozniacka R, Suder A. Influence of some anthropometric parameters on the risk of development of distal complications after mastectomy carried out because of breast carcinoma. Am J Hum Biol. 2003;15:433-439. (Pubitemid 36546304)
78. Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. Am J Surg. 2004;187:69-72. (Pubitemid 38045505)
79. van der Veen P, De Voogdt N, Lievens P, Duquet W, Lamote J, Sacre R. Lymphoedema development following breast cancer surgery with full axillary section. Lymphology. 2004;37:206-208. (Pubitemid 40082906)
80. Francis WP, Abghari P, Du W, Rymal C, Suna M, Kosir MA. Improving surgical outcomes: standardizing the reporting of incidence and severity of acute lymphedema after sentinel lymph node biopsy and axillary lymph node dissection. Am J Surg. 2006;192:636-639. (Pubitemid 44634351)
81. Demark-Wahnefried W, Campbell KL, Hayes SC. Weight management and its role in breast cancer rehabilitation. Cancer. 2012;118(suppl 8):2277-2287.
82. Graham P, Jagavkar R, Browne L, Millar E. Supraclavicular radiotherapy must be limited laterally by the coracoid to avoid significant adjuvant breast nodal radiotherapy lymphoedema risk. Australas Radiol. 2006;50:578-582. (Pubitemid 44748083)
83. Wilke LG, McCall LM, Posther KE, et al. Surgical complications associated with sentinel lymph node biopsy: results from a prospective international cooperative group trial. Ann Surg Oncol. 2006;13:491-500.
84. Arrault M, Vignes S. Risk factors for developing upper limb lymphedema after breast cancer treatment [in French]. Bull Cancer. 2006;93:1001-1006. (Pubitemid 44744617)
85. Johansson K, Ohlsson K, Ingvar C, Albertsson M, Ekdahl C. Factors associated with the development of arm lymphedema following breast cancer treatment: a match pair case-control study. Lymphology. 2002;35:59-71. (Pubitemid 34627661)
86. Kwan ML, Darbinian J, Schmitz KH, et al. Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study. Arch Surg. 2010;145:1055-1063.
87. Rockson SG. Precipitating factors in lymphoedema: myths and realities. Cancer. 1998;83:2814-2816. (Pubitemid 29024272)
88. Piller N, Keeley V, Ryan T, Hayes S, Ridner S. Early detection - a strategy to reduce risk and severity. J Lymphoedema. 2009;4:89-95.
89. Pusic AL, Klassen AF, Scott AM, Klok JA, Cordeiro PG, Cano SJ. Development of a new patient-reported outcome measure for breast surgery: the BREAST-Q. Plast Reconstr Surg. 2009;124:345-353.
90. Solway S, Beaton D, McConnell S, Bombardier C. The DASH Outcome Measure User's Manual. 2nd ed. Toronto, Canada: Institute for Work and Health; 2002.
91. Norkin C, White D. Measurement of Joint Motion: A Guide to Goniometry. Philadelphia, PA: FA Davis Company; 1995.
92. Hall C, Brody L. Therapeutic Exercise: Moving Towards Function. In:Hall C,Brody L, eds. Baltimore, MD: Lippincott, Williams, and Wilkins; 2005:57-86.
93. Simons D, Travell J, Simons LS. Myofascial Pain and Dysfunction: The Trigger Point Manual. Vol 1. Upper Half of the Body. 2nd ed. Baltimore, MD: Lippincott, Williams, and Wilkins; 1998.
94. Magarey ME, Jones MA. Dynamic evaluation and early management of altered motor control around the shoulder complex. Man Ther. 2003;8:195-206. (Pubitemid 37314496)
95. Cinar N, Seckin U, Keskin D, Bodur H, Bozkurt B, Cengiz O. The effectiveness of early rehabilitation in patients with modified radical mastectomy. Cancer Nurs. 2008;31:160-165.
96. Na YM, Lee JS, Park JS, Kang SW, Lee HD, Koo JY. Early rehabilitation program in postmastectomy patients: a prospective clinical trial. Yonsei Med J. 1999;40:1-8.
