메뉴 건너뛰기




Volumn 99, Issue 8, 2014, Pages 2795-2803

Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMP-ACTIVATED PROTEIN KINASES; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOWN-REGULATION; ENDOMETRIUM; FEMALE; HUMANS; METFORMIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSCRIPTION FACTORS;

EID: 84905826938     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1593     Document Type: Article
Times cited : (36)

References (30)
  • 1
    • 8444227941 scopus 로고    scopus 로고
    • Endometriosis
    • Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447): 1789-1799.
    • (2004) Lancet. , vol.364 , Issue.9447 , pp. 1789-1799
    • Giudice, L.C.1    Kao, L.C.2
  • 3
    • 28544435662 scopus 로고    scopus 로고
    • Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells
    • Hirota Y, Osuga Y, Hirata T, et al. Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells.HumReprod. 2005;20(12): 3547-3553.
    • (2005) HumReprod. , vol.20 , Issue.12 , pp. 3547-3553
    • Hirota, Y.1    Osuga, Y.2    Hirata, T.3
  • 4
    • 29544446252 scopus 로고    scopus 로고
    • Aromatase and other steroidogenic genes in endometriosis: Translational aspects
    • Attar E, Bulun SE. Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update. 2006; 12(1):49-56.
    • (2006) Hum Reprod Update. , vol.12 , Issue.1 , pp. 49-56
    • Attar, E.1    Bulun, S.E.2
  • 5
    • 58349090850 scopus 로고    scopus 로고
    • Endometriosis
    • Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268-279.
    • (2009) N Engl J Med. , vol.360 , Issue.3 , pp. 268-279
    • Bulun, S.E.1
  • 6
    • 59749105973 scopus 로고    scopus 로고
    • Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis
    • Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94(2):623-631.
    • (2009) J Clin Endocrinol Metab. , vol.94 , Issue.2 , pp. 623-631
    • Attar, E.1    Tokunaga, H.2    Imir, G.3
  • 7
    • 34547784612 scopus 로고    scopus 로고
    • Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5α CpG island in endometriosis
    • Xue Q, Lin Z, Yin P, et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5α CpG island in endometriosis. J Clin Endocrinol Metab. 2007;92(8):3261-3267.
    • (2007) J Clin Endocrinol Metab. , vol.92 , Issue.8 , pp. 3261-3267
    • Xue, Q.1    Lin, Z.2    Yin, P.3
  • 8
    • 23944493604 scopus 로고    scopus 로고
    • Regulation of aromatase expression in estrogen-responsive breast and uterine disease: From bench to treatment
    • Bulun SE, Lin Z, Imir G, et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev. 2005;57(3):359-383.
    • (2005) Pharmacol Rev. , vol.57 , Issue.3 , pp. 359-383
    • Bulun, S.E.1    Lin, Z.2    Imir, G.3
  • 9
    • 0035217708 scopus 로고    scopus 로고
    • Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells
    • Tsai SJ, Wu MH, Lin CC, Sun HS, Chen HM. Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab. 2001;86(12):5765-5773.
    • (2001) J Clin Endocrinol Metab. , vol.86 , Issue.12 , pp. 5765-5773
    • Tsai, S.J.1    Wu, M.H.2    Lin, C.C.3    Sun, H.S.4    Chen, H.M.5
  • 10
    • 0042421806 scopus 로고    scopus 로고
    • Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor
    • Sun HS, Hsiao KY, Hsu CC, Wu MH, Tsai SJ. Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor. Endocrinology. 2003;144(9):3934- 3942.
    • (2003) Endocrinology. , vol.144 , Issue.9 , pp. 3934-3942
    • Sun, H.S.1    Hsiao, K.Y.2    Hsu, C.C.3    Wu, M.H.4    Tsai, S.J.5
  • 11
    • 48749109084 scopus 로고    scopus 로고
    • Cyclic adenosine 3-, 5-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells
    • Hsu CC, Lu CW, Huang BM, Wu MH, Tsai SJ. Cyclic adenosine 3-, 5-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol. 2008;173(2):433-441.
