Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer

Journal of Clinical Oncology

Volumn 32, Issue 23, 2014, Pages 2430-2439

  Zgaga, Lina ^a,c   Theodoratou, Evropi ^a   Farrington, Susan M ^a   Din, Farhat V N ^a   Ooi, Li Yin ^a   Glodzik, Dominik ^a   Johnston, Susan ^b   Tenesa, Albert ^a   Campbell, Harry ^a   Dunlop, Malcolm G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ANTINEOPLASTIC AGENT; VITAMIN D RECEPTOR; 25-HYDROXYVITAMIN D; CALCITRIOL RECEPTOR; VDR PROTEIN, HUMAN; VITAMIN D;

ALLELE; ARTICLE; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER MORTALITY; CANCER SURGERY; CANCER SURVIVAL; COLORECTAL CANCER; COMPUTER PROGRAM; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MOLECULAR INTERACTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW (TOPIC); TANDEM MASS SPECTROMETRY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; BLOOD; CANCER STAGING; CASE CONTROL STUDY; COLORECTAL TUMOR; EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; META ANALYSIS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROSPECTIVE STUDY; RISK FACTOR; UNITED KINGDOM;

CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RECEPTORS, CALCITRIOL; RISK FACTORS; SCOTLAND; VITAMIN D;

EID: 84905833633     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.54.5947     Document Type: Article

References (41)

1. Schöttker B, Haug U, Schomburg L, et al: Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 97:782-793, 2013
2. Ferlay J, Shin HR, Bray F, et al: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893-2917, 2010
3. Giovannucci E: The epidemiology of vitamin D and cancer incidence and mortality: A review (United States). Cancer Causes Control 16:83-95, 2005
4. Zgaga L, Theodoratou E, Farrington SM, et al: Diet, environmental factors, and lifestyle underlie the high prevalence of vitamin D deficiency in healthy adults in Scotland, and supplementation reduces the proportion that are severely deficient. J Nutr 141:1535-1542, 2011
5. Calvo MS, Whiting SJ, Barton CN: Vitamin D intake: A global perspective of current status. J Nutr 135:310-316, 2005 (Pubitemid 40194498)
6. Reid D, Toole BJ, Knox S, et al: The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. Am J Clin Nutr 93:1006-1011, 2011
7. Touvier M, Chan DS, Lau R, et al: Metaanalyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 20:1003-1016, 2011
8. Zgaga L, Agakov F, Theodoratou E, et al: Model selection approach suggests causal association between 25-hydroxyvitamin D and colorectal cancer. PLoS One 8:e63475, 2013
9. Theodoratou E, Farrington SM, Tenesa A, et al: Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer 123:2170-2179, 2008
10. Theodoratou E, Palmer T, Zgaga L, et al: Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: A mendelian randomization analysis. PLoS One 7:e37662, 2012
11. Garland CF, Garland FC: Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9:227-231, 1980 (Pubitemid 11238851)
12. Moan J, Porojnicu AC, Robsahm TE, et al: Solar radiation, vitamin D and survival rate of colon cancer in Norway. J Photochem Photobiol B 78:189-193, 2005 (Pubitemid 40220986)
13. Ng K, Meyerhardt JA, Wu K, et al: Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol 26:2984-2991, 2008
14. Grant WB: The likely role of vitamin D from solar ultraviolet-B irradiance in increasing cancer survival. Anticancer Res 26:2605-2614, 2006
15. Lim HS, Roychoudhuri R, Peto J, et al: Cancer survival is dependent on season of diagnosis and sunlight exposure. Int J Cancer 119:1530-1536, 2006 (Pubitemid 44258757)
16. Ng K, Wolpin BM, Meyerhardt JA, et al: Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer 101:916-923, 2009
17. Maalmi H, Ordóñez-Mena JM, Schöttker B, et al: Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies. Eur J Cancer 50:1510-1521, 2014
18. Ross AC, Manson JE, Abrams SA, et al: The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J Clin Endocrinol Metab 96:53-58, 2011
19. Seamans KM, Cashman KD: Existing and potentially novel functional markers of vitamin D status: A systematic review. Am J Clin Nutr 89:1997S-2008S, 2009
20. Theodoratou E, Kyle J, Cetnarskyj R, et al: Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 16:684-693, 2007 (Pubitemid 46650569)
21. Knox S, Harris J, Calton L, et al: A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography-tandem mass spectrometry. Ann Clin Biochem 46:226-230, 2009
22. Colin EM, Weel AE, Uitterlinden AG, et al: Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D3. Clin Endocrinol (Oxf) 52:211-216, 2000 (Pubitemid 30108268)
23. Uitterlinden AG, Fang Y, Van Meurs JB, et al: Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143-156, 2004 (Pubitemid 39094759)
24. Staal A, van Wijnen AJ, Birkenhäger JC, et al: Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol Endocrinol 10:1444-1456, 1996
25. Yamamoto H, Miyamoto K, Li B, et al: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine. J Bone Miner Res 14:240-247, 1999 (Pubitemid 29066249)
26. Browning SR, Browning BL: Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet 81:1084-1097, 2007 (Pubitemid 47580259)
27. Fedirko V, Riboli E, Tjønneland A, et al: Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European populations. Cancer Epidemiol Biomarkers Prev 21:582-593, 2012
28. Mezawa H, Sugiura T, Watanabe M, et al: Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study. BMC Cancer 10:347, 2010
29. Ng K, Sargent DJ, Goldberg RM, et al: Vitamin D status in patients with stage IV colorectal cancer: Findings from Intergroup trial N9741. J Clin Oncol 29:1599-1606, 2011
30. Tretli S, Schwartz GG, Torjesen PA, et al: Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: A population-based study. Cancer Causes Control 23:363-370, 2012
31. Pilz S, Kienreich K, Tomaschitz A, et al: Vitamin D and cancer mortality: Systematic review of prospective epidemiological studies. Anticancer Agents Med Chem 13:107-117, 2013
32. Tenesa A, Campbell H, Theodoratou E, et al: Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population. Int J Obes (Lond) 33:284-288, 2009
33. Fedirko V, Bostick RM, Flanders WD, et al: Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: A randomized, double-blind, placebo-controlled clinical trial. Cancer Prev Res (Phila) 2:213-223, 2009
34. Fernandez-Garcia NI, Palmer HG, Garcia M, et al: 1alpha,25- Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells. Oncogene 24:6533-6544, 2005 (Pubitemid 41486636)
35. Iseki K, Tatsuta M, Uehara H, et al: Inhibition of angiogenesis as a mechanism for inhibition by 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by azoxymethane in Wistar rats. Int J Cancer 81:730-733, 1999 (Pubitemid 29214382)
36. Pálmer HG, González-Sancho JM, Espada J, et al: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 154:369-387, 2001 (Pubitemid 34286147)
37. Fedirko V, Bostick RM, Flanders WD, et al: Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: A randomized clinical trial. Cancer Epidemiol Biomarkers Prev 18:2933-2941, 2009
38. Deeb KK, Trump DL, Johnson CS: Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer 7:684-700, 2007 (Pubitemid 47327412)
39. Hopkins MH, Owen J, Ahearn T, et al: Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: A randomized, controlled clinical trial. Cancer Prev Res (Phila) 4:1645-1654, 2011
40. Fedirko V, Bostick RM, Long Q, et al: Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: A randomized clinical trial. Cancer Epidemiol Biomarkers Prev 19:280-291, 2010
41. Ahearn TU, Shaukat A, Flanders WD, et al: A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC/beta-catenin pathway in the normal mucosa of colorectal adenoma patients. Cancer Prev Res (Phila) 5:1247-1256, 2012