97. Todd J, Topping A. A survey of written information on the use of post-operative exercises after breast cancer surgery. Physiotherapy. 2005;91:87-93. (Pubitemid 44296129)
98. Shamley DR, Barker K, Simonite V, Beardshaw A. Delayed versus immediate exercises following surgery for breast cancer: a systematic review. Breast Cancer Res Treat. 2005;90:263-271. (Pubitemid 40576840)
99. Beurskens CHG, van Uden CJT, Strobbe LJA, Oostendorp RAB, Wobbes T. The efficacy of physiotherapy upon shoulder function following axillary dissection in breast cancer, a randomised controlled study. BMC Cancer. 2007;7:166.
100. Loftus LS, Laronga C. Evaluating patients with chronic pain after breast cancer surgery: the search for relief. JAMA. 2009;302:2034-2035.
101. Lee SA, Kang JY, Kim YD, et al. Effects of a scapula-oriented shoulder exercise programme on upper limb dysfunction in breast cancer survivors: a randomized controlled pilot trial. Clin Rehabil. 2010;24:600-613.
102. Stegink-Jansen CW, Buford WL Jr, Patterson RM, Gould LJ. Computer simulation of pectoralis major muscle strain to guide exercise protocols for patients after breast cancer surgery. J Orthop Sports Phys Ther. 2011;41:417-426.
103. Crawford JS, Simpson J, Crawford P. Myofascial release provides symptomatic relief from chest wall tenderness occasionally seen following lumpectomy and radiation in breast cancer patients. Int J Radiat Oncol Biol Phys. 1996;34:1188-1189. (Pubitemid 26105462)
104. Box RC, Reul-Hirche HM, Bullock-Saxton JE, Furnival CM. Physiotherapy after breast cancer surgery: results of a randomised controlled study to minimise lymphoedema. Breast Cancer Res Treat. 2002;75:51-64.
105. Torres Lacomba M, Jose Yuste Sanchez M, Zapico Goni A, et al. Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial. BMJ. 2010;340:b5396.
106. Todd J, Scally A, Dodwell D, Horgaan K, Topping A. A randomised controlled trial of two programmes of shoulder exercise following axillary lymph node dissection for invasive breast cancer. Physiotherapy. 2008;94:265-273.
107. Petrek JA, Pressman P, Smith R. Lymphoedema: current issues in research and management. CA Cancer J Clin. 2000;50:292-307.
108. Schmitz K, Ahmed R, Troxel A, et al. Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA. 2010;304:2699-2705.
109. Badger C, Preston N, Seers K, Mortimer P. Physical therapies for reducing and controlling lymphoedema of the limbs [review]. Cochrane Database Syst Rev. 2004;(4):CD003141.
110. Moseley AL, Carati CJ, Piller NB. A systematic review of common conservative therapies for arm lymphoedema secondary to breast cancer treatment. Ann Oncol. 2007;18:639-646. (Pubitemid 46523265)
111. Langbecker D, Hayes SC, Newman B, Janda M. Treatment for upper-limb and lower-limb lymphedema by professionals specialising in lymphedema care. Eur J Cancer Care. 2008;17: 557-564.
112. Dirican A, Andacoglu O, Johnson R, McGuire K, Mager L, Soran A. The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedema. Support Care Cancer. 2011;19:685-690.
113. Carati CJ, Anderson SN, Gannon BJ, Piller NB. Treatment of postmastectomy lymphedema with low-level laser therapy. Cancer. 2003;98:1114-1122.
114. Lau RW, Cheing GL. Managing postmastectomy lymphedema with low-level laser therapy. Photomed Laser Surg. 2009;27:763-769.
115. Kozanoglu E, Basaran S, Paydas S, Sarpel T. Efficacy of pneumatic compression and low-level laser therapy in the treatment of postmastectomy lymphoedema: a randomized controlled trial. Clin Rehabil. 2009;23:117-124.
116. Piller NB, Thelander A. A cost effective treatment to reduce post mastectomy lymphoedema. Lymphology. 1996;31:74-86.