    • (2008) Am J Pathol. , vol.173 , Issue.2 , pp. 433-441
    • Hsu, C.C.1    Lu, C.W.2    Huang, B.M.3    Wu, M.H.4    Tsai, S.J.5
  • 12
    • 27744565691 scopus 로고    scopus 로고
    • Metformin revisited: Re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents
    • Goodarzi MO, Bryer-Ash M. Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab. 2005;7(6):654-665.
    • (2005) Diabetes Obes Metab. , vol.7 , Issue.6 , pp. 654-665
    • Goodarzi, M.O.1    Bryer-Ash, M.2
  • 13
    • 70349326296 scopus 로고    scopus 로고
    • Metformin inhibits aromatase via an extracellular signal-regulated kinasemediated pathway
    • Rice S, Pellatt L, Ramanathan K, Whitehead SA, Mason HD. Metformin inhibits aromatase via an extracellular signal-regulated kinasemediated pathway. Endocrinology. 2009;150(10):4794-4801.
    • (2009) Endocrinology. , vol.150 , Issue.10 , pp. 4794-4801
    • Rice, S.1    Pellatt, L.2    Ramanathan, K.3    Whitehead, S.A.4    Mason, H.D.5
  • 14
    • 84883696576 scopus 로고    scopus 로고
    • Metformin inhibits follicle-stimulating hormone (FSH) action in human granulosa cells: Relevance to polycystic ovary syndrome
    • Rice S, Elia A, Jawad Z, Pellatt L, Mason HD. Metformin inhibits follicle-stimulating hormone (FSH) action in human granulosa cells: relevance to polycystic ovary syndrome. J Clin Endocrinol Metab. 2013;98(9):E1491-E1500.
    • (2013) J Clin Endocrinol Metab. , vol.98 , Issue.9
    • Rice, S.1    Elia, A.2    Jawad, Z.3    Pellatt, L.4    Mason, H.D.5
  • 15
    • 77956150294 scopus 로고    scopus 로고
    • Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase
    • Brown KA, Hunger NI, Docanto M, Simpson ER. Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Res Treat. 2010;123(2):591-596.
    • (2010) Breast Cancer Res Treat. , vol.123 , Issue.2 , pp. 591-596
    • Brown, K.A.1    Hunger, N.I.2    Docanto, M.3    Simpson, E.R.4
  • 16
    • 77949956305 scopus 로고    scopus 로고
    • The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model
    • Oner G, Ozcelik B, Ozgun MT, Serin IS, Ozturk F, Basbug M. The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. Hum Reprod. 2010; 25(4):932-937.
    • (2010) Hum Reprod. , vol.25 , Issue.4 , pp. 932-937
    • Oner, G.1    Ozcelik, B.2    Ozgun, M.T.3    Serin, I.S.4    Ozturk, F.5    Basbug, M.6
  • 18
    • 0142091390 scopus 로고    scopus 로고
    • Identification of a family ofcAMPresponse element-binding protein coactivators by genomescale functional analysis in mammalian cells
    • Iourgenko V, Zhang W, Mickanin C, et al. Identification of a family ofcAMPresponse element-binding protein coactivators by genomescale functional analysis in mammalian cells. Proc Natl Acad Sci U S A. 2003;100(21):12147-12152.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.21 , pp. 12147-12152
    • Iourgenko, V.1    Zhang, W.2    Mickanin, C.3
  • 19
    • 84871364913 scopus 로고    scopus 로고
    • Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2
    • Luo Q, Viste K, Urday-Zaa JC, et al. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. Proc Natl Acad Sci U S A. 2012;109(51):20865-20870.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , Issue.51 , pp. 20865-20870
    • Luo, Q.1    Viste, K.2    Urday-Zaa, J.C.3
  • 20
    • 79951962147 scopus 로고    scopus 로고
    • CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals
    • Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol. 2011;12(3):141-151.
    • (2011) Nat Rev Mol Cell Biol. , vol.12 , Issue.3 , pp. 141-151
    • Altarejos, J.Y.1    Montminy, M.2
  • 21
    • 34250814515 scopus 로고    scopus 로고
    • Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
    • Ravnskjaer K, Kester H, Liu Y, et al. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 2007;26(12):2880-2889.
