Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke

Clinical Science

Volumn 127, Issue 12, 2014, Pages 679-689

  Yang, Zhong Bao ^a   Zhang, Zhen ^b   Li, Ting Bo ^a   Lou, Zheng ^a   Li, Shu Yu ^b   Yang, Huan ^b   Yang, Jie ^b   Luo, Xiu Ju ^a,c   Peng, Jun ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Central South University   (China)

Author keywords

Brain injury; Glutamate; Glutamate transporter 1 (GLT 1); Ischaemic stroke; miR 107

Indexed keywords

MICRORNA 107; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD LEVEL; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; EXCITOTOXICITY; HYPOXIA; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION;

ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; DOWN-REGULATION; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GLUTAMIC ACID; HUMANS; MALE; MICRORNAS; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, ANTISENSE; STROKE; UP-REGULATION;

EID: 84905902943     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20140084     Document Type: Article

References (29)

1. Wu, T. C. and Grotta, J. C. (2013) Hypothermia for acute ischaemic stroke. Lancet Neurol. 12, 275-284
2. Sugunan, S., Joseph, D. B. and Rajanikant, G. K. (2013) Evolving therapeutic targets in ischemic stroke: a concise review. Curr. Drug. Targets 14, 497-506
3. Campos, F., Rodriguez-Yanez, M., Castellanos, M., Arias, S., Perez-Mato, M., Sobrino, T., Blanco, M., Serena, J. and Castillo, J. (2011) Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels. Clin. Sci. 121, 11-17
4. Eltzschig, H. K. and Eckle, T. (2011) Ischemia and reperfusion - from mechanism to translation. Nat. Med. 17, 1391-1401
5. Fu, S. H., Zhang, H. F., Yang, Z. B., Li, T. B., Liu, B., Lou, Z., Ma, Q. L., Luo, X. J. and Peng, J. (2014) Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Naunyn. Schmiedebergs Arch. Pharmacol. 387, 87-94.
6. Kostandy, B. B. (2012) The role of glutamate in neuronal ischemic injury: the role of spark in fire. Neurol. Sci. 33, 223-237
7. Yang, J. L., Sykora, P., Wilson, III, D. M., Mattson, M. P. and Bohr, V. A. (2011) The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency. Mech. Ageing Dev. 132, 405-411
8. Ketheeswaranathan, P., Turner, N. A., Spary, E. J., Batten, T. F., McColl, B. W. and Saha, S. (2011) Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia. Brain Res. 1418, 93-103
9. Fang, Q., Hu, W. W., Wang, X. F., Yang, Y., Lou, G. D., Jin, M. M., Yan, H. J., Zeng, W. Z., Shen, Y., Zhang, S. H. et al. (2013) Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury. Neuropharmacology 77, 156-166
10. Ameres, S. L. and Zamore, P. D. (2013) Diversifying microRNA sequence and function. Nat. Rev. Mol. Cell Biol. 14, 475-488
11. Jung, H. J., Coffinier, C., Choe, Y., Beigneux, A. P., Davies, B. S., Yang, S. H., Barnes, II, R. H., Hong, J., Sun, T., Pleasure, S. J. et al. (2012) Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc. Natl. Acad. Sci. U.S.A. 109, E423-E431
12. Xia, H., Cheung, W. K., Ng, S. S., Jiang, X., Jiang, S., Sze, J., Leung, G. K., Lu, G., Chan, D. T., Bian, X. W. et al. (2012) Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. J. Biol. Chem. 287, 9962-9971
13. Laterza, O. F., Lim, L., Garrett-Engele, P. W., Vlasakova, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D. and Glaab, W. E. (2009) Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin. Chem. 55, 1977-1983
14. Sayed, A. S., Xia, K., Yang, T. L. and Peng, J. (2013) Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarction. Dis. Markers 35, 561-566
15. Tan, K. S., Armugam, A., Sepramaniam, S., Lim, K. Y., Setyowati, K. D., Wang, C. W. and Jeyaseelan, K. (2009) Expression profile of MicroRNAs in young stroke patients. PLoS ONE 4, e7689
16. Dharap, A., Bowen, K., Place, R., Li, L. C. and Vemuganti, R. (2009) Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J. Cereb. Blood Flow Metab. 29, 675-687
17. Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M. and Greenberg, M. E. (2006) A brain-specific microRNA regulates dendritic spine development. Nature 439, 283-289
18. Lin, Q., Wei, W., Coelho, C. M., Li, X., Baker-Andresen, D., Dudley, K., Ratnu, V. S., Boskovic, Z., Kobor, M. S., Sun, Y. E. and Bredy, T. W. (2011) The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat. Neurosci. 14, 1115-1117
19. Khudayberdiev, S., Fiore, R. and Schratt, G. (2009) MicroRNA as modulators of neuronal responses. Commun. Integr. Biol. 2, 411-413
20. Xu, J., Liao, X., Lu, N., Liu, W. and Wong, C. W. (2011) Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines. Int. J. Cancer 129, 2527-2531
21. Wang, W. X., Wilfred, B. R., Hu, Y., Stromberg, A. J. and Nelson, P. T. (2010) Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA 16, 394-404
22. Schabitz, W. R., Schade, H., Heiland, S., Kollmar, R., Bardutzky, J., Henninger, N., Muller, H., Carl, U., Toyokuni, S., Sommer, C. and Schwab, S. (2004) Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI. Stroke 35, 1175-1179
23. Asdaghi, N., Jeerakathil, T., Hameed, B., Saini, M., McCombe, J. A., Shuaib, A., Emery, D. and Butcher, K. (2011) Oxfordshire community stroke project classification poorly differentiates small cortical and subcortical infarcts. Stroke 42, 2143-2148
24. Chen, J. C., Hsu-Chou, H., Lu, J. L., Chiang, Y. C., Huang, H. M., Wang, H. L., Wu, T., Liao, J. J. and Yeh, T. S. (2005) Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia. Neuropharmacology 49, 703-714
25. Jeyaseelan, K., Lim, K. Y. and Armugam, A. (2008) MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 39, 959-966
26. Liu, D. Z., Tian, Y., Ander, B. P., Xu, H., Stamova, B. S., Zhan, X., Turner, R. J., Jickling, G. and Sharp, F. R. (2010) Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J. Cereb. Blood Flow Metab. 30, 92-101
27. Liu, X., Li, F., Zhao, S., Luo, Y., Kang, J., Zhao, H., Yan, F., Li, S. and Ji, X. (2013) MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Stroke 44, 1973-1980
28. Zhu, F., Liu, J. L., Li, J. P., Xiao, F., Zhang, Z. X. and Zhang, L. (2014) MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia/reperfusion. J. Mol. Neurosci. 52, 148-155
29. Li, H., Sun, C., Wang, Y., Gao, Y., Liu, Y., Gao, Y., Li, X. and Zhang, C. (2013) Dynamic expression pattern of neurooncological ventral antigen 1 (Nova1) in the rat brain after focal cerebral ischemia/reperfusion insults. J. Histochem. Cytochem. 61, 45-54