117. McClure MK, McClure RJ, Day R, Brufsky AM. Randomized controlled trial of the Breast Cancer Recovery Program for women with breast cancer-related lymphedema. Am J Occup Ther. 2010; 64:59-72.
118. Tidhar D, Katz-Leurer M. Aqua lymphatic therapy in women who suffer from breast cancer treatment-related lymphedema: a randomized controlled study. Support Care Cancer. 2010;18:383-392.
119. Hayes SC, Reul-Hirche H, Turner J. Exercise and secondary lymphedema: safety, potential benefits, and research issues. Med Sci Sports Exerc. 2009;41:483-489.
120. Ahmed RL, Thomas W, Yee D, Schmitz KH. Randomized controlled trial of weight training and lymphedema in breast cancer survivors. J Clin Oncol. 2006;24:2765-2772. (Pubitemid 46630574)
121. Schmitz KH, Ahmed RL, Troxel A, et al. Weight lifting in women with breast-cancer-related lymphoedema. New Engl J Med. 2009;361:661-673.
122. Schmitz KH. Balancing lymphedema risk: exercise versus deconditioning for breast cancer survivors. Exerc Sport Sci Rev. 2010;38:17-24.
123. Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema. Cancer. 2007;109:1949-1956. (Pubitemid 46744187)
124. Shaw C, Mortimer P, Judd PA. A randomized controlled trial of weight reduction as a treatment for breast cancer-related lymphedema. Cancer. 2007;110:1868-1874. (Pubitemid 47557313)
125. Badger C, Preston N, Seers K, Mortimer P. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2003;(4):CD003140.
126. Dennert G, Horneber M. Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients. Cochrane Database Syst Rev. 2006;(3):CD005037.
127. Magnusson M, Hoglund P, Johansson K, et al. Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5). Eur J Cancer. 2009;45:2488-2495.
128. Bagheri S, Ohlin K, Olsson G, Brorson H. Tissue tonometry before and after liposuction of arm lymphedema following breast cancer. Lymphat Res Biol. 2005;3:66-80. (Pubitemid 41386629)
129. Brorson H, Ohlin K, Olsson G, Langstrom G, Wiklund I, Svensson H. Quality of life following liposuction and conservative treatment of arm lymphedema. Lymphology. 2006;39:8-25.
130. Brorson H, Ohlin K, Olsson G, Nilsson M. Adipose tissue dominates chronic arm lymphedema following breast cancer: an analysis using volume rendered CT images. Lymphat Res Biol. 2006; 4:199-210.
131. Matsubara S, Sakuda H, Nakaema M, Kuniyoshi Y. Long-term results of microscopic lymphatic vessel-isolated vein anastomosis for secondary lymphedema of the lower extremities. Surg Today. 2006;36:859-864. (Pubitemid 44453910)
132. Damstra RJ, Voesten HG, van Schelven WD, van der Lei B. Lymphatic venous anastomosis (LVA) for treatment of secondary arm lymphedema. A prospective study of 11 LVA procedures in 10 patients with breast cancer related lymphedema and a critical review of the literature. Breast Cancer Res Treat. 2009;113:199-206.
133. National Breast and Ovarian Cancer Centre. Resource: Lymphoedema, What You Need to Know. Available at: http://canceraustralia.nbocc.org.au/view- document-details/lnkc-lymphoedema-what-you-need-to-know Accessed August 30, 2011.
134. Harris SR, Hugi MR, Olivotto IA, Levine M, for the Steering Committee for Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema. CMAJ. 2001;164:191-199. (Pubitemid 32157741)
135. European Society for Breast Cancer Specialists. Available at: http://www.eusoma.org/Index.aspx Accessed August 30, 2011.
136. Swedish Cancer Society. Available at: http://www.cancerfonden.se/sv/ Information-in-English/ Accessed August 30, 2011.
137. National Institute for Health and Clinical Excellence. Breast Cancer: Completed Guidelines. Available at: http://guidance.nice.org.uk/Topic/Cancer/ Breast Accessed August 30, 2011.
