Arterial lesions induced by phosphodiesterase III (PDE III) inhibitors and DA1 agonists

Toxicology Letters

Volumn 112-113, Issue , 2000, Pages 537-546

  Joseph, E Clive ^a  

^a Sanofi Synthelabo Inc   (United Kingdom)

Author keywords

Arterial toxicity; Haemodynamic; Vasodilator

Indexed keywords

5 (4 ACETAMIDOPHENYL) 2(1H) PYRAZINONE; 6 [4 (1,4 DIHYDRO 4 OXO 1 PYRIDYL)PHENYL] 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; DOPAMINE 1 RECEPTOR STIMULATING AGENT; FENOLDOPAM; MINOXIDIL; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL STIMULATING AGENT; SIGUAZODAN; SKF 94418; UNCLASSIFIED DRUG; WIN 62582;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY LESION; BLEEDING; BLOOD PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; DOG; MUSCLE NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CORONARY DISEASE; DOGS; DOPAMINE AGONISTS; FENOLDOPAM; HEMODYNAMIC PROCESSES; MESENTERIC ARTERIES; MINOXIDIL; RATS; VASODILATOR AGENTS;

CANIS FAMILIARIS;

EID: 17044440916     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00221-0     Document Type: Conference Paper

References (24)

1. Bugelski P.J., Walsh Vockley C.M., Sowinski J.M., Arena E., Berkowitz B.A., Morgan D.G. Ultrastructure of an arterial lesion induced in rats by fenoldopam mesylate, a dopaminergic vasodilator. Br. J. Exp. Pathol. 70:1989;153-165.
2. Chelly J.E., Doursout M.F., Begaud B., Tsao C.C., Hartley C.J. Effects of hydralazine on regional blood flow in conscious dogs. J. Pharmacol. Exp. Ther. 238:1986;665-669.
3. Cook N.S. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. 9:1988;21-28.
4. De Wit R.H., Peter G.K., Fitzgerald J.E., de la Iglasia F. Preliminary toxicologic evaluation of a novel cardiotonic agent. Toxicologist. 5:1985;84. abstract.
5. Dogterom P., Zbinden G., Reznik G.K. Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview. Crit. Rev. Toxicol. 22:1992;203-241.
6. Gristwood R.W., Comer M.B., Eden R.J., Taylor E.M., Turner J.A., Wallduck M., Owen D.A.A. In vivo pharmacological studies with SK&F 94836, a potent inotrope/vasodilator with a sustained duration of action. Br. J. Pharmacol. 93:1988;893-901.
7. Harleman J.H., Joseph E.C., Eden R.J., Walker T.F., Major I.R., Lamb M.S. Cardiotoxicity of a new inotrope/vasodilator drug (SK&F 94120) in the dog. Arch. Toxicol. 59:1986;51-55.
8. Isaacs K.R., Joseph E.C., Betton G.R. Coronary vascular lesions in dogs treated with phosphodiesterase III inhibitors. Toxicol. Pathol. 17:1989;153-163.
9. Jayasekara M.V., De Wit R.H., Peter G.K., Fitzgerald J.E. Subchronic toxicity of CI-930, a novel cardiotonic agent in rats and dogs. Toxicologist. 6:1986;203. abstract.
10. Joseph E.C., Jones H.B., Kerns W.D. Characterization of coronary arterial lesions in the dog following administration of SK&F 95654, a phosphodiesterase III inhibitor. Toxicol. Pathol. 24:1996;429-435.
11. Joseph E.C., Rees J.A., Dayan A.D. Mesenteric arteriopathy in the rat induced by phosphodiesterase III inhibitors: an investigation of morphological, ultrastructural and hemodynamic changes. Toxicol. Pathol. 24:1996;436-450.
12. Joseph E.C., Mesfin G.M., Kerns W.D. Pathogenesis of arterial lesions caused by vasoactive compounds in laboratory animals. Bishop S.P., Kerns W.D. Cardiovascular Toxicology. 1997;279-307 Pergamon, New York.
13. Kerns W.D., Arena E., Morgan D.G. Role of dopaminergic and adrenergic receptors in the pathogenesis of arterial lesions induced by fenoldopam mesylate and dopamine in the rat. Am. J. Pathol. 135:1989;339-349.
14. Liang C.S., Thomas A., Imai N., Stone C.K., Kawashima S., Hood W.B.J. Effects of milrinone on systemic hemodynamics and regional circulation in dogs with congestive heart failure:comparison with dobutamine. J. Cardiovasc. Pharmacol. 15:1987;509-516.
15. Mesfin G.M., Shawaryn G.G., Higgins M.J. Cardiovascular alterations in dogs treated with hydralazine. Toxicol. Pathol. 15:1987;409-416.
16. Mesfin G.M., Piper R.C., DuCharme D.W., Carlson R.G., Humphrey S.J., Zins G.R. Pathogenesis of cardiovascular alterations in dogs treated with minoxidil. Toxicol. Pathol. 17:1989;164-181.
17. Mesfin G.M., Robinson F., Higgins M., Zhong W., DuCharme D. The cardiovascular toxicity of minoxidil in the dog is related to its exaggerated pharmacological effects. Vet. Pathol. 31:1994;577.
18. Metz A.L., Dominick M.A., Suchanek G., Gough A.W. Acute cardiovascular toxicity induced by an adenosine agonist-antihypertensive in Beagles. Toxicol. Pathol. 19:1991;98-107.
19. Morgan D.G., Bugelski P.J., Berkowitz B.A., Valocik E., Arena E. Medial necrosis and hemorrhage in arteries of rats infused with dopaminergic agents. Lab. Invest. 48:1983;60A.
20. + channels. Trends Pharmacol. Sci. 10:1989;431-435.
21. Sandusky, G.E., Means, J.R., Todd, G.C., 1990. Comparative cardiovascular toxicity in dogs given intropic agents by continuous intravenenous infusion. Toxicol. Pathol. 18, 268-278.
22. Steffen R.P., Eldon C.M., Evans D.B. The effect of the cardiotonic imazodan (CI-914) on myocardial and peripheral hemodynamics in the anesthetized dog. J. Cardiovasc. Pharmacol. 8:1986;520-526.
23. Westwood F.R., Iswaran T.J., Greaves P. Pathologic changes in blood vesels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam. Appl. Toxicol. 14:1990;797-809.
24. Yuhas E.M., Morgan D.G., Arena E., Kupp R.P., Saunders L.Z., Lewis H.B. Arterial medial necrosis and hemorrhage induced in rats by intravenous infusion of fenoldopam mesylate, a dopaminergic vasodilator. Am. J. Pathol. 119:1985;83-91.