Incidental Histopathological Findings in Hearts of Control Beagle Dogs in Toxicity Studies

Toxicologic Pathology

Volumn 42, Issue 6, 2014, Pages 997-1003

  Bodié, Karen ^a   Decker, Joshua H ^a  

^a ABBVIE INC   (United States)

Author keywords

artifact; dog; heart; histopathology; historical control data; incidental finding; postmortem change

Indexed keywords

ANIMAL; CHEMICALLY INDUCED; CONTROL GROUP; DOG; DOG DISEASE; DRUG EFFECTS; FEMALE; HEART; HEART MUSCLE; MALE; PATHOLOGY; PROCEDURES; TOXICITY TESTING;

ANIMALS; CONTROL GROUPS; DOG DISEASES; DOGS; FEMALE; HEART; MALE; MYOCARDIUM; TOXICITY TESTS;

EID: 84905827889     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623313508480     Document Type: Article

References (19)

1. Boeck P. (1989). Romeis Mikroskopische Technik, 17. Auflage, pp. 499–500. Urban & Schwarzenberb, Muenchen-Wien-Baltimore.
2. F.F.S., Clemo, W.E., Evering, P.W., Snyder, M.A., Albassam, Differentiating spontaneous from drug-induced vascular injury in the dog, Toxicol Pathol, (2003), 31, 25-31
3. Gerdes J. Schwab U. Lemke H. Stein H. (1983). Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31, 13–20.
4. Greaves P. (2007). Histopathology of Preclinical Toxicity Studies, pp. 270–333. Academic Press, London, UK.
5. Isaacs K. R. Joseph E. C. Betton G. R. (1989). Coronary vascular lesions in dogs treated with phosphodiesterase III inhibitors. Toxicol Pathol 17, 153–63.
6. Joseph E. C. (2000). Arterial lesions induced by phosphodiesterase III (PDE III) inhibitors and DA1 agonists. Toxicol Lett 112-113, 537–46.
7. Keenan C. M. Vidal J. D. (2006). Standard morphologic evaluation of the heart in the laboratory dog and monkey. Toxicol Pathol 34, 67–74.
8. J.J.A., McManus, Histological and histochemical uses of periodic acid, Biotechnic & Histochemistry, (1948), 23, 99-108
9. Mesfin G. M. (1990). Spontaneous epicardial fibrous fronds on the atria of beagle dogs. Vet Pathol 27, 458–61.
10. Mesfin G. M. Piper R. C. DuCharme D. W. Carlson R. G. Humphrey S. J. Zins G. R. (1989). Pathogenesis of cardiovascular alterations in dogs treated with minoxidil. Toxicol Pathol 17, 164–81.
11. Obert L. A. Sobocinski G. P. Bobrowski W. F. Metz A. L. Rolsma M. D. Altrogge D. M. Dunstan R. W. (2007). An immunhistochemical approach to differentiate hepatic lipidosis from hepatic phospholipidosis in rats. Tox Path 35, 728–34.
12. Puchtler H. Sweat F. Levine M. (1962). On the binding of Congo red by amyloid. J Histochem Cytochem 10, 355–64.
13. Samuelson D. A. (2007). Textbook of Veterinary Histology, p. 176. Saunders Elsevier, St. Louis, MO.
14. Schwarz T. Sullivan M. Störk C. K. Willis R. Harley R. Mellor D.J. (2002). Aortic and cardiac mineralization in the dog. Vet Radiol Ultrasound 43, 419–27.
15. Snyder P. W. Kazacos E. A. Scott-Moncrieff J. C. HogenEsch H. Carlton W. W. Glickman L. T. Felsburg P. J. (1995). Pathologic features of naturally occurring juvenile polyarteritis in beagle dogs. Vet Pathol 32, 337–45.
16. Son W. C. (2004). Idiopathic canine polyarteritis in control beagle dogs from toxicity studies. J Vet Sci 5, 147–50.
17. Takeda T. Makita T. Nakamura N. Kimizuka G. (1991). Morphologic aspects and morphogenesis of blood cysts on canine cardiac valves. Vet Pathol 28, 16–21.
18. Uhley H. N. Leeds S. E. (1976). Lymphatics of the canine papillary muscles. Lymphology 9, 72–4.
19. Urasawa N. Wada M. R. Machida N. Yuasa K. Shimatsu Y. Wakao Y. Yuasa S. Sano T. Nonaka I. Nakamura A. Takeda S. (2008). Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Circulation 117, 2437–48.