Induction of autophagy by tongxinluo through the MEK/ERK pathway protects human cardiac microvascular endothelial cells from hypoxia/reoxygenation injury

Journal of Cardiovascular Pharmacology

Volumn 64, Issue 2, 2014, Pages 180-190

  Cui, Hehe ^a   Li, Xiangdong ^a   Li, Na ^a   Qi, Kang ^a   Li, Qing ^a   Jin, Chen ^a   Zhang, Qian ^a   Jiang, Leipei ^a   Yang, Yuejin ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

autophagy; cardiac microvascular endothelial cells; myocardial ischemia reperfusion injury; signaling pathway; tongxinluo

Indexed keywords

HERBACEOUS AGENT; OXYGEN; TONGXINLUO;

APOPTOSIS; AUTOPHAGY; CELL HYPOXIA; CELL LINE; CORONARY BLOOD VESSEL; CULTURE TECHNIQUE; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; HUMAN; METABOLISM; MICROVASCULATURE; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

APOPTOSIS; AUTOPHAGY; CELL CULTURE TECHNIQUES; CELL HYPOXIA; CELL LINE; CORONARY VESSELS; DRUGS, CHINESE HERBAL; ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVESSELS; MYOCARDIAL REPERFUSION INJURY; OXYGEN;

EID: 84906051999     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000104     Document Type: Article

References (56)

1. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: A neglected therapeutic target. J Clin Invest. 2013;123:92-100.
2. Zhao N, Liu YY, Wang F, et al. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol. 2010;298:H1166-H1176.
3. Brutsaert DL. Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev. 2003;83:59-115. (Pubitemid 36459878)
4. Leucker TM, Bienengraeber M, Muravyeva M, et al. Endothelial- cardiomyocyte crosstalk enhances pharmacological cardioprotection. J Mol Cell Cardiol. 2011;51:803-811.
5. Hedhli N, Huang Q, Kalinowski A, et al. Endothelium-derived neuregulin protects the heart against ischemic injury/clinical perspective. Circulation. 2011;123:2254-2262.
6. Singhal AK, Symons JD, Boudina S, et al. Role of endothelial cells in myocardial ischemia-reperfusion injury. Vasc Dis Prev. 2010;7:1-14.
7. Tsao PS, Aoki N, Lefer DJ, et al. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation. 1990;82:1402-1412.
8. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science. 2000;290:1717-1721. (Pubitemid 32004796)
9. Shimomura H, Terasaki F, Hayashi T, et al. Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy. Jpn Circ J. 2001;65:965-968.
10. Hein S, Elsasser A, Kostin S, et al. Functional disturbances due to structural remodeling in the failing human heart. Arch Mal Coeur Vaiss. 2002; 95:815-820.
11. Ouimet M. Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems. Biochim Biophys Acta. 2013;1831: 1124-1133.
12. Hamacher-Brady A, Brady NR, Logue SE, et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 2007;14:146-157. (Pubitemid 44911902)
13. Przyklenk K, Dong Y, Undyala VV, et al. Autophagy as a therapeutic target for ischaemia/reperfusion injury? Concepts, controversies, and challenges. Cardiovasc Res. 2012;94:197-205.
14. Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion. Circ Res. 2007;100:914-922
15. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37-40. (Pubitemid 32225829)
16. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1993;268:14553-14556. (Pubitemid 23206581)
17. Karalliedde LD, Kappagoda CT. The challenge of traditional Chinese medicines for allopathic practitioners. Am J Physiol Heart Circ Physiol. 2009;297:H1967-H1969.
18. Zhang L, Liu Y, Lu XT, et al. Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: A comparison with a high-dose simvastatin therapy. Am J Physiol Heart Circ Physiol. 2009;297:H2004-H2014.
19. Chen WQ, Zhong L, Zhang L, et al. Chinese medicine tongxinluo significantly lowers serum lipid levels and stabilizes vulnerable plaques in a rabbit model. J Ethnopharmacol. 2009;124:103-110.
20. Wu T, Harrison RA, Chen X, et al. Tongxinluo (Tong xin luo or Tongxin-luo) capsule for unstable angina pectoris. Cochrane Database Syst Rev. 2006;CD004474.
21. You SJ, Yang YJ, Chen KJ, et al. The protective effects of Tong-xin-luo on myocardium and microvasculature after reperfusion in acute myocardial infarction [Article in Chinese]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33:433-437.
22. Zhang HT, Jia ZH, Zhang J, et al. No-reflow protection and long-term efficacy for acute myocardial infarction with Tongxinluo: A randomized double-blind placebo-controlled multicenter clincal trial (ENLEAT Trial). Chin Med J (Engl). 2010;123:2858-2864.
23. Li XD, Yang YJ, Geng YJ, et al. Tongxinluo reduces myocardial noreflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway. Am J Physiol Heart Circ Physiol. 2010;299:H1255-H1261.
24. Cheng YT, Yang YJ, Zhang HT, et al. Pretreatment with Tongxinluo protects porcine myocardium from ischaemia/reperfusion injury through a nitric oxide related mechanism. Chin Med J (Engl). 2009;122:1529-1538.
25. Liang JQ, Wu K, Jia ZH, et al. Chinese medicine Tongxinluo modulates vascular endothelial function by inducing eNOS expression via the PI-3K/Akt/HIF-dependent signaling pathway. J Ethnopharmacol. 2011;133: 517-523.
26. Yan J, Liu Q, Dou Y, et al. Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against beta-amyloid peptide-induced human endothelial cells apoptosis. J Ethnopharmacol. 2013;147:456-466.
27. Chen T, Guo ZP, Jiao XY, et al. Peoniflorin suppresses tumor necrosis factor-alpha induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-kappaB and ERK pathway. Arch Dermatol Res. 2011;303:351-360.
28. Chen T, Guo ZP, Jiao XY, et al. Protective effects of peoniflorin against hydrogen peroxide-induced oxidative stress in human umbilical vein endothelial cells. Can J Physiol Pharmacol. 2011;89:445-453.
29. Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res. 2009;104:150-158.
30. Zhang Q, Yang YJ, Wang H, et al. Autophagy activation: A novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of rapamycin pathway. Stem Cells Dev. 2012;21:1321-1332.
31. Gurusamy N, Lekli I, Mukherjee S, et al. Cardioprotection by resveratrol: A novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res. 2010;86:103-112.
32. Jee SH, Chu CY, Chiu HC, et al. Interleukin-6 induced basic fibroblast growth factor-dependent angiogenesis in basal cell carcinoma cell line via JAK/STAT3 and PI3-kinase/Akt pathways. J Invest Dermatol. 2004; 123:1169-1175.
33. Therade-Matharan S, Laemmel E, Carpentier S, et al. Reactive oxygen species production by mitochondria in endothelial cells exposed to reoxygenation after hypoxia and glucose depletion is mediated by ceramide. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1756-R1762. (Pubitemid 41643221)
34. Therade-Matharan S, Laemmel E, Duranteau J, et al. Reoxygenation after hypoxia and glucose depletion causes reactive oxygen species production by mitochondria in HUVEC. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1037-R1043. (Pubitemid 39391047)
35. Chandrasekar B, Vemula K, Surabhi RM, et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem. 2004;279:20221-20233. (Pubitemid 38623467)
36. Shahani T, Lavend'homme R, Luttun A, et al. Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool. Blood. 2010;115:4902-4909.
37. Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol. 2006;40:846-852. (Pubitemid 43817043)
38. Zhang ZL, Fan Y, Liu ML. Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation. Mol Cell Biochem. 2012;365:243-250.
39. Huang C, Yitzhaki S, Perry C, et al. Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res. 2010;3:365-373.
40. Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem. 2006;281:29776-29787. (Pubitemid 44536987)
41. Guo H, Chen Y, Liao L, et al. Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway. Cardiovasc Drugs Ther. 2013;27:189-198.
42. Chen G, Zhang W, Li YP, et al. Hypoxia-induced autophagy in endothelial cells: A double-edged sword in the progression of infantile haemangioma? Cardiovasc Res. 2013;98:437-448.
43. Saeki K, Yuo A, Okuma E, et al. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ. 2000;7:1263-1269. (Pubitemid 32042234)
44. Hausenloy D, Yellon D. Reperfusion injury salvage kinase signalling: Taking a RISK for cardioprotection. Heart Fail Rev. 2007;12:217-234. (Pubitemid 350176695)
45. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res. 2004;61:448-460. (Pubitemid 38210151)
46. Zeng Y, Yang X, Wang J, et al. Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells. PLoS One. 2012;7:e30312.
47. Xie LN, Zeng DY, Zhang HS, et al. Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery. J Ethnopharmacol. 2010;131:300-305.
48. Su W, Sun A, Xu D, et al. Tongxinluo inhibits oxidized low-density lipoprotein-induced maturation of human dendritic cells via activating peroxisome proliferator-activated receptor gamma pathway. J Cardiovasc Pharmacol. 2010;56:177-183.
49. Zhou H, Hou SZ, Luo P, et al. Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism. J Ethnopharmacol. 2011;135:287-298.
50. Zhu D, Wu L, Li CR, et al. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem. 2009;108:117-124.
51. Li CP, Qin G, Shi RZ, et al. Ginsenoside Rg1 reduces toxicity of PM(2.5) on human umbilical vein endothelial cells by upregulating intracellular antioxidative state. Environ Toxicol Pharmacol. 2013;35:21-29.
52. Wei XH, Liu YY, Li Q, et al. Treatment with cardiotonic pills after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013;20:17-29.
53. Tang NY, Liu CH, Hsieh CT, et al. The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats. Am J Chin Med. 2010;38:51-64.
54. Nizamutdinova IT, Jin YC, Kim JS, et al. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med. 2008;74:14-18. (Pubitemid 351251377)
55. Liu R, Zhang L, Lan X, et al. Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: Involvement of antioxidation and anti-inflammation through nuclear transcription factor kappaappaB signaling pathway. Neuroscience. 2011;176:408-419.
56. Li XD, Yang YJ, Cheng YT, et al. Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts. Chin Med J (Engl). 2013;126:1469-1479.