Preeclampsia induced by cadmium in rats is related to abnormal local glucocorticoid synthesis in placenta

Reproductive Biology and Endocrinology

Volumn 12, Issue 1, 2014, Pages

  Wang, Fan ^a   Zhang, Qiong ^a   Zhang, Xiaojie ^b   Luo, Shunqun ^c   Ye, Duyun ^d   Guo, Yi ^b   Chen, Sisi ^b   Huang, Yinping ^b  

^a THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cadmium; Glucocorticoid synthesis; Placenta; Preeclampsia; Rat

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CADMIUM; CORTICOSTERONE; GLUCOCORTICOID; STEROID 11BETA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; CADMIUM CHLORIDE; CYP21A1 PROTEIN, RAT; POLLUTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MATERNAL HYPERTENSION; NONHUMAN; PLACENTA; PREECLAMPSIA; PREGNANCY; PROTEIN EXPRESSION; PROTEINURIA; RAT; STEROIDOGENESIS; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; CADMIUM POISONING; DOSE RESPONSE; DRUG EFFECTS; ENZYME INDUCTION; ENZYME REPRESSION; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHARMACOKINETICS; POLLUTANT; PRE-ECLAMPSIA; PREGNANCY COMPLICATION; RANDOMIZATION; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; TOXICITY; UPREGULATION;

RATTUS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CADMIUM CHLORIDE; CADMIUM POISONING; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; ENZYME REPRESSION; FEMALE; GLUCOCORTICOIDS; INJECTIONS, INTRAPERITONEAL; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; STEROID 11-BETA-HYDROXYLASE; STEROID 21-HYDROXYLASE; TISSUE DISTRIBUTION; UP-REGULATION;

EID: 84905986048     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-12-77     Document Type: Article

References (30)

1. Frank T, Wing-Kee L. Toxicology of cadmium and its damage to mammalian organs. Cadmium: From Toxicity to Essentiality Volume 11, Metal Ions in Life Sciences 2013, 415-490. Sigel: Springer Netherlands, Astrid S, Helmut S, Roland KO.
2. Kah M, Levy L, Brown C. Potential for effects of land contamination on human health: 1. the case of cadmium. J Toxicol Environ Health B Crit Rev 2012, 15(5):348-363.
3. Nawrot TS, Staessen JA, Roels HA, Munters E, Cuypers A, Richart T, Ruttens A, Smeets K, Clijsters H, Vangronsveld J. Cadmium exposure in the population: from health risks to strategies of prevention. Bio Metals 2010, 23(5):769-782.
4. Nishijo M, Satarug S, Honda R, Tsuritani I, Aoshima K. The gender differences in health effects of environmental cadmium exposure and potential mechanisms. Mol Cell Biochem 2004, 255(1-2):87-92.
5. Lyall F, Robson SC, Bulmer JN. Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension 2013, 62(6):1046-1054.
6. Minire A, Mirton M, Imri V, Lauren M, Aferdita M. Maternal complications of preeclampsia. Med Arh 2013, 67(5):339-341.
7. Raghupathy R. Cytokines as key players in the pathophysiology of preeclampsia. Med Princ Pract 2013, 22(Suppl 1):8-19.
8. Kippler M, Lo¨nnerdal B, Goessler W, Ekstro¨m EC, Arifeen SE, Vahter M. Cadmium interacts with the transport of essential micronutrients in the mammary gland-a study in rural Bangladeshi women. Toxicology 2009, 257(1-2):64-69.
9. Menai M, Heude B, Slama R, Forhan A, Sahuquillo J, Charles MA, Yazbeck C. Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study. Reprod Toxicol 2012, 34(4):622-627.
10. Kippler M, Tofail F, Gardner R, Rahman A, Hamadani JD, Matteo B, Marie V. Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study. Environ Health Perspect 2012, 120(2):284-289.
11. Takiguchi M, Yoshihara S. New aspects of cadmium as endocrine disruptor. Environ Sci 2006, 13(2):107-116.
12. Henson MC, Chedrese PJ. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 2004, 229(5):383-392.
13. Pandya C, Pillai P, Nampoothiri LP, Bhatt N, Gupta S, Andrologia GS. Effect of lead and cadmium co-exposure on testicular steroid metabolism and antioxidant system of adult male rats. Andrologia 2012, 44(Suppl 1):813-822.
14. Piasek M, Laskey JW, Kostial K, Blanusa M. Assessment of steroid disruption using cultures of whole ovary and/or placenta in rat and in human placental tissue. Int Arch Occup Environ Health 2002, 75(Suppl):S36-S44.
15. Ronco AM, Urrutia M, Montenegro M, Llanos MN. Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids. Toxicol Lett 2009, 188(3):186-191.
16. Taves MD, Gomez-Sanchez CE, Soma KK. Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function. Am J Physiol Endocrinol Metab 2011, 301(1):E11-E24.
17. Vianna P, Bauer ME, Dornfeld D, Chies JA. Distress conditions during pregnancy may lead to pre-eclampsia by increasing cortisol levels and altering lymphocyte sensitivity to glucocorticoids. Med Hypotheses 2011, 77(2):188-191.
18. Go¨kalp SO, Do¨nmez S, Dogan M, Demirin H, Kara HY, Su¨tcu¨ R, Cicek E, Ozer MK, Delibas N. Impairment of endothelium-dependent vasorelaxation in cadmium-hypertensive rats. Toxicol Ind Health 2009, 25(7):447-453.
19. Mollaoglu H, Gokcimen A, Ozguner F, Oktem F, Koyu A, Kocak A, Demirin H, Gokalp O, Cicek E. Caffeic acid phenethyl ester prevents cadmium-induced cardiac impairment in rat. Toxicology 2006, 227(1-2):15-20.
20. Mark PJ, Augustus S, Lewis JL, Hewitt DP, Waddell BJ. Changes in the placental glucocorticoid barrier during rat pregnancy: impact on placental corticosterone levels and regulation by progesterone. Biol Reprod 2009, 80(6):1209-1215.
21. Sullivan MHF. Endocrine cell lines from the placenta. Mol Cell Endocrinol 2004, 228:103-119.
22. Tuckey RC. Progesterone synthesis by the human placenta. Placenta 2005, 26(4):273-281.
23. Luu-The V. Assessment of steroidogenesis and steroidogenic enzyme functions. J Steroid Biochem Mol Biol 2013, 137:176-182.
24. Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 2004, 25(6):947-970.
25. Sybulski S, Venning EH. The possibility of corticosteroid production by human and rat placental tissue under in vitro conditions. Can J Biochem Physiol 1961, 39:203-214.
26. Evenas J, Forsen S, Malmendal A, Akke M. Backbone dynamics and energetics of a calmodulin domain mutant exchanging between closed and open conformations. J Mol Biol 1999, 289(3):603-617.
27. He P, Chen Z, Sun Q, Li Y, Gu H, Ni X. Reduced expression of 11β-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPARγ but increased PPARα expression. Endocrinology 2014, 155(1):299-309.
28. Aufdenblatten M, Baumann M, Raio L, Dick B, Frey BM, Schneider H, Surbek D, Hocher B, Mohaupt MG. Prematurity is related to high placental cortisol in preeclampsia. Pediatr Res 2009, 65(2):198-202.
29. Yang K, Julan L, Rubio F, Sharma A, Guan H. Cadmium reduces 11-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am J Physiol Endocrinol Metab 2006, 290:E135-E142.
30. Olszowski T, Baranowska-Bosiacka I, Gutowska I, Chlubek D. Pro-inflammatory properties of cadmium. Acta Biochim Pol 2012, 59(4):475-482.