Histopathology and biomarkers in prediction of renal function in children after kidney transplantation

Transplant Immunology

Volumn 31, Issue 2, 2014, Pages 105-111

  Miettinen, Jenni ^a   Helin, Heikki ^b   Pakarinen, Mikko ^a   Jalanko, Hannu ^a   Lauronen, Jouni ^c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c FINNISH RED CROSS BLOOD SERVICE   (Finland)

Author keywords

Biomarker; Children; Glomerular filtration rate; Kidney transplantation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 4; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; VIMENTIN; ACTA2 PROTEIN, HUMAN; ACTIN; BIOLOGICAL MARKER; MEMBRANE PROTEIN; P-SELECTIN LIGAND PROTEIN;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; ALLOGRAFT; BIOSYNTHESIS; DELAYED GRAFT FUNCTION; FIBROSIS; GRAFT REJECTION; IMMUNOLOGY; INFANT; INJURIES; KIDNEY; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; SURGERY;

ACTINS; ADOLESCENT; ALLOGRAFTS; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; COLLAGEN TYPE IV; DELAYED GRAFT FUNCTION; FEMALE; FIBROSIS; GLOMERULAR FILTRATION RATE; GRAFT REJECTION; HUMANS; INFANT; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; VIMENTIN;

EID: 84906044036     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2014.04.006     Document Type: Article

References (30)

1. Lamb K.E., Lodhi S., Meier-Kriesche H.- Long-term renal allograft survival in the United States: a critical reappraisal. Am J Transplant 2011, 11:450-462.
2. Meier-Kriesche H.U., Schold J.D., Srinivas T.R., Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004, 4:378-383.
3. Galichon P., Xu-Dubois Y.C., Finianos S., Hertig A., Rondeau E. Clinical and histological predictors of long-term kidney graft survival. Nephrol Dial Transplant 2013, 28:1362-1370.
4. Galichon P., Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?. Fibrogenesis Tissue Repair 2011, 4:11.
5. Rastaldi M.P., Ferrario F., Giardino L., Dell'Antonio G., Grillo C., Grillo P., et al. Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 2002, 62:137-146.
6. Vongwiwatana A., Tasanarong A., Rayner D.C., Melk A., Halloran P.F. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 2005, 5:1367-1374.
7. Hertig A., Anglicheau D., Verine J., Pallet N., Touzot M., Ancel P.Y., et al. Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol 2008, 19:1584-1591.
8. Birk P.E. Surveillance biopsies in children post-kidney transplant. Pediatr Nephrol 2012, 27:753-760.
9. Schwarz A., Mengel M., Gwinner W., Radermacher J., Hiss M., Kreipe H., et al. Risk factors for chronic allograft nephropathy after renal transplantation: a protocol biopsy study. Kidney Int 2005, 67:341-348.
10. Valta H., Makitie O., Ronnholm K., Jalanko H. Bone health in children and adolescents after renal transplantation. J Bone Miner Res 2009, 24:1699-1708.
11. 51Cr-EDTA clearance method for determination of renal function in children and adults. Part I: analytically correct relationship between total and one-pool clearance. Scand J Clin Lab Invest 2009, 69:305-313.
12. Solez K., Colvin R.B., Racusen L.C., Sis B., Halloran P.F., Birk P.E., et al. Banff '05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007, 7:518-526.
13. Ley K. The role of selectins in inflammation and disease. Trends Mol Med 2003, 9:263-268.
14. Mannon R.B., Matas A.J., Grande J., Leduc R., Connett J., Kasiske B., et al. Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure. Am J Transplant 2010, 10:2066-2073.
15. Mengel M., Reeve J., Bunnag S., Einecke G., Jhangri G.S., Sis B., et al. Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts. Am J Transplant 2009, 9:1859-1867.
16. Park W.D., Griffin M.D., Cornell L.D., Cosio F.G., Stegall M.D. Fibrosis with inflammation at one year predicts transplant functional decline. J Am Soc Nephrol 2010, 21:1987-1997.
17. Sellares J., de Freitas D.G., Mengel M., Sis B., Hidalgo L.G., Matas A.J., et al. Inflammation lesions in kidney transplant biopsies: association with survival is due to the underlying diseases. Am J Transplant 2011, 11:489-499.
18. Mengel M., Gwinner W., Schwarz A., Bajeski R., Franz I., Brocker V., et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007, 7:356-365.
19. de Matos A.C., Camara N.O., Tonato E.J., Durao Mde S., Franco M.F., Moura L.A., et al. Vimentin expression and myofibroblast infiltration are early markers of renal dysfunction in kidney transplantation: an early stage of chronic allograft dysfunction?. Transplant Proc 2010, 42:3482-3488.
20. Kers J., Xu-Dubois Y.C., Rondeau E., Claessen N., Idu M.M., Roelofs J.J., et al. Intragraft tubular vimentin and CD44 expression correlate with long-term renal allograft function and interstitial fibrosis and tubular atrophy. Transplantation 2010, 90:502-509.
21. Xu-Dubois Y.C., Baugey E., Peltier J., Colombat M., Ouali N., Jouanneau C., et al. Epithelial phenotypic changes are associated with a tubular active fibrogenic process in human renal grafts. Hum Pathol 2013, 44:125-161.
22. Xu-Dubois Y.C., Hertig A., Lebranchu Y., Hurault de Ligny B., Thervet E., Jaureguy M., et al. Progression of pulse pressure in kidney recipients durably exposed to CsA is a risk factor for epithelial phenotypic changes: an ancillary study of the CONCEPT trial. Transpl Int 2014, 27:344-352.
23. Muramatsu M., Miyagi M., Ishikawa Y., Aikawa A., Mizuiri S., Ohara T., et al. Estimation of damaged tubular epithelium in renal allografts by determination of vimentin expression. Int J Urol 2004, 11:954-962.
24. Vitalone M.J., O'Connell P.J., Jimenez-Vera E., Yuksel A., Wavamunno M., Fung C.L., et al. Epithelial-to-mesenchymal transition in early transplant tubulointerstitial damage. J Am Soc Nephrol 2008, 19:1571-1583.
25. Roberts I.S., Burrows C., Shanks J.H., Venning M., McWilliam L.J. Interstitial myofibroblasts: predictors of progression in membranous nephropathy. J Clin Pathol 1997, 50:123-127.
26. Goumenos D.S., Brown C.B., Shortland J., el Nahas A.M. Myofibroblasts, predictors of progression of mesangial IgA nephropathy?. Nephrol Dial Transplant 1994, 9:1418-1425.
27. Yan Q., Sui W., Xie S., Chen H., Xie S., Zou G., et al. Expression and role of integrin-linked kinase and collagen IV in human renal allografts with interstitial fibrosis and tubular atrophy. Transpl Immunol 2010, 23:1-5.
28. Nankivell B.J., Borrows R.J., Fung C.L., O'Connell P.J., Allen R.D., Chapman J.R. The natural history of chronic allograft nephropathy. N Engl J Med 2003, 349:2326-2333.
29. Dart A.B., Schall A., Gibson I.W., Blydt-Hansen T.D., Birk P.E. Patterns of chronic injury in pediatric renal allografts. Transplantation 2010, 89:334-340.
30. Kanzelmeyer N.K., Ahlenstiel T., Kreuzer M., Becker J.U., Pape L. Correlations with six-month protocol biopsy findings in pediatric transplant recipients on low- and regular-dose CNI regimens. Clin Transplant 2013, 27:319-323.