138. National Lymphedema Network. Lymphedema Position Papers. Available at: http://www.lymphnet.org/lymphedemaFAQs/positionPapers.htm Accessed August 30, 2011.
139. Agency for Healthcare Research and Quality. Technology Assessment: Diagnosis and Treatment of Secondary Lymphedema. Available at: http://www.cms.gov/medicare-coverage-database/details/technology-assessments- details.aspx?TAId=66&bc=BAAgAAAAAAAA& Accessed August 30, 2011.
140. Oncology Nursing Society. Lymphedema. Available at: http://www.ons.org/ Research/PEP/Lymphedema Accessed August 30, 2011.
141. Cheville AL, Beck LA, Petersen TL, Marks RS, Gamble GL. The detection and treatment of cancer-related functional problems in an outpatient setting. Support Care Cancer. 2009;17:61-67.
142. Cheville AL, Troxel AB, Basford JR, Kornblith AB. Prevalence and treatment patterns of physical impairments in patients with metastatic breast cancer. J Clin Oncol. 2008;26:2621-2629.
143. Stout Gergich NL, Pfalzer LA, McGarvey C, Springer B, Gerber LH, Soballe P. Preoperative assessment enables the early diagnosis and successful treatment of lymphedema. Cancer. 2008;112:2809-2819. (Pubitemid 351969228)
144. Mahamaneerat WK, Shyu C-R, Stewart BR, Armer JM. Breast cancer treatment, BMI, post-op swelling/lymphoedema. J Lymphedema. 2008;3:38-44.
145. Johansson K, Branje E. Arm lymphoedema in a cohort of breast cancer survivors 10 years after diagnosis. Acta Oncol. 2010;49:166-173.
146. Shih YC, Xu Y, Cormier JN, et al. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol. 2009;27:2007-2014.
147. Stout NL, Andrews K, Binkley JM, Schmitz KH, Smith RA. Prospective surveillance model for rehabilitation for women with breast cancer. Cancer. 2012;118(suppl 8):2191-2200.
148. Ward L, Winall A, Isenring E, et al. Assessment of bilateral limb lymphedema by bioelectrical impedance spectroscopy. Int J Gynecol Cancer. 2011;21:409-418.
149. Fu MR, Chen CM, Haber J, Guth AA, Axelrod D. The effect of providing information about lymphedema on the cognitive and symptom outcomes of breast cancer survivors. Ann Surg Oncol. 2010;17:1847-1853.
150. Devoogdt N, Kampen M, Christiaens M, et al. Short- and long-term recovery of upper limb function after axillary lymph node dissection. Eur J Cancer Care. 2011;20:77-86.
151. Helyer L, Varnic M, Le L, Leong W, McCready D. Obesity is a risk factor for development postoperative lymphedema in breast cancer patients. Breast J. 2010;16:48-54.
152. Bennett Britton TM, Buczacki SJA, Turner CL, Vowler SL, Pain SJ, Purushotham AD. Venous changes and lymphoedema 4 years after axillary surgery for breast cancer. Br J Surg. 2007;94:833-834. (Pubitemid 47051205)
153. Nesvold I, Dahl A, Lokkevik E, Marit Mengshoel A, Fossa S. Arm and shoulder morbidity in breast cancer patients after breastconserving therapy versus mastectomy. Acta Oncol. 2008;47:835-842. (Pubitemid 351882726)
154. Celebioglu F, Perbeck L, Frisell J, Grondal E, Svensson L, Danielsson R. Lymph drainage studied by lymphoscintigraphy in the arms after sentinel node biopsy compared with axillary lymph node dissection following conservative breast cancer surgery. Acta Radiol. 2007;48:488-495. (Pubitemid 46801819)
155. McLaughlin S, Wright M, Morris K, et al. Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements. J Clin Oncol. 2008;26:5213-5219.
156. Wernicke A, Goodman R, Turner B, et al. A 10-year follow-up of treatment outcomes in patients with early stage breast cancer and clinically negative axillary nodes treated with tangential breast irradiation following sentinel lymph node dissection or axillary clearance. Breast Cancer Res Treat. 2011;125:893-902.