    • (2007) EMBO J. , vol.26 , Issue.12 , pp. 2880-2889
    • Ravnskjaer, K.1    Kester, H.2    Liu, Y.3
  • 22
    • 67650462947 scopus 로고    scopus 로고
    • Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women
    • Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR, Simpson ER. Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. Cancer Res. 2009;69(13):5392-5399.
    • (2009) Cancer Res. , vol.69 , Issue.13 , pp. 5392-5399
    • Brown, K.A.1    McInnes, K.J.2    Hunger, N.I.3    Oakhill, J.S.4    Steinberg, G.R.5    Simpson, E.R.6
  • 23
    • 33847234345 scopus 로고    scopus 로고
    • Effects of metformin on bovine granulosa cells steroidogenesis: Possible involvement of adenosine 5α monophosphate-activated protein kinase (AMPK)
    • Tosca L, Chabrolle C, Uzbekova S, Dupont J. Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5α monophosphate-activated protein kinase (AMPK). Biol Reprod. 2007;76(3):368-378.
    • (2007) Biol Reprod. , vol.76 , Issue.3 , pp. 368-378
    • Tosca, L.1    Chabrolle, C.2    Uzbekova, S.3    Dupont, J.4
  • 24
    • 0028323555 scopus 로고
    • Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro
    • Ryan IP, Schriock ED, Taylor RN. Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. J Clin Endocrinol Metab. 1994;78(3):642-649.
    • (1994) J Clin Endocrinol Metab. , vol.78 , Issue.3 , pp. 642-649
    • Ryan, I.P.1    Schriock, E.D.2    Taylor, R.N.3
  • 25
    • 0032789150 scopus 로고    scopus 로고
    • Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes
    • Wiernsperger NF. Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes. Diabetes Metab. 1999;25(2):110-127.
    • (1999) Diabetes Metab. , vol.25 , Issue.2 , pp. 110-127
    • Wiernsperger, N.F.1
  • 26
    • 79551489371 scopus 로고    scopus 로고
    • Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
    • Kim HG, Hien TT, Han EH, et al. Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation. Br J Pharmacol. 2011;162(5):1096-1108.
    • (2011) Br J Pharmacol. , vol.162 , Issue.5 , pp. 1096-1108
    • Kim, H.G.1    Hien, T.T.2    Han, E.H.3
  • 27
    • 81755184076 scopus 로고    scopus 로고
    • Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression
    • Jung JW, Park SB, Lee SJ, Seo MS, Trosko JE, Kang KS. Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One. 2011;6(11):e28068.
    • (2011) PLoS One. , vol.6 , Issue.11
    • Jung, J.W.1    Park, S.B.2    Lee, S.J.3    Seo, M.S.4    Trosko, J.E.5    Kang, K.S.6
  • 28
    • 84155184239 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300
    • Lim JY, Oh MA, Kim WH, Sohn HY, Park SI. AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. J Cell Physiol. 2012;227(3):1081- 1089.
    • (2012) J Cell Physiol. , vol.227 , Issue.3 , pp. 1081-1089
    • Lim, J.Y.1    Oh, M.A.2    Kim, W.H.3    Sohn, H.Y.4    Park, S.I.5
  • 29
    • 34547764908 scopus 로고    scopus 로고
    • Metformin suppresses interleukin (IL)-1β-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells
    • Takemura Y, Osuga Y, Yoshino O, et al. Metformin suppresses interleukin (IL)-1β-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells. J Clin Endocrinol Metab. 2007;92(8):3213-3218.
    • (2007) J Clin Endocrinol Metab. , vol.92 , Issue.8 , pp. 3213-3218
    • Takemura, Y.1    Osuga, Y.2    Yoshino, O.3
  • 30
    • 79953644936 scopus 로고    scopus 로고
    • Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin( mTOR)in endometrial cancer cells
    • Xie Y, Wang YL, Yu L, et al. Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin( mTOR)in endometrial cancer cells. J Steroid Biochem Mol Biol. 2011;126(3-5):113-120.
    • (2011) J Steroid Biochem Mol Biol. , vol.126 , Issue.3-5 , pp. 113-120
    • Xie, Y.1    Wang, Y.L.2    Yu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.