Expression and role of integrin-linked kinase and collagen IV in human renal allografts with interstitial fibrosis and tubular atrophy

Transplant Immunology

Volumn 23, Issue 1-2, 2010, Pages 1-5

  Yan, Qiang ^a   Sui, Weiguo ^a   Xie, Shuiyong ^a   Chen, Huaizhou ^a   Xie, Shenping ^a   Zou, Guimian ^a   Guo, Junjun ^a   Zou, Hequn ^b  

^a The 181th Hospital of PLA   (China)

^b THE THIRD AFFILIATED HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Integrin linked kinase; Interstitial fibrosis and tubular atrophy (IF TA); Transforming growth factor 1 (TGF 1)

Indexed keywords

COLLAGEN TYPE 4; CYCLOSPORIN A; INTEGRIN LINKED KINASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA1; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

ADULT; ATROPHY; CHRONIC ALLOGRAFT NEPHROPATHY; CLINICAL ARTICLE; COMPUTER ASSISTED DIAGNOSIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GRAFT RECIPIENT; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; KIDNEY TUBULE ATROPHY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; ALLOTRANSPLANTATION; ENZYMOLOGY; FIBROSIS; GENE EXPRESSION REGULATION; INTERSTITIAL NEPHRITIS; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULE; METABOLISM; PATHOPHYSIOLOGY;

COLLAGEN TYPE IV; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; NEPHRITIS, INTERSTITIAL; PROTEIN-SERINE-THREONINE KINASES; TRANSPLANTATION, HOMOLOGOUS;

EID: 77953811799     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.04.001     Document Type: Review

References (14)

1. Campistol J.M., Sacks S.H. Mechanisms of nephrotoxicity. Transplantation 2000, 69(suppl 12):ss5-ss10.
2. Morales J.M., Andres A., Rengel M., Rodicio J.L. Influence of cyclosporine, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation. Nephrol Dial Transplant 2001, 16(5):121-124.
3. Solez K., Colvin R.B., Racusen L.C., Sis B., Halloran P.F., Birk P.E., et al. Banff, 05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy("IF/TA"). Am J Transplant 2007, 7(3):518-526.
4. Border W.A., Noble N.A. TGF-β in kidney fibrosis: a target for gene therapy. Kidney Int 1997, 51(5):1388-1396.
5. Ishii H., Tada H., Isogai S. An aldose reductese inhibitor prevents glucose-induced increase in transforming growth factor-β and protein kinase C activity in cultured mesangial cells. Diabetolongia 1998, 41(3):362-364.
6. Baboolal K., Jones G.A., Janezic A., Griffiths D.R., Jurewicz W.A. Molecular and structural consequences of early renal allograft injury. Kidney Int 2002, 61(2):686-696.
7. Mas V., Diller A., Albano S., Giraudo C., Alvarellos T., Sena J., et al. Intragraft expression of transforming growth factor-beta1 by a noxel quantitative reverse transcription polymerase chain reaction ELISA in long lasting kidney recipients. Transplantation 2000, 70(4):612-616.
8. Viklicky O., Matl I., Voska L., Böhmová R., Jaresová M., Lácha J., et al. TGF-beta1 expression and chronic allograft nephropathy in protocol kidney graft biopsy. Physiol Res 2003, 52(3):353-360.
9. Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta1-integrin -linked protein kinase. Nature 1996, 379(6560):79-96.
10. Wang Y., Zou H., Lv T., Shi Y., Chen L., Zhou W., et al. Role and mechanism of integrin-linked kinase in the pathogenesis of chronic allograft nephropathy. J Transplant Med 2007, 2(4):208-217.
11. Li Y.J., Yang J.W., Dai C.S., Wu C., Liu Y. Role for integrin-linked kinase inmediating tubular epithelial to mesenchymal tran sition and renal interstitial fibregenesis. J Clin Invest 2003, 112(4):503-516.
12. Guo L., Sanders P.W., Woods A., Wu C. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. Am J Pathol 2001, 159(5):1735-1742.
13. Eddy A. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996, 7(12):495-2508.
14. Zou H., Yao J., Wang Y., Li D., Shi Y., Wang P. Dramatic early event in chronic allograft nephropathy: increased but not decreased expression of MMP-9 gene. J Transplant Med 2006, 1:16-29.