Cognitive function and neurodevelopmental outcomes in HIV-infected children older than 1 year of age randomized to early versus deferred antiretroviral therapy: The PREDICT neurodevelopmental study

Pediatric Infectious Disease Journal

Volumn 32, Issue 5, 2013, Pages 501-508

  Puthanakit, Thanyawee ^a   Ananworanich, Jintanat ^a,b,f,g   Vonthanak, Saphonn ^c   Kosalaraksa, Pope ^d   Hansudewechakul, Rawiwan ^e   Van Der Lugt, Jasper ^a,f   Kerr, Stephen J ^a,g   Kanjanavanit, Suparat ^h   Ngampiyaskul, Chaiwat ⁱ   Wongsawat, Jurai ^j   Luesomboon, Wicharn ^k   Vibol, Ung ^l   Pruksakaew, Kanchana ^a   Suwarnlerk, Tulathip ^a   Apornpong, Tanakorn ^a   Ratanadilok, Kattiya ^m   Paul, Robert ⁿ   Mofenson, Lynne M ^o   Fox, Lawrence ^p   Valcour, Victor ^b,q   Brouwers, Pirn ^r   Ruxrungtham, Kiat ^a   more..

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b THAI RED CROSS AIDS RESEARCH CENTRE   (Thailand)

^c National Center for HIV/AIDS Dermatology and STDs   (Cambodia)

^d KHON KAEN UNIVERSITY   (Thailand)

^e CHIANGRAI PRACHANUKROH HOSPITAL   (Thailand)

^f AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT   (Netherlands)

^g UNIVERSITY OF NEW SOUTH WALES   (Australia)

^h NAKORNPING HOSPITAL   (Thailand)

ⁱ PRAPOKKLAO HOSPITAL   (Thailand)

^j Bamrasnaradura Infectious Diseases Institute   (Thailand)

^k Queen Savang Vadhana Memorial Hospital   (Thailand)

^l National Pediatric Hospital   (Cambodia)

^m MINISTRY OF JUSTICE   (Thailand)

ⁿ UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^o EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^p NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^q UNIVERSITY OF CALIFORNIA   (United States)

^r NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

more..

Author keywords

Antiretroviral therapy; Children; HIV; Neurodevelopment; Resource limited settings

Indexed keywords

LAMIVUDINE; LOPINAVIR; NEVIRAPINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; CAREGIVER SUPPORT; CD4 LYMPHOCYTE COUNT; CHILD; CHILD BEHAVIOR CHECKLIST; CHILDHOOD DISEASE; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; INCOME; INFANT; INTELLECT; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEMORY; NERVE CELL DIFFERENTIATION; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SOCIAL STATUS; TREATMENT DURATION; WECHSLER INTELLIGENCE SCALE;

EID: 85027938434     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e31827fb19d     Document Type: Article

References (31)

1. Global report: UNAIDS report on the global AIDS epidemic 2010. Available at: http://www.unaids.org/en/media/unaids/contentassets/dataimport/pub/report/ 2009/jc1700-epi-update-2009-en.pdf Accessed December 10, 2011.
2. Chiriboga CA, Fleishman S, Champion S, et al. Incidence and prevalence of HIV encephalopathy in children with HIV infection receiving highly active anti-retroviral therapy (HAART). J Pediatr. 2005; 146:402-407.
3. Puthanakit T, Aurpibul L, Louthrenoo O, et al. Poor cognitive functioning of school-aged children in thailand with perinatally acquired HIV infection taking antiretroviral therapy. AIDS Patient Care STDS. 2010;24:141-146.
4. Nachman S, Chernoff M, Williams P, et al. Human immunodeficiency virus disease severity, psychiatric symptoms, and functional outcomes in perinatally infected youth. Arch Pediatr Adolesc Med. 2012;166:528-535.
5. Smith R, Chernoff M, Williams PL, et al.; Pediatric HIV/AIDS Cohort Study (PHACS) Team. Impact of HIV severity on cognitive and adaptive functioning during childhood and adolescence. Pediatr Infect Dis J. 2012;31:592-598.
6. Thomaidis L, Bertou G, Critselis E, et al. Cognitive and psychosocial development of HIV pediatric patients receiving highly active anti-retroviral therapy: a case-control study. BMC Pediatr. 2010;10:99.
7. Wood SM, Shah SS, Steenhoff AP, et al. The impact of AIDS diagnoses on long-term neurocognitive and psychiatric outcomes of surviving adolescents with perinatally acquired HIV AIDS. 2009;23:1859-1865.
8. Epstein LG, Sharer LR, Oleske JM, et al. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics. 1986;78:678-687.
9. Van Rie A, Harrington PR, Dow A, et al. Neurologic and neurodevelop-mental manifestations of pediatric HIV/AIDS: a global perspective. Eur J Paediatr Neurol. 2007;11:1-9.
10. Jeremy RJ, Kim S, Nozyce M, et al.; Pediatric AIDS Clinical Trials Group (PACTG) 338 & 377 Study Teams. Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected children. Pediatrics. 2005;115:380-387.
11. Lowick S, Sawry S, Meyers T Neurodevelopmental delay among HIV-infected preschool children receiving antiretroviral therapy and healthy preschool children in Soweto, South Africa. Psychol Health Med. 2012;17:599-610.
12. Laughton B, Cornell M, Grove D, et al. Early antiretroviral therapy improves neurodevelopmental outcomes in infants. AIDS. 2012;26:1685-1690.
13. Puthanakit T, Saphonn V, Ananworanich J, et al.; on behalf of the PREDICT Study Group. Early versus deferred antiretroviral therapy for children older than 1 year infected with HIV (PREDICT): a multicentre, randomised, open-label trial. lancet Infect Dis. 2012;12:933-941.
14. Puthanakit T, Tangsathapornpongb A, Ananworanich J, et al. for the Thai National HIV Guidelines Working Group. Thai National guidelines for the use of antiretroviral therapy in pediatric HIV infection in 2010. Asian Biomedicine. 2010;4:505-513.
15. UNAIDS. Ministry of Health. National Center for HIV/AIDS, Dermatology and STD Report of a Consensus Workshop. HIV Estimates and Projections for Cambodia 2006-2012. Surveillance Unit Phnom Penh, 25-29 June 2007. Available at: http://www.unaids.org/en/dataanalysis/knowyourepidemic/ countryreportsonhivestimates/cambodia-hiv-estimation-report-2006-en.pdf Accessed October 5, 2012.
16. DHHS Pediatric Panel Notice on Nelfinavir FDA-Pfizer Letter. September 11, 2007. Available at: http://aidsinfo.nih.gov/contentfiles/PedNFVnoticel.pdf Accessed December 10, 2011.
17. NCHADS. National Guidelines for the Use of Pediatric Antiretroviral Therapy in Cambodia, 3rd Edition. June 27, 2011. Available at: http://wwwmedicam-cambodia.org/publication/details.asp?publication-id= 52&pub-language=English. Accessed October 10, 2012.
18. Geneva: World Health Organization 2010. Antiretroviral therapy for HIV infection in infants and children: towards universal access-recommendations for a public health approach. Available at: www.who.int. Accessed April 20, 2012.
19. Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children. Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. August 11, 2011. Available at: http://aidsinfo.nih.gov/Content-Files/ PediatricGuidelines.pdf Accessed April 20, 2012.
20. Nyandiko WM, Otieno-Nyunya B, Musick B, et al. Outcomes of HIV-exposed children in western Kenya: efficacy of prevention of mother to child transmission in a resource-constrained setting. J Acquir Immune Defic Syndr. 2010;54:42-50.
21. Mirkuzie AH, Hinderaker SG, Sisay MM, et al. Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study. J Int AIDS Soc. 2011;14:50.
22. Nuwagaba-Biribonwoha H, Werq-Semo B, Abdallah A, et al. Introducing a multi-site program for early diagnosis of HIV infection among HIV-exposed infants in Tanzania. BMC Pediatr. 2010;10:44.
23. Ruel TD, Boivin MJ, Boal HE, et al. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012;54:1001-1009.
24. Lindsey JC, Malee KM, Brouwers P, et al.; PACTG 219C Study Team. Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy. Pediatrics. 2007;119:e681-e693.
25. Nozyce ML, Lee SS, Wiznia A, et al. A behavioral and cognitive profile of clinically stable HIV-infected children. Pediatrics. 2006;117:763-770.
26. Dowshen N, D'Angelo L. Health care transition for youth living with HIV/AIDS. Pediatrics. 2011;128:762-771.
27. Kapetanovic S, Wiegand RE, Dominguez K, et al.; LEGACY Consortium. Associations of medically documented psychiatric diagnoses and risky health behaviors in highly active antiretroviral therapy-experienced perinatally HIV-infected youth. AIDS Patient Care STDS. 2011;25: 493-501.
28. Anderson V, Godfrey C, Rosenfeld JV, et al. Predictors of cognitive function and recovery 10 years after traumatic brain injury in young children. Pediatrics. 2012;129:e254-e261.
29. Grantham-McGregor S, Cheung YB, Cueto S, et al.; International Child Development Steering Group. Developmental potential in the first 5 years for children in developing countries. lancet. 2007;369:60-70.
30. Violari A, Cotton MF, Gibb DM, et al.; CHER Study Team. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med. 2008;359:2233-2244.
31. Lester P, Stein JA, Bursch B, et al. Family-based processes associated with adolescent distress, substance use and risky sexual behavior in families affected by maternal HIV J Clin Child Adolesc Psychol. 2010;39:328-340.